ATE49199T1 - 2-phenylalkyl-3-aminoalkyl-4(3h)-chinazolinonen verfahren zu deren herstellung, pharmazeutische zusammenstellungen und verwendung. - Google Patents
2-phenylalkyl-3-aminoalkyl-4(3h)-chinazolinonen verfahren zu deren herstellung, pharmazeutische zusammenstellungen und verwendung.Info
- Publication number
- ATE49199T1 ATE49199T1 AT85109193T AT85109193T ATE49199T1 AT E49199 T1 ATE49199 T1 AT E49199T1 AT 85109193 T AT85109193 T AT 85109193T AT 85109193 T AT85109193 T AT 85109193T AT E49199 T1 ATE49199 T1 AT E49199T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- carbon atoms
- sub
- sup
- integer
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000002213 calciumantagonistic effect Effects 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15408684A JPS6136273A (ja) | 1984-07-26 | 1984-07-26 | ２−フエニルアルキル−４（３ｈ）−キナゾリノン誘導体 |
| EP85109193A EP0169537B1 (de) | 1984-07-26 | 1985-07-23 | 2-Phenylalkyl-3-aminoalkyl-4(3H)-Chinazolinonen, Verfahren zu deren Herstellung, pharmazeutische Zusammenstellungen und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE49199T1 true ATE49199T1 (de) | 1990-01-15 |
Family
ID=15576584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85109193T ATE49199T1 (de) | 1984-07-26 | 1985-07-23 | 2-phenylalkyl-3-aminoalkyl-4(3h)-chinazolinonen verfahren zu deren herstellung, pharmazeutische zusammenstellungen und verwendung. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4668682A (de) |
| EP (1) | EP0169537B1 (de) |
| JP (1) | JPS6136273A (de) |
| KR (1) | KR860001078A (de) |
| AT (1) | ATE49199T1 (de) |
| CA (1) | CA1266266A (de) |
| DE (1) | DE3575132D1 (de) |
| DK (1) | DK339685A (de) |
| HU (1) | HU194836B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2037630C (en) * | 1990-03-07 | 2001-07-03 | Akira Morimoto | Nitrogen-containing heterocylic compounds, their production and use |
| GB9116207D0 (en) * | 1991-07-26 | 1991-09-11 | Ici Plc | Novel compounds |
| US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| IT1266992B1 (it) * | 1993-04-16 | 1997-01-24 | Alfa Wassermann Spa | Composti eterociclici, a struttura correlabile alle banzammidi, attivi nelle patologie gastro-intestinali, ad attivita' procinetica ed |
| US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| DE19501481A1 (de) * | 1995-01-19 | 1996-07-25 | Bayer Ag | 2,8-Disubstituierte Chinazolinone |
| AU6837096A (en) * | 1995-09-07 | 1997-03-27 | Kissei Pharmaceutical Co. Ltd. | 2-acylaminobenzamide derivatives and preventive and remedy for diseases caused by the supermultiplication of vascular intimal cells |
| DE69842109D1 (de) * | 1997-08-21 | 2011-03-10 | Shiseido Co Ltd | Chinazolin-4-on Derivate, deren Herstellung und deren Verwendung als Haarwuchsmittel oder in äusserlich anzuwendenden Hautpflegemitteln |
| US6444816B1 (en) | 1997-10-27 | 2002-09-03 | Dr. Reddy's Research Foundation | Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof |
| US6337332B1 (en) * | 1998-09-17 | 2002-01-08 | Pfizer Inc. | Neuropeptide Y receptor antagonists |
| US6890930B1 (en) | 1999-09-28 | 2005-05-10 | 3-Dimensional Pharmaceuticals, Inc. | Quinazolinones |
| CA2385921A1 (en) * | 1999-09-28 | 2001-04-05 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Quinazolinones |
| US6967251B2 (en) * | 2000-10-02 | 2005-11-22 | Molecular Probes, Inc. | Reagents for labeling biomolecules having aldehyde or ketone moieties |
| CA2444704C (en) * | 2001-04-23 | 2012-07-10 | University Of Virginia Patent Foundation | Synthesis and evaluation of phthalimide mimics as anti-angiogenic agents |
| US7053216B2 (en) * | 2001-11-19 | 2006-05-30 | Iconix Pharmaceuticals, Inc. | Modulators of Rho C activity |
| JP4384053B2 (ja) * | 2002-12-13 | 2009-12-16 | エフ．ホフマン−ラ ロシュ アーゲー | ３ｈ−キナゾリン−４−オン誘導体 |
| KR100610731B1 (ko) * | 2004-02-24 | 2006-08-09 | 한국과학기술연구원 | Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2020234A1 (de) * | 1970-04-25 | 1971-11-18 | Cassella Farbwerke Mainkur Ag | Basisch substituierte Derivate des 4(3H)-Chinazolinons |
-
1984
- 1984-07-26 JP JP15408684A patent/JPS6136273A/ja active Pending
-
1985
- 1985-07-10 US US06/753,708 patent/US4668682A/en not_active Expired - Fee Related
- 1985-07-15 CA CA000486793A patent/CA1266266A/en not_active Expired - Lifetime
- 1985-07-23 AT AT85109193T patent/ATE49199T1/de not_active IP Right Cessation
- 1985-07-23 DE DE8585109193T patent/DE3575132D1/de not_active Expired - Lifetime
- 1985-07-23 EP EP85109193A patent/EP0169537B1/de not_active Expired - Lifetime
- 1985-07-25 DK DK339685A patent/DK339685A/da not_active Application Discontinuation
- 1985-07-25 KR KR1019850005302A patent/KR860001078A/ko not_active Withdrawn
- 1985-07-26 HU HU852850A patent/HU194836B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR860001078A (ko) | 1986-02-22 |
| DE3575132D1 (de) | 1990-02-08 |
| HUT39166A (en) | 1986-08-28 |
| HU194836B (en) | 1988-03-28 |
| US4668682A (en) | 1987-05-26 |
| EP0169537A2 (de) | 1986-01-29 |
| EP0169537B1 (de) | 1990-01-03 |
| EP0169537A3 (en) | 1987-03-25 |
| JPS6136273A (ja) | 1986-02-20 |
| DK339685D0 (da) | 1985-07-25 |
| CA1266266A (en) | 1990-02-27 |
| DK339685A (da) | 1986-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |