ATE464309T1 - Indolizinderivate und deren verwendung als crth2- antagonisten - Google Patents

Indolizinderivate und deren verwendung als crth2- antagonisten

Info

Publication number
ATE464309T1
ATE464309T1 AT06755627T AT06755627T ATE464309T1 AT E464309 T1 ATE464309 T1 AT E464309T1 AT 06755627 T AT06755627 T AT 06755627T AT 06755627 T AT06755627 T AT 06755627T AT E464309 T1 ATE464309 T1 AT E464309T1
Authority
AT
Austria
Prior art keywords
c1c6alkyl
hydrogen
fully
partially fluorinated
independently
Prior art date
Application number
AT06755627T
Other languages
English (en)
Inventor
George Hynd
Nicholas Ray
Harry Finch
David Middlemiss
Michael CRAMP
Paul Blaney
Karen Williams
Yan A Griffon
Trevor Keith Harrison
Peter Crackett
Original Assignee
Argenta Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argenta Discovery Ltd filed Critical Argenta Discovery Ltd
Application granted granted Critical
Publication of ATE464309T1 publication Critical patent/ATE464309T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06755627T 2005-06-24 2006-06-26 Indolizinderivate und deren verwendung als crth2- antagonisten ATE464309T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0512944.0A GB0512944D0 (en) 2005-06-24 2005-06-24 Indolizine compounds
PCT/GB2006/002341 WO2006136859A2 (en) 2005-06-24 2006-06-26 Indoli zine derivatives and their use as crth2 antagonists

Publications (1)

Publication Number Publication Date
ATE464309T1 true ATE464309T1 (de) 2010-04-15

Family

ID=34856120

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06755627T ATE464309T1 (de) 2005-06-24 2006-06-26 Indolizinderivate und deren verwendung als crth2- antagonisten

Country Status (8)

Country Link
US (1) US20090163534A1 (de)
EP (1) EP1910357B1 (de)
JP (1) JP2008543921A (de)
CN (1) CN101243086A (de)
AT (1) ATE464309T1 (de)
DE (1) DE602006013643D1 (de)
GB (1) GB0512944D0 (de)
WO (1) WO2006136859A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101411820B1 (ko) 2006-08-07 2014-06-24 액테리온 파마슈티칼 리미티드 (3-아미노-1,2,3,4-테트라하이드로-9ｈ-카르바졸-9-일)-아세트산 유도체
JP2010513429A (ja) * 2006-12-21 2010-04-30 アージェンタ ディスカバリー リミテッド Ｃｒｔｈ２アンタゴニスト
GB0625842D0 (en) * 2006-12-22 2007-02-07 Argenta Discovery Ltd Indolizine derivatives
WO2008113965A1 (en) * 2007-03-21 2008-09-25 Argenta Discovery Limited Indolizine acetic acid derivatives as crth2 antagonists
US20100144786A1 (en) * 2007-03-29 2010-06-10 Michael Colin Cramp Quinoline derivatives as crth2 receptor ligands
TW200920373A (en) * 2007-09-25 2009-05-16 Actimis Pharmaceuticals Inc 2-S-benzyl substituted pyrimidines as CRTH2 antagonists
GB0719521D0 (en) * 2007-10-05 2007-11-14 Argenta Discovery Ltd Compounds
SI2327693T1 (sl) 2007-12-14 2012-09-28 Pulmagen Therapeutics Asthma Ltd Fulmer Hal Windmil Road Indoli in njihova terapevtska raba
US8101645B2 (en) * 2008-02-15 2012-01-24 Abbott Laboratories Thienopyrroles and pyrrolothiazoles as new therapeutic agents
EP2331541B1 (de) 2008-09-04 2015-04-22 Boehringer Ingelheim International GmbH Indolizine als inhibitoren der leukotrienproduktion
NZ591914A (en) 2008-11-17 2013-04-26 Hoffmann La Roche Naphthylacetic acids
AR077428A1 (es) 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
BR112012024114B1 (pt) 2010-03-22 2021-02-09 Idorsia Pharmaceuticals Ltd Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica
EP2457900A1 (de) 2010-11-25 2012-05-30 Almirall, S.A. Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten
CN103459389B (zh) 2011-04-14 2016-03-30 埃科特莱茵药品有限公司 7-(杂芳基-氨基)-6,7,8,9-四氢吡啶并[1,2-a]吲哚乙酸衍生物和其作为前列腺素D2受体调节剂的用途
WO2013088109A1 (en) 2011-12-16 2013-06-20 Oxagen Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
PE20161177A1 (es) 2014-03-17 2016-11-18 Actelion Pharmaceuticals Ltd Derivados del acido acetico azaindol y su uso como moduladores del receptor de prostaglandina d2
US9850241B2 (en) 2014-03-18 2017-12-26 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators
TWI711616B (zh) 2015-09-15 2020-12-01 瑞士商愛杜西亞製藥有限公司 結晶型式

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174124A (en) * 1967-06-30 1969-12-10 Beecham Group Ltd Pharmacologically Active Indolizine Compounds
GB1268424A (en) * 1969-10-04 1972-03-29 Beecham Group Ltd Indolizine derivatives
ES421284A1 (es) * 1973-12-07 1976-04-16 Farmasimes S A Procedimiento para la preparacion de derivados de acidos pirrocolinaceticos.
CA2542716A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds having crth2 antagonist activity
WO2005040112A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds with pgd2 antagonist activity
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
GB2407318A (en) * 2003-10-23 2005-04-27 Oxagen Ltd Substituted Indol-3-yl acetic acid derivatives

Also Published As

Publication number Publication date
WO2006136859A3 (en) 2007-04-05
US20090163534A1 (en) 2009-06-25
EP1910357B1 (de) 2010-04-14
DE602006013643D1 (de) 2010-05-27
WO2006136859A2 (en) 2006-12-28
JP2008543921A (ja) 2008-12-04
CN101243086A (zh) 2008-08-13
GB0512944D0 (en) 2005-08-03
EP1910357A2 (de) 2008-04-16

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