ATE512139T1 - Wasserlösliche phenylpyridazinderivate und diese enthaltende arzneimittel - Google Patents
Wasserlösliche phenylpyridazinderivate und diese enthaltende arzneimittelInfo
- Publication number
- ATE512139T1 ATE512139T1 AT02768055T AT02768055T ATE512139T1 AT E512139 T1 ATE512139 T1 AT E512139T1 AT 02768055 T AT02768055 T AT 02768055T AT 02768055 T AT02768055 T AT 02768055T AT E512139 T1 ATE512139 T1 AT E512139T1
- Authority
- AT
- Austria
- Prior art keywords
- water
- alkyl
- products containing
- containing same
- medicinal products
- Prior art date
Links
- XWSSUYOEOWLFEI-UHFFFAOYSA-N 3-phenylpyridazine Chemical class C1=CC=CC=C1C1=CC=CN=N1 XWSSUYOEOWLFEI-UHFFFAOYSA-N 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004990 dihydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000019189 interleukin-1 beta production Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32456901P | 2001-09-26 | 2001-09-26 | |
| PCT/JP2002/009863 WO2003027077A1 (fr) | 2001-09-26 | 2002-09-25 | Derives de phenylpyridazine solubles dans l'eau et medicaments contenant ceux-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE512139T1 true ATE512139T1 (de) | 2011-06-15 |
Family
ID=23264178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02768055T ATE512139T1 (de) | 2001-09-26 | 2002-09-25 | Wasserlösliche phenylpyridazinderivate und diese enthaltende arzneimittel |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6869954B2 (de) |
| EP (1) | EP1431293B1 (de) |
| JP (1) | JP4280165B2 (de) |
| KR (1) | KR20040039377A (de) |
| CN (1) | CN1304379C (de) |
| AT (1) | ATE512139T1 (de) |
| AU (1) | AU2002332286B2 (de) |
| BR (1) | BR0212848A (de) |
| CA (1) | CA2461806A1 (de) |
| HK (1) | HK1070068A1 (de) |
| HU (1) | HUP0402149A3 (de) |
| MX (1) | MXPA04002939A (de) |
| NO (1) | NO327425B1 (de) |
| NZ (1) | NZ531982A (de) |
| PL (1) | PL368340A1 (de) |
| RU (1) | RU2302413C2 (de) |
| WO (1) | WO2003027077A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078751A1 (ja) * | 2003-03-07 | 2004-09-16 | Kowa Co., Ltd. | ベンゾフラン誘導体 |
| KR20050113627A (ko) * | 2003-03-18 | 2005-12-02 | 코와 가부시키가이샤 | 수용성 페닐피리다진 유도체 및 이를 함유하는 의약 |
| WO2021124346A1 (en) * | 2019-12-18 | 2021-06-24 | Abida / | Novel 4-(6-oxo-3-substituted phenylpyridazin-1(6 h)-yl)benzaldehydes of pharmaceutical interest |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4404203A (en) * | 1981-05-14 | 1983-09-13 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| ES2324126T3 (es) | 1997-11-19 | 2009-07-30 | Kowa Co., Ltd. | Derivados de piridazina y medicamentos que los contienen como ingrediente activo. |
| TWI241295B (en) * | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| JP2000247959A (ja) | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−３−オン誘導体及びこれを含有する医薬 |
| US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
| EP1319659B1 (de) * | 2000-09-18 | 2009-03-11 | Eisai R&D Management Co., Ltd. | Triazinone sowie deren medizinale anwendung |
| US6861428B2 (en) | 2001-09-26 | 2005-03-01 | Kowa Co., Ltd. | Water-soluble phenylpyridazine compounds and compositions containing the same |
-
2002
- 2002-09-25 RU RU2004112532/04A patent/RU2302413C2/ru not_active IP Right Cessation
- 2002-09-25 PL PL02368340A patent/PL368340A1/xx not_active Application Discontinuation
- 2002-09-25 NZ NZ531982A patent/NZ531982A/en not_active IP Right Cessation
- 2002-09-25 BR BR0212848-9A patent/BR0212848A/pt not_active IP Right Cessation
- 2002-09-25 KR KR10-2004-7003995A patent/KR20040039377A/ko not_active Application Discontinuation
- 2002-09-25 HU HU0402149A patent/HUP0402149A3/hu unknown
- 2002-09-25 AT AT02768055T patent/ATE512139T1/de not_active IP Right Cessation
- 2002-09-25 MX MXPA04002939A patent/MXPA04002939A/es active IP Right Grant
- 2002-09-25 US US10/253,523 patent/US6869954B2/en not_active Expired - Fee Related
- 2002-09-25 JP JP2003530668A patent/JP4280165B2/ja not_active Expired - Lifetime
- 2002-09-25 EP EP02768055A patent/EP1431293B1/de not_active Expired - Lifetime
- 2002-09-25 WO PCT/JP2002/009863 patent/WO2003027077A1/ja active IP Right Grant
- 2002-09-25 CN CNB02818940XA patent/CN1304379C/zh not_active Expired - Fee Related
- 2002-09-25 CA CA002461806A patent/CA2461806A1/en not_active Abandoned
- 2002-09-25 AU AU2002332286A patent/AU2002332286B2/en not_active Ceased
-
2004
- 2004-03-25 NO NO20041250A patent/NO327425B1/no not_active IP Right Cessation
- 2004-10-12 US US10/960,993 patent/US7087606B2/en not_active Expired - Fee Related
-
2005
- 2005-04-04 HK HK05102797A patent/HK1070068A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1304379C (zh) | 2007-03-14 |
| HK1070068A1 (en) | 2005-06-10 |
| HUP0402149A2 (hu) | 2005-02-28 |
| RU2004112532A (ru) | 2005-03-27 |
| RU2302413C2 (ru) | 2007-07-10 |
| PL368340A1 (en) | 2005-03-21 |
| EP1431293B1 (de) | 2011-06-08 |
| KR20040039377A (ko) | 2004-05-10 |
| WO2003027077A1 (fr) | 2003-04-03 |
| US20050085480A1 (en) | 2005-04-21 |
| HUP0402149A3 (en) | 2005-08-29 |
| AU2002332286B2 (en) | 2007-10-18 |
| JP4280165B2 (ja) | 2009-06-17 |
| NO20041250L (no) | 2004-03-25 |
| US20030119838A1 (en) | 2003-06-26 |
| EP1431293A1 (de) | 2004-06-23 |
| CA2461806A1 (en) | 2003-04-03 |
| CN1558903A (zh) | 2004-12-29 |
| US7087606B2 (en) | 2006-08-08 |
| JPWO2003027077A1 (ja) | 2005-01-06 |
| BR0212848A (pt) | 2004-08-17 |
| MXPA04002939A (es) | 2004-06-18 |
| NZ531982A (en) | 2005-08-26 |
| US6869954B2 (en) | 2005-03-22 |
| EP1431293A4 (de) | 2004-12-22 |
| NO327425B1 (no) | 2009-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20015172L (no) | 1-metyl-erytromycin-derivater | |
| DE60006216D1 (de) | Chinolinderivate und chinazolinderivate | |
| HUP0204245A2 (hu) | Új N-aza-biciklo-amid-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| PL396946A1 (pl) | Pochodne pirazolu i kompozycje farmaceutyczne zawierające je oraz ich zastosowanie do leczenia HIV | |
| MXPA04000577A (es) | Derivados de dolastatina 10. | |
| SG128491A1 (en) | Heterocyclic sulfonamide inhibitors of beta amyloid production | |
| DK1029853T3 (da) | Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler | |
| WO2002051819A3 (en) | Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them | |
| ATE370735T1 (de) | Phenylpyridazinderivate und diese enthaltende arzneimittel | |
| ATE233754T1 (de) | Diphenyl-piperidin derivate | |
| PT992509E (pt) | Novos derivados macrolidos | |
| MXPA02004441A (es) | Derivados de isoxazol como inhibidores de la fosfodiesterasa. | |
| HK1070068A1 (en) | Water-soluble phenylpyridazine derivatives and drugs containing the same | |
| DK0982305T3 (da) | Indan-1-ol-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende derivaterne | |
| ES2124413T3 (es) | Derivados de piridazinona con actividad farmaceutica. | |
| NZ543068A (en) | Substituted 4-(alkyl-amide)-piperidine derivatives, processes for their preparation, and pharmaceutical compositions containing them | |
| AP2002002595A0 (en) | Heterocyclic amide derivatives. | |
| HUP0002715A2 (hu) | Benzotiofénszármazékok alkalmazása trombocitaszám csökkentésére szolgáló gyógyszerkészítmények előállítására | |
| HUP0303004A2 (hu) | Új [(alkil-fenil)-imino]-imidazolidin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk vizeletinkontinencia kezelésére szolgáló gyógyszerkészítmények előállítására | |
| DK0952157T3 (da) | 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin | |
| ATE241604T1 (de) | Polyhydroxyalkylpyrazine derivate und deren herstellung und diese enthaltende arzneimittel | |
| AP2002002707A0 (en) | 4, 5-Dihydro-Thiazo-2-Ylamine Derivatives and their Use as NO-Synthase Inhibitors. | |
| HUP0202237A2 (hu) | Amin, módosított pszeudomicin vegyületek, azokat tartalmazó gyógyászati készítmény és alkalmazásuk |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |