ATE518140T1 - Stabilisierung von strukturell uneindeutiger helix zur vorbeugung von amyloidbildung - Google Patents

Stabilisierung von strukturell uneindeutiger helix zur vorbeugung von amyloidbildung

Info

Publication number
ATE518140T1
ATE518140T1 AT01996742T AT01996742T ATE518140T1 AT E518140 T1 ATE518140 T1 AT E518140T1 AT 01996742 T AT01996742 T AT 01996742T AT 01996742 T AT01996742 T AT 01996742T AT E518140 T1 ATE518140 T1 AT E518140T1
Authority
AT
Austria
Prior art keywords
helix
stabilization
amyloid formation
prevent amyloid
methods
Prior art date
Application number
AT01996742T
Other languages
English (en)
Inventor
Jan Johansson
Original Assignee
Alphabeta Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphabeta Ab filed Critical Alphabeta Ab
Application granted granted Critical
Publication of ATE518140T1 publication Critical patent/ATE518140T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
AT01996742T 2000-11-20 2001-11-20 Stabilisierung von strukturell uneindeutiger helix zur vorbeugung von amyloidbildung ATE518140T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25369500P 2000-11-20 2000-11-20
US25166200P 2000-12-06 2000-12-06
PCT/GB2001/005117 WO2002041002A2 (en) 2000-11-20 2001-11-20 Discordant helix stabilization for prevention of amyloid formation

Publications (1)

Publication Number Publication Date
ATE518140T1 true ATE518140T1 (de) 2011-08-15

Family

ID=26941745

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01996742T ATE518140T1 (de) 2000-11-20 2001-11-20 Stabilisierung von strukturell uneindeutiger helix zur vorbeugung von amyloidbildung

Country Status (6)

Country Link
US (4) US6716589B2 (de)
EP (1) EP1337855B1 (de)
AT (1) ATE518140T1 (de)
AU (1) AU2002223843A1 (de)
CA (1) CA2429180C (de)
WO (1) WO2002041002A2 (de)

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* Cited by examiner, † Cited by third party
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AU2003297312B2 (en) * 2002-09-12 2008-08-21 Universiteit Gent A method for the identification of drug targets
AU2006217544B8 (en) * 2005-02-28 2012-04-05 Alphabeta Ab Compounds for reducing aggregation of amyloid beta-peptide
US9801865B2 (en) * 2008-09-24 2017-10-31 The United States Of America As Represented By The Department Of Veteran Affairs Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation
WO2010087771A1 (en) 2009-01-30 2010-08-05 Alphabeta Ab Compound and method for treatment of alzheimer's disease
WO2011162655A1 (en) 2010-06-24 2011-12-29 Alphabeta Ab Compound and method for treatment of alzheimer's disease and familial dementia
US9522170B2 (en) 2011-04-05 2016-12-20 Alphabeta Ab Methods of screening compounds for the fibril formation of Aβ peptides based on a decreased trimer/monomer ratio of a chaperone protein
WO2018150276A2 (en) 2017-02-16 2018-08-23 Universidad San Sebastian The combination of cotinine plus antioxidant for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other neuropathological conditions
EP3635398A1 (de) * 2017-06-08 2020-04-15 Institut National de la Sante et de la Recherche Medicale (INSERM) Chimärer rezeptor zur verwendung in ganzzelligen sensoren zur detektion von analyten von interesse

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Also Published As

Publication number Publication date
US9580460B2 (en) 2017-02-28
EP1337855A2 (de) 2003-08-27
US20140187747A1 (en) 2014-07-03
AU2002223843A1 (en) 2002-05-27
US20020143105A1 (en) 2002-10-03
EP1337855B1 (de) 2011-07-27
WO2002041002A2 (en) 2002-05-23
US6716589B2 (en) 2004-04-06
US20100130431A1 (en) 2010-05-27
WO2002041002A3 (en) 2003-05-15
CA2429180A1 (en) 2002-05-23
CA2429180C (en) 2013-08-20
US20050059084A1 (en) 2005-03-17

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