ATE472558T1 - Zusammensetzungen und verfahren zur modulierung der interaktion zwischen dendritischer und t- zellen - Google Patents

Zusammensetzungen und verfahren zur modulierung der interaktion zwischen dendritischer und t- zellen

Info

Publication number
ATE472558T1
ATE472558T1 AT04078220T AT04078220T ATE472558T1 AT E472558 T1 ATE472558 T1 AT E472558T1 AT 04078220 T AT04078220 T AT 04078220T AT 04078220 T AT04078220 T AT 04078220T AT E472558 T1 ATE472558 T1 AT E472558T1
Authority
AT
Austria
Prior art keywords
cells
antibody
sign
modulating
cell
Prior art date
Application number
AT04078220T
Other languages
German (de)
English (en)
Inventor
Carl Gustav Figdor
Teunis Bernard Herman Geijtenbeek
Kooyk Yvette Van
Ruurd Torensma
Original Assignee
Univ Nijmegen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nijmegen filed Critical Univ Nijmegen
Application granted granted Critical
Publication of ATE472558T1 publication Critical patent/ATE472558T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
AT04078220T 1999-04-19 2000-04-19 Zusammensetzungen und verfahren zur modulierung der interaktion zwischen dendritischer und t- zellen ATE472558T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19990201204 EP1046651A1 (en) 1999-04-19 1999-04-19 Composition and method for modulating dendritic cell-T interaction
US17692400P 2000-01-20 2000-01-20

Publications (1)

Publication Number Publication Date
ATE472558T1 true ATE472558T1 (de) 2010-07-15

Family

ID=8240111

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04078220T ATE472558T1 (de) 1999-04-19 2000-04-19 Zusammensetzungen und verfahren zur modulierung der interaktion zwischen dendritischer und t- zellen
AT00921181T ATE398140T1 (de) 1999-04-19 2000-04-19 Zusammensetzung und verfahren zur modulierung der dendritischer-zell - t-zell wechselwirkungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00921181T ATE398140T1 (de) 1999-04-19 2000-04-19 Zusammensetzung und verfahren zur modulierung der dendritischer-zell - t-zell wechselwirkungen

Country Status (13)

Country Link
US (4) US7148329B1 (https=)
EP (3) EP1046651A1 (https=)
JP (2) JP4989820B2 (https=)
KR (3) KR100923340B1 (https=)
AT (2) ATE472558T1 (https=)
AU (1) AU776317B2 (https=)
CA (1) CA2330231C (https=)
DE (2) DE60044621D1 (https=)
DK (2) DK1516881T3 (https=)
ES (2) ES2346877T3 (https=)
NZ (1) NZ508723A (https=)
PT (2) PT1086137E (https=)
WO (1) WO2000063251A1 (https=)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1046651A1 (en) 1999-04-19 2000-10-25 Koninklijke Universiteit Nijmegen Composition and method for modulating dendritic cell-T interaction
US6515124B2 (en) * 2000-02-09 2003-02-04 Hoffman-La Roche Inc. Dehydroamino acids
KR100881471B1 (ko) 2000-05-08 2009-02-05 셀덱스 쎄라퓨틱스, 인크. 수상세포에 대한 인간 모노클로날 항체
US7560534B2 (en) 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
JP4322504B2 (ja) * 2000-12-21 2009-09-02 スチヒティング カソリーケ ユニバーシテット， ラッドボウド ユニバーシティ ネイメヘン メディカル センター 肝臓およびリンパ節中の類洞内皮細胞上において、新規なｉｃａｍ−３結合レセプターの結合活性を調節するための方法
US7022323B2 (en) 2001-06-26 2006-04-04 Progenics Pharmaceuticals, Inc. Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection
US20030013081A1 (en) 2001-06-26 2003-01-16 Olson William C. Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection
ES2197826B1 (es) * 2002-06-21 2005-04-01 Consejo Superior De Investigaciones Cientificas Compuesto terapeutico frente a la infeccion por leishmania y su uso.
WO2004026326A2 (en) * 2002-09-20 2004-04-01 Stichting Katholieke Universiteit Antigen uptake receptor for candida albicans on dendritic cells
WO2004026909A2 (en) * 2002-09-20 2004-04-01 Stichting Katholieke Universiteit Method of treating rheumatoid arthritis by interfering with expression of dc-sign by macrophages and diagnosis thereof
US20040146948A1 (en) * 2002-10-18 2004-07-29 Centenary Institute Of Cancer Medicine And Cell Biology Compositions and methods for targeting antigen-presenting cells with antibody single-chain variable region fragments
AU2003301804A1 (en) * 2002-11-05 2004-06-07 Institut National De La Sante Et De La Recherche Medicale Dc-sign blockers and their use for preventing or treating viral infections.
US7427469B2 (en) 2002-11-05 2008-09-23 Institut Pasteur Method of treating cytomegalovirus with DC-SIGN blockers
EP1417965A1 (en) * 2002-11-07 2004-05-12 Vereniging Voor Christelijk Wetenschappelijk Onderwijs C-type lectin binding molecules, identification and uses thereof
US9259459B2 (en) 2003-01-31 2016-02-16 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
ATE552860T1 (de) 2003-01-31 2012-04-15 Celldex Res Corp Antikörper-vakzine-konjugate und ihre verwendungen
EP2591786B1 (en) * 2003-10-16 2017-04-12 Cancure Limited Immunomodulating compositions and uses therefor
AU2011211337B2 (en) * 2003-10-16 2014-10-02 Cancure Limited Immunomodulating compositions and uses therefor
WO2005058244A2 (en) * 2003-12-15 2005-06-30 Alexion Pharmaceuticals, Inc. Novel anti-dc-sign antibodies
WO2005092288A1 (en) 2004-03-19 2005-10-06 Let There Be Hope Medical Research Institute Carbohydrate-derivatized liposomes for targeting cellular carbohydrate recognition domains of ctl/ctld lectins, and intracellular delivery of therapeutically active compounds
CA2566199C (en) * 2004-05-12 2013-10-22 Baxter International Inc. Delivery of as-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes
EP1765294B1 (en) * 2004-05-12 2008-09-24 Baxter International Inc. Nucleic acid microspheres, production and delivery thereof
EP1885186B1 (en) * 2005-06-01 2015-09-02 California Institute Of Technology Method of targeted gene delivery using viral vectors
FR2895262B1 (fr) * 2005-12-22 2009-07-17 Lab Francais Du Fractionnement Inhibition de la reponse immunitaire anti-fviii
AT503387B1 (de) * 2006-03-27 2008-05-15 Univ Wien Pharmazeutische zusammensetzung zur vorbeugung von infektionen
US8329162B2 (en) * 2006-07-21 2012-12-11 California Institute Of Technology Targeted gene delivery for dendritic cell vaccination
TWI422594B (zh) 2007-02-02 2014-01-11 Baylor Res Inst 經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑
CN101657464A (zh) * 2007-02-02 2010-02-24 贝勒研究院 与靶向人源化单克隆抗体复合的多变量抗原
KR20090114430A (ko) 2007-02-02 2009-11-03 베일러 리서치 인스티튜트 항원-제시 세포 상에서 발현된 ｄｃｉｒ에 대한 항원 표적화에 기초한 백신
US8426565B2 (en) 2007-08-30 2013-04-23 Walter And Eliza Hall Institute Of Medical Research Dendritic cell marker and uses thereof
RU2010121862A (ru) 2007-10-29 2011-12-10 Вирджиния Тек Интеллекчуал Пропертиз, Инк. (Us) DC-SIGN, ICAM-3 И LSECtin СВИНЬИ И ИХ ПРИМЕНЕНИЯ
CN101888856B (zh) 2007-11-07 2014-08-27 塞尔德克斯医疗公司 结合人树突和上皮细胞205(dec-205)的抗体
RS53257B2 (sr) 2009-07-24 2018-06-29 Immune Design Corp Lentiviralni vektori pseudotipizirani sa omotačem od glikobelančevine iz sindbis-virusa
US20120322085A1 (en) * 2009-11-05 2012-12-20 Osaka University Therapeutic agent for autoimmune diseases or allergy, and method for screening for the therapeutic agent
JP5690132B2 (ja) 2010-06-17 2015-03-25 株式会社マーレ フィルターシステムズ エンジンの換気システム
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
EP2603520A4 (en) 2010-08-10 2014-02-19 Ecole Polytech ERYTHROCYTE BINDING THERAPEUTICS
WO2013149167A1 (en) 2012-03-30 2013-10-03 Immune Design Corp. Lentiviral vector particles having improved transduction efficiency for cells expressing dc- sign
US8323662B1 (en) 2012-03-30 2012-12-04 Immune Design Corp. Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
DK2833914T3 (en) * 2012-04-04 2019-03-11 Vaxform Llc ADMINISTRATIVE SYSTEM FOR ORAL VACCINE ADMINISTRATION
JP6427493B2 (ja) 2012-09-18 2018-11-21 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション Ｃｄ１８０への抗原標的化のための組成物および方法
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
SG11201606761RA (en) 2014-02-21 2016-09-29 Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto Glycotargeting therapeutics
WO2015175957A1 (en) 2014-05-16 2015-11-19 Baylor Research Institute Methods and compositions for treating autoimmune and inflammatory conditions
JP7228824B2 (ja) 2015-06-30 2023-02-27 国立大学法人大阪大学 抗プレキシンａ１アゴニスト抗体
CN108210503A (zh) * 2016-12-10 2018-06-29 高尚先 甘露糖在用于提高Treg细胞数量及其Foxp3因子表达水平的新用途
WO2018232176A1 (en) 2017-06-16 2018-12-20 The University Of Chicago Compositions and methods for inducing immune tolerance
EP3790577A4 (en) 2018-05-09 2022-04-27 The University of Chicago COMPOSITIONS AND METHODS RELATED TO IMMUNTOLERANCE

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US891992A (en) 1907-06-27 1908-06-30 Henry Hess Method of forming conically-shaped ends upon rollers and other objects.
US5332567A (en) 1989-08-24 1994-07-26 Immunomedics Detection and treatment of infections with immunoconjugates
US6248332B1 (en) * 1990-10-05 2001-06-19 Medarex, Inc. Targeted immunostimulation with bispecific reagents
IL102508A0 (en) * 1991-07-16 1993-01-14 Bristol Myers Squibb Co Inhibition of non-cd4 mediated hiv infection
AU7339294A (en) 1993-07-22 1995-02-20 Precision Valve Corporation Multi-directional actuation overcap
US6084067A (en) 1993-07-26 2000-07-04 Dana-Farber Cancer Institute CTLA4/CD28 ligands and uses therefor
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
WO1995032734A1 (en) 1994-05-26 1995-12-07 Innogenetics N.V. New methods and compounds for the selective modulation of antigen-specific t-cell responsiveness
US5548275A (en) * 1995-01-23 1996-08-20 Shambayati; Ali Alarm system for enclosing and protecting an area
US5643786A (en) 1995-01-27 1997-07-01 The United States Of America As Represented By The Department Of Health And Human Services Method for isolating dendritic cells
JPH10513350A (ja) * 1995-01-31 1998-12-22 ザ ロックフェラー ユニヴァーシティ ＤＥＣ（樹状細胞及び上皮細胞、２０５ ｋＤａ）の同定、Ｃ型レクチンドメインを有するレセプター、ＤＥＣをコードする核酸、及びこれらの使用
US5871964A (en) * 1996-07-15 1999-02-16 Incyte Pharmaceuticals, Inc. Human C-type lectin
US6046158A (en) * 1996-12-20 2000-04-04 Board Of Regents The University Of Texas Systems Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
US5935813A (en) * 1997-03-20 1999-08-10 Incyte Pharmaceuticals, Inc. Human pancreatitis-associated protein
WO1998049306A1 (en) * 1997-04-29 1998-11-05 Incyte Pharmaceuticals, Inc. Human c-type lectin
AU7549498A (en) * 1997-06-03 1998-12-21 Protegene Inc. Human proteins having transmembrane domains and dnas encoding these prot eins
US6273443B1 (en) * 1998-06-01 2001-08-14 Sunrise Medical Hhg Inc. Universal elevating leg rest assembly
EP1046651A1 (en) 1999-04-19 2000-10-25 Koninklijke Universiteit Nijmegen Composition and method for modulating dendritic cell-T interaction
PT1200590E (pt) * 1999-08-12 2009-03-24 Agensys Inc Antigénio transmembranar lectina tipo c expresso em cancro da próstata humano e utilizações do mesmo
JP4322504B2 (ja) 2000-12-21 2009-09-02 スチヒティング カソリーケ ユニバーシテット， ラッドボウド ユニバーシティ ネイメヘン メディカル センター 肝臓およびリンパ節中の類洞内皮細胞上において、新規なｉｃａｍ−３結合レセプターの結合活性を調節するための方法
US20030232745A1 (en) 2001-06-26 2003-12-18 Olson William C. Uses of DC-sign and DC-Signr for inhibiting hepatitis C virus infection
US7022323B2 (en) 2001-06-26 2006-04-04 Progenics Pharmaceuticals, Inc. Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection
EP1542354B1 (en) * 2003-12-09 2021-02-03 Synergy Microwave Corporation Integrated ultra low noise microwave wideband push-push vco

Also Published As

Publication number Publication date
EP1516881B1 (en) 2010-06-30
KR20080098678A (ko) 2008-11-11
DK1086137T3 (da) 2008-10-27
KR20070094990A (ko) 2007-09-27
JP4989820B2 (ja) 2012-08-01
ES2307502T3 (es) 2008-12-01
EP1086137A1 (en) 2001-03-28
NZ508723A (en) 2003-12-19
HK1036285A1 (en) 2001-12-28
US20050220804A1 (en) 2005-10-06
DE60044621D1 (de) 2010-08-12
PT1086137E (pt) 2008-09-09
US20080160041A1 (en) 2008-07-03
KR100952883B1 (ko) 2010-04-16
ATE398140T1 (de) 2008-07-15
DE60039151D1 (de) 2008-07-24
AU4152600A (en) 2000-11-02
US7285642B2 (en) 2007-10-23
JP2010285450A (ja) 2010-12-24
KR100923340B1 (ko) 2009-10-22
CA2330231A1 (en) 2000-10-26
ES2346877T3 (es) 2010-10-21
EP1046651A1 (en) 2000-10-25
PT1516881E (pt) 2010-08-25
EP1516881A2 (en) 2005-03-23
JP2003502283A (ja) 2003-01-21
DK1516881T3 (da) 2010-09-27
US8105599B2 (en) 2012-01-31
JP5363432B2 (ja) 2013-12-11
AU776317B2 (en) 2004-09-02
EP1516881A3 (en) 2005-08-31
EP1086137B1 (en) 2008-06-11
US20050118168A1 (en) 2005-06-02
US7148329B1 (en) 2006-12-12
WO2000063251A1 (en) 2000-10-26
KR20010071530A (ko) 2001-07-28
US8058400B2 (en) 2011-11-15
CA2330231C (en) 2013-07-16

Similar Documents

Publication Publication Date Title
ATE472558T1 (de) Zusammensetzungen und verfahren zur modulierung der interaktion zwischen dendritischer und t- zellen
US20240270860A1 (en) Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
AU2016263198C1 (en) Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
JP6998763B2 (ja) Ｔ細胞またはｎｋ細胞を活性化および増加させるための、可溶性抗体複合体
JP2022515611A5 (https=)
MX2012012833A (es) Cebado cruzado de celulas t cd8 positivas humanos moderada por inmunoreceptores de celulas dendriticas (dcir).
TW202313671A (zh) 嵌合抗原和ｔ細胞受體及使用方法
WO2017197347A1 (en) METHODS FOR SELECTIVE EXPANSION OF γδ T-CELL POPULATIONS AND COMPOSITIONS THEREOF
KR20180099641A (ko) 세포의 배양 방법 및 이를 위한 키트와 장치
JPH10179151A (ja) 二特異的抗体を用いた幹細胞移植における汚染腫瘍細胞の除去
KR20090127886A (ko) 수지상 세포 렉틴 유사 산화된 ｌｄｌ 수용체-1(ｌｏｘ-1)을 통한 사람 항원제시세포의 활성화
KR20090114466A (ko) 덱틴-1을 통한 사람 항원제시세포 활성화의 치료학적 적용
CN106999556A (zh) 细胞因子诱导的杀伤细胞的双特异性抗体介导的癌症治疗
KR102832078B1 (ko) 항-글리코-muc1 항체 및 이의 용도
CA3178806A1 (en) Immune cells with enhanced function
US12577534B2 (en) Transduction and expansion of cells
CN121240869A (zh) Sirp变体及其用途
CN118354789A (zh) 抗糖-cMET抗体及其用途
CN121003685A (zh) 博来霉素作为免疫增强剂的用途
CN119215188B (zh) 抗Trop2抗体和抗5T4抗体-自然杀伤细胞偶联物及其用途
CN119280420B (zh) 多特异性偶联物及其应用
KR102584306B1 (ko) 항종양제 및 항종양 효과 증강제
WO2025261427A1 (zh) 用于评估抗体免疫激动剂偶联物产生ada的方法及其应用
CN118354788A (zh) 抗糖-muc4抗体及其用途