ATE457733T1 - Lipid-a- und andere kohlenhydrat-liganden-analoga - Google Patents
Lipid-a- und andere kohlenhydrat-liganden-analogaInfo
- Publication number
- ATE457733T1 ATE457733T1 AT03726743T AT03726743T ATE457733T1 AT E457733 T1 ATE457733 T1 AT E457733T1 AT 03726743 T AT03726743 T AT 03726743T AT 03726743 T AT03726743 T AT 03726743T AT E457733 T1 ATE457733 T1 AT E457733T1
- Authority
- AT
- Austria
- Prior art keywords
- lipid
- analogs
- useful
- replacement
- nature
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 150000001720 carbohydrates Chemical class 0.000 title abstract 2
- 150000002632 lipids Chemical class 0.000 title abstract 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 7
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002337 glycosamines Chemical group 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37864502P | 2002-05-09 | 2002-05-09 | |
| PCT/US2003/014633 WO2003094850A2 (en) | 2002-05-09 | 2003-05-09 | Lipid a and other carbohydrate ligand analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE457733T1 true ATE457733T1 (de) | 2010-03-15 |
Family
ID=29420423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03726743T ATE457733T1 (de) | 2002-05-09 | 2003-05-09 | Lipid-a- und andere kohlenhydrat-liganden-analoga |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7820627B2 (de) |
| EP (1) | EP1549322B1 (de) |
| JP (1) | JP5014573B2 (de) |
| AT (1) | ATE457733T1 (de) |
| AU (1) | AU2003228966C1 (de) |
| CA (1) | CA2485253C (de) |
| DE (1) | DE60331330D1 (de) |
| ES (1) | ES2343788T3 (de) |
| WO (1) | WO2003094850A2 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8198400B2 (en) | 2001-03-27 | 2012-06-12 | Oncothyreon, Inc. | Vaccine for modulating between T1 and T2 immune responses |
| ES2343788T3 (es) | 2002-05-09 | 2010-08-10 | Oncothyreon Inc. | Analogos de lipido a y de otros ligandos glucidicos. |
| TW201204410A (en) | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
| WO2007015171A2 (en) | 2005-06-28 | 2007-02-08 | Biomira, Inc. | Method of treating patients with a mucinous glycoprotein (muc-1) vaccine |
| US8568705B2 (en) | 2005-07-18 | 2013-10-29 | Nektar Therapeutics | Method for preparing branched functionalized polymers using branched polyol cores |
| ITMI20060530A1 (it) * | 2006-03-22 | 2007-09-23 | Univ Milano Bicocca | Antinfiammatori a struttura monosaccaridica |
| US9115358B2 (en) | 2006-08-11 | 2015-08-25 | President And Fellows Of Harvard College | Moenomycin biosynthesis-related compositions and methods of use thereof |
| DK2068918T4 (da) | 2006-09-26 | 2024-09-02 | Access To Advanced Health Inst | Vaccinesammensætning omfattende syntetisk adjuvant |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| KR101012587B1 (ko) * | 2007-06-04 | 2011-02-01 | 엘지전자 주식회사 | 디스플레이 장치 |
| EP2205074A4 (de) * | 2007-10-04 | 2013-07-31 | Harvard College | Moenomycin-analoga, syntheseverfahren und verwendung |
| EP2398466B1 (de) | 2008-11-24 | 2021-02-17 | Massachusetts Institute of Technology | Verfahren und zusammensetzungen zur lokalisierten nanopartikel-abgabe an tumoren |
| EP3124491B1 (de) | 2009-06-05 | 2019-10-30 | Infectious Disease Research Institute | Synthetische glucopyranosyl-lipid-adjuvanzien und impfstoffzusammensetzungen sowie pharmazeutische zusammensetzungen die diese enthalten |
| CN102329335B (zh) * | 2010-07-13 | 2014-01-22 | 哈尔滨工业大学 | 基于季戊四醇的复合脂质，制备方法及用途 |
| US9149432B2 (en) | 2010-03-19 | 2015-10-06 | Massachusetts Institute Of Technology | Lipid vesicle compositions and methods of use |
| CA2793604C (en) | 2010-03-19 | 2015-10-06 | Massachusetts Institute Of Technology | Lipid vesicle compositions and methods of use |
| US20110229556A1 (en) * | 2010-03-19 | 2011-09-22 | Massachusetts Institute Of Technology | Lipid-coated polymer particles for immune stimulation |
| AU2012222188A1 (en) | 2011-02-24 | 2013-08-15 | Oncothyreon Inc. | MUC1 based glycolipopeptide vaccine with adjuvant |
| JP6054942B2 (ja) | 2011-04-08 | 2016-12-27 | イミューン デザイン コーポレイション | 免疫原性組成物、ならびに体液性および細胞性免疫応答を誘発するための該組成物の使用方法 |
| US9273084B2 (en) | 2012-04-06 | 2016-03-01 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
| US10106833B2 (en) | 2012-04-06 | 2018-10-23 | President And Fellows Of Harvard College | Methods and compounds for identifying glycosyltransferase inhibitors |
| US9902985B2 (en) | 2012-04-06 | 2018-02-27 | President And Fellows Of Harvard College | Chemoenzymatic methods for synthesizing moenomycin analogs |
| CN107540730B (zh) | 2012-05-16 | 2021-07-16 | 免疫设计公司 | 用于hsv-2的疫苗 |
| BR112015025709A2 (pt) | 2013-04-18 | 2017-07-18 | Immune Design Corp | monoterapia com gla para uso em tratamento de câncer |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| EP3049114B1 (de) | 2013-09-27 | 2021-11-10 | Massachusetts Institute of Technology | Trägerfreie biologisch aktive proteinnanostrukturen |
| WO2016109880A1 (en) * | 2015-01-06 | 2016-07-14 | Immunovaccine Technologies Inc. | Lipid a mimics, methods of preparation, and uses thereof |
| US11034752B2 (en) | 2015-08-12 | 2021-06-15 | Massachusetts Institute Of Technology | Cell surface coupling of nanoparticles |
| EP3468581A1 (de) | 2016-06-13 | 2019-04-17 | Torque Therapeutics, Inc. | Verfahren und zusammensetzungen zur förderung der immunzellenfunktionen |
| JP7285828B2 (ja) | 2017-09-05 | 2023-06-02 | トルク セラピューティクス， インコーポレイテッド | 治療用タンパク質組成物ならびにその作製および使用方法 |
| BR112020016314A2 (pt) | 2018-02-12 | 2020-12-15 | Inimmune Corporation | Compostos ou um sais farmaceuticamente aceitáveis, composição farmacêutica, kit, e, métodos para elicitar, intensificar ou modificar uma resposta imunológica, para tratar, prevenir ou reduzir a suscetibilidade a câncer, para tratar, prevenir ou reduzir a suscetibilidade a uma doença infecciosa, para tratar, prevenir ou reduzir a suscetibilidade a uma alergia, para tratar, prevenir ou reduzir a suscetibilidade a uma afecção autoimune, para tratar, prevenir ou reduzir a suscetibilidade em um sujeito à infecção bacteriana, viral, priônica, autoimunidade, câncer ou alergia, para tratar, prevenir ou reduzir a suscetibilidade à autoimunidade, alergia, reperfusão de isquemia ou sepse, para tratar, prevenir ou reduzir a gravidade de ataques epiléticos e para tratar, prevenir ou reduzir a suscetibilidade a doenças oculares como degeneração macular, hipertensão ocular e infecção ocular |
| WO2022255037A1 (ja) * | 2021-05-31 | 2022-12-08 | 三菱瓦斯化学株式会社 | 新規アミノ化合物及びその製造方法、並びに、及びこれを用いたエポキシ樹脂用硬化剤、エポキシ樹脂組成物及びエポキシ樹脂硬化物 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB614215A (en) * | 1946-07-09 | 1948-12-10 | Leslie Bradford | Manufacture of polyureas |
