ATE457988T1 - A2a-adenosin-rezeptor-antagonisten - Google Patents

A2a-adenosin-rezeptor-antagonisten

Info

Publication number
ATE457988T1
ATE457988T1 AT07796492T AT07796492T ATE457988T1 AT E457988 T1 ATE457988 T1 AT E457988T1 AT 07796492 T AT07796492 T AT 07796492T AT 07796492 T AT07796492 T AT 07796492T AT E457988 T1 ATE457988 T1 AT E457988T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
adenosine receptor
alkyl
compounds
cns diseases
Prior art date
Application number
AT07796492T
Other languages
German (de)
English (en)
Inventor
Martin C Clasby
Samuel Chackalamannil
Andrew Stamford
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE457988T1 publication Critical patent/ATE457988T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07796492T 2006-06-26 2007-06-25 A2a-adenosin-rezeptor-antagonisten ATE457988T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81651606P 2006-06-26 2006-06-26
PCT/US2007/014886 WO2008002596A2 (en) 2006-06-26 2007-06-25 Adenosine a2a receptor antagonists

Publications (1)

Publication Number Publication Date
ATE457988T1 true ATE457988T1 (de) 2010-03-15

Family

ID=38846284

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07796492T ATE457988T1 (de) 2006-06-26 2007-06-25 A2a-adenosin-rezeptor-antagonisten

Country Status (10)

Country Link
US (1) US7713985B2 (ja)
EP (1) EP2038285B1 (ja)
JP (1) JP2010509189A (ja)
CN (1) CN101506215A (ja)
AT (1) ATE457988T1 (ja)
CA (1) CA2655987A1 (ja)
DE (1) DE602007004851D1 (ja)
ES (1) ES2339502T3 (ja)
MX (1) MX2009000104A (ja)
WO (1) WO2008002596A2 (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009222047A1 (en) * 2008-03-04 2009-09-11 Schering Corporation 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists
WO2009136578A1 (ja) * 2008-05-09 2009-11-12 パイオニア株式会社 空間映像表示装置
AU2010222289B2 (en) 2009-03-13 2013-07-11 Advinus Therapeutics Private Limited Substituted fused pyrimidine compounds
TWI548411B (zh) 2009-04-28 2016-09-11 Kyowa Hakko Kirin Co Ltd Exercise disorder treatment
EP2509983B1 (en) 2009-11-16 2014-09-17 Merck Sharp & Dohme Corp. FUSED TRICYCLIC COMPOUNDS WITH ADENOSINE A2a RECEPTOR ANTAGONIST ACTIVITY
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
CN103261202B (zh) * 2010-09-24 2016-01-20 阿迪维纳斯疗法有限公司 作为腺苷受体拮抗剂的稠合三环化合物
JP6042968B2 (ja) * 2012-04-20 2016-12-14 ユセベ ファルマ ソシエテ アノニム パーキンソン病の処置方法
CN102659620A (zh) * 2012-05-18 2012-09-12 东南大学 2,4-双(三氟甲基)苄肼的合成方法
WO2014101113A1 (en) * 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Piperazine-substituted 7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
CN105025899B (zh) * 2012-12-28 2017-08-18 默沙东公司 具有A2A拮抗剂性质的杂二环取代的‑[1,2,4]三唑并[1,5‑c]喹唑啉‑5‑胺化合物
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
KR102653800B1 (ko) 2018-11-30 2024-04-01 머크 샤프 앤드 돔 엘엘씨 아데노신 수용체 길항제로서의 9-치환된 아미노 트리아졸로 퀴나졸린 유도체, 제약 조성물 및 그의 용도
WO2021191376A1 (en) 2020-03-26 2021-09-30 Astrazeneca Ab Triazolone compounds
WO2021191379A1 (en) 2020-03-26 2021-09-30 Astrazeneca Ab 5-amino-8-(4-pyridyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one compounds for use against cancer
WO2021191380A1 (en) 2020-03-26 2021-09-30 Astrazeneca Ab Triazolone compounds
CN115867282A (zh) 2020-03-26 2023-03-28 赫普泰雅治疗有限公司 用于抗癌的5-氨基-8-(4-吡啶基)-[1,2,4]三唑并[4,3-c]嘧啶-3-酮化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955465A (en) * 1996-03-22 1999-09-21 Neurogen Corporation 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones
WO2004058974A1 (en) * 2002-12-27 2004-07-15 Actar Ab A method of drug screening to select agonists or antagonists of g protein coupled receptors (gpcr).
US7452892B2 (en) * 2005-06-17 2008-11-18 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
ATE538123T1 (de) * 2005-09-19 2012-01-15 Schering Corp 2-heteroarylpyrazoloä4,3-eü-1, 2, 4-triazolo-ä1,5-cü-pyrimidine als antagonisten des adenosin-a2a- rezeptors

Also Published As

Publication number Publication date
EP2038285A2 (en) 2009-03-25
MX2009000104A (es) 2009-01-23
ES2339502T3 (es) 2010-05-20
US20080255156A1 (en) 2008-10-16
CN101506215A (zh) 2009-08-12
WO2008002596A2 (en) 2008-01-03
CA2655987A1 (en) 2008-01-03
JP2010509189A (ja) 2010-03-25
US7713985B2 (en) 2010-05-11
EP2038285B1 (en) 2010-02-17
DE602007004851D1 (de) 2010-04-01
WO2008002596A3 (en) 2008-07-03

Similar Documents

Publication Publication Date Title
ATE457988T1 (de) A2a-adenosin-rezeptor-antagonisten
TW200726765A (en) Triazolopyridine cannabinoid receptor 1 antagonists
JO2613B1 (ar) مركبات عضوية
PL1891029T3 (pl) Związki organiczne do leczenia stanów zapalnych lub alergicznych
MX340965B (es) Combinaciones para el tratamiento de enfermedades que involucran la proliferacion celular.
GEP20084551B (en) 4-phenylamino-quinazolin-6-yl-amides
GEP20115174B (en) Triazolopyrazine derivatives useful as anti-cancer agents
IL176110A0 (en) Azabicyclic heterocycles as cannabinoid receptor modulators
MA28706B1 (fr) Antagoniste des recepteurs du glucagon, preparation et utilisations therapeutiques
MX2007013624A (es) Inhibidores de proteina cinasa.
NO20084853L (no) Forbindelser som er agonister av muscarinreseptorer og som kan vaere effektive i behandling av smerte, Alzheimers sykdom og/eller schizofreni
TW200637863A (en) Organic compounds
TW200630366A (en) Organic compounds
MX2012004848A (es) Compuestos heterociclicos triciclicos.
HK1138262A1 (en) Novel phosphodiesterase inhibitors
MX2010001020A (es) Derivados de pirimidina utiles para el tratamiento de condiciones inflamatorias o alergicas.
MX2010006230A (es) Derivados de arilamida substituidos con triazol y su uso como antagonistas de receptor purinergico p2x3 y/o p2x2/3.
TW200639156A (en) New compounds
MX2007007027A (es) Derivados piperazinilpiridina como agentes anti-obesidad.
MY169274A (en) Fused, tricyclic sulfonamide inhibitors of gamma secretase
MX2010002938A (es) Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.
TW200745130A (en) 2-Heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
WO2006055434A3 (en) Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease
TW200716547A (en) Piperidin-4-yl-amide derivatives
MX2009011059A (es) Aminopirimidinas utiles como inhibidores de cinasas.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties