ATE450510T1 - Thieno 2,3-b pyridin-derivate als antagonisten des gonadotropin-freisetzenden hormons - Google Patents
Thieno 2,3-b pyridin-derivate als antagonisten des gonadotropin-freisetzenden hormonsInfo
- Publication number
- ATE450510T1 ATE450510T1 AT04078019T AT04078019T ATE450510T1 AT E450510 T1 ATE450510 T1 AT E450510T1 AT 04078019 T AT04078019 T AT 04078019T AT 04078019 T AT04078019 T AT 04078019T AT E450510 T1 ATE450510 T1 AT E450510T1
- Authority
- AT
- Austria
- Prior art keywords
- antagonists
- releasing hormone
- gonadotropin
- thieno
- pyridine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25482700P | 2000-12-12 | 2000-12-12 | |
| US09/992,785 US6583153B2 (en) | 2000-12-12 | 2001-11-14 | 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE450510T1 true ATE450510T1 (de) | 2009-12-15 |
Family
ID=26944257
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01990166T ATE337303T1 (de) | 2000-12-12 | 2001-12-11 | 7-heterocyclyl-substituierte chinolin- und thieno 2,3-böpyridin-derivate als antagonisten des gonadotropin-freisetzenden hormons |
| AT04078019T ATE450510T1 (de) | 2000-12-12 | 2001-12-11 | Thieno 2,3-b pyridin-derivate als antagonisten des gonadotropin-freisetzenden hormons |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01990166T ATE337303T1 (de) | 2000-12-12 | 2001-12-11 | 7-heterocyclyl-substituierte chinolin- und thieno 2,3-böpyridin-derivate als antagonisten des gonadotropin-freisetzenden hormons |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6583153B2 (de) |
| EP (2) | EP1345907B1 (de) |
| JP (1) | JP4427251B2 (de) |
| CN (1) | CN1288137C (de) |
| AT (2) | ATE337303T1 (de) |
| AU (2) | AU2002229033B2 (de) |
| CA (1) | CA2431617C (de) |
| CY (2) | CY1105712T1 (de) |
| DE (2) | DE60140700D1 (de) |
| DK (2) | DK1520855T3 (de) |
| ES (2) | ES2269499T3 (de) |
| HK (1) | HK1055957A1 (de) |
| PT (2) | PT1520855E (de) |
| WO (1) | WO2002048112A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| TW200413351A (en) * | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
| WO2004035541A1 (en) * | 2002-10-15 | 2004-04-29 | Janssen Pharmaceutica, N.V. | Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators |
| CA2631917A1 (en) * | 2005-12-05 | 2007-06-14 | Merck & Co., Inc. | Quinolone m1 receptor positive allosteric modulators |
| WO2011049731A1 (en) * | 2009-10-21 | 2011-04-28 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone m1 receptor positive allosteric modulators |
| CN116239498B (zh) * | 2023-05-11 | 2023-07-21 | 北京元延医药科技股份有限公司 | 制备克立硼罗中间体的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659691A (en) | 1985-02-08 | 1987-04-21 | Merck & Co., Inc. | Novel cyclic Hexapeptide LHRH antagonists |
| US5140009A (en) | 1988-02-10 | 1992-08-18 | Tap Pharmaceuticals, Inc. | Octapeptide LHRH antagonists |
| US5171835A (en) | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
| TW449600B (en) | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
| US5607939A (en) | 1994-04-28 | 1997-03-04 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| JPH10500402A (ja) | 1994-04-29 | 1998-01-13 | 武田薬品工業株式会社 | 縮合複素環化合物またはその塩、その製造法および用途 |
| WO1996038438A1 (en) | 1995-06-01 | 1996-12-05 | Takeda Chemical Industries, Ltd. | TRICYCLIC DIAZEPINES USEFUL AS GnRH RECEPTOR ANTAGONISTS |
| DE69623655T2 (de) | 1995-10-19 | 2003-04-24 | Takeda Chemical Industries Ltd | Chinolinderivate als gnrh antagonisten |
| AU7333396A (en) | 1995-10-19 | 1997-05-07 | Takeda Chemical Industries Ltd. | Thienopyridine derivatives as gonadotropin releasing hormone antagonists |
| EP0871624A1 (de) | 1995-12-14 | 1998-10-21 | Merck & Co., Inc. | Antagonisten des gonadotropin-releasing hormons |
| CZ183198A3 (cs) | 1995-12-14 | 1998-10-14 | Merck And Co., Inc. | Nepeptidové deriváty, antagonizující hormon, uvolňující gonadotropin a farmaceutický prostředek |
| EP0900222A1 (de) | 1996-04-26 | 1999-03-10 | Takeda Chemical Industries, Ltd. | Thienopyridinderivate, ihre herstellung und verwendung |
| CA2250908C (en) | 1996-04-30 | 2012-03-13 | Takeda Chemical Industries, Ltd. | Combined use of gnrh agonist and antagonist |
| JP2000511532A (ja) | 1996-05-20 | 2000-09-05 | メルク エンド カンパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモンのアンタゴニスト |
| JP2000511182A (ja) | 1996-05-20 | 2000-08-29 | メルク エンド カンパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモンのアンタゴニスト |
| EP0920319A4 (de) | 1996-05-20 | 2002-05-02 | Merck & Co Inc | Antagonisten des gonadotropin freisetzenden hormins |
| AU706818B2 (en) | 1996-05-20 | 1999-06-24 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| GB9610813D0 (en) | 1996-05-23 | 1996-07-31 | Pharmacia Spa | Combinatorial solid phase synthesis of a library of benzufuran derivatives |
-
2001
- 2001-11-14 US US09/992,785 patent/US6583153B2/en not_active Expired - Lifetime
- 2001-12-11 DK DK04078019.9T patent/DK1520855T3/da active
- 2001-12-11 CN CNB018225985A patent/CN1288137C/zh not_active Expired - Lifetime
- 2001-12-11 DK DK01990166T patent/DK1345907T3/da active
- 2001-12-11 ES ES01990166T patent/ES2269499T3/es not_active Expired - Lifetime
- 2001-12-11 AU AU2002229033A patent/AU2002229033B2/en not_active Expired
- 2001-12-11 ES ES04078019T patent/ES2337898T3/es not_active Expired - Lifetime
- 2001-12-11 AU AU2903302A patent/AU2903302A/xx active Pending
- 2001-12-11 AT AT01990166T patent/ATE337303T1/de active
- 2001-12-11 AT AT04078019T patent/ATE450510T1/de active
- 2001-12-11 WO PCT/US2001/048119 patent/WO2002048112A2/en active IP Right Grant
- 2001-12-11 PT PT04078019T patent/PT1520855E/pt unknown
- 2001-12-11 CA CA2431617A patent/CA2431617C/en not_active Expired - Lifetime
- 2001-12-11 EP EP01990166A patent/EP1345907B1/de not_active Expired - Lifetime
- 2001-12-11 DE DE60140700T patent/DE60140700D1/de not_active Expired - Lifetime
- 2001-12-11 PT PT01990166T patent/PT1345907E/pt unknown
- 2001-12-11 EP EP04078019A patent/EP1520855B1/de not_active Expired - Lifetime
- 2001-12-11 JP JP2002549643A patent/JP4427251B2/ja not_active Expired - Lifetime
- 2001-12-11 DE DE60122575T patent/DE60122575T2/de not_active Expired - Lifetime
-
2003
- 2003-04-03 US US10/406,393 patent/US6765011B2/en not_active Expired - Lifetime
- 2003-11-12 HK HK03108228A patent/HK1055957A1/xx not_active IP Right Cessation
-
2006
- 2006-10-18 CY CY20061101492T patent/CY1105712T1/el unknown
-
2010
- 2010-02-09 CY CY20101100121T patent/CY1110589T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002048112A3 (en) | 2002-08-22 |
| EP1345907B1 (de) | 2006-08-23 |
| DE60122575T2 (de) | 2007-09-13 |
| JP4427251B2 (ja) | 2010-03-03 |
| CY1110589T1 (el) | 2015-04-29 |
| HK1055957A1 (en) | 2004-01-30 |
| AU2903302A (en) | 2002-06-24 |
| EP1345907A2 (de) | 2003-09-24 |
| CN1288137C (zh) | 2006-12-06 |
| PT1520855E (pt) | 2010-01-06 |
| DE60140700D1 (de) | 2010-01-14 |
| ES2337898T3 (es) | 2010-04-30 |
| US20020123506A1 (en) | 2002-09-05 |
| US6583153B2 (en) | 2003-06-24 |
| US20030216429A1 (en) | 2003-11-20 |
| EP1520855A1 (de) | 2005-04-06 |
| PT1345907E (pt) | 2006-11-30 |
| JP2004515541A (ja) | 2004-05-27 |
| CA2431617C (en) | 2011-07-12 |
| CA2431617A1 (en) | 2002-06-20 |
| DK1520855T3 (da) | 2010-03-15 |
| EP1520855B1 (de) | 2009-12-02 |
| ATE337303T1 (de) | 2006-09-15 |
| DE60122575D1 (de) | 2006-10-05 |
| CY1105712T1 (el) | 2010-12-22 |
| AU2002229033B2 (en) | 2007-09-13 |
| ES2269499T3 (es) | 2007-04-01 |
| DK1345907T3 (da) | 2006-11-13 |
| WO2002048112A2 (en) | 2002-06-20 |
| US6765011B2 (en) | 2004-07-20 |
| CN1489579A (zh) | 2004-04-14 |
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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