ATE452973T1 - Genetische veränderung von somatischen zellen und deren verwendungen - Google Patents
Genetische veränderung von somatischen zellen und deren verwendungenInfo
- Publication number
- ATE452973T1 ATE452973T1 AT00907792T AT00907792T ATE452973T1 AT E452973 T1 ATE452973 T1 AT E452973T1 AT 00907792 T AT00907792 T AT 00907792T AT 00907792 T AT00907792 T AT 00907792T AT E452973 T1 ATE452973 T1 AT E452973T1
- Authority
- AT
- Austria
- Prior art keywords
- somatic cells
- genetic modification
- cells
- genetically modified
- loci
- Prior art date
Links
- 238000012239 gene modification Methods 0.000 title abstract 2
- 230000005017 genetic modification Effects 0.000 title abstract 2
- 235000013617 genetically modified food Nutrition 0.000 title abstract 2
- 230000000392 somatic effect Effects 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 238000010363 gene targeting Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 210000001082 somatic cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L41/00—Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks
- H04L41/02—Standardisation; Integration
- H04L41/0213—Standardised network management protocols, e.g. simple network management protocol [SNMP]
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L41/00—Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks
- H04L41/22—Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks comprising specially adapted graphical user interfaces [GUI]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/60—Vectors containing traps for, e.g. exons, promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Computer Networks & Wireless Communication (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Signal Processing (AREA)
- Mycology (AREA)
- Human Computer Interaction (AREA)
- Crystallography & Structural Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9905033.8A GB9905033D0 (en) | 1999-03-04 | 1999-03-04 | Methods |
GBGB9917023.5A GB9917023D0 (en) | 1999-07-20 | 1999-07-20 | Methods |
US09/475,674 US20020012660A1 (en) | 1999-03-04 | 1999-12-30 | Method of preparing a somatic cells for nuclear transfer |
PCT/GB2000/000778 WO2000051424A2 (en) | 1999-03-04 | 2000-03-03 | Genetic modification of somatic cells and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE452973T1 true ATE452973T1 (de) | 2010-01-15 |
Family
ID=27269662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00907792T ATE452973T1 (de) | 1999-03-04 | 2000-03-03 | Genetische veränderung von somatischen zellen und deren verwendungen |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP1159415B1 (de) |
JP (2) | JP2002537785A (de) |
AT (1) | ATE452973T1 (de) |
AU (1) | AU780754B2 (de) |
CA (1) | CA2361943C (de) |
DE (1) | DE60043578D1 (de) |
DK (1) | DK1159415T3 (de) |
ES (1) | ES2338631T3 (de) |
NZ (1) | NZ514620A (de) |
PT (1) | PT1159415E (de) |
WO (1) | WO2000051424A2 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3842597B2 (ja) * | 2001-08-14 | 2006-11-08 | 家畜受精卵移植技術研究組合 | G1期細胞の収集方法及び該細胞を用いた核移植方法 |
IL163875A0 (en) | 2002-03-07 | 2005-12-18 | Univ Delaware | Methods, compositions, and kits for enhancing oli gonucleotide mediated nucleic acid sequence alteration using compositions comprising a histone de |
ES2338111T3 (es) | 2002-08-21 | 2010-05-04 | Revivicor, Inc. | Animales porcinos que carecen de cualquier expresion de alfa 1,3 galactosiltransferasa funcional. |
US7429690B2 (en) | 2002-11-08 | 2008-09-30 | Kirin Holdings Kabushiki Kaisha | Transgenic bovines having reduced prion protein production |
EP1609857B1 (de) * | 2003-03-06 | 2010-10-20 | Toudai Tlo, Ltd. | Verfahren zur demethylierung einer methylierten zielregion genomischer dna |
AU2004246022A1 (en) | 2003-06-06 | 2004-12-16 | University Of Pittsburgh | Porcine CMP-N-acetylneuraminic acid hydroxylase gene |
WO2005047469A2 (en) | 2003-11-05 | 2005-05-26 | University Of Pittsburgh | PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION |
JP2007529278A (ja) | 2004-03-17 | 2007-10-25 | レビビコア, インコーポレイテッド | 機能的α1,3ガラクトシルトランスフェラーゼを欠く動物に由来する組織生成物 |
US7420099B2 (en) | 2004-04-22 | 2008-09-02 | Kirin Holdings Kabushiki Kaisha | Transgenic animals and uses thereof |
AU2005243169A1 (en) | 2004-05-07 | 2005-11-24 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region |
AU2005299413A1 (en) | 2004-10-22 | 2006-05-04 | Revivicor, Inc. | Ungulates with genetically modified immune systems |
US20080026457A1 (en) | 2004-10-22 | 2008-01-31 | Kevin Wells | Ungulates with genetically modified immune systems |
AU2006292827B2 (en) | 2005-08-09 | 2013-02-14 | Revivicor, Inc. | Transgenic ungulates expressing CTLA4-IG and uses thereof |
JP5524610B2 (ja) | 2006-04-07 | 2014-06-18 | ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク | トランスコバラミン受容体ポリペプチド、核酸およびその調節因子、ならびに細胞の増殖の調節ならびにガンおよびコバラミン欠損症の処置に使用する関連方法 |
US8323815B2 (en) | 2006-06-16 | 2012-12-04 | Porous Power Technology, LLC | Optimized microporous structure of electrochemical cells |
JP5327733B2 (ja) * | 2007-09-18 | 2013-10-30 | 国立大学法人名古屋大学 | 魚類胚の作製方法及びその利用 |
DK2348827T3 (en) | 2008-10-27 | 2015-07-20 | Revivicor Inc | IMMUNICIPLY COMPROMATED PETS |
CN102804297A (zh) | 2009-05-20 | 2012-11-28 | 多孔渗透电力技术公司 | 用于微孔膜的处理和胶粘剂 |
KR101236724B1 (ko) | 2010-11-23 | 2013-02-26 | 대한민국 | 단백질 과발현 카세트를 포함하는 유전자 타겟팅 넉인 벡터, 이의 제조 방법 및 이 벡터가 도입된 이종간 이식용 형질전환 복제동물 |
NZ759163A (en) | 2011-02-14 | 2023-03-31 | Revivicor Inc | Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof |
AU2021385081A1 (en) | 2020-11-20 | 2023-06-29 | Revivicor, Inc. | Multi-transgenic pigs with growth hormone receptor knockout for xenotransplantation |
US20230255185A1 (en) | 2021-09-20 | 2023-08-17 | Revivicor, Inc. | Multitransgenic pigs comprising ten genetic modifications for xenotransplantation |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0625195T3 (da) * | 1991-11-15 | 1999-08-30 | Univ California | Behandling af centralnervesystemet med genetisk modificerede celler |
HUT74597A (en) * | 1993-06-23 | 1997-01-28 | Genesys Pharma Inc | Antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection |
GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
US5905042A (en) | 1996-04-01 | 1999-05-18 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Cultured inner cell mass cell lines derived from bovine or porcine embryos |
US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
AU3056697A (en) * | 1996-04-12 | 1997-11-07 | Academy Of Finland | Synthesis of human procollagens and collagens in recombinant dna systems |
AU740709B2 (en) | 1996-08-19 | 2001-11-15 | University Of Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplanta tion |
US6225290B1 (en) * | 1996-09-19 | 2001-05-01 | The Regents Of The University Of California | Systemic gene therapy by intestinal cell transformation |
JPH10146193A (ja) * | 1996-09-23 | 1998-06-02 | Chihiro Koike | 相同組換え用dnaコンストラクト、このコンストラクトを用いた形質転換体の選別方法及び相同組換え法 |
US6235969B1 (en) | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
DE69835360T2 (de) * | 1997-01-17 | 2007-08-16 | Maxygen, Inc., Redwood City | EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION |
GB9703550D0 (en) * | 1997-02-20 | 1997-04-09 | Ppl Therapeutics Scotland Ltd | Cell mediated transgenesis |
WO1998039416A1 (en) | 1997-03-06 | 1998-09-11 | Infigen, Inc. | Method of cloning animals |
US6504081B1 (en) * | 1997-06-13 | 2003-01-07 | President And Fellow Of Harvard College | Methods and uses for transposon-based gene targeting |
BR9811657A (pt) | 1997-07-03 | 2000-09-05 | Univ Massachusetts Public Inst | Clonagem usando-se núcleos doadores oriundos de células diferenciadas não-carentes de soro |
GB9715064D0 (en) | 1997-07-17 | 1997-09-24 | Ppl Therapeutics Scotland Ltd | Protein expression |
-
2000
- 2000-03-03 AT AT00907792T patent/ATE452973T1/de active
- 2000-03-03 PT PT00907792T patent/PT1159415E/pt unknown
- 2000-03-03 AU AU29267/00A patent/AU780754B2/en not_active Expired
- 2000-03-03 WO PCT/GB2000/000778 patent/WO2000051424A2/en active IP Right Grant
- 2000-03-03 JP JP2000601905A patent/JP2002537785A/ja not_active Withdrawn
- 2000-03-03 NZ NZ514620A patent/NZ514620A/en not_active IP Right Cessation
- 2000-03-03 EP EP00907792A patent/EP1159415B1/de not_active Expired - Lifetime
- 2000-03-03 ES ES00907792T patent/ES2338631T3/es not_active Expired - Lifetime
- 2000-03-03 DE DE60043578T patent/DE60043578D1/de not_active Expired - Lifetime
- 2000-03-03 DK DK00907792.6T patent/DK1159415T3/da active
- 2000-03-03 CA CA2361943A patent/CA2361943C/en not_active Expired - Lifetime
- 2000-03-03 EP EP09015852A patent/EP2199392A3/de not_active Withdrawn
-
2011
- 2011-07-08 JP JP2011151655A patent/JP2011188873A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2199392A3 (de) | 2010-12-15 |
PT1159415E (pt) | 2010-03-31 |
DE60043578D1 (de) | 2010-02-04 |
EP1159415A2 (de) | 2001-12-05 |
NZ514620A (en) | 2004-04-30 |
CA2361943C (en) | 2011-05-17 |
EP1159415B1 (de) | 2009-12-23 |
EP2199392A2 (de) | 2010-06-23 |
AU780754B2 (en) | 2005-04-14 |
JP2011188873A (ja) | 2011-09-29 |
AU2926700A (en) | 2000-09-21 |
CA2361943A1 (en) | 2000-09-08 |
DK1159415T3 (da) | 2010-05-03 |
WO2000051424A3 (en) | 2001-03-22 |
WO2000051424A2 (en) | 2000-09-08 |
ES2338631T3 (es) | 2010-05-11 |
JP2002537785A (ja) | 2002-11-12 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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