ATE515704T1 - Verfahren zum nachweis von antikörpern aus körperflüssigkeiten durch eine immunreaktion mit glykoprotein 2 (gp2) aus zymogenen granula des pankreas zur differentialdiagnose von entzündlichen darmerkrankungen und chronischer pankreatitis - Google Patents
Verfahren zum nachweis von antikörpern aus körperflüssigkeiten durch eine immunreaktion mit glykoprotein 2 (gp2) aus zymogenen granula des pankreas zur differentialdiagnose von entzündlichen darmerkrankungen und chronischer pankreatitisInfo
- Publication number
- ATE515704T1 ATE515704T1 AT08706848T AT08706848T ATE515704T1 AT E515704 T1 ATE515704 T1 AT E515704T1 AT 08706848 T AT08706848 T AT 08706848T AT 08706848 T AT08706848 T AT 08706848T AT E515704 T1 ATE515704 T1 AT E515704T1
- Authority
- AT
- Austria
- Prior art keywords
- glycoprotein
- pancreas
- immune reaction
- body fluid
- inflammatory bowel
- Prior art date
Links
- 210000001124 body fluid Anatomy 0.000 title abstract 2
- 239000010839 body fluid Substances 0.000 title abstract 2
- 239000008187 granular material Substances 0.000 title abstract 2
- 230000008105 immune reaction Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000003462 zymogenic effect Effects 0.000 title abstract 2
- 101000904196 Homo sapiens Pancreatic secretory granule membrane major glycoprotein GP2 Proteins 0.000 title 2
- 102100024019 Pancreatic secretory granule membrane major glycoprotein GP2 Human genes 0.000 title 2
- 208000000668 Chronic Pancreatitis Diseases 0.000 title 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 title 1
- 206010033649 Pancreatitis chronic Diseases 0.000 title 1
- 238000003748 differential diagnosis Methods 0.000 title 1
- 210000000496 pancreas Anatomy 0.000 title 1
- 238000001514 detection method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4733—Acute pancreatitis-associated protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/067—Pancreatitis or colitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Rehabilitation Therapy (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Developmental Biology & Embryology (AREA)
- Marine Sciences & Fisheries (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE200710004909 DE102007004909A1 (de) | 2007-01-26 | 2007-01-26 | Verfahren zum Nachweis von Antikörpern aus Körperflüssigkeiten durch eine Immunreaktion mit Glykoprotein 2(GP2) aus zymogenen Granula des Pankreas zur Differentialdiagnose von entzündlichen Darmerkrankungen und chronischer Pankreatitis |
| EP07090010A EP1950222A1 (de) | 2007-01-26 | 2007-01-26 | Verfahren zum Nachweis von Antikörpern aus Körperflüssigkeiten durch eine Immunreaktion mit Glykoprotein 2 (GP2) aus zymogenen Granula des Pankreas zur Differentialdiagnose von entzündlichen Darmerkrankungen und chronischer Pankreatitis |
| PCT/DE2008/000183 WO2008089756A2 (de) | 2007-01-26 | 2008-01-28 | Verfahren zum nachweis von antikörpern aus körperflüssigkeiten durch eine immunreaktion mit glykoprotein 2 (gp2) aus zymogenen granula des pankreas zur differentialdiagnose von entzündlichen darmerkrankungen und chronischer pankreatitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE515704T1 true ATE515704T1 (de) | 2011-07-15 |
Family
ID=39644915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08706848T ATE515704T1 (de) | 2007-01-26 | 2008-01-28 | Verfahren zum nachweis von antikörpern aus körperflüssigkeiten durch eine immunreaktion mit glykoprotein 2 (gp2) aus zymogenen granula des pankreas zur differentialdiagnose von entzündlichen darmerkrankungen und chronischer pankreatitis |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8058019B2 (enExample) |
| EP (1) | EP2126582B1 (enExample) |
| JP (1) | JP5603083B2 (enExample) |
| KR (1) | KR101283710B1 (enExample) |
| CN (1) | CN101611320B (enExample) |
| AT (1) | ATE515704T1 (enExample) |
| AU (1) | AU2008209176B2 (enExample) |
| CA (1) | CA2674021C (enExample) |
| DK (1) | DK2126582T3 (enExample) |
| ES (1) | ES2369544T3 (enExample) |
| PL (1) | PL2126582T3 (enExample) |
| PT (1) | PT2126582E (enExample) |
| WO (1) | WO2008089756A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7195759B2 (en) * | 2001-06-06 | 2007-03-27 | The University Of Manitoba | Therapeutic uses of glandular kallikrein |
