ATE479124T1 - Mikroskopbeleuchtungsvorrichtung und adapter dafür - Google Patents

Mikroskopbeleuchtungsvorrichtung und adapter dafür

Info

Publication number
ATE479124T1
ATE479124T1 AT05747542T AT05747542T ATE479124T1 AT E479124 T1 ATE479124 T1 AT E479124T1 AT 05747542 T AT05747542 T AT 05747542T AT 05747542 T AT05747542 T AT 05747542T AT E479124 T1 ATE479124 T1 AT E479124T1
Authority
AT
Austria
Prior art keywords
light
adapter
light source
transmission
spacer
Prior art date
Application number
AT05747542T
Other languages
English (en)
Inventor
Vitaly Vodyanoy
Oleg Pustovyy
Original Assignee
Univ Auburn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Auburn filed Critical Univ Auburn
Application granted granted Critical
Publication of ATE479124T1 publication Critical patent/ATE479124T1/de

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/12—Condensers affording bright-field illumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/10—Condensers affording dark-field illumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Eye Examination Apparatus (AREA)
AT05747542T 2004-04-16 2005-04-15 Mikroskopbeleuchtungsvorrichtung und adapter dafür ATE479124T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US56317504P 2004-04-16 2004-04-16
US63485004P 2004-12-10 2004-12-10
US65060705P 2005-02-06 2005-02-06
US65580505P 2005-02-24 2005-02-24
US66048405P 2005-03-10 2005-03-10
PCT/US2005/013054 WO2005101086A2 (en) 2004-04-16 2005-04-15 Microsope illumination device and adapter therefor

Publications (1)

Publication Number Publication Date
ATE479124T1 true ATE479124T1 (de) 2010-09-15

Family

ID=34969464

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05747542T ATE479124T1 (de) 2004-04-16 2005-04-15 Mikroskopbeleuchtungsvorrichtung und adapter dafür

Country Status (7)

Country Link
US (1) US7564623B2 (de)
EP (1) EP1738212B1 (de)
JP (1) JP2007532982A (de)
CN (1) CN101069115B (de)
AT (1) ATE479124T1 (de)
DE (1) DE602005023141D1 (de)
WO (1) WO2005101086A2 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9033870B2 (en) * 2004-09-24 2015-05-19 Vivid Medical, Inc. Pluggable vision module and portable display for endoscopy
US8858425B2 (en) * 2004-09-24 2014-10-14 Vivid Medical, Inc. Disposable endoscope and portable display
US8878924B2 (en) * 2004-09-24 2014-11-04 Vivid Medical, Inc. Disposable microscope and portable display
US8827899B2 (en) * 2004-09-24 2014-09-09 Vivid Medical, Inc. Disposable endoscopic access device and portable display
CN101263411B (zh) * 2005-07-15 2010-09-29 奥本大学 显微镜照明装置和用于暗-和亮-场照明的适配器
WO2007035864A2 (en) * 2005-09-20 2007-03-29 Cell Biosciences, Inc. Electrophoresis standards, methods and kits
NL1030102C2 (nl) * 2005-10-03 2007-04-04 Ccm Beheer Bv Fluorescentiemicroscoop.
WO2007064959A2 (en) * 2005-12-01 2007-06-07 Auburn University High resolution optical microscope
US7688505B2 (en) * 2005-12-09 2010-03-30 Auburn University Simultaneous observation of darkfield images and fluorescence using filter and diaphragm
EP1801593A1 (de) * 2005-12-22 2007-06-27 Koninklijke Philips Electronics N.V. Abbildungsmethode von biologischen Proben unter Verwendung von inorganischen Nanopartikeln als Markierungsagentien
JP4654934B2 (ja) * 2006-02-17 2011-03-23 株式会社日立製作所 微量液滴の搬送方法
WO2007098137A2 (en) * 2006-02-20 2007-08-30 Auburn University Applications for mixing and combining light utilizing a transmission filter, iris, aperture apparatus
DE102006008840B4 (de) * 2006-02-25 2009-05-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Beleuchtungsvorrichtung für zylindrische Objekte, damit durchgeführtes Oberflächenuntersuchungsverfahren und Computerprogrammprodukt
CZ2006352A3 (cs) * 2006-05-31 2007-12-12 Ústav prístrojové techniky AV CR, v.v.i. Zarízení pro pripojení zdroje zárení k objektivu mikroskopu
JP2008051772A (ja) * 2006-08-28 2008-03-06 Hamamatsu Photonics Kk 蛍光画像取得装置、及び蛍光画像取得方法
JP5021254B2 (ja) * 2006-09-06 2012-09-05 オリンパス株式会社 顕微鏡装置の制御方法、顕微鏡装置
US8537461B2 (en) * 2007-11-26 2013-09-17 Carl Zeiss Microimaging Gmbh Method and configuration for the optical detection of an illuminated specimen
JP5082894B2 (ja) * 2008-01-31 2012-11-28 ソニー株式会社 光電伝送用コネクタ、光電伝送デバイスおよび電子機器
TW200946954A (en) * 2008-05-05 2009-11-16 Raydium Semiconductor Corp Light module, apparatus of providing optical tweezers and dark field microscope
DE102008028490A1 (de) * 2008-06-16 2009-12-17 Carl Zeiss Microimaging Gmbh Beleuchtungsanordnung für die TIRF-Mikroskopie
JP5095663B2 (ja) * 2009-03-31 2012-12-12 独立行政法人科学技術振興機構 蛍光顕微鏡、蛍光観察方法
JP5293468B2 (ja) 2009-07-10 2013-09-18 ソニー株式会社 蛍光像取得装置、蛍光像取得方法及び蛍光像取得プログラム
US9224031B2 (en) 2010-05-21 2015-12-29 Chemometec A/S Compact dark field light source and dark field image analysis at low magnification
US8390926B2 (en) * 2010-08-12 2013-03-05 Photon Dynamics, Inc. High speed acquisition vision system and method for selectively viewing object features
DE102010041426A1 (de) * 2010-09-27 2012-05-03 Siemens Aktiengesellschaft Messeinheit und Verfahren zur optischen Untersuchung einer Flüssigkeit zur Bestimmung einer Analyt-Konzentration
US8681215B2 (en) * 2011-04-29 2014-03-25 ProteinSimple Method and particle analyzer for determining a broad particle size distribution
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
DE102011055294B4 (de) * 2011-11-11 2013-11-07 Leica Microsystems Cms Gmbh Mikroskopische Einrichtung und Verfahren zur dreidimensionalen Lokalisierung von punktförmigen Objekten in einer Probe
DE102012201286A1 (de) * 2012-01-30 2013-08-01 Carl Zeiss Microscopy Gmbh Mikroskop und Verfahren für die wellenlängenselektive und örtlich hochauflösende Mikroskopie
JP2013254889A (ja) * 2012-06-08 2013-12-19 Idec Corp 光源装置および照明装置
AU2013295679A1 (en) 2012-07-25 2015-01-29 Theranos, Inc. Image analysis and measurement of biological samples
US9513224B2 (en) 2013-02-18 2016-12-06 Theranos, Inc. Image analysis and measurement of biological samples
CA3209249A1 (en) * 2013-02-18 2014-08-21 Theranos Ip Company, Llc Image analysis and measurement of biological samples
WO2014165091A2 (en) 2013-03-12 2014-10-09 Cytoviva, Inc. Three-dimensional image processing to locate nanoparticles in biolgical and nonbiological media
US9562860B1 (en) 2013-06-19 2017-02-07 Theranos, Inc. Methods and devices for sample analysis
CN107533217A (zh) 2015-03-13 2018-01-02 格尼亚Ip控股私人有限公司 用于显微技术的方法与装置
WO2017007690A1 (en) * 2015-07-06 2017-01-12 Indiana University Research And Technology Corporation Fluorescent microscope
WO2020206362A1 (en) 2019-04-04 2020-10-08 Inscopix, Inc. Multi-modal microscopic imaging
AU2017229690B2 (en) 2016-03-08 2021-12-16 Enspectra Health, Inc. Non-invasive detection of skin disease
DE202016102771U1 (de) 2016-05-24 2016-08-03 Andreas Gerzen Mikroskopheizsystem
US10768105B1 (en) 2016-07-29 2020-09-08 Labrador Diagnostics Llc Image analysis and measurement of biological samples
EP3513238B1 (de) 2016-09-13 2024-06-26 Inscopix, Inc. Adapter für mikroskopische bildgebung
US10908072B2 (en) 2016-12-15 2021-02-02 The Board Of Regents Of The University Of Texas System Total internal reflection and transmission illumination fluorescence microscopy imaging system with improved background suppression
WO2018175346A1 (en) * 2017-03-20 2018-09-27 Spectral Platforms, Inc. Spectroscopic methods to detect and characterize microorganisms
EP3614915A4 (de) 2017-04-28 2021-01-20 Enspectra Health, Inc. Systeme und verfahren zur bildgebung und messung von sarkomeren
CN107367829B (zh) * 2017-08-16 2023-10-31 桂林优利特医疗电子有限公司 单镜头分光变倍显微镜系统
CN109425592B (zh) * 2017-08-31 2021-06-01 清华大学 一种一维纳米材料的观测装置
FR3075372B1 (fr) * 2017-12-18 2020-08-28 Commissariat Energie Atomique Dispositif et procede d'observation d'un echantillon avec un systeme optique chromatique
JP6901510B2 (ja) * 2019-02-19 2021-07-14 日本電子株式会社 観察方法、画像処理装置、および電子顕微鏡
TWI702397B (zh) * 2019-05-29 2020-08-21 麗寶大數據股份有限公司 螢光顯微成像裝置
US20210302710A1 (en) * 2020-02-24 2021-09-30 Massachusetts Institute Of Technology Bragg light source for dark-field imaging devices
CN111479097B (zh) * 2020-03-25 2022-02-22 清华大学 基于深度学习的散射透镜成像系统
US11914131B1 (en) * 2020-08-16 2024-02-27 Gregory Dimitrenko Optical testing system for detecting infectious disease, testing device, specimen collector and related methods
CN112162395A (zh) * 2020-10-27 2021-01-01 江苏三米科思半导体设备有限公司 一种深紫外斜入射高分辨率暗场照明光学系统
CN114689523B (zh) * 2022-03-25 2024-07-16 江苏省农业科学院 光学检测食源性致病菌的系统和方法
CN116482848B (zh) * 2023-04-28 2023-10-24 广州市明美光电技术有限公司 一种用于光学仪器的匀光光源系统、方法及显微镜

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE408638C (de) * 1924-01-17 1925-01-22 Ernst Leitz Spiegelkondensor fuer Dunkelfeldbeleuchtung
US1951636A (en) * 1931-03-03 1934-03-20 Zeiss Carl Fa Illuminating device for microscopes
US1943510A (en) * 1931-10-15 1934-01-16 Zeiss Carl Fa Device for light-field and darkfield illumination of microscopic objects
US1996920A (en) * 1932-09-14 1935-04-09 Zeiss Carl Fa Revolving nose-piece for microscopes
US2130494A (en) * 1935-08-12 1938-09-20 Leitz Ernst Gmbh Relief condenser
US2129562A (en) * 1938-02-17 1938-09-06 Ilex Optical Company Lens and diaphragm assembly
US2674157A (en) * 1949-08-15 1954-04-06 Leitz Ernst Gmbh Phase microscope
US2642775A (en) * 1949-12-21 1953-06-23 John T Rooney Vertical illuminator
US3666362A (en) 1970-12-22 1972-05-30 Johnson Research Foundation Me Dual wavelength spectrophotometry
DE2331750C3 (de) * 1973-06-22 1978-04-20 Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar Auflicht-Beleuchtungseinrichtung für wahlweise Hell- und Dunkelfeldbeleuchtung
DE2542075A1 (de) * 1975-09-20 1977-07-21 Leitz Ernst Gmbh Auflicht-beleuchtungseinrichtung fuer hell- und dunkelfeldbeleuchtung
US4109304A (en) * 1976-02-23 1978-08-22 Khvalovsky Vladimir Vasilievic Device for coherent lighting of objects
US4246488A (en) * 1979-03-09 1981-01-20 Picker Corporation Radiation collimator
DD145805B1 (de) * 1979-08-27 1982-06-30 Johannes Grosser Beleuchtungsanordnung fuer mikroskope
DE3100662A1 (de) * 1980-01-31 1981-11-26 Jenoptik Jena Gmbh, Ddr 6900 Jena "vorrichtung zur dunkelfeldbeleuchtung in auflichtmikroskopen"
US4894760A (en) 1982-11-19 1990-01-16 Michael Callahan Additive color-mixing light fixture employing a single moveable multi-filter array
DE3442218A1 (de) * 1984-11-19 1986-05-28 Fa. Carl Zeiss, 7920 Heidenheim Auflichtbeleuchtungsapparat fuer mikroskope
DE3527322A1 (de) * 1985-07-31 1987-02-12 Zeiss Carl Fa Autofokuseinrichtung fuer auflichtmikroskope
GB2195467A (en) 1986-06-04 1988-04-07 Aire Scient Limited Optical microscope with beam controlling device for coupling to a spectrometer
GB2195432B (en) * 1986-09-11 1990-10-24 Tasco Ltd An illumination lamp apparatus
CN1009867B (zh) * 1987-09-04 1990-10-03 湖北省医学科学院 显微镜色偏振干涉差照明装置
US5113332A (en) * 1989-05-24 1992-05-12 Morpheus Lights, Inc. Selectable mechanical and electronic pattern generating aperture module
US4974094A (en) * 1989-12-04 1990-11-27 Yuhkoh Morito Direct lighting/illuminating system for miniature CCD camera
JPH0527181A (ja) * 1991-07-24 1993-02-05 Olympus Optical Co Ltd 落射暗視野照明装置
US5325231A (en) 1991-03-22 1994-06-28 Olympus Optical Co., Ltd. Microscope illuminating apparatus
JPH05173078A (ja) * 1991-04-10 1993-07-13 Olympus Optical Co Ltd システム顕微鏡
JPH0593869A (ja) * 1991-03-22 1993-04-16 Olympus Optical Co Ltd 顕微鏡の照明装置
US5528368A (en) * 1992-03-06 1996-06-18 The United States Of America As Represented By The Department Of Health And Human Services Spectroscopic imaging device employing imaging quality spectral filters
US5394268A (en) * 1993-02-05 1995-02-28 Carnegie Mellon University Field synthesis and optical subsectioning for standing wave microscopy
DE69418131D1 (de) * 1993-03-01 1999-06-02 Gen Signal Corp Vorrichtung zur erzeugung einer einstellbaren ringförmigen beleuchtung für einen photolithograpischen projektionsapparat
US5400135A (en) * 1993-06-08 1995-03-21 Nikon Corporation Automatic defect inspection apparatus for color filter
US5734498A (en) * 1994-05-09 1998-03-31 The Regents Of The University Of California Illuminator elements for conventional light microscopes
US5820250A (en) * 1995-10-24 1998-10-13 Dolan-Jenner Industries, Inc. Dark field illuminator ringlight adaptor
US5841577A (en) * 1996-02-16 1998-11-24 Carnegie Mellon University Light microscope having acousto-optic tunable filters
JPH09288237A (ja) * 1996-02-20 1997-11-04 Bunshi Bio Photonics Kenkyusho:Kk 暗視野落射顕微鏡
US6004001A (en) 1996-09-12 1999-12-21 Vdo Adolf Schindling Ag Illumination for a display
