ATE457733T1 - Lipid-a- und andere kohlenhydrat-liganden-analoga - Google Patents
Lipid-a- und andere kohlenhydrat-liganden-analogaInfo
- Publication number
- ATE457733T1 ATE457733T1 AT03726743T AT03726743T ATE457733T1 AT E457733 T1 ATE457733 T1 AT E457733T1 AT 03726743 T AT03726743 T AT 03726743T AT 03726743 T AT03726743 T AT 03726743T AT E457733 T1 ATE457733 T1 AT E457733T1
- Authority
- AT
- Austria
- Prior art keywords
- lipid
- analogs
- useful
- replacement
- nature
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 150000001720 carbohydrates Chemical class 0.000 title abstract 2
- 150000002632 lipids Chemical class 0.000 title abstract 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 7
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002337 glycosamines Chemical group 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37864502P | 2002-05-09 | 2002-05-09 | |
| PCT/US2003/014633 WO2003094850A2 (en) | 2002-05-09 | 2003-05-09 | Lipid a and other carbohydrate ligand analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE457733T1 true ATE457733T1 (de) | 2010-03-15 |
Family
ID=29420423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03726743T ATE457733T1 (de) | 2002-05-09 | 2003-05-09 | Lipid-a- und andere kohlenhydrat-liganden-analoga |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7820627B2 (de) |
| EP (1) | EP1549322B1 (de) |
| JP (1) | JP5014573B2 (de) |
| AT (1) | ATE457733T1 (de) |
| AU (1) | AU2003228966C1 (de) |
| CA (1) | CA2485253C (de) |
| DE (1) | DE60331330D1 (de) |
| ES (1) | ES2343788T3 (de) |
| WO (1) | WO2003094850A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2441809C (en) | 2001-03-27 | 2014-07-22 | Biomira, Inc. | Liposomal vaccines comprising dilipopeptides for modulating t1 and t2 immune responses |
| AU2003228966C1 (en) | 2002-05-09 | 2010-05-13 | Oncothyreon Inc. | Lipid A and other carbohydrate ligand analogs |
| TW201204410A (en) | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
| TWI511738B (zh) | 2005-06-28 | 2015-12-11 | Oncothyreon Inc | 以黏液性糖蛋白(ｍｕｃ-１）疫苗治療病人之方法 |
| ATE524509T1 (de) | 2005-07-18 | 2011-09-15 | Nektar Therapeutics | Verzweigte funktionalisierte polymere unter verwendung von verzweigten polyolen als kernen |
| ITMI20060530A1 (it) * | 2006-03-22 | 2007-09-23 | Univ Milano Bicocca | Antinfiammatori a struttura monosaccaridica |
| WO2008021367A2 (en) | 2006-08-11 | 2008-02-21 | President And Fellows Of Harvard College | Moenomycin biosynthesis-related compositions and methods of use thereof |
| PT2484375T (pt) | 2006-09-26 | 2018-07-09 | Infectious Disease Res Inst | Composição para vacina contendo adjuvante sintético |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| KR101012587B1 (ko) * | 2007-06-04 | 2011-02-01 | 엘지전자 주식회사 | 디스플레이 장치 |
| WO2009046314A2 (en) * | 2007-10-04 | 2009-04-09 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
| US9283184B2 (en) | 2008-11-24 | 2016-03-15 | Massachusetts Institute Of Technology | Methods and compositions for localized agent delivery |
| HRP20161585T1 (hr) | 2009-06-05 | 2016-12-30 | Infectious Disease Research Institute | Sintetski glukopiranozilni lipidi kao adjuvansi i cjepivni pripravci koji ih sadrže |
| CN102329335B (zh) * | 2010-07-13 | 2014-01-22 | 哈尔滨工业大学 | 基于季戊四醇的复合脂质，制备方法及用途 |
| US20110229556A1 (en) * | 2010-03-19 | 2011-09-22 | Massachusetts Institute Of Technology | Lipid-coated polymer particles for immune stimulation |
| MX2012010810A (es) * | 2010-03-19 | 2013-02-07 | Massachusetts Inst Technology | Composiciones de vesícula de lípido y métodos de uso. |
| US9149432B2 (en) | 2010-03-19 | 2015-10-06 | Massachusetts Institute Of Technology | Lipid vesicle compositions and methods of use |
| BR112013021779A2 (pt) | 2011-02-24 | 2017-09-19 | Oncothyreon Inc | vacina de glicolipopeptídeo baseada em muc1 com adjuvante. |
| EP3632463A1 (de) | 2011-04-08 | 2020-04-08 | Immune Design Corp. | Immunogene zusammensetzungen und verfahren zur verwendung der zusammensetzungen zur induzierung humoraler und zellulärer immunreaktionen |
| WO2013152277A2 (en) | 2012-04-06 | 2013-10-10 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
| WO2013151697A1 (en) | 2012-04-06 | 2013-10-10 | President And Fellows Of Harvard College | Methods and compounds for identifying glycosyltransferase inhibitors |
| US9902985B2 (en) | 2012-04-06 | 2018-02-27 | President And Fellows Of Harvard College | Chemoenzymatic methods for synthesizing moenomycin analogs |
| US9555099B2 (en) | 2012-05-16 | 2017-01-31 | Immune Design Corp. | Vaccines for HSV-2 |
| AU2014253791B2 (en) | 2013-04-18 | 2019-05-02 | Immune Design Corp. | GLA monotherapy for use in cancer treatment |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| EP4043036A1 (de) | 2013-09-27 | 2022-08-17 | Massachusetts Institute of Technology | Trägerfreie biologisch aktive proteinnanostrukturen |
| CN107531736B (zh) | 2015-01-06 | 2022-04-15 | 免疫疫苗科技公司 | 脂质a模拟物、其制备方法和用途 |
| US11034752B2 (en) | 2015-08-12 | 2021-06-15 | Massachusetts Institute Of Technology | Cell surface coupling of nanoparticles |
| JP7185530B2 (ja) | 2016-06-13 | 2022-12-07 | トルク セラピューティクス， インコーポレイテッド | 免疫細胞機能を促進するための方法および組成物 |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| US11458151B2 (en) | 2018-02-12 | 2022-10-04 | Inimmune Corporation | Toll-like receptor ligands |
| JPWO2022255037A1 (de) * | 2021-05-31 | 2022-12-08 | ||
| CN114399151A (zh) * | 2021-11-29 | 2022-04-26 | 阿里巴巴新加坡控股有限公司 | 运力订单分配方法、装置、可读程序产品及导航方法 |
| CN116162115B (zh) * | 2022-12-27 | 2025-09-26 | 华中师范大学 | Toll样受体4免疫激动剂及其应用、抗病毒疫苗分子及其制备方法和应用 |
| KR102827958B1 (ko) | 2025-04-09 | 2025-07-03 | 주식회사 로우맵 | 피부흡수 촉진용 히알루론산 나노캡슐, 이의 제조방법 및 이를 포함한 화장료 조성물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB614215A (en) * | 1946-07-09 | 1948-12-10 | Leslie Bradford | Manufacture of polyureas |
| GB699080A (en) | 1950-05-31 | 1953-10-28 | Ici Ltd | Production of new esters of ortho-phosphoric acid and salts thereof |
| US3930024A (en) * | 1969-09-02 | 1975-12-30 | Parke Davis & Co | Pharmaceutical compositions and methods |
| DE3127503A1 (de) | 1981-07-11 | 1983-02-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4464383A (en) * | 1981-11-24 | 1984-08-07 | Itaru Yamamoto | Immunomodulator containing trithiazole pentamethine cyanine derivative |
| US4783402A (en) * | 1983-04-11 | 1988-11-08 | Meito Sangyo Kabushiki Kaisha | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
| GR860379B (en) * | 1985-02-22 | 1986-06-11 | Akzo Nv | Novel disaccharide and trisaccharide derivatives of the lipid a type |
| WO1986005687A1 (en) | 1985-04-03 | 1986-10-09 | Wisconsin Alumni Research Foundation | Method of preventing diseases caused by gram-negative endotoxin in mammals |
| JPS63139186A (ja) | 1986-11-29 | 1988-06-10 | Hidetoshi Tsuchida | 三本鎖型リン脂質化合物およびその製造方法 |
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5041427A (en) * | 1989-07-21 | 1991-08-20 | Wisconsin Alumni Research Foundation | Lipid A derivatives |
| JPH0655749B2 (ja) * | 1989-09-20 | 1994-07-27 | 日本たばこ産業株式会社 | リピッドａ単糖類縁体 |
| FR2702306B1 (fr) | 1993-03-05 | 1995-04-14 | Alcatel Nv | Procédé d'auto-alignement d'un contact métallique sur un substrat de matériau semi-conducteur. |
| IT1264690B1 (it) * | 1993-07-08 | 1996-10-04 | Bracco Spa | Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi |
| DE4408248A1 (de) * | 1994-03-11 | 1995-09-14 | Hoechst Ag | Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung |
| AU2247095A (en) | 1994-04-12 | 1995-10-30 | Biomira Inc. | Cellular immune response-specific antigens and uses therefor |
| US6764840B2 (en) * | 1997-05-08 | 2004-07-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) * | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| IT1295460B1 (it) | 1997-10-02 | 1999-05-12 | Borgotec Tecnologie Autom Spa | Metodo per impilare pacchi di piastre di circuiti stampati e relativo dispositivo di carico e scarico di pacchi per una macchina utensile. |
| US6043390A (en) * | 1998-04-03 | 2000-03-28 | The Regents Of The University Of California | Pentaerythritol lipid derivatives and nucleic-acid complexes |
| EP1097122B1 (de) * | 1998-07-21 | 2004-09-22 | Lonza A.G. | Verfahren zur herstellung von aminen |
| US7491707B1 (en) | 1999-11-15 | 2009-02-17 | Biomira, Inc. | Synthetic lipid-a-analogs and uses thereof |
| US6699846B2 (en) * | 2000-03-17 | 2004-03-02 | Corixa Corporation | Mono- and disaccharides for the treatment of nitric oxide related disorders |
| ES2164013B1 (es) | 2000-04-14 | 2003-06-16 | Consejo Superior Investigacion | Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales. |
| AU2003203079B8 (en) * | 2002-02-04 | 2009-01-15 | Oncothyreon Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
| US20060069238A1 (en) | 2002-04-15 | 2006-03-30 | Biomira, Inc. | Synthetic glyco-lipo-peptides as vaccines |
| AU2003228966C1 (en) | 2002-05-09 | 2010-05-13 | Oncothyreon Inc. | Lipid A and other carbohydrate ligand analogs |
-
2003
- 2003-05-09 AU AU2003228966A patent/AU2003228966C1/en not_active Ceased
- 2003-05-09 EP EP03726743A patent/EP1549322B1/de not_active Expired - Lifetime
- 2003-05-09 ES ES03726743T patent/ES2343788T3/es not_active Expired - Lifetime
- 2003-05-09 DE DE60331330T patent/DE60331330D1/de not_active Expired - Lifetime
- 2003-05-09 WO PCT/US2003/014633 patent/WO2003094850A2/en not_active Ceased
- 2003-05-09 US US10/513,556 patent/US7820627B2/en not_active Expired - Fee Related
- 2003-05-09 JP JP2004502938A patent/JP5014573B2/ja not_active Expired - Fee Related
- 2003-05-09 AT AT03726743T patent/ATE457733T1/de active
- 2003-05-09 CA CA2485253A patent/CA2485253C/en not_active Expired - Fee Related
-
2010
- 2010-06-30 US US12/827,810 patent/US8097593B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003228966B2 (en) | 2009-10-01 |
| CA2485253A1 (en) | 2003-11-20 |
| US8097593B1 (en) | 2012-01-17 |
| ES2343788T3 (es) | 2010-08-10 |
| AU2003228966C1 (en) | 2010-05-13 |
| DE60331330D1 (de) | 2010-04-01 |
| EP1549322A2 (de) | 2005-07-06 |
| US7820627B2 (en) | 2010-10-26 |
| CA2485253C (en) | 2012-07-10 |
| WO2003094850A3 (en) | 2004-07-29 |
| WO2003094850A2 (en) | 2003-11-20 |
| US20120003295A1 (en) | 2012-01-05 |
| JP5014573B2 (ja) | 2012-08-29 |
| EP1549322A4 (de) | 2006-07-26 |
| JP2005538050A (ja) | 2005-12-15 |
| EP1549322B1 (de) | 2010-02-17 |
| US20060040891A1 (en) | 2006-02-23 |
| AU2003228966A1 (en) | 2003-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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