ATE477485T1 - Neuartige mittel und verfahren zur behandlung von gehörverlust und phantomhören - Google Patents
Neuartige mittel und verfahren zur behandlung von gehörverlust und phantomhörenInfo
- Publication number
- ATE477485T1 ATE477485T1 AT08004076T AT08004076T ATE477485T1 AT E477485 T1 ATE477485 T1 AT E477485T1 AT 08004076 T AT08004076 T AT 08004076T AT 08004076 T AT08004076 T AT 08004076T AT E477485 T1 ATE477485 T1 AT E477485T1
- Authority
- AT
- Austria
- Prior art keywords
- fragment
- seq
- nucleic acid
- protein
- sequence
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90209—Oxidoreductases (1.) acting on NADH or NADPH (1.6), e.g. those with a heme protein as acceptor (1.6.2) (general), Cytochrome-b5 reductase (1.6.2.2) or NADPH-cytochrome P450 reductase (1.6.2.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/14—Disorders of ear, nose or throat
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Biophysics (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04013266A EP1602926A1 (de) | 2004-06-04 | 2004-06-04 | Neue Mittel und Verfahren zur Behandlung von Gehörverlust oder Tinnitus |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE477485T1 true ATE477485T1 (de) | 2010-08-15 |
Family
ID=34925261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08004076T ATE477485T1 (de) | 2004-06-04 | 2005-06-06 | Neuartige mittel und verfahren zur behandlung von gehörverlust und phantomhören |
Country Status (7)
Country | Link |
---|---|
US (3) | US8088359B2 (de) |
EP (3) | EP1602926A1 (de) |
AT (1) | ATE477485T1 (de) |
DE (1) | DE602005022948D1 (de) |
DK (1) | DK1923702T3 (de) |
ES (1) | ES2349894T3 (de) |
WO (1) | WO2005119251A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU782966B2 (en) | 1999-06-08 | 2005-09-15 | University Of Iowa Research Foundation, The | Compounds and methods to enhance RAAV transduction |
US8241622B2 (en) | 2001-07-13 | 2012-08-14 | University Of Iowa Research Foundation | Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences |
JP2006521825A (ja) | 2003-03-31 | 2006-09-28 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | rAAV導入を高めるための化合物および方法 |
JP2009521928A (ja) * | 2005-12-30 | 2009-06-11 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | 神経細胞変性疾患の治療に有用な化合物を特定する方法 |
US7825099B2 (en) | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
WO2007127464A2 (en) * | 2006-04-28 | 2007-11-08 | University Of Iowa Research Foundation | Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection, method to identify a viral receptor or co-receptor |
JP2010507387A (ja) | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のsiRNAおよびその使用方法 |
WO2009044294A2 (en) * | 2007-06-15 | 2009-04-09 | Université De Geneve | Means and methods for the treatment of cataract and presbyopia |
ES2474176T3 (es) | 2007-06-27 | 2014-07-08 | Quark Pharmaceuticals, Inc. | Composiciones y métodos para inhibir la expresión de genes pro-apopt�ticos |
WO2009023025A1 (en) * | 2007-08-13 | 2009-02-19 | Board Of Trustees Of Southern Illinois University | Methods for treatment and prevention of ototoxicity by sirna |
RU2487716C2 (ru) | 2007-10-03 | 2013-07-20 | Кварк Фармасьютикалс, Инк. | Новые структуры малых интерферирующих рнк (sirna) |
EP2219602A1 (de) * | 2007-11-15 | 2010-08-25 | Amgen, Inc | Wässrige formulierung von mit antioxidantien stabilisiertem erythropoese-stimulierendem protein zur parenteralen verabreichung |
US8431692B2 (en) * | 2008-06-06 | 2013-04-30 | Quark Pharmaceuticals, Inc. | Compositions and methods for treatment of ear disorders |
WO2010080452A2 (en) | 2008-12-18 | 2010-07-15 | Quark Pharmaceuticals, Inc. | siRNA COMPOUNDS AND METHODS OF USE THEREOF |
SG11201401648RA (en) | 2011-11-03 | 2014-05-29 | Quark Pharmaceuticals Inc | Methods and compositions for neuroprotection |
US20140364484A1 (en) | 2012-01-12 | 2014-12-11 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
US11702672B2 (en) | 2016-02-08 | 2023-07-18 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
CA3016985C (en) | 2016-03-07 | 2023-07-04 | University Of Iowa Research Foundation | Aav-mediated expression using a synthetic promoter and enhancer |
US11142775B2 (en) | 2017-01-13 | 2021-10-12 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding RNA and uses thereof |
US20220054640A1 (en) * | 2018-12-11 | 2022-02-24 | Decibel Therapeutics, Inc. | Compositions and methods for the delivery of therapeutic agents across the round window membrane |
Family Cites Families (34)
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US4394448A (en) | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