| BE503349A (de) | 1950-05-31 | |||
| US3930024A (en) * | 1969-09-02 | 1975-12-30 | Parke Davis & Co | Pharmaceutical compositions and methods |
| DE3127503A1 (de) | 1981-07-11 | 1983-02-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4464383A (en) * | 1981-11-24 | 1984-08-07 | Itaru Yamamoto | Immunomodulator containing trithiazole pentamethine cyanine derivative |
| US4783402A (en) | 1983-04-11 | 1988-11-08 | Meito Sangyo Kabushiki Kaisha | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
| GR860379B (en) * | 1985-02-22 | 1986-06-11 | Akzo Nv | Novel disaccharide and trisaccharide derivatives of the lipid a type |
| WO1986005687A1 (en) | 1985-04-03 | 1986-10-09 | Wisconsin Alumni Research Foundation | Method of preventing diseases caused by gram-negative endotoxin in mammals |
| JPS63139186A (ja) | 1986-11-29 | 1988-06-10 | Hidetoshi Tsuchida | 三本鎖型リン脂質化合物およびその製造方法 |
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5041427A (en) * | 1989-07-21 | 1991-08-20 | Wisconsin Alumni Research Foundation | Lipid A derivatives |
| JPH0655749B2 (ja) * | 1989-09-20 | 1994-07-27 | 日本たばこ産業株式会社 | リピッドａ単糖類縁体 |
| FR2702306B1 (fr) | 1993-03-05 | 1995-04-14 | Alcatel Nv | Procédé d'auto-alignement d'un contact métallique sur un substrat de matériau semi-conducteur. |
| IT1264690B1 (it) | 1993-07-08 | 1996-10-04 | Bracco Spa | Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi |
| DE4408248A1 (de) * | 1994-03-11 | 1995-09-14 | Hoechst Ag | Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung |
| WO1995027505A1 (en) | 1994-04-12 | 1995-10-19 | Biomira, Inc. | Cellular immune response-specific antigens and uses therefor |
| US6764840B2 (en) * | 1997-05-08 | 2004-07-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) * | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| IT1295460B1 (it) | 1997-10-02 | 1999-05-12 | Borgotec Tecnologie Autom Spa | Metodo per impilare pacchi di piastre di circuiti stampati e relativo dispositivo di carico e scarico di pacchi per una macchina utensile. |
| US6043390A (en) * | 1998-04-03 | 2000-03-28 | The Regents Of The University Of California | Pentaerythritol lipid derivatives and nucleic-acid complexes |
| WO2000005190A1 (de) * | 1998-07-21 | 2000-02-03 | Lonza Ag | Verfahren zur herstellung von aminen |
| US7491707B1 (en) | 1999-11-15 | 2009-02-17 | Biomira, Inc. | Synthetic lipid-a-analogs and uses thereof |
| US6699846B2 (en) * | 2000-03-17 | 2004-03-02 | Corixa Corporation | Mono- and disaccharides for the treatment of nitric oxide related disorders |
| ES2164013B1 (es) | 2000-04-14 | 2003-06-16 | Consejo Superior Investigacion | Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales. |
| WO2003066649A1 (en) | 2002-02-04 | 2003-08-14 | Biomira Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
| EP1572918B1 (de) | 2002-04-15 | 2011-10-19 | Oncothyreon Inc. | Synthetische glykolipopeptide als impfstoffe |
| ES2343788T3 (es) | 2002-05-09 | 2010-08-10 | Oncothyreon Inc. | Analogos de lipido a y de otros ligandos glucidicos. |
-
2003
- 2003-05-09 ES ES03726743T patent/ES2343788T3/es not_active Expired - Lifetime
- 2003-05-09 AT AT03726743T patent/ATE457733T1/de active
- 2003-05-09 EP EP03726743A patent/EP1549322B1/de not_active Expired - Lifetime
- 2003-05-09 JP JP2004502938A patent/JP5014573B2/ja not_active Expired - Fee Related
- 2003-05-09 DE DE60331330T patent/DE60331330D1/de not_active Expired - Lifetime
- 2003-05-09 CA CA2485253A patent/CA2485253C/en not_active Expired - Fee Related
- 2003-05-09 WO PCT/US2003/014633 patent/WO2003094850A2/en active Application Filing
- 2003-05-09 AU AU2003228966A patent/AU2003228966C1/en not_active Ceased
- 2003-05-09 US US10/513,556 patent/US7820627B2/en not_active Expired - Fee Related
-
2010
- 2010-06-30 US US12/827,810 patent/US8097593B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003228966A1 (en) | 2003-11-11 |
| US20060040891A1 (en) | 2006-02-23 |
| WO2003094850A2 (en) | 2003-11-20 |
| WO2003094850A3 (en) | 2004-07-29 |
| ES2343788T3 (es) | 2010-08-10 |
| CA2485253A1 (en) | 2003-11-20 |
| CA2485253C (en) | 2012-07-10 |
| US7820627B2 (en) | 2010-10-26 |
| EP1549322A2 (de) | 2005-07-06 |
| DE60331330D1 (de) | 2010-04-01 |
| US20120003295A1 (en) | 2012-01-05 |
| US8097593B1 (en) | 2012-01-17 |
| AU2003228966B2 (en) | 2009-10-01 |
| EP1549322A4 (de) | 2006-07-26 |
| JP5014573B2 (ja) | 2012-08-29 |
| AU2003228966C1 (en) | 2010-05-13 |
| EP1549322B1 (de) | 2010-02-17 |
| JP2005538050A (ja) | 2005-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE457733T1 (de) | Lipid-a- und andere kohlenhydrat-liganden-analoga | |
| TR200000815T2 (tr) | In vitro hematopoietik hücrelerin stimulasyonu. | |
| CY1116768T1 (el) | Συνθεσεις οι οποιες περιεχουν βλαστοκυτταρα θηλυκης γαμετικης σειρας και μεθοδοι χρησης αυτων | |
| IL169896A0 (en) | Methods and compositions for administering therapeutic and diagnostic agents | |
| PE20110358A1 (es) | Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias | |
| TNSN05166A1 (en) | Isolating ingredients from biological material | |
| GB2458430A (en) | Method for generating a reference signal sequence using grouping | |
| ATE497976T1 (de) | Spezifisch an vygfvracl-hla-a24 bindende t-zellen-rezeptoren | |
| MX2007007723A (es) | Un biomaterial implantable y un metodo para producirlo. | |
| DE60025474D1 (de) | Elastisches lager für einen elektrischen generator | |
| MY147516A (en) | Compositions and method of vascular injury repair cross-reference to related applications | |
| SG166788A1 (en) | Use of b cell expansion agents in generating antibodies | |
| IL152111A0 (en) | Tamandarin and didemnin analogs and methods of making and using them | |
| ATE328173T1 (de) | Stützenschuh für betonpfeiler | |
| GB2388190B (en) | Methods for measuring enzyme activity | |
| AR046123A1 (es) | Aislamiento de celulas simil-celulas madre, uso de las mismas | |
| BRPI0417943A (pt) | antagonistas de receptor de crf e métodos relacionados para essa finalidade | |
| MX2007012954A (es) | Sistemas de expresion en mamiferos. | |
| ATE407999T1 (de) | Reinigungsmittel für harte oberflächen | |
| GT200600512A (es) | Enzimas para reducir el estres inmunologico | |
| WO2004022782A3 (en) | Compositions and methods for tissue specific or inducible inhibition of gene expression | |
| MXPA06009711A (es) | Uso de carboxipeptidasa g para combatir la toxicidad de antifolato. | |
| AU2003288621A8 (en) | Rna bioassay | |
| EP1601687A4 (de) | Verfahren zur erhöhung der ausbreitung von b-zellen | |
| ATE447628T1 (de) | Einzelsequenzhybridisierungssonden |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1549322 Country of ref document: EP |