| GB0905076D0 (en) * | 2009-03-24 | 2009-05-06 | Total Scient Ltd | Diagnostic kits and methods |
| WO2011082416A2 (en) * | 2010-01-04 | 2011-07-07 | Mayo Foundation For Medical Education And Research | Peripherin-specific autoantibodies as a marker for neurological and endocrinological disease |
| WO2013173923A1 (en) | 2012-05-25 | 2013-11-28 | Diamedica, Inc. | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
| CA2880085C (en) | 2012-06-04 | 2021-09-07 | Diamedica Inc. | Human tissue kallikrein 1 glycosylation isoforms |
| ES2790577T3 (es) | 2014-02-28 | 2020-10-28 | Ga Generic Assays Gmbh | Isoformas de GP2 y su uso en la captura de autoanticuerpos |
| US11340235B2 (en) * | 2014-02-28 | 2022-05-24 | Ga Generic Assays Gmbh | GP2 isoforms and their use in autoantibody capture |
| EP3299818B1 (en) * | 2016-09-26 | 2019-12-04 | GA Generic Assays GmbH | Method for the diagnosis of acute pancreatitis (ap) by detection of glycoprotein 2 isoform alpha (gp2a) |
| EP3523657B1 (en) * | 2016-10-04 | 2023-06-21 | F. Hoffmann-La Roche AG | System and method for identification of a synthetic classifier |
| US11857608B2 (en) | 2017-03-09 | 2024-01-02 | Diamedica Inc. | Dosage forms of tissue kallikrein 1 |
| EP3477300A1 (de) * | 2017-10-25 | 2019-05-01 | Euroimmun Medizinische Labordiagnostika AG | Zellulose-basierter immunadsorber |
| EP4034137A4 (en) * | 2019-09-27 | 2023-09-20 | Duke University | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF PANCREATITIS |
| CN110806485A (zh) * | 2019-11-12 | 2020-02-18 | 广州医科大学附属第二医院 | 一种胶质纤维酸性蛋白抗体检测试剂盒及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663315A (en) | 1994-12-06 | 1997-09-02 | Alphagene, Inc. | Isolated DNA encoding human GP2 |
| DE19630557C2 (de) * | 1996-07-18 | 1998-07-02 | Schuppan Detlef Priv Doz Dr Dr | Verfahren zum Nachweis von Antikörpern aus Körperflüssigkeiten durch eine Immunreaktion mit Gewebe-Transglutaminase (tTG) sowie die Verwendung von tTG in Diagnose und Therapie |
| US6100098A (en) * | 1997-02-18 | 2000-08-08 | Mcgill University | Anti-AGE IgG and uses thereof for the diagnosis of severe disease |
| US20020082207A1 (en) * | 2000-06-07 | 2002-06-27 | Hirst Shannon K. | Compositions and methods for the therapy and diagnosis of pancreatic cancer |
| JP2004005319A (ja) | 2002-04-24 | 2004-01-08 | Japan Science & Technology Corp | 遺伝子データベース作成方法、遺伝子データベース作成装置、遺伝子データベース作成プログラム、および遺伝子データベース作成プログラムを記録したコンピュータ読み取り可能な記録媒体 |
| US20070275422A1 (en) | 2004-07-26 | 2007-11-29 | The Board Of Trustees Of The Leland Stanford Jr. U | Methods and Compositions for Detecting Pancreatic Disease |
-
2008
- 2008-01-28 PL PL08706848T patent/PL2126582T3/pl unknown
- 2008-01-28 AU AU2008209176A patent/AU2008209176B2/en active Active
- 2008-01-28 CN CN2008800030495A patent/CN101611320B/zh active Active
- 2008-01-28 CA CA2674021A patent/CA2674021C/en active Active
- 2008-01-28 JP JP2009546652A patent/JP5603083B2/ja active Active
- 2008-01-28 WO PCT/DE2008/000183 patent/WO2008089756A2/de not_active Ceased
- 2008-01-28 ES ES08706848T patent/ES2369544T3/es active Active
- 2008-01-28 EP EP08706848A patent/EP2126582B1/de active Active
- 2008-01-28 KR KR1020097014809A patent/KR101283710B1/ko active Active
- 2008-01-28 PT PT08706848T patent/PT2126582E/pt unknown
- 2008-01-28 DK DK08706848.2T patent/DK2126582T3/da active
- 2008-01-28 US US12/523,997 patent/US8058019B2/en active Active
- 2008-01-28 AT AT08706848T patent/ATE515704T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101611320B (zh) | 2013-11-06 |
| AU2008209176B2 (en) | 2013-01-31 |
| CA2674021A1 (en) | 2008-07-31 |
| ES2369544T3 (es) | 2011-12-01 |
| PT2126582E (pt) | 2011-10-11 |
| WO2008089756A2 (de) | 2008-07-31 |
| US8058019B2 (en) | 2011-11-15 |
| AU2008209176A2 (en) | 2009-09-10 |
| KR101283710B1 (ko) | 2013-07-15 |
| EP2126582A2 (de) | 2009-12-02 |
| DK2126582T3 (da) | 2011-10-10 |
| PL2126582T3 (pl) | 2011-12-30 |
| WO2008089756A3 (de) | 2008-10-16 |
| US20100184662A1 (en) | 2010-07-22 |
| JP2010519180A (ja) | 2010-06-03 |
| JP5603083B2 (ja) | 2014-10-08 |
| CA2674021C (en) | 2018-10-16 |
| EP2126582B1 (de) | 2011-07-06 |
| AU2008209176A1 (en) | 2008-07-31 |
| KR20090107034A (ko) | 2009-10-12 |
| CN101611320A (zh) | 2009-12-23 |
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