ATE435031T1 - Methode und zusammensetzung zur angiogenese- inhibierung mit antagonisten gegen mmp-9 und beta1-integrine - Google Patents

Methode und zusammensetzung zur angiogenese- inhibierung mit antagonisten gegen mmp-9 und beta1-integrine

Info

Publication number
ATE435031T1
ATE435031T1 AT00950330T AT00950330T ATE435031T1 AT E435031 T1 ATE435031 T1 AT E435031T1 AT 00950330 T AT00950330 T AT 00950330T AT 00950330 T AT00950330 T AT 00950330T AT E435031 T1 ATE435031 T1 AT E435031T1
Authority
AT
Austria
Prior art keywords
antagonists
composition
mmp
beta1 integrins
protein
Prior art date
Application number
AT00950330T
Other languages
English (en)
Inventor
Peter Brooks
Loubna Hassanieh
Dorothy Rodriguez
Original Assignee
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Application granted granted Critical
Publication of ATE435031T1 publication Critical patent/ATE435031T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
AT00950330T 1999-07-13 2000-07-13 Methode und zusammensetzung zur angiogenese- inhibierung mit antagonisten gegen mmp-9 und beta1-integrine ATE435031T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14358199P 1999-07-13 1999-07-13
US15249599P 1999-09-02 1999-09-02
PCT/US2000/019095 WO2001004157A2 (en) 1999-07-13 2000-07-13 NOVEL METHOD AND COMPOSITION FOR INHIBITION OF ANGIOGENESIS USING ANTAGONISTS BASED ON MMP-9 AND β1 INTEGRINS

Publications (1)

Publication Number Publication Date
ATE435031T1 true ATE435031T1 (de) 2009-07-15

Family

ID=26841194

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00950330T ATE435031T1 (de) 1999-07-13 2000-07-13 Methode und zusammensetzung zur angiogenese- inhibierung mit antagonisten gegen mmp-9 und beta1-integrine

Country Status (10)

Country Link
US (1) US7566449B2 (de)
EP (1) EP1203025B1 (de)
JP (1) JP2003508352A (de)
CN (1) CN1379685A (de)
AT (1) ATE435031T1 (de)
AU (1) AU783019B2 (de)
CA (1) CA2379373A1 (de)
DE (1) DE60042487D1 (de)
ES (1) ES2327812T3 (de)
WO (1) WO2001004157A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004110478A1 (en) * 2003-06-19 2004-12-23 Ctt Cancer Targeting Technologies Oy Inhibitors of cell migration
US7390885B2 (en) 2001-11-26 2008-06-24 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7365167B2 (en) 2001-11-26 2008-04-29 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US20090131303A1 (en) * 2007-11-16 2009-05-21 Bor-Shyue Hong Methods and compositions for treating dry eye
JP2011506614A (ja) 2007-12-17 2011-03-03 ダイアックス コーポレーション Ｍｍｐ−１４結合タンパク質を含む、骨溶解性障害を処置するための組成物および方法
US8039596B2 (en) 2008-02-05 2011-10-18 Bristol-Myers Squibb Company Alpha 5-beta 1 antibodies and their uses
US8013125B2 (en) 2008-03-03 2011-09-06 Dyax Corp. Metalloproteinase 9 and metalloproteinase 2 binding proteins
US8008445B2 (en) * 2008-03-03 2011-08-30 Dyax Corp. Metalloproteinase 9 binding proteins
WO2011028883A2 (en) * 2009-09-03 2011-03-10 Dyax Corp. Metalloproteinase 9 and metalloproteinase 2 binding proteins
KR101930179B1 (ko) 2010-08-27 2018-12-17 길리아드 바이오로직스, 인크. 매트릭스 메탈로프로테이나제 ９에 대한 항체
WO2013059439A2 (en) 2011-10-21 2013-04-25 Dyax Corp. Combination therapy comprising an mmp-14 binding protein
CA2865530C (en) 2012-02-29 2019-02-19 Gilead Biologics, Inc. Antibodies to matrix metalloproteinase 9
EP2819697A4 (de) 2012-02-29 2016-03-09 Gilead Biologics Inc Antikörper gegen matrix-metalloproteinase-9

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320970A (en) 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP3105629B2 (ja) 1991-04-23 2000-11-06 サングスタット メディカル コーポレイション 特異的結合ペアのメンバーの細胞活性調節接合体
WO1995004282A1 (de) 1993-07-28 1995-02-09 Boehringer Mannheim Gmbh Immunoassay zum nachweis von kollagen oder kollagenfragmenten
WO1994014070A1 (en) 1992-12-04 1994-06-23 Shriners Hospitals For Crippled Children Immunoassay for the measurement of collagen cleavage in cartilage
US6132976A (en) 1992-12-04 2000-10-17 Shriners Hospitals For Children Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
US5541295A (en) 1993-02-12 1996-07-30 The Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations Detection of type II collagen and its peptides
US5981478A (en) * 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
US5763272A (en) 1994-12-23 1998-06-09 Boehringer Mannheim Gmbh Hybridoma for producing antibody for collagen I
AU3304597A (en) 1996-05-23 1997-12-09 Shriners Hospital For Children Cartilage type ii collagen as an angiogenic factor
US6492508B1 (en) 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
GB9702252D0 (en) 1997-02-06 1997-03-26 Univ Sheffield Medical The Sch Collagen assay
JP2001512143A (ja) 1997-07-31 2001-08-21 メトラ バイオシステムズ， インコーポレイテッド コラーゲン−ペプチドアッセイ法
US6030792A (en) 1997-11-13 2000-02-29 Pfizer Inc Assays for measurement of protein fragments in biological media
EP2327451B1 (de) * 1998-05-08 2013-10-23 The Regents of the University of California Verfahren zur Detektion und Hemmung von Angiogenese
US7101975B1 (en) * 1999-07-13 2006-09-05 University Of Southern California Method and composition for inhibition of angiogenesis using antagonists based on MMP-9 and β1 integrins

Also Published As

Publication number Publication date
EP1203025A2 (de) 2002-05-08
US7566449B2 (en) 2009-07-28
ES2327812T3 (es) 2009-11-04
WO2001004157A9 (en) 2002-07-25
CN1379685A (zh) 2002-11-13
DE60042487D1 (de) 2009-08-13
US20060062777A1 (en) 2006-03-23
JP2003508352A (ja) 2003-03-04
WO2001004157A2 (en) 2001-01-18
AU6344700A (en) 2001-01-30
EP1203025B1 (de) 2009-07-01
CA2379373A1 (en) 2001-01-18
AU783019B2 (en) 2005-09-15
WO2001004157A3 (en) 2001-05-17

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