ATE454141T1 - Guanylhydrazone die nützlich sind zur behandlung von mit t-zellen verbundenen krankheiten - Google Patents
Guanylhydrazone die nützlich sind zur behandlung von mit t-zellen verbundenen krankheitenInfo
- Publication number
- ATE454141T1 ATE454141T1 AT97948263T AT97948263T ATE454141T1 AT E454141 T1 ATE454141 T1 AT E454141T1 AT 97948263 T AT97948263 T AT 97948263T AT 97948263 T AT97948263 T AT 97948263T AT E454141 T1 ATE454141 T1 AT E454141T1
- Authority
- AT
- Austria
- Prior art keywords
- treating
- guanylhydrazones
- useful
- related diseases
- cell related
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000031886 HIV Infections Diseases 0.000 abstract 2
- 208000037357 HIV infectious disease Diseases 0.000 abstract 2
- 230000006044 T cell activation Effects 0.000 abstract 2
- 208000037765 diseases and disorders Diseases 0.000 abstract 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 2
- 102000043136 MAP kinase family Human genes 0.000 abstract 1
- 108091054455 MAP kinase family Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3106196P | 1996-11-15 | 1996-11-15 | |
| PCT/US1997/020670 WO1998020868A1 (en) | 1996-11-15 | 1997-11-14 | Guanylhydrazones useful for treating diseases associated with t cell activation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE454141T1 true ATE454141T1 (de) | 2010-01-15 |
Family
ID=21857458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97948263T ATE454141T1 (de) | 1996-11-15 | 1997-11-14 | Guanylhydrazone die nützlich sind zur behandlung von mit t-zellen verbundenen krankheiten |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6143728A (de) |
| EP (1) | EP0963197B1 (de) |
| JP (1) | JP2001503775A (de) |
| AT (1) | ATE454141T1 (de) |
| AU (1) | AU746647B2 (de) |
| CA (1) | CA2271693C (de) |
| DE (1) | DE69739734D1 (de) |
| ES (1) | ES2339306T3 (de) |
| WO (1) | WO1998020868A1 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001503775A (ja) * | 1996-11-15 | 2001-03-21 | ザ ピコワー インスティテュート フォー メディカル リサーチ | T細胞の活性化に関係する疾患を治療するために有用なグアニルヒドラゾン |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| EP1140062B1 (de) * | 1999-01-07 | 2005-04-06 | Warner-Lambert Company LLC | Behandlung von asthma anhand von mek-inhibitoren |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| RU2319693C9 (ru) | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ES2250363T3 (es) * | 2000-02-02 | 2006-04-16 | Dorian Bevec | Guanilhidrazonas aromaticas farmaceuticamente activas. |
| US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| WO2002000613A2 (en) * | 2000-06-27 | 2002-01-03 | Axxima Pharmaceuticals Ag | Inhibitors of hepatitis b virus infection |
| US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| US20080108672A1 (en) * | 2002-01-11 | 2008-05-08 | Bernd Riedl | Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors |
| US20030216396A1 (en) | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
| US7838541B2 (en) | 2002-02-11 | 2010-11-23 | Bayer Healthcare, Llc | Aryl ureas with angiogenesis inhibiting activity |
| CA2476896A1 (en) * | 2002-02-26 | 2003-09-04 | North Shore-Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors |
| EP1389480A1 (de) * | 2002-08-14 | 2004-02-18 | Mondobiotech Interferon SA | Therapeutische Anwendung von Guanylhydrazone zur Hemmung von CD83 abhängige Verfahren und Reifung der dendritischen Zellen |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| JP2006527197A (ja) * | 2003-06-06 | 2006-11-30 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | p38キナーゼ阻害剤組成物及びその使用方法 |
| RS52625B (sr) | 2003-07-23 | 2013-06-28 | Bayer Healthcare Llc | Fluoro supstituisana omega-karboksiaril difenil urea za lečenje i prevenciju bolesti i stanja bolesti |
| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| CA2560756A1 (en) | 2004-03-25 | 2005-10-06 | The Feinstein Institute For Medical Research | Methods and devices for reducing bleed time using vagus nerve stimulation |
| US7244765B2 (en) * | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
| MX2007001928A (es) | 2004-08-17 | 2007-04-17 | Cytokine Pharmasciences Inc | Metodos para producir y utilizar los compuestos o composiciones de guanilhidrazona. |
| US20060253100A1 (en) | 2004-10-22 | 2006-11-09 | Medtronic, Inc. | Systems and Methods to Treat Pain Locally |
| DE602005025020D1 (de) | 2004-12-27 | 2011-01-05 | The Feinstein Inst Medical Res | Behandlung von entzündlichen erkrankungen durch el |
| US11207518B2 (en) | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| DE102006028371A1 (de) * | 2006-06-19 | 2007-12-20 | Rheinische Friedrich-Wilhelms Universität | Mittel gegen Malaria |
| CA2655632A1 (en) * | 2006-06-23 | 2008-01-03 | The Feinstein Institute For Medical Research | Inhibitors of a.beta. and synuclein aggregation |
| US8391970B2 (en) | 2007-08-27 | 2013-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
| US9211409B2 (en) | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
| ES2452484T3 (es) | 2008-11-18 | 2014-04-01 | Setpoint Medical Corporation | Dispositivos para optimizar la colocación de electrodos para la estimulación antiinflamatoria |
| US20100239632A1 (en) | 2009-03-23 | 2010-09-23 | Warsaw Orthopedic, Inc. | Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| CN102573986B (zh) | 2009-06-09 | 2016-01-20 | 赛博恩特医疗器械公司 | 用于无导线刺激器的具有袋部的神经封套 |
| US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| WO2014169145A1 (en) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| CN102821814B (zh) | 2009-12-23 | 2015-07-15 | 赛博恩特医疗器械公司 | 用于治疗慢性炎症的神经刺激设备和系统 |
| CA2808165A1 (en) * | 2010-08-18 | 2012-02-23 | Universite Laval | Compounds and therapeutic applications related to inhibition of dendritic cell immunoreceptor (dcir) activity and signaling events |
| US12172017B2 (en) | 2011-05-09 | 2024-12-24 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| WO2012154865A2 (en) | 2011-05-09 | 2012-11-15 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| WO2016126807A1 (en) | 2015-02-03 | 2016-08-11 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
| US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| CN108882885A (zh) | 2016-01-20 | 2018-11-23 | 赛博恩特医疗器械公司 | 迷走神经刺激的控制 |
| WO2017127758A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Implantable microstimulators and inductive charging systems |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| WO2019036470A1 (en) | 2017-08-14 | 2019-02-21 | Setpoint Medical Corporation | TESTING TEST FOR STIMULATION OF NERVE WAVE |
| US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
| US12343535B2 (en) | 2019-04-12 | 2025-07-01 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| JP2023512447A (ja) | 2020-01-13 | 2023-03-27 | ザ ファインスタイン インスティチューツ フォー メディカル リサーチ | 脾臓への高密度集束超音波刺激による出血及び出血性疾患の治療 |
| US11938324B2 (en) | 2020-05-21 | 2024-03-26 | The Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
| US12444497B2 (en) | 2021-05-17 | 2025-10-14 | Setpoint Medical Corporation | Neurostimulation parameter authentication and expiration system for neurostimulation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8901507A (nl) * | 1989-06-14 | 1991-01-02 | Tno | Vluchtige aardkalimetaal-organische verbindingen en werkwijze voor de bereiding van gelaagde materialen met aardkalimetaaloxiden of -fluoriden uit deze verbindingen. |
| DD292376A5 (de) * | 1989-08-29 | 1991-08-01 | Berlin-Chemie Ag,De | Verfahren zur herstellung eines mittels gegen retrovirale erkrankungen |
| DD299041A5 (de) * | 1989-08-29 | 1992-03-26 | Berlin-Chemie Ag,De | Verfahren zur herstellung eines mittels gegen retrovirale erkrankungen |
| DD299038A5 (de) * | 1989-08-29 | 1992-03-26 | Berlin-Chemie Ag,De | Verfahren zur herstellung eines mittels gegen retrovirale erkrankungen |
| US4969305A (en) * | 1989-08-31 | 1990-11-13 | Philip Morris Incorporated | Indicia applying apparatus |
| DE69233479T2 (de) * | 1991-02-08 | 2006-03-16 | Scion Pharmaceuticals, Inc., Medford | Substituierte Guanidine und Derivate hiervon als Modulatoren der Freisetzung von Neurotransmittern und neue Methode zur Identifizierung von Inhibitoren der Neurotransmitter-Freisetzung |
| US5753446A (en) * | 1993-04-15 | 1998-05-19 | National Jewish Center For Immunology & Respiratory Medicine | Mitogen ERK kinase kinase (MEKK) assay |
| US5616578A (en) * | 1993-08-26 | 1997-04-01 | The Dupont Merck Pharmaceutical Company | Method of treating human immunodeficiency virus infection using a cyclic protease inhibitor in combination with a reverse transcriptase inhibitor |
| US6008255A (en) | 1994-01-21 | 1999-12-28 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US5599984A (en) | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US5574040A (en) * | 1995-01-06 | 1996-11-12 | Picower Institute For Medical Research | Pyrimidine compounds and methods of use to derivatize neighboring lysine residues in proteins under physiologic conditions |
| US6369068B1 (en) * | 1995-06-07 | 2002-04-09 | Smithkline Beecham Corporation | Amino substituted pyrimidine containing compounds |
| WO1997034137A2 (en) * | 1996-03-12 | 1997-09-18 | Smithkline Beecham Corporation | Methods of the identification of pharmaceutically active compounds |
| JP2001503775A (ja) | 1996-11-15 | 2001-03-21 | ザ ピコワー インスティテュート フォー メディカル リサーチ | T細胞の活性化に関係する疾患を治療するために有用なグアニルヒドラゾン |
| US6180686B1 (en) * | 1998-09-17 | 2001-01-30 | Thomas M. Kurth | Cellular plastic material |
-
1997
- 1997-11-14 JP JP52280198A patent/JP2001503775A/ja not_active Ceased
- 1997-11-14 US US08/970,973 patent/US6143728A/en not_active Expired - Lifetime
- 1997-11-14 EP EP97948263A patent/EP0963197B1/de not_active Expired - Lifetime
- 1997-11-14 AT AT97948263T patent/ATE454141T1/de active
- 1997-11-14 WO PCT/US1997/020670 patent/WO1998020868A1/en not_active Ceased
- 1997-11-14 ES ES97948263T patent/ES2339306T3/es not_active Expired - Lifetime
- 1997-11-14 DE DE69739734T patent/DE69739734D1/de not_active Expired - Lifetime
- 1997-11-14 CA CA002271693A patent/CA2271693C/en not_active Expired - Lifetime
- 1997-11-14 AU AU54360/98A patent/AU746647B2/en not_active Expired
-
2000
- 2000-11-02 US US09/705,581 patent/US6673777B1/en not_active Expired - Lifetime
-
2003
- 2003-07-16 US US10/619,426 patent/US7741372B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0963197B1 (de) | 2010-01-06 |
| US6143728A (en) | 2000-11-07 |
| AU5436098A (en) | 1998-06-03 |
| EP0963197A4 (de) | 2003-04-09 |
| DE69739734D1 (de) | 2010-02-25 |
| WO1998020868A1 (en) | 1998-05-22 |
| US6673777B1 (en) | 2004-01-06 |
| US20040171695A1 (en) | 2004-09-02 |
| AU746647B2 (en) | 2002-05-02 |
| EP0963197A1 (de) | 1999-12-15 |
| US7741372B2 (en) | 2010-06-22 |
| CA2271693A1 (en) | 1998-05-22 |
| JP2001503775A (ja) | 2001-03-21 |
| CA2271693C (en) | 2009-01-20 |
| ES2339306T3 (es) | 2010-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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