ATE480550T1 - Hybridisierungskettenreaktion - Google Patents

Hybridisierungskettenreaktion

Info

Publication number
ATE480550T1
ATE480550T1 AT05730392T AT05730392T ATE480550T1 AT E480550 T1 ATE480550 T1 AT E480550T1 AT 05730392 T AT05730392 T AT 05730392T AT 05730392 T AT05730392 T AT 05730392T AT E480550 T1 ATE480550 T1 AT E480550T1
Authority
AT
Austria
Prior art keywords
nucleic acid
chain reaction
initiator
hybridization chain
monomers
Prior art date
Application number
AT05730392T
Other languages
English (en)
Inventor
Robert Dirks
Niles Pierce
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of ATE480550T1 publication Critical patent/ATE480550T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Bipolar Transistors (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT05730392T 2004-03-25 2005-03-22 Hybridisierungskettenreaktion ATE480550T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55614704P 2004-03-25 2004-03-25
PCT/US2005/009471 WO2005098049A2 (en) 2004-03-25 2005-03-22 Hybridization chain reaction

Publications (1)

Publication Number Publication Date
ATE480550T1 true ATE480550T1 (de) 2010-09-15

Family

ID=35125688

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05730392T ATE480550T1 (de) 2004-03-25 2005-03-22 Hybridisierungskettenreaktion

Country Status (5)

Country Link
US (2) US7632641B2 (de)
EP (1) EP1730161B1 (de)
AT (1) ATE480550T1 (de)
DE (1) DE602005023426D1 (de)
WO (1) WO2005098049A2 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632641B2 (en) 2004-03-25 2009-12-15 California Institute Of Technology Hybridization chain reaction
US20060234261A1 (en) * 2005-03-08 2006-10-19 Pierce Niles A Colorimetric readout of hybridization chain reaction
US7727721B2 (en) * 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
ATE526975T1 (de) 2005-10-07 2011-10-15 California Inst Of Techn Pkr-aktivierung mittels hybridisierungskettenreaktion
WO2008106658A2 (en) * 2007-03-01 2008-09-04 California Institute Of Technology TRIGGERED RNAi
US8043810B2 (en) * 2007-05-02 2011-10-25 Eagle Eye Research, Inc. Analyte detection using autocatalytic chain reactions
WO2008144562A1 (en) 2007-05-16 2008-11-27 California Institute Of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US20100021904A1 (en) * 2008-05-21 2010-01-28 Pierce Niles A Shielded cross-linking probes
US20100021901A1 (en) * 2008-05-22 2010-01-28 Peng Yin Compositions and methods for detecting analytes
US8241854B2 (en) 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
US9925278B2 (en) * 2008-10-23 2018-03-27 Koninklijke Philips N.V. Molecular imaging
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
EP2444501A1 (de) * 2010-10-22 2012-04-25 Université de Fribourg Sensor
ES2618127T3 (es) * 2010-10-27 2017-06-20 President And Fellows Of Harvard College Composiciones de dúplex de cebador de extremos cohesivos y métodos de uso
CN102653789A (zh) * 2012-03-14 2012-09-05 河北大学 一种生物分子的定量检测方法
AU2013300171B2 (en) 2012-08-09 2017-09-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for preparing biological specimens for microscopic analysis
WO2014169206A2 (en) 2013-04-11 2014-10-16 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
WO2014169216A2 (en) 2013-04-11 2014-10-16 Carnegie Mellon University TEMPLATE-DIRECTED γPNA SYNTHESIS AND γPNA TARGETING COMPOUNDS
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
EP3084051B1 (de) * 2013-12-16 2020-01-01 William Marsh Rice University Feinabgestimmte ultraspezifische nukleinsäure-hybridisierungssonden
CN104726548A (zh) * 2013-12-20 2015-06-24 深圳先进技术研究院 一种基于杂交链式反应的dna、rna或蛋白质检测探针、检测方法及试剂盒
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
US10851407B2 (en) 2014-05-08 2020-12-01 Carnegie Mellon University Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
US11091799B2 (en) 2015-04-24 2021-08-17 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
WO2017106314A1 (en) 2015-12-14 2017-06-22 The Penn State Research Foundation Polymer-based signal amplification for protein and cell detection
US11254974B2 (en) 2016-02-10 2022-02-22 The Board Of Trustees Of The Leland Stanford Junior University RNA fixation and detection in clarity-based hydrogel tissue
EP3449016B1 (de) 2016-04-25 2025-07-23 President and Fellows of Harvard College Hybridisierungskettenreaktionsverfahren für in-situ-moleküldetektion
DK3481843T3 (en) 2016-07-05 2022-02-07 California Inst Of Techn Fractional initiator hybridization chain reaction
IT201600073964A1 (it) 2016-07-14 2018-01-14 Ulisse Biomed S R L Nanointerruttore basato su nucleotidi e metodi per la rilevazione di anticorpi e altri analiti
CA3034617A1 (en) 2016-08-30 2018-03-08 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
CN114907272A (zh) 2016-09-26 2022-08-16 卡耐基梅隆大学 二价核碱基化合物及其用途
WO2018194755A1 (en) 2017-04-17 2018-10-25 University Of Southern California Method to generate biocompatible dendritic polymers for analyte detection with multimodal labeling and signal amplification
EP4647508A2 (de) 2018-04-02 2025-11-12 Enumera Molecular, Inc. Verfahren, systeme und zusammensetzungen zum zählen von nukleinsäuremolekülen
CN108624620A (zh) * 2018-04-02 2018-10-09 湖南大学 DNA纳米四分体实现对核酸高效输送及miRNA的超灵敏检测方法
US11414701B2 (en) 2018-05-24 2022-08-16 The Broad Institute, Inc. Multimodal readouts for quantifying and sequencing nucleic acids in single cells
GB201818742D0 (en) 2018-11-16 2019-01-02 Cartana Ab Method for detection of RNA
EP3947718A4 (de) 2019-04-02 2022-12-21 Enumera Molecular, Inc. Verfahren, systeme und zusammensetzungen zum zählen von nukleinsäuremolekülen
CN110257520B (zh) * 2019-07-04 2020-12-25 福州大学 一种利用短毛细管高速电泳检测肺癌细胞中miRNA的技术
US20220349005A1 (en) * 2019-08-19 2022-11-03 Northwestern University Controlling the dna hybridization chain reaction
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
JP2023517054A (ja) 2020-03-06 2023-04-21 カリフォルニア インスティチュート オブ テクノロジー ハイブリダイゼーション連鎖反応を介した試料内の標的分子の分析
GB202100760D0 (en) * 2021-01-20 2021-03-03 Qbiotix Ltd Target-dependent polymerisation of oligonucleotides
US11873485B2 (en) 2021-01-26 2024-01-16 California Institute Of Technology Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas
US12275984B2 (en) 2021-03-02 2025-04-15 10X Genomics, Inc. Sequential hybridization and quenching
US20220282319A1 (en) 2021-03-03 2022-09-08 10X Genomics, Inc. Analyte detection in situ using nucleic acid origami
CN117396613A (zh) 2021-06-01 2024-01-12 10X基因组学有限公司 用于分析物检测和探针解析的方法和组合物
WO2022256422A1 (en) 2021-06-02 2022-12-08 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
EP4367262A1 (de) 2021-07-09 2024-05-15 10X Genomics, Inc. Verfahren zum nachweis von analyten mit spärlicher markierung
WO2023288225A1 (en) 2021-07-13 2023-01-19 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
CA3224093A1 (en) 2021-07-30 2023-02-02 Jorge Ivan Hernandez Neuta Methods and compositions for synchronizing reactions in situ
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
EP4326898B1 (de) 2021-08-16 2024-07-31 10X Genomics, Inc. Sonden mit einem geteilten strichcodebereich und verfahren zur verwendung
JP2024538662A (ja) 2021-10-08 2024-10-23 ユニバーシティ オブ ロチェスター 液滴蒸発により増強される核酸ハイブリダイゼーションカスケード
CN114062672B (zh) * 2021-11-12 2023-04-25 福州大学 一种检测covid-19抗体的血糖生物传感器
WO2023108139A2 (en) 2021-12-10 2023-06-15 10X Genomics, Inc. Multi-resolution in situ decoding
CN114231632B (zh) * 2021-12-20 2023-09-22 深圳大学 一种可刺激性响应的dna水凝胶微针贴片及其制备方法与应用
WO2023129898A2 (en) 2021-12-27 2023-07-06 10X Genomics, Inc. Methods and compositions for rolling circle amplification
EP4466376A1 (de) 2022-01-21 2024-11-27 10X Genomics, Inc. Mehrere auslesesignale zur analyse einer probe
EP4482982A1 (de) 2022-02-21 2025-01-01 Kanvas Biosciences, Inc Hochmultiplexierter nachweis von genexpression mit hybridisierungskettenreaktion
CN118974836A (zh) 2022-03-08 2024-11-15 10X基因组学有限公司 将光学拥挤最小化的原位代码设计方法
WO2023192302A1 (en) 2022-03-29 2023-10-05 10X Genomics, Inc. Spectral unmixing combined with decoding for super-multiplexed in situ analysis
AU2023243205A1 (en) 2022-04-01 2024-09-19 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
CN119234045A (zh) 2022-04-06 2024-12-31 10X基因组学有限公司 用于多重细胞分析的方法
EP4519674A1 (de) 2022-05-06 2025-03-12 10X Genomics, Inc. Analyse von antigen- und antigenrezeptorinteraktionen
JP2025516589A (ja) 2022-05-11 2025-05-30 10エックス ジェノミクス インコーポレイテッド インサイチュー配列決定のための組成物及び方法
US20240035071A1 (en) 2022-06-17 2024-02-01 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
EP4602344A1 (de) 2022-10-14 2025-08-20 10X Genomics, Inc. Verfahren zur analyse biologischer proben
US12372771B2 (en) 2022-11-18 2025-07-29 10X Genomics, Inc. Systems and methods for actively mitigating vibrations
US20240218424A1 (en) 2022-12-21 2024-07-04 10X Genomics, Inc. Methods for tethering ribonucleic acids in biological samples
IL322924A (en) 2023-04-04 2025-10-01 California Inst Of Techn Ultra-sensitive molecular detection using hybridization chain reaction
US20240368678A1 (en) 2023-05-03 2024-11-07 10X Genomics, Inc. Methods and compositions for spatial assay
EP4461816A1 (de) 2023-05-10 2024-11-13 10X Genomics, Inc. Boronsäurezusammensetzungen und verfahren zur bindung von ribonukleinsäuren in biologischen proben
US20250012786A1 (en) 2023-07-07 2025-01-09 10X Genomics, Inc. Systems and methods for tissue bounds detection
US12417646B2 (en) 2023-08-16 2025-09-16 10X Genomics, Inc. Systems and methods for image segmentation
US20250117932A1 (en) 2023-10-06 2025-04-10 10X Genomics, Inc. Feature pyramiding for in situ data visualizations (aka dynamic display of molecular information dependent on zoom level)
US20250163502A1 (en) 2023-11-22 2025-05-22 10X Genomics, Inc. Methods for processing ribonucleic acids in biological samples
WO2025122890A1 (en) 2023-12-07 2025-06-12 10X Genomics, Inc. Graphical user interface and method of estimating an instrument run completion time
US12406371B2 (en) 2024-01-25 2025-09-02 10X Genomics, Inc. Systems and methods for image segmentation using multiple stain indicators
US20250285229A1 (en) 2024-03-08 2025-09-11 10X Genomics, Inc. Multi-focus image fusion with background removal
WO2025194033A1 (en) 2024-03-15 2025-09-18 10X Genomics, Inc. Systems and methods for covering and sealing an open well

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965204A (en) 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
US4714680B1 (en) 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
EP0273085A1 (de) 1986-12-29 1988-07-06 IntraCel Corporation Verfahren zur Einführung fremder Nukleinsäuren in eukaryotische Zellen
US5057410A (en) 1988-08-05 1991-10-15 Cetus Corporation Chimeric messenger RNA detection methods
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
JPH08501928A (ja) 1992-07-02 1996-03-05 ハイブライドン インコーポレイテッド 治療剤としての自己安定化オリゴヌクレオチド
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
EP0871755A1 (de) 1995-03-23 1998-10-21 Cantab Pharmaceuticals Research Limited Vektoren zur verabreichung von genen
AU727531B2 (en) 1995-07-25 2000-12-14 Crucell Holland B.V. Methods and means for targeted gene delivery
US5579793A (en) 1995-11-15 1996-12-03 Rubbermaid Health Care Products, Inc. Foldable walker
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5928823A (en) * 1996-12-20 1999-07-27 Fuji Photo Film Co., Ltd. Method for preparation of waterless lithographic printing plate by electrophotographic process
US20020017295A1 (en) 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
AU9692498A (en) 1997-10-10 1999-05-03 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Complex of biotinylated viral vector and ligand for targeted gene delivery
GB9721909D0 (en) 1997-10-17 1997-12-17 Cantab Pharma Res Gene delivery vectors and their uses
EP1049803A4 (de) 1997-12-15 2002-08-21 Nexstar Pharmaceuticals Inc Gleichmässige erkennung von zielmolekül durch nukleinsäure ligand - beacon ligand interaktion
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US5989823A (en) * 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AU3358999A (en) 1998-03-20 1999-10-11 Genzyme Corporation Chimeric adenoviral vectors for targeted gene delivery
WO2000001850A2 (en) 1998-07-02 2000-01-13 Gen-Probe Incorporated Molecular torches
DE19843415A1 (de) * 1998-09-22 2000-03-23 Philips Corp Intellectual Pty Induktives Bauelement mit einem Stabkern
US6899871B2 (en) 1998-10-01 2005-05-31 University Of Southern California Gene delivery system and methods of use
EP1059357A1 (de) 1999-06-09 2000-12-13 Universite Pierre Et Marie Curie Paris Vi Replizierende oder 'semi-replizierende' retrovirale Konstrukte, ihre Herstellung und Verwendungen für den Gentransfer
DE19937800B4 (de) 1999-08-10 2005-06-16 Gea Energietechnik Gmbh Anlage zur Kondensation von Dampf
ATE364722T1 (de) * 2000-06-02 2007-07-15 Bayer Corp Verfahren zum nachweis und zur lokalisierung von genen in situ durch hybridisierung einer verzweigten dna
US20040223953A1 (en) 2003-03-17 2004-11-11 Hsiang-Fu Kung Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects
US7632641B2 (en) 2004-03-25 2009-12-15 California Institute Of Technology Hybridization chain reaction
US7727721B2 (en) * 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US20060234261A1 (en) * 2005-03-08 2006-10-19 Pierce Niles A Colorimetric readout of hybridization chain reaction
EP1885892A2 (de) 2005-05-03 2008-02-13 Ensemble Discovery Corporation Umsatzsonden und ihre verwendung zum nachweis von nukleinsäuren
ATE526975T1 (de) * 2005-10-07 2011-10-15 California Inst Of Techn Pkr-aktivierung mittels hybridisierungskettenreaktion
WO2008144562A1 (en) 2007-05-16 2008-11-27 California Institute Of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways

Also Published As

Publication number Publication date
US20050260635A1 (en) 2005-11-24
WO2005098049A2 (en) 2005-10-20
EP1730161A2 (de) 2006-12-13
EP1730161B1 (de) 2010-09-08
US7632641B2 (en) 2009-12-15
EP1730161A4 (de) 2008-05-21
US8105778B2 (en) 2012-01-31
DE602005023426D1 (de) 2010-10-21
WO2005098049A3 (en) 2006-05-11
US20100047926A1 (en) 2010-02-25

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