AU2002223843A1 - Discordant helix stabilization for prevention of amyloid formation - Google Patents
Discordant helix stabilization for prevention of amyloid formationInfo
- Publication number
- AU2002223843A1 AU2002223843A1 AU2002223843A AU2384302A AU2002223843A1 AU 2002223843 A1 AU2002223843 A1 AU 2002223843A1 AU 2002223843 A AU2002223843 A AU 2002223843A AU 2384302 A AU2384302 A AU 2384302A AU 2002223843 A1 AU2002223843 A1 AU 2002223843A1
- Authority
- AU
- Australia
- Prior art keywords
- discordant
- prevention
- amyloid formation
- discordant helix
- helix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Abstract
The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compounds that stabilize the α-helix of a discordant helix-containing polypeptide. Compounds discovered using these methods are useful for treating or preventing disorders in which amyloid is produced. Such disorders include Alzheimer's disease and prion-associated disorders.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25369500P | 2000-11-20 | 2000-11-20 | |
US60/253,695 | 2000-11-20 | ||
US25166200P | 2000-12-06 | 2000-12-06 | |
US60/251,662 | 2000-12-06 | ||
PCT/GB2001/005117 WO2002041002A2 (en) | 2000-11-20 | 2001-11-20 | Discordant helix stabilization for prevention of amyloid formation |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002223843A1 true AU2002223843A1 (en) | 2002-05-27 |
Family
ID=26941745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002223843A Abandoned AU2002223843A1 (en) | 2000-11-20 | 2001-11-20 | Discordant helix stabilization for prevention of amyloid formation |
Country Status (6)
Country | Link |
---|---|
US (4) | US6716589B2 (en) |
EP (1) | EP1337855B1 (en) |
AT (1) | ATE518140T1 (en) |
AU (1) | AU2002223843A1 (en) |
CA (1) | CA2429180C (en) |
WO (1) | WO2002041002A2 (en) |
Families Citing this family (8)
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DK1537421T3 (en) * | 2002-09-12 | 2008-03-31 | Vlaams Interuniv Inst Biotech | A method for identifying drug targets |
EP1858912B1 (en) * | 2005-02-28 | 2012-04-11 | Alphabeta AB | Compounds for reducing aggregation of amyloid beta-peptide |
US9801865B2 (en) * | 2008-09-24 | 2017-10-31 | The United States Of America As Represented By The Department Of Veteran Affairs | Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation |
JP5801206B2 (en) | 2009-01-30 | 2015-10-28 | アルファベータ・エービーAlphaBeta AB | Compounds and methods for the treatment of Alzheimer's disease |
WO2011162655A1 (en) | 2010-06-24 | 2011-12-29 | Alphabeta Ab | Compound and method for treatment of alzheimer's disease and familial dementia |
JP6227523B2 (en) | 2011-04-05 | 2017-11-08 | アルファベータ・エービーAlphaBeta AB | Amyrodosis targets useful in therapeutic methods and for compound screening |
US11260050B2 (en) | 2017-02-16 | 2022-03-01 | United States Government As Represented By The Department Of Veterans Affairs | Combination of cotinine plus antioxidant for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other neuropathological |
EP3635398A1 (en) * | 2017-06-08 | 2020-04-15 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Chimeric receptor for use in whole-cell sensors for detecting analytes of interest |
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-
2001
- 2001-11-19 US US09/988,842 patent/US6716589B2/en not_active Expired - Fee Related
- 2001-11-20 CA CA2429180A patent/CA2429180C/en not_active Expired - Fee Related
- 2001-11-20 AU AU2002223843A patent/AU2002223843A1/en not_active Abandoned
- 2001-11-20 AT AT01996742T patent/ATE518140T1/en not_active IP Right Cessation
- 2001-11-20 WO PCT/GB2001/005117 patent/WO2002041002A2/en not_active Application Discontinuation
- 2001-11-20 EP EP01996742A patent/EP1337855B1/en not_active Expired - Lifetime
-
2004
- 2004-02-04 US US10/772,230 patent/US20050059084A1/en not_active Abandoned
-
2008
- 2008-02-13 US US12/030,481 patent/US20100130431A1/en not_active Abandoned
-
2013
- 2013-11-08 US US14/074,895 patent/US9580460B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US9580460B2 (en) | 2017-02-28 |
ATE518140T1 (en) | 2011-08-15 |
EP1337855A2 (en) | 2003-08-27 |
WO2002041002A3 (en) | 2003-05-15 |
US20140187747A1 (en) | 2014-07-03 |
CA2429180C (en) | 2013-08-20 |
US20050059084A1 (en) | 2005-03-17 |
EP1337855B1 (en) | 2011-07-27 |
US20100130431A1 (en) | 2010-05-27 |
CA2429180A1 (en) | 2002-05-23 |
WO2002041002A2 (en) | 2002-05-23 |
US20020143105A1 (en) | 2002-10-03 |
US6716589B2 (en) | 2004-04-06 |
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