ATE464309T1 - Indolizinderivate und deren verwendung als crth2- antagonisten - Google Patents

Indolizinderivate und deren verwendung als crth2- antagonisten

Info

Publication number
ATE464309T1
ATE464309T1 AT06755627T AT06755627T ATE464309T1 AT E464309 T1 ATE464309 T1 AT E464309T1 AT 06755627 T AT06755627 T AT 06755627T AT 06755627 T AT06755627 T AT 06755627T AT E464309 T1 ATE464309 T1 AT E464309T1
Authority
AT
Austria
Prior art keywords
c1c6alkyl
hydrogen
fully
partially fluorinated
independently
Prior art date
Application number
AT06755627T
Other languages
English (en)
Inventor
George Hynd
Nicholas Ray
Harry Finch
David Middlemiss
Michael CRAMP
Paul Blaney
Karen Williams
Yan A Griffon
Trevor Keith Harrison
Peter Crackett
Original Assignee
Argenta Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argenta Discovery Ltd filed Critical Argenta Discovery Ltd
Application granted granted Critical
Publication of ATE464309T1 publication Critical patent/ATE464309T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06755627T 2005-06-24 2006-06-26 Indolizinderivate und deren verwendung als crth2- antagonisten ATE464309T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0512944.0A GB0512944D0 (en) 2005-06-24 2005-06-24 Indolizine compounds
PCT/GB2006/002341 WO2006136859A2 (en) 2005-06-24 2006-06-26 Indoli zine derivatives and their use as crth2 antagonists

Publications (1)

Publication Number Publication Date
ATE464309T1 true ATE464309T1 (de) 2010-04-15

Family

ID=34856120

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06755627T ATE464309T1 (de) 2005-06-24 2006-06-26 Indolizinderivate und deren verwendung als crth2- antagonisten

Country Status (8)

Country Link
US (1) US20090163534A1 (de)
EP (1) EP1910357B1 (de)
JP (1) JP2008543921A (de)
CN (1) CN101243086A (de)
AT (1) ATE464309T1 (de)
DE (1) DE602006013643D1 (de)
GB (1) GB0512944D0 (de)
WO (1) WO2006136859A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ574705A (en) 2006-08-07 2011-12-22 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
EP2094266A1 (de) * 2006-12-21 2009-09-02 Argenta Discovery Limited Crth2-antagonisten
GB0625842D0 (en) * 2006-12-22 2007-02-07 Argenta Discovery Ltd Indolizine derivatives
MX2009010068A (es) * 2007-03-21 2010-02-24 Argenta Oral Therapeutics Ltd Derivados de acido indolizin acetico como antagonistas de crth2.
AU2007350688B2 (en) * 2007-03-29 2011-02-24 Pulmagen Therapeutics (Asthma) Limited Quinoline derivatives as CRTH2 receptor ligands
MX2010003178A (es) * 2007-09-25 2010-04-30 Actimis Pharmaceuticals Inc Primidinas sustituidas con 2-s-bencilo como antagonistas de crth2.
GB0719521D0 (en) * 2007-10-05 2007-11-14 Argenta Discovery Ltd Compounds
EP2327693B9 (de) 2007-12-14 2012-10-24 Pulmagen Therapeutics (Asthma) Limited Indole und ihre therapeutische Verwendung
EP2268281A4 (de) * 2008-02-15 2012-05-02 Abbott Lab Thienopyrrole und pyrrolothiazole als neue therapiemittel
US8618300B2 (en) 2008-09-04 2013-12-31 Boehringer Ingelheim International Gmbh Indolizine inhibitors of leukotriene production
MX2011005120A (es) 2008-11-17 2011-05-30 Hoffmann La Roche Acidos naftilaceticos.
AR077428A1 (es) * 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
KR101444572B1 (ko) 2010-03-22 2014-09-24 액테리온 파마슈티칼 리미티드 3-(헤테로아릴-아미노)-1,2,3,4-테트라히드로-9ｈ-카르바졸 유도체 및 이의 프로스타글란딘 ｄ2 수용체 조절제로서의 용도
EP2457900A1 (de) 2010-11-25 2012-05-30 Almirall, S.A. Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten
DK2697223T3 (en) 2011-04-14 2016-09-05 Actelion Pharmaceuticals Ltd 7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor
WO2013088109A1 (en) 2011-12-16 2013-06-20 Oxagen Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
MX368179B (es) 2014-03-17 2019-09-23 Idorsia Pharmaceuticals Ltd Derivados del acido acetico azaindol y su uso como moduladores de receptor de prostaglandina d2.
MX2016011900A (es) 2014-03-18 2016-12-05 Actelion Pharmaceuticals Ltd Derivados de acido azaindol-acetico y su uso como moduladores del receptor de prostaglandina d2.
PL3350179T3 (pl) 2015-09-15 2021-08-02 Idorsia Pharmaceuticals Ltd Krystaliczne postacie

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174124A (en) * 1967-06-30 1969-12-10 Beecham Group Ltd Pharmacologically Active Indolizine Compounds
GB1268424A (en) * 1969-10-04 1972-03-29 Beecham Group Ltd Indolizine derivatives
ES421284A1 (es) * 1973-12-07 1976-04-16 Farmasimes S A Procedimiento para la preparacion de derivados de acidos pirrocolinaceticos.
WO2005040112A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds with pgd2 antagonist activity
CA2542716A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds having crth2 antagonist activity
GB2407318A (en) * 2003-10-23 2005-04-27 Oxagen Ltd Substituted Indol-3-yl acetic acid derivatives
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy

Also Published As

Publication number Publication date
CN101243086A (zh) 2008-08-13
GB0512944D0 (en) 2005-08-03
EP1910357B1 (de) 2010-04-14
US20090163534A1 (en) 2009-06-25
WO2006136859A2 (en) 2006-12-28
DE602006013643D1 (de) 2010-05-27
JP2008543921A (ja) 2008-12-04
EP1910357A2 (de) 2008-04-16
WO2006136859A3 (en) 2007-04-05

Similar Documents

Publication Publication Date Title
ATE464309T1 (de) Indolizinderivate und deren verwendung als crth2- antagonisten
CU20100021A7 (es) Derivado de oxopirazina y herbicida
AR062409A1 (es) Compuesto y composicion farmaceutica, utiles como agentes terapeuticos en el tratamiento, prevencion o mejoramiento de enfermedad o trastorno caracterizado por depositos o niveles de b-amiloide elevados o para inhibir o elucidar la enzima b-secretasa, y proceso para la preparacion del compuesto
RS51137B (sr) Derivat benzimidazola i njegova upotreba kao antagonista receptora aii
TNSN06203A1 (en) Derivatives of n- (1,5-diphenyl-1h-pyrazol-3-yl) sulphonamide with cb1 receptor affinity
NO20071642L (no) N-Benzensulfonylsubstituerte anilino-pyrimidinanaloger
GB0510584D0 (en) Organic compounds
ATE537830T1 (de) Nicotinamid derivate und ihre verwendung als therapeutika
MX2010008361A (es) Derivados de arilamida oxazepinopirimidona sustituidos.
RS51654B (en) DERIVATIVES OF THE SUBSTITUTED BICYCLIC PIRIMIDONE
MY148988A (en) Terphenyl derivatives for treatment of alzheimer's disease
UA96947C2 (ru) Производные циннамоил-пиперазина и их применение как антагонистов par-1
NO20082096L (no) Azaindol-2-karboksamidderivativer
MX339668B (es) Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina.
ATE478054T1 (de) Benzimidazolderivate
DE602005007064D1 (de) Chromanderivate und ihre verwendung als liganden des 5-ht-rezeptors
MX2009012377A (es) Compuestos de arilamida pirimidona.
MX2009012383A (es) Derivados de arilamida pirimidona para el tratamiento de enfermedades neurodegenerativas.
DE602006018359D1 (de) Heterocyclische derivate, deren herstellung und therapeutische verwendung
BRPI0719869A2 (pt) Composto ou um sal do mesmo, prodroga, composição farmacêutica, método para prevenir ou tratar distúrbio do sono em uma mamífero, e, uso do composto.
NO20082436L (no) Forbindelser med medisinske effekter grunnet interaksjonen med glukokortikoidreseptor
ATE414692T1 (de) Pyridinketone mit herbizideffekt
EA201070814A1 (ru) Производные 6-гетероциклоимидазо[1,2-а]пиридин-2-карбоксамидов, их получение и их применение в терапии
CY1114798T1 (el) Ενωσεις σουλφοναμιδιου για τη θεραπευτικη αντιμετωπιση αναπνευστικων διαταραχων
MX349697B (es) Nuevo derivado de fenilpiridina y farmaco que contiene el mismo.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties