ATE431825T1 - Neue antagonisten für den vitronectinrezeptor, verfahren zu deren herstellung, deren verwendung als arzneimittel und pharmazeutische zusammensetzung, die diese enthalten - Google Patents

Neue antagonisten für den vitronectinrezeptor, verfahren zu deren herstellung, deren verwendung als arzneimittel und pharmazeutische zusammensetzung, die diese enthalten

Info

Publication number
ATE431825T1
ATE431825T1 AT03799611T AT03799611T ATE431825T1 AT E431825 T1 ATE431825 T1 AT E431825T1 AT 03799611 T AT03799611 T AT 03799611T AT 03799611 T AT03799611 T AT 03799611T AT E431825 T1 ATE431825 T1 AT E431825T1
Authority
AT
Austria
Prior art keywords
production
pharmaceutical compositions
compositions containing
medicinal products
vitronectin receptor
Prior art date
Application number
AT03799611T
Other languages
English (en)
Inventor
Jean-Marie Ruxer
Jean-Michel Lefrancois
Bertrand Heckmann
Original Assignee
Galapagos Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Sas filed Critical Galapagos Sas
Application granted granted Critical
Publication of ATE431825T1 publication Critical patent/ATE431825T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03799611T 2002-11-19 2003-11-12 Neue antagonisten für den vitronectinrezeptor, verfahren zu deren herstellung, deren verwendung als arzneimittel und pharmazeutische zusammensetzung, die diese enthalten ATE431825T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0214429A FR2847254B1 (fr) 2002-11-19 2002-11-19 Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
PCT/FR2003/003349 WO2004048375A1 (fr) 2002-11-19 2003-11-12 Nouveaux derives antagonistes du recepteur de la vitronectine leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ATE431825T1 true ATE431825T1 (de) 2009-06-15

Family

ID=32187700

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03799611T ATE431825T1 (de) 2002-11-19 2003-11-12 Neue antagonisten für den vitronectinrezeptor, verfahren zu deren herstellung, deren verwendung als arzneimittel und pharmazeutische zusammensetzung, die diese enthalten
AT09003174T ATE518842T1 (de) 2002-11-19 2003-11-12 Neue antagonistische derivate des vitronektinrezeptors, ihr herstellungsverfahren, ihre anwendung als arzneimittel und die pharmazeutischen zusammensetzungen, die sie enthalten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT09003174T ATE518842T1 (de) 2002-11-19 2003-11-12 Neue antagonistische derivate des vitronektinrezeptors, ihr herstellungsverfahren, ihre anwendung als arzneimittel und die pharmazeutischen zusammensetzungen, die sie enthalten

Country Status (28)

Country Link
US (2) US7582640B2 (de)
EP (2) EP2070914B1 (de)
JP (1) JP4567459B2 (de)
KR (1) KR101140752B1 (de)
CN (2) CN101928287A (de)
AR (2) AR042068A1 (de)
AT (2) ATE431825T1 (de)
AU (2) AU2003299330B2 (de)
BR (1) BR0316307A (de)
CA (1) CA2506310C (de)
CO (1) CO5700761A2 (de)
CY (1) CY1112218T1 (de)
DE (1) DE60327712D1 (de)
DK (2) DK2070914T3 (de)
ES (2) ES2369561T3 (de)
FR (1) FR2847254B1 (de)
HK (2) HK1076277A1 (de)
IL (2) IL168136A (de)
MA (1) MA27492A1 (de)
MX (1) MXPA05005340A (de)
NO (1) NO20052491D0 (de)
PL (1) PL376866A1 (de)
PT (2) PT2070914E (de)
RU (1) RU2412185C2 (de)
SI (2) SI1565467T1 (de)
TW (1) TW200412969A (de)
WO (1) WO2004048375A1 (de)
ZA (1) ZA200502850B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2847254B1 (fr) 2002-11-19 2005-01-28 Aventis Pharma Sa Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
FR2870541B1 (fr) * 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine
US20110189174A1 (en) 2010-02-01 2011-08-04 Afshin Shafiee Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization
US20110237605A1 (en) 2010-03-26 2011-09-29 Eric Phillips Molecular Crystal of (4-(1,8-Naphthyridin-2-YL)Piperidin-1-YL)Pyrimidine Derivative
HUE051802T2 (hu) 2018-08-17 2021-03-29 Oxurion NV Integrin antagonisták
WO2021165206A1 (en) 2020-02-19 2021-08-26 Oxurion NV Treatment of dry amd with integrin antagonists
CA3183338A1 (en) 2020-06-29 2022-01-06 Thomas S. Ickovic Systems, methods, and program products for digital pet identification

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204350A (en) 1991-08-09 1993-04-20 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives
US5217994A (en) 1991-08-09 1993-06-08 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives
AU674553B2 (en) 1992-10-14 1997-01-02 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2150550A1 (en) 1992-12-01 1994-06-09 Melissa S. Egbertson Fibrinogen receptor antagonists
CA2190870A1 (en) 1994-05-27 1995-12-07 George D. Hartman Compounds for inhibiting osteoclast-mediated bone resorption
EP0762882A4 (de) * 1994-06-29 2002-09-11 Smithkline Beecham Corp Vibronectin-rezeptor-antagonisten
WO1996000730A1 (en) 1994-06-29 1996-01-11 Smithkline Beecham Corporation Vitronectin receptor antagonists
CA2259224A1 (en) 1996-06-28 1998-01-08 Merck Patent Gesellschaft Mit Beschraenkter Haftung Phenylalamine derivatives as integrin inhibitors
DE19629816A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
US6723727B1 (en) 1996-12-20 2004-04-20 Hoechst Aktiengesellschaft Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them
EP0933367A1 (de) * 1997-12-19 1999-08-04 Hoechst Marion Roussel Deutschland GmbH Acylguanidin Derivate als Inhibitoren von Knochenaufsauge und als Vitronectin Rezeptor Antagonisten
SK10632000A3 (sk) 1998-01-23 2001-02-12 Aventis Pharma Deutschland Gmbh Sulfónamidové deriváty ako inhibítory resorpcie kostí a inhibítory bunkovej adhézie
EP1054871A2 (de) * 1998-04-01 2000-11-29 Du Pont Pharmaceuticals Company Pyrimidine und triazine als integrinantagonisten
HUP0103090A3 (en) * 1998-08-07 2002-12-28 Smithkline Beecham Corp Vitronectin receptor antagonist oxazole derivatives, process for their preparation, pharmaceutical compositions containing them and their use
EP1194151A4 (de) 1999-06-23 2003-01-15 Merck & Co Inc Antagonisten der integrin rezeptoren
EP1065208A1 (de) * 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Substituierte Purin Derivate als Inhibitoren der Zell-Adhäsion
EP1065207A1 (de) 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Naphthyridin derivate, Verfahren zu ihrer Herstellung, ihre Anwendung und sie enthaltende pharmazeutische Zusammenfassungen
ATE248646T1 (de) * 1999-10-05 2003-09-15 Element Six Pty Ltd Wachstum von diamantclustern
DE10042655A1 (de) 2000-08-31 2002-03-14 Aventis Pharma Gmbh Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion
FR2847254B1 (fr) * 2002-11-19 2005-01-28 Aventis Pharma Sa Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
FR2870541B1 (fr) * 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine

Also Published As

Publication number Publication date
IL205693A (en) 2011-06-30
JP2006508999A (ja) 2006-03-16
ES2325616T3 (es) 2009-09-10
CN1738817A (zh) 2006-02-22
AU2003299330B2 (en) 2009-09-17
NO20052491L (no) 2005-05-23
HK1129372A1 (en) 2009-11-27
CO5700761A2 (es) 2006-11-30
FR2847254A1 (fr) 2004-05-21
DE60327712D1 (de) 2009-07-02
MXPA05005340A (es) 2005-11-17
PT1565467E (pt) 2009-07-15
ZA200502850B (en) 2005-10-25
CN1738817B (zh) 2011-12-21
AU2009212779B2 (en) 2011-09-01
CA2506310A1 (fr) 2004-06-10
AU2009212779A1 (en) 2009-09-17
EP1565467B1 (de) 2009-05-20
HK1076277A1 (en) 2006-01-13
DK2070914T3 (da) 2011-11-21
RU2005119163A (ru) 2006-02-27
SI2070914T1 (sl) 2012-02-29
FR2847254B1 (fr) 2005-01-28
CN101928287A (zh) 2010-12-29
BR0316307A (pt) 2005-09-27
PL376866A1 (pl) 2006-01-09
ATE518842T1 (de) 2011-08-15
EP2070914B1 (de) 2011-08-03
SI1565467T1 (sl) 2009-10-31
KR101140752B1 (ko) 2012-05-03
US20060052398A1 (en) 2006-03-09
RU2412185C2 (ru) 2011-02-20
AU2003299330A1 (en) 2004-06-18
PT2070914E (pt) 2011-10-12
CY1112218T1 (el) 2015-12-09
ES2369561T3 (es) 2011-12-01
NO20052491D0 (no) 2005-05-23
EP2070914A1 (de) 2009-06-17
WO2004048375A1 (fr) 2004-06-10
US20090149476A1 (en) 2009-06-11
JP4567459B2 (ja) 2010-10-20
KR20050083926A (ko) 2005-08-26
DK1565467T3 (da) 2009-09-14
AR042068A1 (es) 2005-06-08
TW200412969A (en) 2004-08-01
IL168136A (en) 2012-06-28
CA2506310C (fr) 2014-04-08
MA27492A1 (fr) 2005-08-01
US7763621B2 (en) 2010-07-27
AR077476A2 (es) 2011-08-31
EP1565467A1 (de) 2005-08-24
US7582640B2 (en) 2009-09-01

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