ATE447579T1 - Verfahren zur herstellung von 1-hydroxy-2- substituierten cyclohexylazetidin-2-on- verbindungen - Google Patents
Verfahren zur herstellung von 1-hydroxy-2- substituierten cyclohexylazetidin-2-on- verbindungenInfo
- Publication number
- ATE447579T1 ATE447579T1 AT06792145T AT06792145T ATE447579T1 AT E447579 T1 ATE447579 T1 AT E447579T1 AT 06792145 T AT06792145 T AT 06792145T AT 06792145 T AT06792145 T AT 06792145T AT E447579 T1 ATE447579 T1 AT E447579T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- compound
- trifluoromethanesulfonate
- nucleophile
- microwave irradiation
- Prior art date
Links
- -1 1-HYDROXY-2-SUBSTITUTED CYCLOHEXYLAZETIdine-2-ONE COMPOUNDS Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000012038 nucleophile Substances 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- 239000007858 starting material Substances 0.000 abstract 3
- 150000002118 epoxides Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229910017717 NH4X Inorganic materials 0.000 abstract 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- XSVCYDUEICANRJ-UHFFFAOYSA-K dysprosium(3+);trifluoromethanesulfonate Chemical compound [Dy+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F XSVCYDUEICANRJ-UHFFFAOYSA-K 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000007142 ring opening reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 abstract 1
- AHZJKOKFZJYCLG-UHFFFAOYSA-K trifluoromethanesulfonate;ytterbium(3+) Chemical compound [Yb+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F AHZJKOKFZJYCLG-UHFFFAOYSA-K 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200500269 | 2005-09-21 | ||
| PCT/EP2006/009101 WO2007039099A1 (en) | 2005-09-21 | 2006-09-19 | Process for preparing 1’-hydroxy-2’-substituted cyclohexyl azetidin-2-one compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE447579T1 true ATE447579T1 (de) | 2009-11-15 |
Family
ID=37498010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06792145T ATE447579T1 (de) | 2005-09-21 | 2006-09-19 | Verfahren zur herstellung von 1-hydroxy-2- substituierten cyclohexylazetidin-2-on- verbindungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090234139A1 (de) |
| EP (1) | EP1940853B1 (de) |
| JP (1) | JP2009508898A (de) |
| CN (1) | CN101268086A (de) |
| AT (1) | ATE447579T1 (de) |
| AU (1) | AU2006299169A1 (de) |
| CA (1) | CA2621327A1 (de) |
| DE (1) | DE602006010228D1 (de) |
| SI (1) | SI1940853T1 (de) |
| WO (1) | WO2007039099A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015527376A (ja) * | 2012-09-05 | 2015-09-17 | 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． | アゼチジノン化合物の結晶及びその調製方法 |
| CN109134335B (zh) * | 2017-06-27 | 2022-05-17 | 苏州引航生物科技有限公司 | 一种制备手性(1r,2s)-1-苯基-2-(1-吡咯烷基)丙烷-1-醇的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9104832D0 (en) * | 1991-03-07 | 1991-04-17 | Glaxo Spa | Heterocyclic compounds |
| JP4257827B2 (ja) * | 2002-12-27 | 2009-04-22 | ミヨシ油脂株式会社 | 両性界面活性剤の製造方法 |
-
2006
- 2006-09-19 EP EP06792145A patent/EP1940853B1/de not_active Not-in-force
- 2006-09-19 SI SI200630552T patent/SI1940853T1/sl unknown
- 2006-09-19 JP JP2008531600A patent/JP2009508898A/ja active Pending
- 2006-09-19 WO PCT/EP2006/009101 patent/WO2007039099A1/en active Application Filing
- 2006-09-19 CN CNA2006800341052A patent/CN101268086A/zh active Pending
- 2006-09-19 AT AT06792145T patent/ATE447579T1/de active
- 2006-09-19 US US11/992,212 patent/US20090234139A1/en not_active Abandoned
- 2006-09-19 AU AU2006299169A patent/AU2006299169A1/en not_active Abandoned
- 2006-09-19 CA CA002621327A patent/CA2621327A1/en not_active Abandoned
- 2006-09-19 DE DE602006010228T patent/DE602006010228D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1940853B1 (de) | 2009-11-04 |
| DE602006010228D1 (de) | 2009-12-17 |
| CN101268086A (zh) | 2008-09-17 |
| SI1940853T1 (sl) | 2010-03-31 |
| AU2006299169A1 (en) | 2007-04-12 |
| CA2621327A1 (en) | 2007-04-12 |
| WO2007039099A1 (en) | 2007-04-12 |
| US20090234139A1 (en) | 2009-09-17 |
| EP1940853A1 (de) | 2008-07-09 |
| JP2009508898A (ja) | 2009-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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