ATE501262T1 - Einfügen von transgenen in adenovirale vektoren - Google Patents
Einfügen von transgenen in adenovirale vektorenInfo
- Publication number
- ATE501262T1 ATE501262T1 AT05791283T AT05791283T ATE501262T1 AT E501262 T1 ATE501262 T1 AT E501262T1 AT 05791283 T AT05791283 T AT 05791283T AT 05791283 T AT05791283 T AT 05791283T AT E501262 T1 ATE501262 T1 AT E501262T1
- Authority
- AT
- Austria
- Prior art keywords
- sites
- adenoviral vectors
- signals
- transgenes
- processing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
- C12N2840/445—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor for trans-splicing, e.g. polypyrimidine tract, branch point splicing
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Image Processing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Compression, Expansion, Code Conversion, And Decoders (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58980404P | 2004-07-22 | 2004-07-22 | |
US66054205P | 2005-03-11 | 2005-03-11 | |
PCT/US2005/025833 WO2006012393A2 (en) | 2004-07-22 | 2005-07-21 | Addition of transgenes into adenoviral vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE501262T1 true ATE501262T1 (de) | 2011-03-15 |
Family
ID=35786690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05791283T ATE501262T1 (de) | 2004-07-22 | 2005-07-21 | Einfügen von transgenen in adenovirale vektoren |
Country Status (7)
Country | Link |
---|---|
US (1) | US20060292682A1 (de) |
EP (1) | EP1771570B1 (de) |
JP (1) | JP2008507279A (de) |
AT (1) | ATE501262T1 (de) |
CA (1) | CA2574698A1 (de) |
DE (1) | DE602005026814D1 (de) |
WO (1) | WO2006012393A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602004024041D1 (de) | 2003-03-05 | 2009-12-24 | Halozyme Inc | Lösliches hyaluronidase-glycoprotein (shasegp), verfahren zu seiner herstellung, verwendungen und dieses enthaltende pharmazeutische zusammensetzungen |
EP1636360A4 (de) * | 2003-06-03 | 2006-11-08 | Cell Genesys Inc | Zusammensetzungen und verfahren zur verstärkten expression rekombinanter polypeptide von einem vektor unter verwendung einer peptidspaltstelle |
US20050136035A1 (en) * | 2003-06-03 | 2005-06-23 | Derek Ko | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site |
US7632509B2 (en) | 2005-07-19 | 2009-12-15 | Biosante Pharmaceuticals, Inc. | Methods to express recombinant proteins from lentiviral vectors |
US20070292922A1 (en) * | 2006-03-31 | 2007-12-20 | Cell Genesys, Inc. | Regulated expression of recombinant proteins from adeno-associated viral vectors |
EP2268129B1 (de) * | 2008-04-21 | 2015-06-17 | Danziger Innovations Ltd. | Virale expressionsvektoren aus pflanzen und ihre verwendung zur erzeugung genotypischer variationen bei pflanzengenomen |
US9206440B2 (en) | 2009-01-23 | 2015-12-08 | Roger Williams Hospital | Viral vectors encoding multiple highly homologus non-viral polypeptides and the use of same |
ES2385251B1 (es) * | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
KR20120052369A (ko) * | 2009-07-31 | 2012-05-23 | 팍스박스, 인코포레이티드 | 아데노바이러스계 벡터 |
WO2011048600A1 (en) | 2009-10-21 | 2011-04-28 | Danziger Innovations Ltd. | Generating genotypic variations in plant genomes by gamete infection |
WO2012003287A2 (en) * | 2010-06-30 | 2012-01-05 | The Johns Hopkins University | Compositions and methods for detecting and quantifying circulating tumor cells ctcs |
US9540657B2 (en) * | 2012-05-25 | 2017-01-10 | California Institute Of Technology | Expression of secreted and cell-surface polypeptides |
EP2971008B1 (de) | 2013-03-14 | 2018-07-25 | Salk Institute for Biological Studies | Onkolytische adenoviruszusammensetzungen |
GB201322851D0 (en) | 2013-12-23 | 2014-02-12 | Psioxus Therapeutics Ltd | Method |
SG11201602887QA (en) | 2013-10-25 | 2016-05-30 | Psioxus Therapeutics Ltd | Oncolytic adenoviruses armed with heterologous genes |
GB201406608D0 (en) * | 2014-04-12 | 2014-05-28 | Psioxus Therapeutics Ltd | Virus |
GB201415344D0 (en) * | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Protein |
WO2016084084A1 (en) | 2014-11-27 | 2016-06-02 | Danziger Innovations Ltd. | Nucleic acid constructs for genome editing |
CN108396015B (zh) * | 2015-04-30 | 2022-02-18 | 皮斯奥克斯治疗公司 | 编码b7蛋白质的溶瘤腺病毒 |
KR20180107105A (ko) | 2015-12-17 | 2018-10-01 | 싸이오서스 테라퓨틱스 엘티디. | 항-tcr-복합체 항체 또는 단편을 암호화하는 군 b 아데노바이러스 |
KR102471633B1 (ko) | 2016-02-23 | 2022-11-25 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
EP3390428B1 (de) | 2016-02-23 | 2019-09-25 | Salk Institute for Biological Studies | Test mit hohem durchsatz zur messung der adenovirusreplikationskinetik |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
AU2017375633C1 (en) | 2016-12-12 | 2023-04-27 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
NZ759833A (en) * | 2017-05-26 | 2023-01-27 | Epicentrx Inc | Recombinant adenoviruses carrying transgenes |
GB202013834D0 (en) | 2020-09-03 | 2020-10-21 | Valo Therapeutics Oy | PeptiVAX therapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5518913A (en) * | 1991-10-10 | 1996-05-21 | National Research Council Of Canada | High level recombinant protein production using conditional helper-free adenovirus vector |
US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
US7232899B2 (en) * | 1996-09-25 | 2007-06-19 | The Scripps Research Institute | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use |
US20050175589A1 (en) * | 2001-07-13 | 2005-08-11 | Btg International Limited | Anti-neoplastic viral agents |
US20030021768A1 (en) * | 2001-07-23 | 2003-01-30 | Yuqiao Shen | Viral mutants that selectively replicate in targeted human cancer cells |
WO2003072703A2 (en) * | 2002-02-05 | 2003-09-04 | Cornell Research Foundation, Inc. | Adenoviral vector with replication-dependent transgene expression |
US20040213764A1 (en) * | 2003-03-28 | 2004-10-28 | William Wold | Adenovirus replication-competent vectors expressing trail |
-
2005
- 2005-07-15 US US11/181,850 patent/US20060292682A1/en not_active Abandoned
- 2005-07-21 WO PCT/US2005/025833 patent/WO2006012393A2/en active Application Filing
- 2005-07-21 JP JP2007522731A patent/JP2008507279A/ja active Pending
- 2005-07-21 CA CA002574698A patent/CA2574698A1/en not_active Abandoned
- 2005-07-21 EP EP05791283A patent/EP1771570B1/de active Active
- 2005-07-21 DE DE602005026814T patent/DE602005026814D1/de active Active
- 2005-07-21 AT AT05791283T patent/ATE501262T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2006012393A3 (en) | 2006-09-21 |
WO2006012393A2 (en) | 2006-02-02 |
CA2574698A1 (en) | 2006-02-02 |
EP1771570A2 (de) | 2007-04-11 |
JP2008507279A (ja) | 2008-03-13 |
DE602005026814D1 (de) | 2011-04-21 |
US20060292682A1 (en) | 2006-12-28 |
EP1771570B1 (de) | 2011-03-09 |
EP1771570A4 (de) | 2008-03-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE501262T1 (de) | Einfügen von transgenen in adenovirale vektoren | |
CA3033327A1 (en) | Programmable cas9-recombinase fusion proteins and uses thereof | |
WO2007136865A3 (en) | Recombinant vectors | |
EA200200960A1 (ru) | Промоторы вируса желтого скручивания листьев цестровых | |
DE60144248D1 (de) | Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen | |
ATE514783T1 (de) | Plasmidsystem zur expression mehrerer gene | |
DK1427828T3 (da) | Tilfældig integration af et polynucleotid efter in vivo-linearisering | |
CY1110002T1 (el) | Τροποποιημενη πρωτεϊνη ηεχον αδενοϊου και χρησεις αυτης | |
MX2009010492A (es) | Elementos de vector de expresion recombinante (reves) para mejorar la expresion de proteinas recombinantes en celulas huesped. | |
DK2152880T3 (da) | Sammensætninger og fremgangsmåder til hæmning af endogene immunoglobulingener og produktion af transgene, humane idiotype antistoffer | |
WO2000053724A3 (en) | Compositions and methods for the modification of gene transcription | |
ATE428790T1 (de) | Verbessertes system zur regulation der transgenexpression | |
DE602004030315D1 (de) | Induzierbare sirna expressionskonstrukte zur gezielten genabschaltung | |
WO2003087313A3 (en) | Enhanced silk exsertion under stress | |
TNSN07295A1 (en) | Nucleic acid constructs | |
DK1954811T3 (da) | Inducerbare ekspressionssystemer | |
EA201390034A1 (ru) | Мутантные гены протопорфириноген ix оксидазы (ppx) | |
DK1539981T3 (da) | Vævsspecifik ekspression af eksogene proteiner i transgene kyllinger | |
DK1412505T3 (da) | DNA-sekvenser til regulering af transkription | |
ATE406094T1 (de) | Identifizierung und charakterisierung von genen | |
MX2022004107A (es) | Celulas con expresion transgenica sostenida. | |
DE602005015823D1 (de) | Veränderung der wurzelstruktur während der pflanzenentwicklung | |
MX2022006846A (es) | Conjugados y metodos para tratar la fibrosis hepatica. | |
ATE334592T1 (de) | Biologische bekämpfung von nematoden | |
WO2007121467A3 (en) | Compositions and methods for increasing transgene expression in the plastids of higher plants |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |