ATE457733T1 - Lipid-a- und andere kohlenhydrat-liganden-analoga - Google Patents
Lipid-a- und andere kohlenhydrat-liganden-analogaInfo
- Publication number
- ATE457733T1 ATE457733T1 AT03726743T AT03726743T ATE457733T1 AT E457733 T1 ATE457733 T1 AT E457733T1 AT 03726743 T AT03726743 T AT 03726743T AT 03726743 T AT03726743 T AT 03726743T AT E457733 T1 ATE457733 T1 AT E457733T1
- Authority
- AT
- Austria
- Prior art keywords
- lipid
- analogs
- useful
- replacement
- nature
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 150000001720 carbohydrates Chemical class 0.000 title abstract 2
- 150000002632 lipids Chemical class 0.000 title abstract 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 7
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002337 glycosamines Chemical group 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37864502P | 2002-05-09 | 2002-05-09 | |
| PCT/US2003/014633 WO2003094850A2 (en) | 2002-05-09 | 2003-05-09 | Lipid a and other carbohydrate ligand analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE457733T1 true ATE457733T1 (de) | 2010-03-15 |
Family
ID=29420423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03726743T ATE457733T1 (de) | 2002-05-09 | 2003-05-09 | Lipid-a- und andere kohlenhydrat-liganden-analoga |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7820627B2 (de) |
| EP (1) | EP1549322B1 (de) |
| JP (1) | JP5014573B2 (de) |
| AT (1) | ATE457733T1 (de) |
| AU (1) | AU2003228966C1 (de) |
| CA (1) | CA2485253C (de) |
| DE (1) | DE60331330D1 (de) |
| ES (1) | ES2343788T3 (de) |
| WO (1) | WO2003094850A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8198400B2 (en) | 2001-03-27 | 2012-06-12 | Oncothyreon, Inc. | Vaccine for modulating between T1 and T2 immune responses |
| EP1549322B1 (de) | 2002-05-09 | 2010-02-17 | Oncothyreon Inc. | Lipid-a- und andere kohlenhydrat-liganden-analoga |
| TW201204410A (en) | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
| EP1896051B1 (de) | 2005-06-28 | 2014-10-15 | Oncothyreon Inc. | Verfahren zur behandlung von patienten mit einem muzin-(muc-1)-impfstoff |
| ATE524509T1 (de) | 2005-07-18 | 2011-09-15 | Nektar Therapeutics | Verzweigte funktionalisierte polymere unter verwendung von verzweigten polyolen als kernen |
| ITMI20060530A1 (it) * | 2006-03-22 | 2007-09-23 | Univ Milano Bicocca | Antinfiammatori a struttura monosaccaridica |
| WO2008021367A2 (en) | 2006-08-11 | 2008-02-21 | President And Fellows Of Harvard College | Moenomycin biosynthesis-related compositions and methods of use thereof |
| ES2657392T3 (es) | 2006-09-26 | 2018-03-05 | Infectious Disease Research Institute | Composición de vacuna que contiene un adyuvante sintético |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| KR101012587B1 (ko) * | 2007-06-04 | 2011-02-01 | 엘지전자 주식회사 | 디스플레이 장치 |
| US8604004B2 (en) * | 2007-10-04 | 2013-12-10 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
| EP3936122A1 (de) | 2008-11-24 | 2022-01-12 | Massachusetts Institute Of Technology | Verfahren und zusammensetzung zur lokalen wirkstoffabgabe |
| PT2437753T (pt) | 2009-06-05 | 2016-11-23 | Infectious Disease Res Inst | Adjuvantes lipídicos de glucopiranosilo sintéticos e composições de vacina contendo os mesmos |
| CN102329335B (zh) * | 2010-07-13 | 2014-01-22 | 哈尔滨工业大学 | 基于季戊四醇的复合脂质，制备方法及用途 |
| US20110229556A1 (en) * | 2010-03-19 | 2011-09-22 | Massachusetts Institute Of Technology | Lipid-coated polymer particles for immune stimulation |
| US9149432B2 (en) | 2010-03-19 | 2015-10-06 | Massachusetts Institute Of Technology | Lipid vesicle compositions and methods of use |
| WO2011115684A2 (en) | 2010-03-19 | 2011-09-22 | Massachusetts Institute Of Technology | Lipid vesicle compositions and methods of use |
| AU2012222188A1 (en) * | 2011-02-24 | 2013-08-15 | Oncothyreon Inc. | MUC1 based glycolipopeptide vaccine with adjuvant |
| EP3632463A1 (de) | 2011-04-08 | 2020-04-08 | Immune Design Corp. | Immunogene zusammensetzungen und verfahren zur verwendung der zusammensetzungen zur induzierung humoraler und zellulärer immunreaktionen |
| US9273084B2 (en) | 2012-04-06 | 2016-03-01 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
| WO2013152279A1 (en) | 2012-04-06 | 2013-10-10 | President And Fellows Of Harvard College | Chemoenzymatic methods for synthesizing moenomycin analogs |
| WO2013151697A1 (en) | 2012-04-06 | 2013-10-10 | President And Fellows Of Harvard College | Methods and compounds for identifying glycosyltransferase inhibitors |
| SMT201800368T1 (it) | 2012-05-16 | 2018-09-13 | Immune Design Corp | Vaccini per l'infezione da virus-2 herpes simplex |
| EP3711768A1 (de) | 2013-04-18 | 2020-09-23 | Immune Design Corp. | Gla-monotherapie zur verwendung in der krebsbehandlung |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| JP7097667B2 (ja) | 2013-09-27 | 2022-07-08 | マサチューセッツ インスティテュート オブ テクノロジー | 無担体生物活性タンパク質ナノ構造体 |
| CA2972635A1 (en) | 2015-01-06 | 2016-07-14 | Immunovaccine Technologies Inc. | Lipid a mimics, methods of preparation, and uses thereof |
| WO2017027843A1 (en) | 2015-08-12 | 2017-02-16 | Massachusetts Institute Of Technology | Cell surface coupling of nanoparticles |
| US11472856B2 (en) | 2016-06-13 | 2022-10-18 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| JP7285828B2 (ja) | 2017-09-05 | 2023-06-02 | トルク セラピューティクス， インコーポレイテッド | 治療用タンパク質組成物ならびにその作製および使用方法 |
| EP3752182B1 (de) | 2018-02-12 | 2024-05-15 | Inimmune Corporation | Toll-like-rezeptorliganden |
| KR20240001118A (ko) * | 2021-05-31 | 2024-01-03 | 미쯔비시 가스 케미칼 컴파니, 인코포레이티드 | 신규 아미노 화합물 및 그의 제조방법, 그리고, 이것을 이용한 에폭시 수지용 경화제, 에폭시 수지 조성물 및 에폭시 수지 경화물 |
| CN114399151A (zh) * | 2021-11-29 | 2022-04-26 | 阿里巴巴新加坡控股有限公司 | 运力订单分配方法、装置、可读程序产品及导航方法 |
| CN116162115B (zh) * | 2022-12-27 | 2025-09-26 | 华中师范大学 | Toll样受体4免疫激动剂及其应用、抗病毒疫苗分子及其制备方法和应用 |
| KR102827958B1 (ko) | 2025-04-09 | 2025-07-03 | 주식회사 로우맵 | 피부흡수 촉진용 히알루론산 나노캡슐, 이의 제조방법 및 이를 포함한 화장료 조성물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB614215A (en) * | 1946-07-09 | 1948-12-10 | Leslie Bradford | Manufacture of polyureas |
| GB699080A (en) | 1950-05-31 | 1953-10-28 | Ici Ltd | Production of new esters of ortho-phosphoric acid and salts thereof |
| US3930024A (en) * | 1969-09-02 | 1975-12-30 | Parke Davis & Co | Pharmaceutical compositions and methods |
| DE3127503A1 (de) * | 1981-07-11 | 1983-02-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4464383A (en) * | 1981-11-24 | 1984-08-07 | Itaru Yamamoto | Immunomodulator containing trithiazole pentamethine cyanine derivative |
| US4783402A (en) * | 1983-04-11 | 1988-11-08 | Meito Sangyo Kabushiki Kaisha | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
| GR860379B (en) * | 1985-02-22 | 1986-06-11 | Akzo Nv | Novel disaccharide and trisaccharide derivatives of the lipid a type |
| EP0219514A4 (de) | 1985-04-03 | 1988-04-26 | Wisconsin Alumni Res Found | Verfahren zum vorbeugen von krankheiten, verursacht durch gram-negatives endotoxin bei säugetieren. |
| JPS63139186A (ja) * | 1986-11-29 | 1988-06-10 | Hidetoshi Tsuchida | 三本鎖型リン脂質化合物およびその製造方法 |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5041427A (en) * | 1989-07-21 | 1991-08-20 | Wisconsin Alumni Research Foundation | Lipid A derivatives |
| JPH0655749B2 (ja) * | 1989-09-20 | 1994-07-27 | 日本たばこ産業株式会社 | リピッドａ単糖類縁体 |
| FR2702306B1 (fr) | 1993-03-05 | 1995-04-14 | Alcatel Nv | Procédé d'auto-alignement d'un contact métallique sur un substrat de matériau semi-conducteur. |
| IT1264690B1 (it) | 1993-07-08 | 1996-10-04 | Bracco Spa | Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi |
| DE4408248A1 (de) | 1994-03-11 | 1995-09-14 | Hoechst Ag | Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung |
| WO1995027505A1 (en) | 1994-04-12 | 1995-10-19 | Biomira, Inc. | Cellular immune response-specific antigens and uses therefor |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6764840B2 (en) | 1997-05-08 | 2004-07-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| IT1295460B1 (it) | 1997-10-02 | 1999-05-12 | Borgotec Tecnologie Autom Spa | Metodo per impilare pacchi di piastre di circuiti stampati e relativo dispositivo di carico e scarico di pacchi per una macchina utensile. |
| US6043390A (en) | 1998-04-03 | 2000-03-28 | The Regents Of The University Of California | Pentaerythritol lipid derivatives and nucleic-acid complexes |
| JP5062647B2 (ja) * | 1998-07-21 | 2012-10-31 | ロンザ アーゲー | アミン類の製造方法 |
| EP1232168B1 (de) | 1999-11-15 | 2011-08-03 | Oncothyreon Inc. | Synthetische lipid-a analogen und verwendungen davon |
| US6699846B2 (en) | 2000-03-17 | 2004-03-02 | Corixa Corporation | Mono- and disaccharides for the treatment of nitric oxide related disorders |
| ES2164013B1 (es) * | 2000-04-14 | 2003-06-16 | Consejo Superior Investigacion | Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales. |
| EP1474432A1 (de) | 2002-02-04 | 2004-11-10 | Biomira Inc. | Immunstimulierende, kovalent lipid-modifizierte oligonukleotide |
| WO2003089574A2 (en) | 2002-04-15 | 2003-10-30 | Biomira, Inc. | Synthetic glyco-lipo-peptides as vaccines |
| EP1549322B1 (de) | 2002-05-09 | 2010-02-17 | Oncothyreon Inc. | Lipid-a- und andere kohlenhydrat-liganden-analoga |
-
2003
- 2003-05-09 EP EP03726743A patent/EP1549322B1/de not_active Expired - Lifetime
- 2003-05-09 AT AT03726743T patent/ATE457733T1/de active
- 2003-05-09 CA CA2485253A patent/CA2485253C/en not_active Expired - Fee Related
- 2003-05-09 JP JP2004502938A patent/JP5014573B2/ja not_active Expired - Fee Related
- 2003-05-09 WO PCT/US2003/014633 patent/WO2003094850A2/en not_active Ceased
- 2003-05-09 ES ES03726743T patent/ES2343788T3/es not_active Expired - Lifetime
- 2003-05-09 AU AU2003228966A patent/AU2003228966C1/en not_active Ceased
- 2003-05-09 US US10/513,556 patent/US7820627B2/en not_active Expired - Fee Related
- 2003-05-09 DE DE60331330T patent/DE60331330D1/de not_active Expired - Lifetime
-
2010
- 2010-06-30 US US12/827,810 patent/US8097593B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1549322B1 (de) | 2010-02-17 |
| CA2485253C (en) | 2012-07-10 |
| CA2485253A1 (en) | 2003-11-20 |
| US7820627B2 (en) | 2010-10-26 |
| ES2343788T3 (es) | 2010-08-10 |
| DE60331330D1 (de) | 2010-04-01 |
| EP1549322A2 (de) | 2005-07-06 |
| AU2003228966A1 (en) | 2003-11-11 |
| WO2003094850A3 (en) | 2004-07-29 |
| WO2003094850A2 (en) | 2003-11-20 |
| AU2003228966B2 (en) | 2009-10-01 |
| US20120003295A1 (en) | 2012-01-05 |
| EP1549322A4 (de) | 2006-07-26 |
| JP2005538050A (ja) | 2005-12-15 |
| US8097593B1 (en) | 2012-01-17 |
| JP5014573B2 (ja) | 2012-08-29 |
| AU2003228966C1 (en) | 2010-05-13 |
| US20060040891A1 (en) | 2006-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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