DE602006017705D1 - Zytotoxische ribonukleasevarianten - Google Patents

Zytotoxische ribonukleasevarianten

Info

Publication number
DE602006017705D1
DE602006017705D1 DE602006017705T DE602006017705T DE602006017705D1 DE 602006017705 D1 DE602006017705 D1 DE 602006017705D1 DE 602006017705 T DE602006017705 T DE 602006017705T DE 602006017705 T DE602006017705 T DE 602006017705T DE 602006017705 D1 DE602006017705 D1 DE 602006017705D1
Authority
DE
Germany
Prior art keywords
rnase
variants
result
cytotoxicity
cytotoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006017705T
Other languages
English (en)
Inventor
Ronald T Raines
Julie C Mitchell
Thomas J Rutkoski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of DE602006017705D1 publication Critical patent/DE602006017705D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE602006017705T 2005-06-16 2006-06-16 Zytotoxische ribonukleasevarianten Active DE602006017705D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69097005P 2005-06-16 2005-06-16
PCT/US2006/023298 WO2006138458A1 (en) 2005-06-16 2006-06-16 Cytotoxic ribonuclease variants

Publications (1)

Publication Number Publication Date
DE602006017705D1 true DE602006017705D1 (de) 2010-12-02

Family

ID=37116805

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006017705T Active DE602006017705D1 (de) 2005-06-16 2006-06-16 Zytotoxische ribonukleasevarianten

Country Status (7)

Country Link
US (6) US7416875B2 (de)
EP (1) EP1910541B1 (de)
JP (1) JP5114392B2 (de)
AT (1) ATE485379T1 (de)
DE (1) DE602006017705D1 (de)
ES (1) ES2354280T3 (de)
WO (1) WO2006138458A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8470315B2 (en) 2004-04-13 2013-06-25 Quintessence Biosciences, Inc. Non-natural ribonuclease conjugates as cytotoxic agents
WO2006138558A2 (en) * 2005-06-16 2006-12-28 Wisconsin Alumni Research Foundation Cytotoxic ribonuclease variants
ATE485379T1 (de) 2005-06-16 2010-11-15 Wisconsin Alumni Res Found Zytotoxische ribonukleasevarianten
JP2009541333A (ja) 2006-06-23 2009-11-26 クインテセンス バイオサイエンシーズ インコーポレーティッド 修飾リボヌクレアーゼ
EP2049151A4 (de) 2006-07-17 2010-03-24 Quintessence Biosciences Inc Verfahren und zusammensetzungen zur behandlung von krebs
EP2185197B1 (de) * 2007-08-22 2018-10-17 Noveome Biotherapeutics, Inc. Neue zellfaktorhaltige lösungszusammensetzungen und deren verwendung in der behandlung von wunden
WO2009048909A1 (en) 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
CN102227443B (zh) 2008-10-01 2014-05-14 昆特森斯生物科学公司 治疗性核糖核酸酶
HUE041426T2 (hu) 2009-11-02 2019-05-28 Univ Washington Terápiás nukleáz-készítmények és eljárások
KR102161657B1 (ko) 2011-04-29 2020-10-06 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 치료적 뉴클레아제 조성물 및 방법
US10988745B2 (en) 2013-10-31 2021-04-27 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
EP4410378A3 (de) 2016-07-01 2024-10-09 Resolve Therapeutics, LLC Optimierte binucleasefusionen und verfahren
US11286469B2 (en) 2017-11-09 2022-03-29 Wisconsin Alumni Research Foundation Combination chemotherapy for the treatment of cancer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389537A (en) 1994-01-21 1995-02-14 Wisconsin Alumni Research Foundation Nuclease having altered specificity
AU2002301972B2 (en) 1997-10-15 2005-12-01 Wisconsin Alumni Research Foundation Human Ribonuclease A with Reduced Ribonuclease Inhibitor Affinity
US5840296A (en) 1997-10-15 1998-11-24 Raines; Ronald T. Engineered cytotoxic ribonuclease A
US6280991B1 (en) 1997-10-15 2001-08-28 Wisconsin Alumni Research Foundation Engineered cytotoxic ribonclease
US6239257B1 (en) 1998-12-30 2001-05-29 Alfacell Corporation Family of proteins belonging to the pancreatic ribonuclease a superfamily
AU2003276711A1 (en) 2002-06-14 2003-12-31 Wisconsin Alumni Research Foundation Ribonuclease zymogen design
US8470315B2 (en) 2004-04-13 2013-06-25 Quintessence Biosciences, Inc. Non-natural ribonuclease conjugates as cytotoxic agents
US20060084771A1 (en) 2004-10-15 2006-04-20 Wong Shing Jane B Method of preparing modified diallyl-N,N-disubstituted ammonium halide polymers
ATE485379T1 (de) 2005-06-16 2010-11-15 Wisconsin Alumni Res Found Zytotoxische ribonukleasevarianten
WO2006138558A2 (en) 2005-06-16 2006-12-28 Wisconsin Alumni Research Foundation Cytotoxic ribonuclease variants
JP2008017144A (ja) 2006-07-05 2008-01-24 Toshiba Corp 無線受信装置および方法
CN102227443B (zh) 2008-10-01 2014-05-14 昆特森斯生物科学公司 治疗性核糖核酸酶

Also Published As

Publication number Publication date
ES2354280T3 (es) 2011-03-11
US7416875B2 (en) 2008-08-26
US8247190B2 (en) 2012-08-21
EP1910541B1 (de) 2010-10-20
US20140004594A1 (en) 2014-01-02
US8524480B2 (en) 2013-09-03
JP2008543312A (ja) 2008-12-04
US20070003537A1 (en) 2007-01-04
US20100233809A1 (en) 2010-09-16
EP1910541A1 (de) 2008-04-16
US20140335593A1 (en) 2014-11-13
US20110287514A1 (en) 2011-11-24
ATE485379T1 (de) 2010-11-15
WO2006138458A1 (en) 2006-12-28
US8802413B2 (en) 2014-08-12
US7977079B2 (en) 2011-07-12
US9255260B2 (en) 2016-02-09
JP5114392B2 (ja) 2013-01-09
US20120322137A1 (en) 2012-12-20

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