ATE458998T1 - Verfahren zum screening von substanzen die die aktivität von gpcrs modulieren - Google Patents

Verfahren zum screening von substanzen die die aktivität von gpcrs modulieren

Info

Publication number
ATE458998T1
ATE458998T1 AT06011710T AT06011710T ATE458998T1 AT E458998 T1 ATE458998 T1 AT E458998T1 AT 06011710 T AT06011710 T AT 06011710T AT 06011710 T AT06011710 T AT 06011710T AT E458998 T1 ATE458998 T1 AT E458998T1
Authority
AT
Austria
Prior art keywords
gpcrs
modulate
activity
screening substances
relates
Prior art date
Application number
AT06011710T
Other languages
English (en)
Inventor
Michael Krohn
Holger Zinke
Original Assignee
Nutrinova Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrinova Gmbh filed Critical Nutrinova Gmbh
Application granted granted Critical
Publication of ATE458998T1 publication Critical patent/ATE458998T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT06011710T 2006-06-07 2006-06-07 Verfahren zum screening von substanzen die die aktivität von gpcrs modulieren ATE458998T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06011710A EP1865316B1 (de) 2006-06-07 2006-06-07 Verfahren zum Screening von Substanzen die die Aktivität von Gpcrs modulieren

Publications (1)

Publication Number Publication Date
ATE458998T1 true ATE458998T1 (de) 2010-03-15

Family

ID=37243512

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06011710T ATE458998T1 (de) 2006-06-07 2006-06-07 Verfahren zum screening von substanzen die die aktivität von gpcrs modulieren

Country Status (7)

Country Link
US (4) US20090004651A1 (de)
EP (1) EP1865316B1 (de)
CN (1) CN101086499B (de)
AT (1) ATE458998T1 (de)
DE (1) DE602006012460D1 (de)
DK (1) DK1865316T3 (de)
ES (1) ES2339960T3 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2726862A1 (en) * 2008-06-30 2010-01-21 Atgcell Inc. Mammalian cell expression vectors and utilization
WO2010125314A1 (fr) * 2009-04-30 2010-11-04 Cis-Bio International Procede de detection de composes modulateurs de dimeres de proteines membranaires a domaine vft
JP2011116693A (ja) * 2009-12-02 2011-06-16 Univ Of Tokyo 甘味物質に対するヒト甘味受容体作用性甘味調節物質
JP5905187B2 (ja) 2009-12-02 2016-04-20 国立大学法人 東京大学 甘味受容体発現コンストラクト、これを発現させた細胞体、及びその利用
WO2012011955A2 (en) * 2010-07-21 2012-01-26 Duke University Compositions and methods for production and screening of monoclonal antibodies
WO2012107203A1 (en) 2011-02-08 2012-08-16 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Sweetener and/or sweetness enhancer, sweetener composition, methods of making the same and consumables containing the same
WO2012107202A1 (en) 2011-02-08 2012-08-16 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Sweetener, sweetener compositions, methods of making the same and consumables containing the same
US20140010939A1 (en) 2011-02-08 2014-01-09 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Sweetness Enhancers, Sweetener Compositions, Methods of Making the Same and Consumables Containing the Same
WO2012107206A1 (en) 2011-02-08 2012-08-16 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Sweetener and/or sweetness enhancer, sweetener compositions, methods of making the same and consumables containing the same
WO2012107207A1 (en) 2011-02-08 2012-08-16 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Sweetener and/or a sweetness enhancer, sweetener compositions, methods of making and using same, and consumables containing same
WO2012107205A1 (en) 2011-02-08 2012-08-16 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Sweetener and/or a sweetness enhancer, sweetener compositions, methods of making the same and consumables containing the same
WO2012107204A1 (en) 2011-02-08 2012-08-16 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Sweetness enhancer, sweetener compositions, methods of making the same and consumables containing the same
US20130078193A1 (en) 2011-09-22 2013-03-28 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Sweetener Compositions, Methods of Making Same and Consumables Containing Same
MX2014006368A (es) 2011-11-28 2014-10-13 Nutrinova Gmbh Composiciones para enmascarar el sabor, composiciones edulcolorantes y composiciones de producto consumible que contienen las mismas.
EP2606747A1 (de) 2011-12-22 2013-06-26 Nutrinova Nutrition Specialties & Food Ingredients GmbH Süßkraftverstärker, Süßstoffzusammensetzungen, und diese enthaltene Produkte für den Verzehr
MX357265B (es) 2012-06-27 2018-07-03 Celanese Sales Germany Gmbh Composiciones enmascarantes del sabor, composiciones edulcorantes y composiciones de productos consumibles que contienen dichas composiciones.
WO2015037764A1 (ko) * 2013-09-16 2015-03-19 서울대학교 산학협력단 Gpcr19 경로의 활성화에 의한 골수 유래 면역 조절 세포 및 면역 조절 b 림프구의 체내외 증폭
JP6592442B2 (ja) * 2013-12-16 2019-10-16 モネル ケミカル センシズ センターＭｏｎｅｌｌ Ｃｈｅｍｉｃａｌ Ｓｅｎｓｅｓ Ｃｅｎｔｅｒ 嗅覚受容体のモジュレーターの同定方法
WO2015163905A1 (en) 2014-04-25 2015-10-29 General Mills, Inc. Food products having sweetness enhancer
US20160183576A1 (en) 2014-12-23 2016-06-30 Celanese Sales Germany Gmbh Taste modifying compositions
WO2016103182A1 (en) 2014-12-23 2016-06-30 Celanese Sales Germany Gmbh Taste modifying compositions
WO2016103184A1 (en) 2014-12-23 2016-06-30 Celanese Sales Germany Gmbh Taste modifying compositions
WO2016103163A1 (en) 2014-12-23 2016-06-30 Celanese Sales Germany Gmbh Taste modifying compositions
EP3147363B1 (de) 2015-09-26 2019-10-16 B.R.A.I.N. Ag Aktivierung von geschmacksrezeptorgenen in säugetierzellen mit hilfe von crispr-cas-9
CA3016206C (en) * 2016-03-01 2021-11-23 Wm. Wrigley Jr. Company Long-lasting sweetener formulations
CN106244627A (zh) * 2016-08-03 2016-12-21 云南中烟工业有限责任公司 一种高效介导t1r2基因过表达的慢病毒载体和慢病毒及其构建方法
CN106244629A (zh) * 2016-08-03 2016-12-21 云南中烟工业有限责任公司 一种t1r3基因过表达慢病毒载体、慢病毒及其构建方法
CN106191121A (zh) * 2016-08-03 2016-12-07 云南中烟工业有限责任公司 一种t1r2基因过表达慢病毒载体、慢病毒及其构建方法
CN106191120A (zh) * 2016-08-03 2016-12-07 云南中烟工业有限责任公司 一种高效介导t1r3基因过表达的慢病毒载体和慢病毒及其构建方法
CN111278981A (zh) * 2017-10-23 2020-06-12 日本烟草产业株式会社 用于表达g蛋白偶联受体或其亚基的构建体及其用途
WO2019113806A1 (zh) * 2017-12-12 2019-06-20 深圳先进技术研究院 Gpr1靶点及其拮抗剂在不孕相关疾病的应用
WO2019119275A1 (zh) * 2017-12-19 2019-06-27 深圳先进技术研究院 一种gpr1拮抗多肽及其衍生物与应用
CN108753727A (zh) * 2018-06-11 2018-11-06 上海科技大学 一种gpcr靶向药物筛选系统及其构建和应用
CN109142298B (zh) * 2018-09-06 2021-04-06 云南中烟工业有限责任公司 一种在细胞水平上甜度的定量测定方法
KR102612096B1 (ko) * 2021-02-04 2023-12-12 대한민국 돼지 고기 원산지 판별용 키트 및 이를 이용한 돼지고기 원산지 판별 방법

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
EP2258726A1 (de) 1995-06-14 2010-12-08 The Regents of the University of California Menschliche Antikörper mit hoher Affinität gegen c-erbB-2
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
HUP9902418A3 (en) 1996-05-09 2001-10-29 Dimensional Pharm Inc Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
EP1012314A1 (de) * 1997-06-18 2000-06-28 Edge Biosystems, Inc. Vektor und verfahren zur herstellung von dna-bibliotheken
IT1303090B1 (it) 1998-07-28 2000-10-30 Miller Europe Spa Dispositivo accendigas elettronico integrato con una morsettiera.
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
US20040235173A1 (en) * 2000-07-03 2004-11-25 Gala Design, Inc. Production of host cells containing multiple integrating vectors by serial transduction
US7763431B1 (en) * 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
AU2002336571A1 (en) 2001-09-18 2003-04-01 Irm, Llc Sweet taste receptors
WO2004069191A2 (en) 2003-02-03 2004-08-19 Senomyx Inc. Identification of t1r and t2r modulators
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors

Also Published As

Publication number Publication date
CN101086499A (zh) 2007-12-12
DE602006012460D1 (de) 2010-04-08
US20090004651A1 (en) 2009-01-01
ES2339960T3 (es) 2010-05-27
CN101086499B (zh) 2015-04-22
US8067236B2 (en) 2011-11-29
US20100112688A1 (en) 2010-05-06
EP1865316B1 (de) 2010-02-24
US20100120141A1 (en) 2010-05-13
EP1865316A1 (de) 2007-12-12
US20130210046A1 (en) 2013-08-15
DK1865316T3 (da) 2010-05-25
US8067235B2 (en) 2011-11-29

Similar Documents

Publication Publication Date Title
ATE458998T1 (de) Verfahren zum screening von substanzen die die aktivität von gpcrs modulieren
ATE523522T1 (de) Verfahren zur amidierung von polypeptiden mit c- terminalen basischen aminosäuren unter verwendung spezifischer endoproteasen
DE60320682D1 (de) Chimäre alpha q-gustducin g-proteine
DE602006014126D1 (de) Zusammensetzungen und verfahren zur trennung von fusionsproteinen
DE602005015974D1 (de) Kopfs und unter verwendung dieses verfahrens erhaltener flüssigkeitsabgabekopf
DE602006006765D1 (de) Verfahren zur Identifizierung von GLP-1-Sekretionsförderern
ATE531727T1 (de) Bioaktive peptide und verfahren zu ihrer verwendung
MY184163A (en) Transgene genetic tags and methods of use
DE602006008094D1 (de) Verfahren zur Quantifizierung von pflanzlichen Resourcen unter Verwendung von GIS
DE60326527D1 (de) Verfahren und Gerät zur Ultraschallkontrastbildformung unter Benutzung von gestuften Chirp-Wellenformen
DE602005023824D1 (de) Apparat und Verfahren zur Reinigung von Nukleinsäuren durch Phasentrennung durch die Verwendung von Laser und Kügelchen
DE60326012D1 (de) Verfahren zur Konzentration von Proteinen
WO2008005777A3 (en) Methods of enhancing protein incorporation into virus like particles
DE602004029029D1 (de) Zusammensetzungen und verfahren zur verbesserung der aufwärmrate von pet unter verwendung von aktivkohle
DE60219575D1 (de) System und Verfahren zum Erzeugen von Aufträgen zur Funktionsblock-Ausführung
ATE423313T1 (de) Methode zum identifizieren von modulatoren der zelloberflächenmembranrezeptoren,nützlich zur behandlung von krankheiten
DE602006012495D1 (de) Verfahren zum aufkonzentrieren von nanosuspensionen
ATE533055T1 (de) Verfahren zum screenen mithilfe von konformationsempfindlichen peptiden
DE602004029961D1 (de) Vorrichtung und Verfahren zur Umschaltung von Rundfunkkanälen unter Verwendung der Verbindungsinformation von virtuellen Kanälen
DE602004032345D1 (de) Reagenzien und verfahren zur bildung von disulfid-bindungen und glykosylierung von proteinen
AT412362B8 (de) Verfahren zum einbringen und verblasen von gesteinsstaub sowie vorrichtung zur durchführung dieses verfahrens
DE602005002508D1 (de) Vorrichtung zur Extraktion von Flüssigkristall durch Erhitzen unter vermindertem Druck und zugehöriges Verfahren
ATE409410T1 (de) Zellen mit defizientem melanocortin-3-rezeptor, transgene mäuse und verfahren zur auswahl von substanzen, die das körpergewicht regulieren können
ATE535605T1 (de) Autoinduzierbarer natriumphosphat-symporter- promotor aus pichia pastoris und verfahren zur herstellung von rekombinantem protein unter verwendung davon
ATA12922002A (de) Verfahren zum zerstäuben und granulieren von schmelzen sowie vorrichtung zur durchführung dieses verfahrens

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties