ATE477224T1 - Verwendung von miniatursierten vorrichtungen zur herstellung von radiomarkierten verbindungen - Google Patents
Verwendung von miniatursierten vorrichtungen zur herstellung von radiomarkierten verbindungenInfo
- Publication number
- ATE477224T1 ATE477224T1 AT03712355T AT03712355T ATE477224T1 AT E477224 T1 ATE477224 T1 AT E477224T1 AT 03712355 T AT03712355 T AT 03712355T AT 03712355 T AT03712355 T AT 03712355T AT E477224 T1 ATE477224 T1 AT E477224T1
- Authority
- AT
- Austria
- Prior art keywords
- devices
- tagted
- radiom
- miniatured
- connections
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/45—Monoamines
- C07C211/48—N-alkylated amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00905—Separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Prostheses (AREA)
- Saccharide Compounds (AREA)
- Nuclear Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Transceivers (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Support Of Aerials (AREA)
- Circuits Of Receivers In General (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0206117.4A GB0206117D0 (en) | 2002-03-15 | 2002-03-15 | Use of microfabricated devices |
PCT/GB2003/001097 WO2003078358A2 (en) | 2002-03-15 | 2003-03-14 | Use of microfabricated devices for radiosynthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE477224T1 true ATE477224T1 (de) | 2010-08-15 |
Family
ID=9933027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03712355T ATE477224T1 (de) | 2002-03-15 | 2003-03-14 | Verwendung von miniatursierten vorrichtungen zur herstellung von radiomarkierten verbindungen |
Country Status (10)
Country | Link |
---|---|
US (2) | US20050226776A1 (de) |
EP (1) | EP1487763B1 (de) |
JP (2) | JP2005520827A (de) |
AT (1) | ATE477224T1 (de) |
AU (1) | AU2003216820A1 (de) |
DE (1) | DE60333736D1 (de) |
DK (1) | DK1487763T3 (de) |
ES (1) | ES2349692T3 (de) |
GB (1) | GB0206117D0 (de) |
WO (1) | WO2003078358A2 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2004093652A2 (en) * | 2003-04-22 | 2004-11-04 | Molecular Technologies, Inc. | System and method for synthesis of molecular imaging probes including fdg |
GB0329812D0 (en) * | 2003-12-23 | 2004-01-28 | Amersham Plc | Romp polymer synthesis |
US20050276751A1 (en) * | 2004-01-20 | 2005-12-15 | Chao K S C | System and method for an automated synthesis of gallium-68 generator-based radiopharmaceutical agents |
US20050232387A1 (en) * | 2004-04-20 | 2005-10-20 | Padgett Henry C | Microfluidic apparatus and method for synthesis of molecular imaging probes |
FI20041388A0 (fi) * | 2004-10-27 | 2004-10-27 | Kari Hartonen | Ainakin yhden vetyisotoopin käsittävien substraattien valmistus |
EP1838431A4 (de) * | 2004-12-03 | 2012-08-22 | California Inst Of Techn | Mikrofluidikvorrichtungen mit kreisläufen für chemische reaktionen |
US20060292073A1 (en) * | 2005-06-23 | 2006-12-28 | Emory University | Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging |
EP1893244A4 (de) | 2005-06-23 | 2009-06-24 | Univ Emory | Kontrastmittel |
ES2379921T3 (es) * | 2005-09-29 | 2012-05-07 | Siemens Medical Solutions Usa, Inc. | Chip microfluídico que puede sintetizar moléculas marcadas radiactivamente en una escala adecuada para la obtención de imágenes en seres humanos con tomografía por emisión de positrones |
EP1772157A1 (de) * | 2005-10-06 | 2007-04-11 | Karl-Heinz Jansen | Modul-Bausatz und Syntheseverfahren zum Herstellen von Radiopharmaka und Radionukliden |
JP4920301B2 (ja) * | 2006-05-10 | 2012-04-18 | 住友重機械工業株式会社 | Ri化合物合成装置及びri化合物合成方法 |
US7998418B1 (en) | 2006-06-01 | 2011-08-16 | Nanotek, Llc | Evaporator and concentrator in reactor and loading system |
US7641860B2 (en) | 2006-06-01 | 2010-01-05 | Nanotek, Llc | Modular and reconfigurable multi-stage microreactor cartridge apparatus |
EP1889849A1 (de) * | 2006-07-18 | 2008-02-20 | Lonza Ag | Reaktionen vom Grignardtyp in Mikroreaktoren |
WO2008015391A1 (en) * | 2006-08-03 | 2008-02-07 | Hammersmith Imanet Limited | Method for the purification of radiolabelled compounds |
US7854902B2 (en) | 2006-08-23 | 2010-12-21 | Nanotek, Llc | Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same |
EP2070937A4 (de) * | 2006-09-06 | 2014-01-01 | Nihon Mediphysics Co Ltd | Verfahren zur herstellung einer mit radioaktivem fluor markierten organischen verbindung und entsprechender syntheseapparat und programm |
CN103772085A (zh) * | 2006-12-21 | 2014-05-07 | 哈默史密斯网上成像有限公司 | 采用微组配装置的亲核放射氟化 |
US9326742B2 (en) * | 2007-01-01 | 2016-05-03 | Bayer Healthcare Llc | Systems for integrated radiopharmaceutical generation, preparation, transportation and administration |
US7829032B2 (en) | 2007-01-23 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography |
US7797988B2 (en) | 2007-03-23 | 2010-09-21 | Advion Biosystems, Inc. | Liquid chromatography-mass spectrometry |
WO2008128201A1 (en) * | 2007-04-12 | 2008-10-23 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
US8071035B2 (en) | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
JP5309312B2 (ja) | 2007-11-01 | 2013-10-09 | Jfeテクノス株式会社 | マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法 |
US8246752B2 (en) | 2008-01-25 | 2012-08-21 | Clear Catheter Systems, Inc. | Methods and devices to clear obstructions from medical tubes |
WO2010021719A1 (en) * | 2008-08-19 | 2010-02-25 | The Regents Of The University Of California | Modular radiochemistry synthesis system |
US9302990B2 (en) | 2008-10-21 | 2016-04-05 | Nutech Ventures | Fluorination of aromatic ring systems |
EP2537826B1 (de) | 2008-10-21 | 2017-03-08 | Nutech Ventures, Inc. | Fluorierung aromatischer Ringsysteme |
WO2010101118A1 (ja) * | 2009-03-04 | 2010-09-10 | 株式会社島津製作所 | マイクロ合成技術を用いた[18f]sfbの合成方法 |
JP5237880B2 (ja) * | 2009-04-30 | 2013-07-17 | Jfeテクノス株式会社 | マイクロチップを用いたpet用標識化合物の製造方法及び装置 |
US8273300B2 (en) | 2009-07-09 | 2012-09-25 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
US8377704B2 (en) * | 2009-10-20 | 2013-02-19 | Nutech Ventures | Detection and quantification of anions |
US8546578B2 (en) * | 2010-02-04 | 2013-10-01 | Nutech Ventures | Iodonium Cyclophanes for SECURE arene functionalization |
CN106110518A (zh) | 2010-06-04 | 2016-11-16 | 拜耳医药保健有限责任公司 | 用于规划和监测在放射性药物注射器上的多剂量放射性药物使用的系统和方法 |
DE102010017511A1 (de) | 2010-06-22 | 2012-02-02 | Abx Advanced Biochemical Compounds Gmbh | Vorrichtung und Verfahren zur Herstellung radiochemischer Verbindungen |
US8980185B2 (en) | 2010-08-26 | 2015-03-17 | The Board Of Trustees Of The University Of Illinois | Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate |
US20130004414A1 (en) * | 2011-06-30 | 2013-01-03 | General Electric Company | Devices and methods for reducing radiolysis of radioisotopes |
US20130005958A1 (en) * | 2011-06-30 | 2013-01-03 | General Electric Company | Devices and methods for reducing radiolysis of radioisotopes |
JP5885548B2 (ja) * | 2012-03-12 | 2016-03-15 | 株式会社神戸製鋼所 | 多流路機器の運転方法及び多流路機器 |
JP2017528509A (ja) | 2014-06-06 | 2017-09-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自己遮蔽ベンチトップ型ケミストリシステム |
GB201418899D0 (en) * | 2014-10-23 | 2014-12-10 | Univ Hull | System for radiopharmaceutical production |
GB201418897D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | Methods and apparatus for the analysis of compounds |
GB201418893D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | Monolithic body |
CN105985385B (zh) * | 2015-05-07 | 2018-12-21 | 陕西正泽生物技术有限公司 | 一种集成流路板合成18f-fdg的方法 |
US10295512B2 (en) * | 2015-12-08 | 2019-05-21 | Dionex Corporation | Multi-lumen mixing device for chromatography |
FR3072301B1 (fr) * | 2017-10-18 | 2022-01-07 | P M B | Cassette microfluidique de synthese d'un radio-traceur et procede de synthese d'un radio-traceur avec une telle cassette |
JP7127164B2 (ja) * | 2021-01-19 | 2022-08-29 | 日本メジフィジックス株式会社 | 2-[18f]フルオロ-2-デオキシ-d-グルコースの製造方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS59216830A (ja) * | 1983-05-25 | 1984-12-06 | Takeda Chem Ind Ltd | 放射性物質を含む化合物の小型自動合成装置 |
JPH0698303B2 (ja) * | 1985-04-25 | 1994-12-07 | 住友重機械工業株式会社 | ミクロ反応及び分取装置 |
AU7817994A (en) * | 1993-10-18 | 1995-05-08 | Imperial Chemical Industries Plc | Catalytic process |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5808020A (en) * | 1996-08-12 | 1998-09-15 | Associated Universities, Inc. | Optical reaction cell and light source for 18F! fluoride radiotracer synthesis |
US5921678A (en) * | 1997-02-05 | 1999-07-13 | California Institute Of Technology | Microfluidic sub-millisecond mixers |
US6235471B1 (en) * | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6391622B1 (en) * | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
JP3654481B2 (ja) * | 1997-06-05 | 2005-06-02 | 独立行政法人理化学研究所 | 生化学反応用マイクロリアクタ |
GB9808836D0 (en) * | 1998-04-27 | 1998-06-24 | Amersham Pharm Biotech Uk Ltd | Microfabricated apparatus for cell based assays |
WO2001034660A2 (en) | 1999-11-09 | 2001-05-17 | Sri International | Screening and analysis of polymers, specialty chemicals and catalysts using radiography |
WO2001034290A2 (en) * | 1999-11-09 | 2001-05-17 | Sri International | Array for generating combinatorial libraries |
US7485454B1 (en) * | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
GB0115929D0 (en) | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase electrophilic fluorination |
GB0115927D0 (en) | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
-
2002
- 2002-03-15 GB GBGB0206117.4A patent/GB0206117D0/en not_active Ceased
-
2003
- 2003-03-14 EP EP03712355A patent/EP1487763B1/de not_active Expired - Lifetime
- 2003-03-14 ES ES03712355T patent/ES2349692T3/es not_active Expired - Lifetime
- 2003-03-14 AT AT03712355T patent/ATE477224T1/de active
- 2003-03-14 DK DK03712355.1T patent/DK1487763T3/da active
- 2003-03-14 JP JP2003576367A patent/JP2005520827A/ja active Pending
- 2003-03-14 DE DE60333736T patent/DE60333736D1/de not_active Expired - Lifetime
- 2003-03-14 AU AU2003216820A patent/AU2003216820A1/en not_active Abandoned
- 2003-03-14 US US10/507,964 patent/US20050226776A1/en not_active Abandoned
- 2003-03-14 WO PCT/GB2003/001097 patent/WO2003078358A2/en active Application Filing
-
2013
- 2013-08-12 JP JP2013167217A patent/JP2014012684A/ja active Pending
-
2014
- 2014-04-15 US US14/253,049 patent/US9169284B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60333736D1 (de) | 2010-09-23 |
EP1487763A2 (de) | 2004-12-22 |
US20050226776A1 (en) | 2005-10-13 |
US9169284B2 (en) | 2015-10-27 |
WO2003078358A3 (en) | 2003-12-31 |
GB0206117D0 (en) | 2002-04-24 |
DK1487763T3 (da) | 2010-11-22 |
JP2005520827A (ja) | 2005-07-14 |
ES2349692T3 (es) | 2011-01-10 |
JP2014012684A (ja) | 2014-01-23 |
AU2003216820A1 (en) | 2003-09-29 |
AU2003216820A8 (en) | 2003-09-29 |
US20140316130A1 (en) | 2014-10-23 |
WO2003078358A2 (en) | 2003-09-25 |
EP1487763B1 (de) | 2010-08-11 |
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