ATE433461T1 - Rana pipiens proteine und deren verwendung in der behandlung von tumoren - Google Patents

Rana pipiens proteine und deren verwendung in der behandlung von tumoren

Info

Publication number
ATE433461T1
ATE433461T1 AT99968949T AT99968949T ATE433461T1 AT E433461 T1 ATE433461 T1 AT E433461T1 AT 99968949 T AT99968949 T AT 99968949T AT 99968949 T AT99968949 T AT 99968949T AT E433461 T1 ATE433461 T1 AT E433461T1
Authority
AT
Austria
Prior art keywords
proteins
rana
pipien
tumors
treatment
Prior art date
Application number
AT99968949T
Other languages
English (en)
Inventor
Wojciech Ardelt
Original Assignee
Alfacell Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfacell Corp filed Critical Alfacell Corp
Application granted granted Critical
Publication of ATE433461T1 publication Critical patent/ATE433461T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT99968949T 1998-12-30 1999-12-24 Rana pipiens proteine und deren verwendung in der behandlung von tumoren ATE433461T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/223,118 US6239257B1 (en) 1998-12-30 1998-12-30 Family of proteins belonging to the pancreatic ribonuclease a superfamily
PCT/US1999/030799 WO2000040608A1 (en) 1998-12-30 1999-12-24 Proteins from rana pipiens and their use in the treatment of tumors

Publications (1)

Publication Number Publication Date
ATE433461T1 true ATE433461T1 (de) 2009-06-15

Family

ID=22835123

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99968949T ATE433461T1 (de) 1998-12-30 1999-12-24 Rana pipiens proteine und deren verwendung in der behandlung von tumoren

Country Status (6)

Country Link
US (1) US6239257B1 (de)
EP (1) EP1141004B1 (de)
JP (1) JP4516216B2 (de)
AT (1) ATE433461T1 (de)
DE (1) DE69940980D1 (de)
WO (1) WO2000040608A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7229824B2 (en) * 2003-07-17 2007-06-12 Alfacell Corporation Ribonucleases and methods of making them recombinantly
JP2008546391A (ja) 2005-06-16 2008-12-25 ウイスコンシン アラムニ リサーチ ファンデーション 細胞傷害性リボヌクレアーゼ変異株
US7416875B2 (en) 2005-06-16 2008-08-26 Wisconsin Alumni Research Foundation Cytotoxic ribonuclease variants
CN100372869C (zh) * 2006-04-18 2008-03-05 河北师范大学 棕点湍蛙抗微生物多肽及其在制药中的应用
KR20240007725A (ko) 2009-11-02 2024-01-16 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 치료학적 뉴클레아제 조성물 및 방법
AU2012249360B2 (en) 2011-04-29 2015-12-24 University Of Washington Therapeutic nuclease compositions and methods
ES2759252T3 (es) 2013-10-31 2020-05-08 Resolve Therapeutics Llc Fusiones y métodos terapéuticos de nucleasa-albúmina
US9919034B2 (en) 2014-03-28 2018-03-20 Tamir Biotechnology, Inc. Methods of treating and prophylactically protecting mammalian patients infected by viruses classified in Baltimore group V
MX2016012536A (es) 2014-03-28 2017-04-06 Tamir Biotechnology Inc Rnasa para su uso en el tratamiento o la prevencion de infecciones virales.
US10835598B2 (en) 2014-08-18 2020-11-17 Orgenesis Inc. Prophylactic protection against viral infections, particularly HIV
US9642794B2 (en) 2014-08-18 2017-05-09 Tamir Biotechnology, Inc. Antiviral pharmaceutical for topical administration
US10293032B2 (en) 2015-06-15 2019-05-21 Tamir Biotechnology, Inc. Methods and pharmaceuticals for treatment of viral infections of the eye
CN108350458B (zh) 2015-09-25 2022-06-07 奥可金公司 用豹蛙酶和/或两栖酶治疗病毒性结膜炎
WO2017142807A1 (en) 2016-02-16 2017-08-24 Tamir Biotechnology, Inc. Treatment or prevention of zika virus infections by administration of a ribonuclease
JP7308034B2 (ja) 2016-07-01 2023-07-13 リゾルブ セラピューティクス， エルエルシー 最適化二重ヌクレアーゼ融合物および方法
US11331378B2 (en) 2016-07-26 2022-05-17 Orgenesis Inc. Prophylactic protection against viral infections
WO2018022774A1 (en) 2016-07-26 2018-02-01 Squiquera Luis Prophylactic protection against viral infections
WO2019040674A1 (en) 2017-08-22 2019-02-28 Sanabio, Llc SOLUBLE INTERFERON RECEPTORS AND USES THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882421A (en) * 1982-09-23 1989-11-21 Alfacell Corporation Pharmaceutical for treating tumors and method for making it
US5559212A (en) * 1988-04-06 1996-09-24 Alfacell Corporation Frog embryo and egg-derived tumor cell anti-proliferation protein
US5728805A (en) * 1988-04-06 1998-03-17 Alfacell Corp. Pharmaceuticals and method for making them
JP2972334B2 (ja) * 1989-11-13 1999-11-08 アルフアセル・コーポレイシヨン 精製された蛋白質および生物活性治療薬
JP3469247B2 (ja) * 1996-02-21 2003-11-25 アメリカ合衆国 組換えリボヌクレアーゼタンパク質

Also Published As

Publication number Publication date
DE69940980D1 (de) 2009-07-23
JP2002534075A (ja) 2002-10-15
WO2000040608A1 (en) 2000-07-13
EP1141004B1 (de) 2009-06-10
US6239257B1 (en) 2001-05-29
JP4516216B2 (ja) 2010-08-04
EP1141004A1 (de) 2001-10-10

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties