ATE475716T1 - Zusammenstellungen zur behandlung von neurodegenerativen erkrankungen - Google Patents
Zusammenstellungen zur behandlung von neurodegenerativen erkrankungenInfo
- Publication number
- ATE475716T1 ATE475716T1 AT02760784T AT02760784T ATE475716T1 AT E475716 T1 ATE475716 T1 AT E475716T1 AT 02760784 T AT02760784 T AT 02760784T AT 02760784 T AT02760784 T AT 02760784T AT E475716 T1 ATE475716 T1 AT E475716T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- treatment
- neurodegenerative diseases
- subjects
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 241000702421 Dependoparvovirus Species 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 238000001476 gene delivery Methods 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 210000004498 neuroglial cell Anatomy 0.000 abstract 1
- 230000003961 neuronal insult Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31583801P | 2001-08-29 | 2001-08-29 | |
PCT/JP2002/008761 WO2003018821A2 (en) | 2001-08-29 | 2002-08-29 | Compositions and methods for treating neurodegenerative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE475716T1 true ATE475716T1 (de) | 2010-08-15 |
Family
ID=23226283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02760784T ATE475716T1 (de) | 2001-08-29 | 2002-08-29 | Zusammenstellungen zur behandlung von neurodegenerativen erkrankungen |
Country Status (10)
Country | Link |
---|---|
US (1) | US20030050273A1 (de) |
EP (1) | EP1421199B1 (de) |
JP (1) | JP4279141B2 (de) |
KR (1) | KR20040039316A (de) |
CN (1) | CN1304581C (de) |
AT (1) | ATE475716T1 (de) |
AU (1) | AU2002326163B2 (de) |
CA (1) | CA2457057C (de) |
DE (1) | DE60237158D1 (de) |
WO (1) | WO2003018821A2 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6815431B2 (en) | 1998-04-15 | 2004-11-09 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
AU2002359786A1 (en) * | 2001-12-19 | 2003-07-09 | Hiroaki Mizukami | Adeno-associated virus-mediated delivery of gdnf to skeletal muscles |
US6998118B2 (en) * | 2001-12-21 | 2006-02-14 | The Salk Institute For Biological Studies | Targeted retrograde gene delivery for neuronal protection |
WO2003055983A2 (en) * | 2001-12-21 | 2003-07-10 | The Salk Institute For Biological Studies | Targeted retrograde gene delivery to motor neurons |
US20060258576A1 (en) * | 2003-09-05 | 2006-11-16 | Licentia, Ltd | Gdnf-related neuropeptides |
JP2007509109A (ja) | 2003-10-20 | 2007-04-12 | エヌエスジーン・アクティーゼルスカブ | パーキンソン病のインビボ遺伝子治療 |
WO2005074605A2 (en) * | 2004-02-03 | 2005-08-18 | University Of Rochester | Recombinant molecular products for expression of heme oxygenase-1, heme oxygenase-2, and/or biliverdin reductase for treatment of neurodegenerative diseases or disorders |
EP1769718B1 (de) | 2004-07-02 | 2011-09-07 | Osaka University | Endoskopbefestigung und endoskop |
EP3058959B1 (de) * | 2005-05-02 | 2019-01-30 | Genzyme Corporation | Gentherapie für neurometabolische erkrankungen |
CA2606490C (en) | 2005-05-02 | 2018-02-06 | Genzyme Corporation | Gene therapy for spinal cord disorders |
EP2389191A2 (de) | 2009-01-23 | 2011-11-30 | NsGene A/S | Expression von neuropeptiden in säugetierzellen |
CN102369024A (zh) * | 2009-01-29 | 2012-03-07 | 加利福尼亚大学董事会 | 用于向整个皮质中分布高水平治疗剂以治疗神经障碍的方法 |
RU2603740C2 (ru) * | 2009-05-02 | 2016-11-27 | Джензим Корпорейшн | Генная терапия нейродегенеративных нарушений |
US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
EP2634253B1 (de) | 2010-10-27 | 2016-05-11 | Jichi Medical University | Adeno-assoziierte virus-virionen zur übertragung von genen in nervenzellen |
CN102618507B (zh) * | 2012-03-23 | 2015-04-22 | 首都医科大学 | 增加腺相关病毒靶向转导效率的重组腺相关病毒及其应用 |
US8999927B2 (en) | 2012-04-02 | 2015-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Glial cell line-derived neurotrophic factor (GDNF) compositions and use thereof |
US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
CN107073051B (zh) | 2014-10-21 | 2021-08-24 | 马萨诸塞大学 | 重组aav变体及其用途 |
JP2019530463A (ja) | 2016-10-13 | 2019-10-24 | ユニバーシティ オブ マサチューセッツ | Aavカプシド設計 |
US20230190958A1 (en) | 2017-01-13 | 2023-06-22 | Jichi Medical University | AAV Vector for Disrupting Coagulation Factor-Related Gene on Liver Genome |
EP3744846A4 (de) | 2018-01-26 | 2021-11-17 | Tokushima University | Adeno-assoziiertes virus-virion zur behandlung von morbus tay-sachs und morbus sandhoff |
CN110499330A (zh) * | 2018-05-16 | 2019-11-26 | 上海市同济医院 | 重组腺相关病毒载体及其应用 |
WO2020026968A1 (ja) | 2018-07-30 | 2020-02-06 | 株式会社遺伝子治療研究所 | Aavベクターによる遺伝子発現を増強する方法 |
WO2021009805A1 (ja) | 2019-07-12 | 2021-01-21 | 株式会社遺伝子治療研究所 | ヒト肝臓への遺伝子導入のためのアデノ随伴ウイルスビリオン |
JPWO2022224372A1 (de) | 2021-04-21 | 2022-10-27 | ||
WO2023093905A1 (zh) * | 2021-11-29 | 2023-06-01 | 上海瑞宏迪医药有限公司 | Aadc、gdnf多核苷酸及其用于治疗帕金森病 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
EP1243652A3 (de) * | 1991-09-20 | 2003-03-26 | Amgen Inc., | Glial neurotropher Faktor |
WO1995005864A1 (en) * | 1993-08-27 | 1995-03-02 | Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Convection-enhanced drug delivery |
ATE386131T1 (de) * | 1994-04-13 | 2008-03-15 | Univ Rockefeller | Aav-vermittelte überbringung von dna in zellen des nervensystems |
US5929041A (en) * | 1996-02-23 | 1999-07-27 | Amgen Inc. | Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product |
IL126626A0 (en) * | 1996-05-03 | 1999-08-17 | Abbott Lab | Novel antiangiogenic peptides polynucleotides encoding same and methods for inhibiting angiogenesis |
DE69941100D1 (de) * | 1998-05-27 | 2009-08-20 | Genzyme Corp | AAV Vektoren zur Herstellung der Medikamente zur konvektion-erhöhten Verabreichung |
CN1228995A (zh) * | 1999-01-26 | 1999-09-22 | 卢杲 | 一种治疗老年性痴呆症、帕金森症、心脑血管病的药物 |
US6800281B2 (en) * | 2000-11-09 | 2004-10-05 | Oxford Biomedica (Uk) Limited | Lentiviral-mediated growth factor gene therapy for neurodegenerative diseases |
-
2002
- 2002-08-28 US US10/230,875 patent/US20030050273A1/en not_active Abandoned
- 2002-08-29 AU AU2002326163A patent/AU2002326163B2/en not_active Ceased
- 2002-08-29 CA CA2457057A patent/CA2457057C/en not_active Expired - Fee Related
- 2002-08-29 CN CNB02821322XA patent/CN1304581C/zh not_active Expired - Fee Related
- 2002-08-29 AT AT02760784T patent/ATE475716T1/de not_active IP Right Cessation
- 2002-08-29 KR KR10-2004-7003027A patent/KR20040039316A/ko active Search and Examination
- 2002-08-29 JP JP2003523668A patent/JP4279141B2/ja not_active Expired - Lifetime
- 2002-08-29 DE DE60237158T patent/DE60237158D1/de not_active Expired - Lifetime
- 2002-08-29 EP EP02760784A patent/EP1421199B1/de not_active Revoked
- 2002-08-29 WO PCT/JP2002/008761 patent/WO2003018821A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN1575340A (zh) | 2005-02-02 |
EP1421199B1 (de) | 2010-07-28 |
US20030050273A1 (en) | 2003-03-13 |
DE60237158D1 (de) | 2010-09-09 |
CA2457057A1 (en) | 2003-03-06 |
CA2457057C (en) | 2011-05-10 |
KR20040039316A (ko) | 2004-05-10 |
CN1304581C (zh) | 2007-03-14 |
AU2002326163B2 (en) | 2007-10-25 |
WO2003018821A2 (en) | 2003-03-06 |
JP4279141B2 (ja) | 2009-06-17 |
EP1421199A2 (de) | 2004-05-26 |
JP2005501127A (ja) | 2005-01-13 |
WO2003018821A3 (en) | 2003-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |