ATE510021T1 - Verfahren zur oxidation von terpenen - Google Patents

Verfahren zur oxidation von terpenen

Info

Publication number
ATE510021T1
ATE510021T1 AT99956167T AT99956167T ATE510021T1 AT E510021 T1 ATE510021 T1 AT E510021T1 AT 99956167 T AT99956167 T AT 99956167T AT 99956167 T AT99956167 T AT 99956167T AT E510021 T1 ATE510021 T1 AT E510021T1
Authority
AT
Austria
Prior art keywords
sub
mutant
cells
amino acid
oxidizing
Prior art date
Application number
AT99956167T
Other languages
German (de)
English (en)
Inventor
Luet Wong
Stephen Bell
Angus Carmichael
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation filed Critical Isis Innovation
Application granted granted Critical
Publication of ATE510021T1 publication Critical patent/ATE510021T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99956167T 1998-11-19 1999-11-19 Verfahren zur oxidation von terpenen ATE510021T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9825421.2A GB9825421D0 (en) 1998-11-19 1998-11-19 Process for oxidising terpenes
PCT/GB1999/003873 WO2000031273A2 (en) 1998-11-19 1999-11-19 Process for oxidising terpenes

Publications (1)

Publication Number Publication Date
ATE510021T1 true ATE510021T1 (de) 2011-06-15

Family

ID=10842737

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99956167T ATE510021T1 (de) 1998-11-19 1999-11-19 Verfahren zur oxidation von terpenen

Country Status (7)

Country Link
US (1) US7211420B1 (enExample)
EP (1) EP1131440B1 (enExample)
JP (2) JP4886930B2 (enExample)
AT (1) ATE510021T1 (enExample)
AU (1) AU1281900A (enExample)
GB (1) GB9825421D0 (enExample)
WO (1) WO2000031273A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9914373D0 (en) 1999-06-18 1999-08-18 Isis Innovation Process for oxidising aromatic compounds
CA2379518A1 (en) 1999-07-27 2001-02-01 Basf Aktiengesellschaft Electron donor system for enzymes and its use for the biochemical conversion of substrates
MY126592A (en) * 1999-07-27 2006-10-31 Basf Ag Novel cytochrome p450 monooxygenases and their use for the oxidation of organic compounds
GB0002201D0 (en) * 2000-01-31 2000-03-22 Imperial College Process
EP1470219A4 (en) 2001-04-16 2005-10-05 California Inst Of Techn PEROXIDE MOLDED CYTOCHROME OXYGENASE P450 OXYGENASE VARIANTS
WO2003008563A2 (en) 2001-07-20 2003-01-30 California Institute Of Technology Improved cytochrome p450 oxygenases
WO2005017105A2 (en) 2003-06-17 2005-02-24 California University Of Technology Regio- and enantioselective alkane hydroxylation with modified cytochrome p450
DK1660646T3 (en) 2003-08-11 2015-03-09 California Inst Of Techn Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use
US11214817B2 (en) 2005-03-28 2022-01-04 California Institute Of Technology Alkane oxidation by modified hydroxylases
US8715988B2 (en) 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
US8026085B2 (en) 2006-08-04 2011-09-27 California Institute Of Technology Methods and systems for selective fluorination of organic molecules
US8252559B2 (en) 2006-08-04 2012-08-28 The California Institute Of Technology Methods and systems for selective fluorination of organic molecules
WO2008073498A2 (en) * 2006-12-12 2008-06-19 The Regents Of The University Of California Artemisinic epoxide and methods for producing same
US8802401B2 (en) 2007-06-18 2014-08-12 The California Institute Of Technology Methods and compositions for preparation of selectively protected carbohydrates
GB0719620D0 (en) * 2007-10-08 2007-11-14 Isis Innovation Mutant Enzymes
WO2010019489A2 (en) * 2008-08-13 2010-02-18 Salk Institute For Biological Studies Method for making terpene derivatives
WO2013016207A2 (en) 2011-07-22 2013-01-31 California Institute Of Technology Stable fungal cel6 enzyme variants
RU2625224C2 (ru) * 2011-11-01 2017-07-12 Фирмениш Са Цитохром p450 и его применение для энзиматического окисления терпенов
JP6435261B2 (ja) * 2012-08-31 2018-12-05 ノバルティス アーゲー Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓに対する免疫化のための安定化されたタンパク質
KR20160138283A (ko) * 2014-03-31 2016-12-02 베링거잉겔하임베트메디카게엠베하 개선된 모듈러 항원 운반 분자 및 이의 용도
CN107002109A (zh) 2014-08-21 2017-08-01 马努斯生物合成股份有限公司 含氧萜烯的生产方法
EP3297442A4 (en) 2015-05-18 2018-11-07 Zymtronix, LLC Magnetically immobilized microbiocidal enzymes
CN109788762B (zh) 2016-08-13 2023-07-11 齐姆特罗尼克斯催化系统股份有限公司 磁性固定化的杀生物酶和杀生物化学品
WO2018102319A1 (en) * 2016-12-03 2018-06-07 Zymtronix Catalytic Systems, Inc. Magnetically immobilized metabolic enzymes and cofactor systems
EP3858986A1 (en) 2020-02-03 2021-08-04 Bayer Aktiengesellschaft P450 bm3 monooxygenase variants for c19-hydroxylation of steroids

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB334841A (en) 1929-06-04 1930-09-04 John Pinder Theft alarm or signal for use on motor vehicles
DE3629890A1 (de) 1986-08-29 1988-03-10 Schering Ag Mikroorganismen und plasmide fuer die 2,4-dichlorphenoxyessigsaeure (2,4-d)-monooxigenase - bildung und verfahren zur herstellung dieser plasmide und staemme
FR2693207B1 (fr) 1992-07-03 1994-09-30 Orsan Souche de levure permettant la co-expression d'une activité mono-oxygénase de cytochrome P450 hétérologue et d'une NADPH-cytochrome P450-réductase endogène ou hétérologue et son utilisation à des fins de bioconversion.
GB9422205D0 (en) * 1994-11-03 1994-12-21 British Gas Plc Enzyme mutant and method
EP0906431A1 (en) * 1995-11-01 1999-04-07 BG plc MUTANT MONO-OXYGENASE CYTOCHROME P450cam
WO1997016553A1 (en) 1995-11-01 1997-05-09 Bg Plc MUTANT MONO-OXYGENASE CYTOCHROME P450cam
US5763237A (en) 1996-05-21 1998-06-09 Board Of Trustees Operating Michigan State University Method for production of monoterpene derivatives of limonene

Also Published As

Publication number Publication date
EP1131440A2 (en) 2001-09-12
JP2012010707A (ja) 2012-01-19
WO2000031273A3 (en) 2000-08-17
EP1131440B1 (en) 2011-05-18
JP2002530112A (ja) 2002-09-17
AU1281900A (en) 2000-06-13
GB9825421D0 (en) 1999-01-13
JP5611151B2 (ja) 2014-10-22
JP4886930B2 (ja) 2012-02-29
WO2000031273A2 (en) 2000-06-02
US7211420B1 (en) 2007-05-01

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