US4670388A (en) | 1982-12-30 | 1987-06-02 | Carnegie Institution Of Washington | Method of incorporating DNA into genome of drosophila |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
JP3046318B2 (ja) | 1987-12-15 | 2000-05-29 | ジーン・シアーズ・ピーティーワイ・リミテッド | リボザイム |
AU631545B2 (en) | 1988-04-15 | 1992-12-03 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
CA1340323C (en) | 1988-09-20 | 1999-01-19 | Arnold E. Hampel | Rna catalyst for cleaving specific rna sequences |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
JPH07509137A (ja) | 1992-07-24 | 1995-10-12 | セル ジェネシス,インク. | 異種抗体の生産 |
GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
ATE301201T1 (de) | 1993-06-07 | 2005-08-15 | Vical Inc | Für die gentherapie verwendbare plasmide |
KR20050085971A (ko) | 1995-04-27 | 2005-08-29 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
CA2225460A1 (en) | 1995-06-23 | 1997-01-09 | Winston Campbell Patterson | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
US5763496A (en) | 1995-11-27 | 1998-06-09 | The Research Foundation Of State University Of New York | Prevention of atherosclerosis using NADPH oxidase inhibitors |
EP1131430B1 (de) | 1998-11-10 | 2007-01-17 | Emory University | Mitogene regulatoren |
US6242473B1 (en) | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
WO2002030453A1 (en) | 2000-10-12 | 2002-04-18 | Beth Israel Deaconess Medical Center, Inc. | Methods of inhibiting angiogenesis using nadph oxidase inhibitors |
JP2004537981A (ja) | 2000-11-16 | 2004-12-24 | エモリー・ユニバーシティ | マイトジェンオキシゲナーゼ調節因子 |
CZ302719B6 (cs) | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
ATE392213T1 (de) * | 2001-02-20 | 2008-05-15 | Gtx Pharmaceuticals Gmbh | Verwendung von gamma-gt inhibitoren zur behandlung von chronischen degenerativerkrankungen |
US6489149B1 (en) | 2001-03-29 | 2002-12-03 | Pe Corporation (Ny) | Isolated human NADPH oxidase, nucleic acid molecules encoding said proteins, and uses thereof |
EP1509285B1 (de) * | 2002-03-25 | 2006-12-20 | Council of Scientific and Industrial Research | Synergistische zusammensetzung aus trans-tetracos-15-ensäure und apocynin, und verwendung davon |
WO2003087399A1 (en) | 2002-04-17 | 2003-10-23 | Glucox Ab | Nad)p)h oxidase inhibitors for increased glucose uptake and treatment of type ii diabetes |
EP1509618B1 (de) | 2002-05-13 | 2008-08-20 | Arexis AB | Autoimmunerkrankungen und nadph-oxidase-defekte |
AU2003253928A1 (en) * | 2002-07-12 | 2004-02-02 | Emory University | Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates |
US7029673B2 (en) | 2002-07-16 | 2006-04-18 | Emory University | Regulatory protein for Nox enzymes |
EP1560931B1 (de) | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Funktionelle und hyperfunktionelle sirna |
US7825099B2 (en) | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
JP2010507387A (ja) | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のsiRNAおよびその使用方法 |
WO2008152636A2 (en) | 2007-06-15 | 2008-12-18 | Quark Pharmaceuticals, Inc. | Compositions and methods for inhibiting nadph oxidase expression |
-
2004
- 2004-06-04 EP EP04013266A patent/EP1602926A1/de not_active Withdrawn
-
2005
- 2005-06-06 ES ES08004076T patent/ES2349894T3/es active Active
- 2005-06-06 EP EP05750543A patent/EP1766390A2/de not_active Withdrawn
- 2005-06-06 US US11/628,419 patent/US8088359B2/en not_active Expired - Fee Related
- 2005-06-06 DE DE602005022948T patent/DE602005022948D1/de active Active
- 2005-06-06 DK DK08004076.9T patent/DK1923702T3/da active
- 2005-06-06 WO PCT/EP2005/006061 patent/WO2005119251A2/en not_active Application Discontinuation
- 2005-06-06 EP EP08004076A patent/EP1923702B1/de not_active Not-in-force
- 2005-06-06 AT AT08004076T patent/ATE477485T1/de active
-
2011
- 2011-12-23 US US13/336,147 patent/US8722639B2/en not_active Expired - Fee Related
-
2014
- 2014-04-07 US US14/246,186 patent/US9650635B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2005119251A3 (en) | 2006-05-26 |
US8088359B2 (en) | 2012-01-03 |
DK1923702T3 (da) | 2010-10-25 |
DE602005022948D1 (de) | 2010-09-23 |
ES2349894T3 (es) | 2011-01-12 |
US20090263323A1 (en) | 2009-10-22 |
US9650635B2 (en) | 2017-05-16 |
EP1602926A1 (de) | 2005-12-07 |
EP1766390A2 (de) | 2007-03-28 |
EP1923702A2 (de) | 2008-05-21 |
WO2005119251A2 (en) | 2005-12-15 |
US8722639B2 (en) | 2014-05-13 |
US20140356457A1 (en) | 2014-12-04 |
US20120252868A1 (en) | 2012-10-04 |
EP1923702B1 (de) | 2010-08-11 |
EP1923702A3 (de) | 2008-08-06 |
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