ATE494378T1 - Triterpen-hydroxylase - Google Patents
Triterpen-hydroxylaseInfo
- Publication number
- ATE494378T1 ATE494378T1 AT05719556T AT05719556T ATE494378T1 AT E494378 T1 ATE494378 T1 AT E494378T1 AT 05719556 T AT05719556 T AT 05719556T AT 05719556 T AT05719556 T AT 05719556T AT E494378 T1 ATE494378 T1 AT E494378T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxylase
- gene
- genetic engineering
- reaction
- triterpene
- Prior art date
Links
- 102000008109 Mixed Function Oxygenases Human genes 0.000 title abstract 3
- 108010074633 Mixed Function Oxygenases Proteins 0.000 title abstract 3
- 150000003648 triterpenes Chemical class 0.000 title 1
- 238000010353 genetic engineering Methods 0.000 abstract 2
- 238000005805 hydroxylation reaction Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- YOQAQNKGFOLRGT-UXXABWCISA-N (3beta,22beta)-olean-12-ene-3,22,24-triol Chemical compound C1C[C@H](O)[C@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)[C@H](O)CC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C YOQAQNKGFOLRGT-UXXABWCISA-N 0.000 abstract 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 101100494440 Glycine max CYP93E1 gene Proteins 0.000 abstract 1
- URRZRRQMNMZIAP-UHFFFAOYSA-N Kudzusapogenol C Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)C(O)CC3(C)CCC21C URRZRRQMNMZIAP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000033444 hydroxylation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229930182495 oleanane-type triterpene Natural products 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- MADZMXIFUWFDJK-AEARDBQCSA-N soyasapogenol B Natural products CC1(C)C[C@@H](O)[C@]2(C)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O)C(=O)O)[C@](C)(CO)[C@@H]5CC[C@@]34C)[C@H]2C1 MADZMXIFUWFDJK-AEARDBQCSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004049123 | 2004-02-25 | ||
| PCT/JP2005/003205 WO2005080572A1 (ja) | 2004-02-25 | 2005-02-25 | トリテルペン水酸化酵素 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE494378T1 true ATE494378T1 (de) | 2011-01-15 |
Family
ID=34879534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05719556T ATE494378T1 (de) | 2004-02-25 | 2005-02-25 | Triterpen-hydroxylase |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7575892B2 (de) |
| EP (2) | EP2145959A3 (de) |
| JP (1) | JP4668176B2 (de) |
| AT (1) | ATE494378T1 (de) |
| DE (1) | DE602005025734D1 (de) |
| ES (1) | ES2357241T3 (de) |
| PT (1) | PT1721983E (de) |
| WO (1) | WO2005080572A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009020231A1 (ja) | 2007-08-06 | 2009-02-12 | Riken | カンゾウ属植物由来トリテルペン酸化酵素、それをコードする遺伝子およびその利用 |
| KR101710853B1 (ko) | 2008-08-29 | 2017-02-27 | 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 | 감초속 식물 유래 트리테르펜 산화 효소, 그것을 코딩하는 유전자 및 그의 이용법 |
| WO2012177825A1 (en) | 2011-06-21 | 2012-12-27 | Bvw Holding Ag | Medical device comprising boswellic acid |
| EP2982752B1 (de) | 2013-04-04 | 2021-06-09 | Riken | Glucuronyltransferase, gen zur codierung davon und verwendung davon |
| CN116286887B (zh) * | 2023-03-06 | 2025-10-28 | 湖南省中医药研究院 | 茯苓酸合成的关键基因及应用 |
| CN118126997B (zh) * | 2024-05-07 | 2024-08-16 | 广州中医药大学(广州中医药研究院) | 一种多功能三萜环化酶及其在制备三萜化合物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6137749A (ja) | 1984-07-31 | 1986-02-22 | Otsuka Pharmaceut Co Ltd | トリテルペン誘導体 |
| JPH10234396A (ja) | 1997-02-25 | 1998-09-08 | Nippon Kayaku Co Ltd | 新規抗腫瘍剤およびソヤサポゲノールｂの製造法 |
| US20040031072A1 (en) * | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
| BR0109258A (pt) * | 2000-03-09 | 2003-06-03 | Du Pont | Enzimas envolvidas em sìntese de triterpeno |
| JP2005137201A (ja) | 2001-04-16 | 2005-06-02 | Meiji Seika Kaisha Ltd | ソヤサポゲノールｂの製造法 |
| US20040010818A1 (en) * | 2002-05-09 | 2004-01-15 | Mcgonigle Brian | Transgenic plants with a suppressed triterpene level |
-
2005
- 2005-02-25 EP EP09167638A patent/EP2145959A3/de not_active Withdrawn
- 2005-02-25 US US10/590,661 patent/US7575892B2/en not_active Expired - Fee Related
- 2005-02-25 WO PCT/JP2005/003205 patent/WO2005080572A1/ja not_active Ceased
- 2005-02-25 JP JP2006510327A patent/JP4668176B2/ja not_active Expired - Fee Related
- 2005-02-25 DE DE602005025734T patent/DE602005025734D1/de not_active Expired - Lifetime
- 2005-02-25 PT PT05719556T patent/PT1721983E/pt unknown
- 2005-02-25 AT AT05719556T patent/ATE494378T1/de not_active IP Right Cessation
- 2005-02-25 EP EP05719556A patent/EP1721983B1/de not_active Expired - Lifetime
- 2005-02-25 ES ES05719556T patent/ES2357241T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2005080572A1 (ja) | 2007-10-25 |
| WO2005080572A1 (ja) | 2005-09-01 |
| EP2145959A2 (de) | 2010-01-20 |
| JP4668176B2 (ja) | 2011-04-13 |
| EP1721983A1 (de) | 2006-11-15 |
| US7575892B2 (en) | 2009-08-18 |
| US20080003639A1 (en) | 2008-01-03 |
| EP1721983B1 (de) | 2011-01-05 |
| DE602005025734D1 (de) | 2011-02-17 |
| EP2145959A3 (de) | 2010-08-25 |
| ES2357241T3 (es) | 2011-04-20 |
| PT1721983E (pt) | 2011-03-01 |
| EP1721983A4 (de) | 2008-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |