ATE492647T1 - Verfahren zur beurteilung der proliferationshemmenden wirkung eines hemmers und verfahren zur screening einer verbindung zur hemmung der tumorproliferation - Google Patents

Verfahren zur beurteilung der proliferationshemmenden wirkung eines hemmers und verfahren zur screening einer verbindung zur hemmung der tumorproliferation

Info

Publication number
ATE492647T1
ATE492647T1 AT07117132T AT07117132T ATE492647T1 AT E492647 T1 ATE492647 T1 AT E492647T1 AT 07117132 T AT07117132 T AT 07117132T AT 07117132 T AT07117132 T AT 07117132T AT E492647 T1 ATE492647 T1 AT E492647T1
Authority
AT
Austria
Prior art keywords
receptor tyrosine
proliferation
inhibitor
assessing
tyrosine kinases
Prior art date
Application number
AT07117132T
Other languages
English (en)
Inventor
Michitaka Notoya
Jun Sato
Tomoko Ohyama
Tomokazu Yoshida
Hideki Ishihara
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Application granted granted Critical
Publication of ATE492647T1 publication Critical patent/ATE492647T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07117132T 2006-09-27 2007-09-25 Verfahren zur beurteilung der proliferationshemmenden wirkung eines hemmers und verfahren zur screening einer verbindung zur hemmung der tumorproliferation ATE492647T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006261699 2006-09-27
JP2007224923A JP5283872B2 (ja) 2006-09-27 2007-08-30 腫瘍細胞に対する阻害剤の増殖抑制効果を評価する方法、及び腫瘍細胞の増殖を阻害する化合物をスクリーニングする方法

Publications (1)

Publication Number Publication Date
ATE492647T1 true ATE492647T1 (de) 2011-01-15

Family

ID=38918544

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07117132T ATE492647T1 (de) 2006-09-27 2007-09-25 Verfahren zur beurteilung der proliferationshemmenden wirkung eines hemmers und verfahren zur screening einer verbindung zur hemmung der tumorproliferation

Country Status (6)

Country Link
US (1) US20080090254A1 (de)
EP (1) EP1905840B1 (de)
JP (1) JP5283872B2 (de)
CN (1) CN101157951B (de)
AT (1) ATE492647T1 (de)
DE (1) DE602007011367D1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1840221A1 (de) * 2006-03-31 2007-10-03 Sysmex Corporation Verfahren zum Messen der Kinaseaktivität
JP4989127B2 (ja) * 2006-06-30 2012-08-01 シスメックス株式会社 チロシンキナーゼの活性測定方法及びチロシンキナーゼの基質
JP2009089672A (ja) * 2007-10-10 2009-04-30 Sysmex Corp がんの再発リスクの判定方法
CN104931317B (zh) * 2015-06-11 2018-05-25 宁波美晶医疗技术有限公司 一种血液前处理液
JP2020162420A (ja) * 2019-03-28 2020-10-08 シスメックス株式会社 サイクリン依存性キナーゼ４／６阻害剤の感受性を判定するための方法、試薬キット、装置及びコンピュータプログラム

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996018626A1 (en) * 1994-12-13 1996-06-20 F. Hoffmann-La Roche Ag Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase
US6667173B2 (en) * 2000-12-01 2003-12-23 The Schepens Eye Research Institute Nucleic acids encoding platelet derived growth factor-alpha receptors
US20020187511A1 (en) 2001-03-30 2002-12-12 Gerald Birk Process for label-free measurement of modified substrate
KR100852167B1 (ko) * 2002-03-08 2008-08-13 삼성전자주식회사 평판 표시 장치
KR100897508B1 (ko) * 2002-11-20 2009-05-15 삼성전자주식회사 램프 구동 장치와, 이를 갖는 백라이트 어셈블리 및 액정표시 장치
WO2004062475A2 (en) * 2003-01-10 2004-07-29 Albert Einstein College Of Medicine Of Yeshiva University Fluorescent assays for protein kinases
US8921057B2 (en) * 2004-05-31 2014-12-30 Sysmex Corporation Method of assessing properties of mammalian cells, and method of diagnosing cancer using the same
JP2008029320A (ja) * 2006-03-31 2008-02-14 Sysmex Corp キナーゼの活性測定方法
EP1840221A1 (de) * 2006-03-31 2007-10-03 Sysmex Corporation Verfahren zum Messen der Kinaseaktivität
JP4989127B2 (ja) * 2006-06-30 2012-08-01 シスメックス株式会社 チロシンキナーゼの活性測定方法及びチロシンキナーゼの基質
JP2009089672A (ja) * 2007-10-10 2009-04-30 Sysmex Corp がんの再発リスクの判定方法

Also Published As

Publication number Publication date
CN101157951B (zh) 2012-02-29
EP1905840B1 (de) 2010-12-22
CN101157951A (zh) 2008-04-09
US20080090254A1 (en) 2008-04-17
JP5283872B2 (ja) 2013-09-04
EP1905840A1 (de) 2008-04-02
DE602007011367D1 (de) 2011-02-03
JP2008104456A (ja) 2008-05-08

Similar Documents

Publication Publication Date Title
ATE492647T1 (de) Verfahren zur beurteilung der proliferationshemmenden wirkung eines hemmers und verfahren zur screening einer verbindung zur hemmung der tumorproliferation
DE602007001103D1 (de) Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2
WO2006084130A3 (en) Ultra-sensitive detection systems using multidimension signals
ATE429702T1 (de) Verfahren zur authentifizierung markierter polymere
DE602006002809D1 (de) Verfahren zur erkennung eines ovarialkarzinoms
TW200632306A (en) Interferometer for determining characteristics of an object surface
ATE521894T1 (de) Verfahren zur beurteilung von kolorektalem krebs anhand einer stuhlprobe durch verwendung einer marker-kombination aus calprotectin und einem hämoglobin/haptoglobin-komplex
WO2008063414A3 (en) Gene expression profiling for identification, monitoring, and treatment of colorectal cancer
WO2014170435A8 (en) Methods and pharmaceutical compositions for inhibiting lymphocyte proliferation in a subject in need thereof
WO2008123866A3 (en) Gene expression profiling for identification, monitoring and treatment of ovarian cancer
WO2006094149A3 (en) Methods and compositions for detecting adenoma
WO2006127190A3 (en) Use of optical skin measurements to determine cosmetic skin properties
ATE420211T1 (de) Vorrichtung und verfahren zum nachweis von geladenen makromolekülen
WO2009054939A3 (en) Cancer classification and methods of use
ATE434178T1 (de) Oberflächenprüfung unter verwendung einer nicht vibrierenden kontaktpotenzialsonde
DE60315715D1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
ATE328112T1 (de) Anaplastisches lymphoma kinase testverfahren, reagenzien und kompositionen davon
SE0301897D0 (sv) Referece standard and method for calibration
BRPI0607016A2 (pt) marcadores polipeptìdicos para o diagnóstico de cáncer de próstata
ATE504846T1 (de) VERFAHREN ZUM TESTEN VON UNBESTÜCKTEN, GROßFLÄCHIGEN LEITERPLATTEN MIT EINEM FINGERTESTER
DE502005002994D1 (de) Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von mindestens zwei Liganden
ATE426168T1 (de) Verwendung von asc als marker fur kolorektalkarzinome
ATE487141T1 (de) Hemmung von gasc1
WO2011034919A3 (en) Sh2 domain profiling to characterize tyrosine phosphorylation signaling in cancer
Demirkhanyan et al. Role of polyphosphate in cancer cell proliferation

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties