ATE464309T1 - Indolizinderivate und deren verwendung als crth2- antagonisten - Google Patents

Indolizinderivate und deren verwendung als crth2- antagonisten

Info

Publication number
ATE464309T1
ATE464309T1 AT06755627T AT06755627T ATE464309T1 AT E464309 T1 ATE464309 T1 AT E464309T1 AT 06755627 T AT06755627 T AT 06755627T AT 06755627 T AT06755627 T AT 06755627T AT E464309 T1 ATE464309 T1 AT E464309T1
Authority
AT
Austria
Prior art keywords
c1c6alkyl
hydrogen
fully
partially fluorinated
independently
Prior art date
Application number
AT06755627T
Other languages
English (en)
Inventor
George Hynd
Nicholas Ray
Harry Finch
David Middlemiss
Michael CRAMP
Paul Blaney
Karen Williams
Yan A Griffon
Trevor Keith Harrison
Peter Crackett
Original Assignee
Argenta Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argenta Discovery Ltd filed Critical Argenta Discovery Ltd
Application granted granted Critical
Publication of ATE464309T1 publication Critical patent/ATE464309T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT06755627T 2005-06-24 2006-06-26 Indolizinderivate und deren verwendung als crth2- antagonisten ATE464309T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0512944.0A GB0512944D0 (en) 2005-06-24 2005-06-24 Indolizine compounds
PCT/GB2006/002341 WO2006136859A2 (en) 2005-06-24 2006-06-26 Indoli zine derivatives and their use as crth2 antagonists

Publications (1)

Publication Number Publication Date
ATE464309T1 true ATE464309T1 (de) 2010-04-15

Family

ID=34856120

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06755627T ATE464309T1 (de) 2005-06-24 2006-06-26 Indolizinderivate und deren verwendung als crth2- antagonisten

Country Status (8)

Country Link
US (1) US20090163534A1 (de)
EP (1) EP1910357B1 (de)
JP (1) JP2008543921A (de)
CN (1) CN101243086A (de)
AT (1) ATE464309T1 (de)
DE (1) DE602006013643D1 (de)
GB (1) GB0512944D0 (de)
WO (1) WO2006136859A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ574705A (en) 2006-08-07 2011-12-22 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
CA2673356A1 (en) * 2006-12-21 2008-06-26 Argenta Discovery Limited Crth2 antagonists
GB0625842D0 (en) * 2006-12-22 2007-02-07 Argenta Discovery Ltd Indolizine derivatives
AU2007349641A1 (en) * 2007-03-21 2008-09-25 Argenta Oral Therapeutics Limited Indolizine acetic acid derivatives as CRTH2 antagonists
EP2129661B1 (de) * 2007-03-29 2012-02-08 Pulmagen Therapeutics (Asthma) Limited Chinolinderivate als crth2-rezeptorliganden
KR20100061746A (ko) * 2007-09-25 2010-06-08 액티미스 파마수티컬스 인코포레이티드 Ｃｒｔｈ２ 길항제로서의 ２－ｓ－벤질 치환된 피리미딘
GB0719521D0 (en) * 2007-10-05 2007-11-14 Argenta Discovery Ltd Compounds
ATE502920T1 (de) 2007-12-14 2011-04-15 Pulmagen Therapeutics Asthma Ltd Indole und ihre therapeutische verwendung
EP2268281A4 (de) * 2008-02-15 2012-05-02 Abbott Lab Thienopyrrole und pyrrolothiazole als neue therapiemittel
JP5552121B2 (ja) 2008-09-04 2014-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のインドリジン阻害剤
MX2011005120A (es) 2008-11-17 2011-05-30 Hoffmann La Roche Acidos naftilaceticos.
AR077428A1 (es) 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
SI2558447T1 (sl) 2010-03-22 2015-01-30 Actelion Pharmaceuticals Ltd. Derivati 3-(heteroaril-amino)-1,2,3,4-tetrahidro-9h-karbazola in njihova uporaba kot modulatorji prostaglandinskega receptorja d2
EP2457900A1 (de) 2010-11-25 2012-05-30 Almirall, S.A. Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten
EP2697223B1 (de) 2011-04-14 2016-07-13 Actelion Pharmaceuticals Ltd. 7-(heteroaryl-amino-)6,7,8,9-tetrahydropyrido-[1,2-a-]indol-essigsäure-derivate und ihre verwendung als prostaglandin-d2-rezeptor-modulatoren
JP2015500326A (ja) 2011-12-16 2015-01-05 アトピックス テラピューティクス リミテッド 好酸球性食道炎の治療のためのｃｒｔｈ２拮抗薬およびプロトンポンプ阻害薬の組み合わせ
HRP20181555T1 (hr) 2014-03-17 2018-11-30 Idorsia Pharmaceuticals Ltd Derivati azaindol-octene kiseline i njihova uporaba kao modulatora receptora prostaglandina d2
EP3119780B1 (de) 2014-03-18 2018-08-29 Idorsia Pharmaceuticals Ltd Azaindolessigsäurederivate und deren verwendung als prostaglandin-d2-rezeptormodulatoren
EA035752B1 (ru) 2015-09-15 2020-08-05 Идорсиа Фармасьютиклз Лтд КРИСТАЛЛИЧЕСКАЯ ФОРМА (S)-2-(8-((5-ХЛОРПИРИМИДИН-2-ИЛ)(МЕТИЛ)-АМИНО)-2-ФТОР-6,7,8,9-ТЕТРАГИДРО-5Н-ПИРИДО[3,2-b]ИНДОЛ-5-ИЛ)УКСУСНОЙ КИСЛОТЫ И СОДЕРЖАЩИЕ ЕЁ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174124A (en) * 1967-06-30 1969-12-10 Beecham Group Ltd Pharmacologically Active Indolizine Compounds
GB1268424A (en) * 1969-10-04 1972-03-29 Beecham Group Ltd Indolizine derivatives
ES421284A1 (es) * 1973-12-07 1976-04-16 Farmasimes S A Procedimiento para la preparacion de derivados de acidos pirrocolinaceticos.
WO2005040112A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds with pgd2 antagonist activity
RU2006109108A (ru) * 2003-10-14 2007-11-20 Оксаген Лимитед (GB) Соединения, обладающие активностью антагонистов crth2 рецепторов
GB2407318A (en) * 2003-10-23 2005-04-27 Oxagen Ltd Substituted Indol-3-yl acetic acid derivatives
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy

Also Published As

Publication number Publication date
DE602006013643D1 (de) 2010-05-27
US20090163534A1 (en) 2009-06-25
GB0512944D0 (en) 2005-08-03
WO2006136859A2 (en) 2006-12-28
WO2006136859A3 (en) 2007-04-05
EP1910357A2 (de) 2008-04-16
CN101243086A (zh) 2008-08-13
EP1910357B1 (de) 2010-04-14
JP2008543921A (ja) 2008-12-04

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