WO1998045744A2 (en) 1997-04-09 1998-10-15 Northern Edge Associates Inc. Uv microscope converting uv image to visible color image
KR100251053B1 (ko) 1997-07-25 2000-05-01 윤종용 2개의 평판을 이용한 광통합 장치 및 광통합 방법
JP3315358B2 (ja) * 1997-12-02 2002-08-19 株式会社ミツトヨ 画像処理測定機の照明装置
CA2243090A1 (en) * 1998-07-10 2000-01-10 Timothy M. Richardson Inverted darkfield contrast microscope and method
DE19903486C2 (de) * 1999-01-29 2003-03-06 Leica Microsystems Verfahren und Vorrichtung zur optischen Untersuchung von strukturierten Oberflächen von Objekten
US6628385B1 (en) 1999-02-05 2003-09-30 Axon Instruments, Inc. High efficiency, large field scanning microscope
US6002484A (en) * 1999-06-18 1999-12-14 Rozema; Jos J. Phase contrast aberroscope
US6437912B2 (en) * 1999-12-08 2002-08-20 Olympus Optical Co., Ltd. Microscope, transillumination condenser therefor, and optical element slider
US6630996B2 (en) * 2000-11-15 2003-10-07 Real Time Metrology, Inc. Optical method and apparatus for inspecting large area planar objects
AU2002248163A1 (en) * 2000-12-01 2002-08-12 Auburn University High-resolution optical microscope
JP2002202459A (ja) * 2000-12-28 2002-07-19 Yoshihiro Ota 暗視野落射顕微鏡
US6597499B2 (en) * 2001-01-25 2003-07-22 Olympus Optical Co., Ltd. Total internal reflection fluorescence microscope having a conventional white-light source
DE10123785A1 (de) * 2001-05-16 2002-11-21 Leica Microsystems Vorrichtung zur Beleuchtung eines Betrachtungsfeldes, beispielsweise eines Objektfeldes unter einem Mikroskop durch zwei Lichtquellen
US6956701B1 (en) 2004-04-26 2005-10-18 Infocus Corporation Method and apparatus for combining light paths of multiple colored light sources through a common integration tunnel
JP4020714B2 (ja) * 2001-08-09 2007-12-12 オリンパス株式会社 顕微鏡
US7359116B2 (en) * 2001-10-16 2008-04-15 Hamilton Thome Biosciences, Inc. Microscope turret mounted laser EPI-illumination port
US6819484B2 (en) * 2001-11-06 2004-11-16 Olympus Optical Co., Ltd. Total internal reflection illumination apparatus and microscope using this total internal reflection illumination apparatus
US6947127B2 (en) * 2001-12-10 2005-09-20 Carl Zeiss Jena Gmbh Arrangement for the optical capture of excited and/or back scattered light beam in a sample
US6755555B2 (en) 2002-01-31 2004-06-29 Hewlett-Packard Development Company, L.P. Auxiliary illuminating device having an adjustable color temperature by controlling the amount of light passing through color filters
JP4172212B2 (ja) * 2002-06-20 2008-10-29 株式会社ニコン 顕微鏡標本の照明方法とこれを用いた照明装置を有する顕微鏡
DE10234757B4 (de) * 2002-07-30 2004-08-26 Leica Microsystems Semiconductor Gmbh Autofokusmodul für Mikroskopbasierte Systeme
US7025513B2 (en) * 2002-11-18 2006-04-11 Olympus Corporation Optical apparatus, shutter device, and camera
JP2004233163A (ja) * 2003-01-29 2004-08-19 Hitachi High-Technologies Corp パターン欠陥検査方法およびその装置
DE10320529B4 (de) * 2003-04-30 2017-09-07 Carl Zeiss Microscopy Gmbh Dunkelfeld-Beleuchtungssystem
JP2004348051A (ja) * 2003-05-26 2004-12-09 Alps Electric Co Ltd 絞り兼用シャッタ駆動装置
US7173256B2 (en) * 2004-03-26 2007-02-06 Fox John S Fluorescent image calibration step wedge, and use thereof in illumination for fluorescent imaging and automatic exposure
KR20050102841A (ko) * 2004-04-23 2005-10-27 삼성전자주식회사 조리개 장치 및 조리개 구동장치 및 이를 가지는카메라유닛과 조리개 제어방법
DE102004036863A1 (de) * 2004-07-29 2006-03-23 Carl Zeiss Jena Gmbh Kondensoranordnung für Hell- und/oder Dunkelfeldbeleuchtung für Lichtmikroskope
CN101263411B (zh) * 2005-07-15 2010-09-29 奥本大学 显微镜照明装置和用于暗-和亮-场照明的适配器
WO2007098137A2 (en) * 2006-02-20 2007-08-30 Auburn University Applications for mixing and combining light utilizing a transmission filter, iris, aperture apparatus

Also Published As

Publication number Publication date
EP1738212A2 (de) 2007-01-03
US20050237605A1 (en) 2005-10-27
DE602005023141D1 (de) 2010-10-07
WO2005101086A3 (en) 2006-01-05
WO2005101086A2 (en) 2005-10-27
US7564623B2 (en) 2009-07-21
CN101069115A (zh) 2007-11-07
EP1738212B1 (de) 2010-08-25
CN101069115B (zh) 2010-05-12
JP2007532982A (ja) 2007-11-15

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