ATE460486T1 - Ganz-zell katalysator der eine hydantoinase, eine racemase und eine carbamoylase enthält - Google Patents

Ganz-zell katalysator der eine hydantoinase, eine racemase und eine carbamoylase enthält

Info

Publication number
ATE460486T1
ATE460486T1 AT00960557T AT00960557T ATE460486T1 AT E460486 T1 ATE460486 T1 AT E460486T1 AT 00960557 T AT00960557 T AT 00960557T AT 00960557 T AT00960557 T AT 00960557T AT E460486 T1 ATE460486 T1 AT E460486T1
Authority
AT
Austria
Prior art keywords
carbamoylase
hydantoinase
racemase
whole
cell catalyst
Prior art date
Application number
AT00960557T
Other languages
English (en)
Inventor
Josef Altenbuchner
Ralf Mattes
Christoph Syldatk
Anja Wiese
Burkard Wilms
Andreas Bommarius
Wilhelm Tischer
Original Assignee
Evonik Degussa Gmbh
Univ Stuttgart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh, Univ Stuttgart filed Critical Evonik Degussa Gmbh
Application granted granted Critical
Publication of ATE460486T1 publication Critical patent/ATE460486T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/009—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving hydantoins or carbamoylamino compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02002—Dihydropyrimidinase (3.5.2.2), i.e. hydantoinase
AT00960557T 1999-09-28 2000-08-31 Ganz-zell katalysator der eine hydantoinase, eine racemase und eine carbamoylase enthält ATE460486T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/407,062 US6713288B1 (en) 1999-09-28 1999-09-28 Whole cell catalysts
PCT/EP2000/008473 WO2001023582A1 (en) 1999-09-28 2000-08-31 Whole cell catalyst comprising a hydantoinase, a racemase and a carbamoylase

Publications (1)

Publication Number Publication Date
ATE460486T1 true ATE460486T1 (de) 2010-03-15

Family

ID=23610441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00960557T ATE460486T1 (de) 1999-09-28 2000-08-31 Ganz-zell katalysator der eine hydantoinase, eine racemase und eine carbamoylase enthält

Country Status (7)

Country Link
US (2) US6713288B1 (de)
EP (1) EP1216304B1 (de)
JP (1) JP2003527095A (de)
AT (1) ATE460486T1 (de)
AU (1) AU7281700A (de)
DE (1) DE60043988D1 (de)
WO (1) WO2001023582A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10037115A1 (de) * 2000-07-28 2002-02-07 Degussa Verfahren zur fermentativen Herstellung von L-Allysinacetal
ATE512217T1 (de) * 2000-09-13 2011-06-15 Ajinomoto Kk 5-substituerte hydantoin racemase, dafür kodierende dna, und verfahren zur herstellung optisch aktiver aminosäure
JP4529338B2 (ja) * 2001-03-08 2010-08-25 味の素株式会社 ヒダントイナーゼをコードするｄｎａ、ｎ−カルバミル−ｌ−アミノ酸ハイドロラーゼをコードするｄｎａ、組み換えｄｎａ、形質転換された細胞、タンパク質の製造方法および光学活性アミノ酸の製造方法
DE10140088A1 (de) 2001-08-16 2003-03-13 Degussa NADH-Oxidase aus Lactobacillus
JPWO2003085108A1 (ja) * 2002-04-10 2005-08-11 味の素株式会社 ヒダントイナーゼ遺伝子及びカルバミラーゼ遺伝子を有する組換えｄｎａ、並びにアミノ酸製造方法
ATE321847T1 (de) 2002-05-23 2006-04-15 Dsm Ip Assets Bv Hydantoinracemase
DE10234764A1 (de) * 2002-07-30 2004-02-19 Degussa Ag Verfahren zur Herstellung von enantiomerenangereichertem tert.-Leucin
PT1570060E (pt) * 2002-12-02 2007-09-13 Basf Ag ''sistema de expressão indutível de l-ramnose''
US7247465B2 (en) * 2003-06-06 2007-07-24 Degussa Ag Screening process for hydantoin racemases
JP4452914B2 (ja) * 2003-09-08 2010-04-21 味の素株式会社 新規トランスポータタンパク質
DE102004028407A1 (de) * 2004-06-14 2005-12-29 Degussa Ag Herstellung optisch aktiver Alkohole mit Hilfe von Ganzzellkatalysatoren
DE102004057966A1 (de) * 2004-11-30 2006-06-01 Degussa Ag Enzymreaktionen in Miniemulsionen
ES2322418B1 (es) * 2006-10-02 2010-03-22 Universidad De Almeria Sistema de coexpresion enzimatica para la produccion de d-aminoacidos.
US20100143981A1 (en) * 2006-12-04 2010-06-10 Rusnak-Mueller Monika Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase
WO2011003702A1 (en) 2009-07-09 2011-01-13 Dsm Ip Assets B.V. Stabilized enzyme compositions
EP4105335A1 (de) 2021-06-16 2022-12-21 Evonik Operations GmbH Enzymatisches verfahren zur herstellung von l-glufosinat-p-alkylestern
WO2023174511A1 (en) 2022-03-14 2023-09-21 Evonik Operations Gmbh Enzymatic method for the production of l-glufosinate p-esters
WO2023232225A1 (en) 2022-05-31 2023-12-07 Evonik Operations Gmbh Enzymatic method for the diastereoselective production of l-glufosinate p-esters

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03251176A (ja) 1990-01-10 1991-11-08 Nippon Soda Co Ltd ５―置換ヒダントイン及びｎ―カルバミルアミノ酸変換酵素
DE4316928C2 (de) * 1993-05-19 1995-03-16 Degussa Neue Mikroorganismen, deren Verwendung und Verfahren zur Herstellung von L-alpha-Aminosäuren
DE19519717C1 (de) 1995-05-30 1996-08-22 Degussa Neuer Mikroorganismus, dessen Verwendung und Verfahren zur Herstellung von L-alpha-Aminosäuren
JP4445668B2 (ja) 1998-04-02 2010-04-07 エボニック デグサ ゲーエムベーハー アースロバクターアウレッセンスからの組み換えｌ−ｎ−カルバモイラーゼ、それによるｌ−アミノ酸の製造方法

Also Published As

Publication number Publication date
EP1216304A1 (de) 2002-06-26
US20030175910A1 (en) 2003-09-18
US6713288B1 (en) 2004-03-30
WO2001023582A1 (en) 2001-04-05
EP1216304B1 (de) 2010-03-10
JP2003527095A (ja) 2003-09-16
US7393679B2 (en) 2008-07-01
AU7281700A (en) 2001-04-30
DE60043988D1 (de) 2010-04-22

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