ATE477499T1 - Embryonenqualitätsbeurteilung auf der grundlage von blastomerenteilung und bewegung - Google Patents
Embryonenqualitätsbeurteilung auf der grundlage von blastomerenteilung und bewegungInfo
- Publication number
- ATE477499T1 ATE477499T1 AT07722668T AT07722668T ATE477499T1 AT E477499 T1 ATE477499 T1 AT E477499T1 AT 07722668 T AT07722668 T AT 07722668T AT 07722668 T AT07722668 T AT 07722668T AT E477499 T1 ATE477499 T1 AT E477499T1
- Authority
- AT
- Austria
- Prior art keywords
- determining
- division period
- division
- inter
- extent
- Prior art date
Links
- 210000001109 blastomere Anatomy 0.000 title 1
- 238000001303 quality assessment method Methods 0.000 title 1
- 230000032823 cell division Effects 0.000 abstract 4
- 230000001413 cellular effect Effects 0.000 abstract 3
- 210000001161 mammalian embryo Anatomy 0.000 abstract 3
- 210000003463 organelle Anatomy 0.000 abstract 3
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0604—Whole embryos; Culture medium therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Pregnancy & Childbirth (AREA)
- Surgery (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Computer Hardware Design (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81411506P | 2006-06-16 | 2006-06-16 | |
| DKPA200600821 | 2006-06-16 | ||
| PCT/DK2006/000581 WO2007042044A1 (en) | 2005-10-14 | 2006-10-16 | Determination of a change in a cell population |
| DKPA200700571 | 2007-04-19 | ||
| PCT/DK2007/000291 WO2007144001A2 (en) | 2006-06-16 | 2007-06-15 | Embryo quality assessment based on blastomere division and movement |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE477499T1 true ATE477499T1 (de) | 2010-08-15 |
Family
ID=43414894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07722668T ATE477499T1 (de) | 2006-06-16 | 2007-06-15 | Embryonenqualitätsbeurteilung auf der grundlage von blastomerenteilung und bewegung |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20100041090A1 (enExample) |
| EP (2) | EP2035548B1 (enExample) |
| JP (2) | JP5731748B2 (enExample) |
| CN (2) | CN101495619B (enExample) |
| AT (1) | ATE477499T1 (enExample) |
| DE (1) | DE602007008419D1 (enExample) |
| DK (1) | DK2035548T3 (enExample) |
| WO (1) | WO2007144001A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5451073B2 (ja) | 2005-10-14 | 2014-03-26 | ユニセンス・ファーティリテック・アクティーゼルスカブ | 細胞集団における変化の決定 |
| ES2363406T3 (es) | 2007-06-29 | 2011-08-03 | Unisense Fertilitech A/S | Dispositivo, sistema y método para monitorizar y/o cultivar objetos microscópicos. |
| GB0719037D0 (en) | 2007-09-28 | 2007-11-07 | Vitrolife Sweden Ab | Sampling needle |
| EP2315823B1 (en) * | 2008-07-05 | 2018-03-07 | Unisense Fertilitech A/S | One to one identification system |
| ES2972747T3 (es) * | 2009-08-22 | 2024-06-14 | Ares Trading Sa | Obtención de imágenes y evaluación de embriones, ovocitos y células madre |
| GB201006046D0 (en) * | 2010-04-12 | 2010-05-26 | Ge Healthcare Uk Ltd | System and method for determining motion of a biological object |
| JP5962828B2 (ja) * | 2010-06-30 | 2016-08-03 | 大日本印刷株式会社 | 体外培養による胚の製造方法、並びに胚を選別するための方法、装置、及びシステム |
| JP5807288B2 (ja) | 2010-06-30 | 2015-11-10 | 大日本印刷株式会社 | 体外培養による胚の製造方法、並びに胚を選別するための方法、装置、及びシステム |
| WO2012047678A2 (en) | 2010-09-27 | 2012-04-12 | Auxogyn, Inc. | Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes, and stem cells |
| RU2441243C1 (ru) * | 2010-11-12 | 2012-01-27 | Федеральное государственное учреждение "Ивановский научно-исследовательский институт материнства и детства имени В.Н. Городкова" Министерства здравоохранения и социального развития Российской Федерации | Способ прогнозирования качества эмбриона при проведении эко у женщин с бесплодием |
| GR1007617B (el) * | 2011-01-24 | 2012-06-20 | Ιδρυμα Τεχνολογιας Και Ερευνας - Ιτε, | Χρηση μη-γραμμικων απεικονιστικων τεχνικων για την αξιολογηση της ποιοτητας εμβρυων προεμφυτευτικου σταδιου και την προωθηση επιτυχους εγκυμοσυνης |
| CA2827945C (en) * | 2011-02-23 | 2021-10-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of detecting aneuploidy in human embryos |
| WO2012163363A1 (en) * | 2011-05-31 | 2012-12-06 | Unisense Fertilitech A/S | Embryo quality assessment based on blastomere cleavage and morphology |
| EP2726864A1 (en) * | 2011-07-02 | 2014-05-07 | Unisense Fertilitech A/S | Adaptive embryo selection criteria optimized through iterative customization and collaboration |
| AU2013269608B2 (en) | 2012-05-31 | 2016-05-05 | Unisense Fertilitech A/S | Embryo quality assessment based on blastocyst development |
| ES2717478T3 (es) | 2012-05-31 | 2019-06-21 | Ares Trading Sa | Métodos de predicción de blastocistos embrionarios in vitro |
| EP2864475A1 (en) * | 2012-06-25 | 2015-04-29 | Unisense Fertilitech A/S | Method and apparatus |
| CN104755608A (zh) * | 2012-08-30 | 2015-07-01 | 尤尼森斯繁殖技术公司 | 体外培养胚胎的自动化监控 |
| WO2014121200A1 (en) | 2013-02-01 | 2014-08-07 | Auxogyn, Inc. | Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential |
| CA2901833C (en) * | 2013-02-28 | 2025-09-16 | Progyny Inc | Apparatus, method, and system for image-based human embryo cell classification |
| JP2014193145A (ja) * | 2013-03-01 | 2014-10-09 | Naoki Yamashita | 胚盤胞培養液中のノルエピネフリン量によるヒト胚盤胞の評価方法 |
| EP3399054B1 (en) * | 2013-06-18 | 2022-03-09 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for determining the quality of an embryo |
| EP3120297B1 (en) * | 2014-03-20 | 2020-12-02 | Ares Trading S.A. | Quantitative measurement of human blastocyst and morula morphology developmental kinetics |
| WO2015192352A1 (zh) * | 2014-06-19 | 2015-12-23 | 湖南光琇高新生命科技有限公司 | 一种根据分裂行为对体外受精治疗胚胎进行评估的等级分类方法 |
| US11494578B1 (en) * | 2015-09-21 | 2022-11-08 | Ares Trading S.A. | Systems and methods for automated assessment of embryo quality using image based features |
| US10510143B1 (en) | 2015-09-21 | 2019-12-17 | Ares Trading S.A. | Systems and methods for generating a mask for automated assessment of embryo quality |
| JP2018014991A (ja) * | 2016-07-13 | 2018-02-01 | ソニー株式会社 | 情報処理装置、情報処理方法及び情報処理システム |
| JP2018022216A (ja) * | 2016-08-01 | 2018-02-08 | ソニー株式会社 | 情報処理装置、情報処理方法、及びプログラム |
| WO2018083984A1 (ja) | 2016-11-02 | 2018-05-11 | ソニー株式会社 | 情報処理装置、情報処理方法及び情報処理システム |
| JP6977293B2 (ja) * | 2017-03-31 | 2021-12-08 | ソニーグループ株式会社 | 情報処理装置、情報処理方法、プログラム及び観察システム |
| JP7100431B2 (ja) * | 2017-07-14 | 2022-07-13 | 株式会社ニコン | 受精卵判定装置、受精卵判定システム、及び受精卵判定プログラム |
| US20210198605A1 (en) | 2017-10-26 | 2021-07-01 | Sony Corporation | Information processing apparatus, information processing method, program, and observation system |
| JP6732722B2 (ja) * | 2017-12-11 | 2020-08-05 | 憲隆 福永 | 胚選抜システム |
| EP3812449A4 (en) * | 2018-06-20 | 2022-03-23 | JCR Pharmaceuticals Co., Ltd. | Analysis software and device for embryo selection |
| GB201810634D0 (en) * | 2018-06-28 | 2018-08-15 | Vitrolife As | Methods and apparatus for assessing embryo development |
| CN109214437A (zh) * | 2018-08-22 | 2019-01-15 | 湖南自兴智慧医疗科技有限公司 | 一种基于机器学习的ivf-et早孕胚胎发育预测系统 |
| EP4026089A4 (en) * | 2019-09-06 | 2022-11-09 | The Brigham & Women's Hospital, Inc. | AUTOMATED EVALUATION OF QUALITY ASSURANCE METRICS FOR SUPPORTED PLAYBACK METHODS |
| IL300312A (en) * | 2020-08-03 | 2023-04-01 | Emgenisys Inc | Evaluation of embryos based on real-time video |
| JP2024054578A (ja) | 2022-10-05 | 2024-04-17 | 株式会社アステック | タイムラプス撮影機能付き培養装置および培養方法 |
| CN116091421A (zh) * | 2022-12-16 | 2023-05-09 | 中山大学 | 一种体外受精胚胎卵裂球图像自动分割及面积计算的方法 |
| CN116758539B (zh) * | 2023-08-17 | 2023-10-31 | 武汉互创联合科技有限公司 | 一种基于数据增强的胚胎图像卵裂球识别方法 |
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| US3618734A (en) * | 1969-06-10 | 1971-11-09 | Res Foundation Of Children S H | Specimen incubator |
| DE2940446C2 (de) * | 1979-10-05 | 1982-07-08 | B. Braun Melsungen Ag, 3508 Melsungen | Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen |
| US4724543A (en) * | 1985-09-10 | 1988-02-09 | Beckman Research Institute, City Of Hope | Method and apparatus for automatic digital image analysis |
| JP2559760B2 (ja) * | 1987-08-31 | 1996-12-04 | 株式会社日立製作所 | 細胞搬送方法 |
| US5196168A (en) * | 1991-12-19 | 1993-03-23 | Eastman Kodak Company | Incubator with positioning device for slide elements |
| EP0590485B1 (en) * | 1992-09-28 | 1998-07-29 | Becton, Dickinson and Company | Cell culture insert |
| US5763279A (en) * | 1993-09-09 | 1998-06-09 | Synthecon, Inc. | Gas permeable bioreactor and method of use |
| US5968340A (en) * | 1997-04-07 | 1999-10-19 | Marine Biological Laboratory | Polarographic self-referencing probe and method for using |
| US6228636B1 (en) * | 1998-09-21 | 2001-05-08 | Matsushita Electric Industrial Co., Ltd. | Incubator |
| DE19903506C2 (de) * | 1999-01-29 | 2002-04-04 | Inst Chemo Biosensorik | Verfahren, Gefäß und Vorrichtung zur Überwachung der Stoffwechselaktivität von Zellkulturen in flüssigen Medien |
| US6391577B1 (en) * | 1999-03-03 | 2002-05-21 | Susan R. Mikkelsen | Rapid electrochemical assay for antibiotic and cytotoxic drug susceptibility in microorganisms |
| JP3442357B2 (ja) * | 2000-08-25 | 2003-09-02 | 株式会社日立製作所 | 両生類卵母細胞試料導入装置、両生類卵母細胞試料導入システム、両生類卵母細胞試料導入方法、両生類卵母細胞の製造方法、両生類卵母細胞及びそれを販売又は譲渡する方法、スクリーニング用のセンサーとして用いる方法、容器、及び解析方法 |
| US6434320B1 (en) * | 2000-10-13 | 2002-08-13 | Comtrak Technologies, Llc | Method of searching recorded digital video for areas of activity |
| US6555365B2 (en) * | 2000-12-07 | 2003-04-29 | Biocrystal, Ltd. | Microincubator comprising a cell culture apparatus and a transparent heater |
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| CA2476072A1 (en) * | 2002-02-13 | 2003-09-18 | Reify Corporation | Method and apparatus for acquisition, compression, and characterization of spatiotemporal signals |
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| WO2005028519A2 (en) * | 2003-02-19 | 2005-03-31 | Vanderbilt University | Polymer matrixes having nanoscale channels and uses |
| US7372985B2 (en) * | 2003-08-15 | 2008-05-13 | Massachusetts Institute Of Technology | Systems and methods for volumetric tissue scanning microscopy |
| US7239719B2 (en) * | 2003-08-22 | 2007-07-03 | Bbn Technologies Corp. | Automatic target detection and motion analysis from image data |
| US20050118563A1 (en) * | 2003-08-28 | 2005-06-02 | Geoffrey Sher | Method for determining embryo quality |
| US20070015289A1 (en) * | 2003-09-19 | 2007-01-18 | Kao H P | Dispenser array spotting |
| JP3950972B2 (ja) * | 2003-11-14 | 2007-08-01 | 国立大学法人名古屋大学 | 生物試料の生物発光測定装置 |
| CA2549928A1 (en) * | 2003-12-19 | 2005-06-30 | University Of Waterloo | Cultured cell and method and apparatus for cell culture |
| US7336401B2 (en) * | 2003-12-19 | 2008-02-26 | Xerox Corporation | Systems and methods for estimating an image marking process using event mapping of scanned image attributes |
| JP4333426B2 (ja) * | 2004-03-19 | 2009-09-16 | ソニー株式会社 | 化合物半導体の製造方法、及び半導体装置の製造方法 |
| JP5451073B2 (ja) * | 2005-10-14 | 2014-03-26 | ユニセンス・ファーティリテック・アクティーゼルスカブ | 細胞集団における変化の決定 |
| US20080056952A1 (en) * | 2006-08-25 | 2008-03-06 | Angros Lee H | Analytic plates with markable portions and methods of use |
-
2007
- 2007-06-15 JP JP2009514641A patent/JP5731748B2/ja active Active
- 2007-06-15 CN CN200780027901.8A patent/CN101495619B/zh not_active Expired - Fee Related
- 2007-06-15 CN CN201210428780.0A patent/CN103074410B/zh not_active Expired - Fee Related
- 2007-06-15 US US12/304,905 patent/US20100041090A1/en not_active Abandoned
- 2007-06-15 EP EP07722668A patent/EP2035548B1/en not_active Revoked
- 2007-06-15 DK DK07722668.6T patent/DK2035548T3/da active
- 2007-06-15 DE DE602007008419T patent/DE602007008419D1/de active Active
- 2007-06-15 EP EP10172399A patent/EP2282210A1/en not_active Withdrawn
- 2007-06-15 AT AT07722668T patent/ATE477499T1/de not_active IP Right Cessation
- 2007-06-15 WO PCT/DK2007/000291 patent/WO2007144001A2/en not_active Ceased
-
2012
- 2012-01-31 US US13/362,895 patent/US20120309043A1/en not_active Abandoned
- 2012-07-31 US US13/562,989 patent/US20130102837A1/en not_active Abandoned
- 2012-10-01 US US13/632,505 patent/US20130225917A1/en not_active Abandoned
-
2013
- 2013-07-05 JP JP2013141334A patent/JP5732110B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5731748B2 (ja) | 2015-06-10 |
| EP2035548B1 (en) | 2010-08-11 |
| JP2009539387A (ja) | 2009-11-19 |
| CN103074410A (zh) | 2013-05-01 |
| CN101495619A (zh) | 2009-07-29 |
| CN101495619B (zh) | 2014-01-08 |
| US20100041090A1 (en) | 2010-02-18 |
| EP2035548A2 (en) | 2009-03-18 |
| US20120309043A1 (en) | 2012-12-06 |
| US20130102837A1 (en) | 2013-04-25 |
| DE602007008419D1 (de) | 2010-09-23 |
| DK2035548T3 (da) | 2010-11-22 |
| CN103074410B (zh) | 2016-12-07 |
| WO2007144001A3 (en) | 2008-06-05 |
| EP2282210A1 (en) | 2011-02-09 |
| JP5732110B2 (ja) | 2015-06-10 |
| US20130225917A1 (en) | 2013-08-29 |
| JP2013198503A (ja) | 2013-10-03 |
| WO2007144001A2 (en) | 2007-12-21 |
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