ATE424795T1 - Ophthalmisches arzneimittelabgabesystem - Google Patents

Ophthalmisches arzneimittelabgabesystem

Info

Publication number
ATE424795T1
ATE424795T1 AT03757353T AT03757353T ATE424795T1 AT E424795 T1 ATE424795 T1 AT E424795T1 AT 03757353 T AT03757353 T AT 03757353T AT 03757353 T AT03757353 T AT 03757353T AT E424795 T1 ATE424795 T1 AT E424795T1
Authority
AT
Austria
Prior art keywords
delivery system
ophthalmic drug
drug delivery
contact lens
ophthalmic
Prior art date
Application number
AT03757353T
Other languages
English (en)
Inventor
Anuj Chauhan
Derya Gulsen
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Application granted granted Critical
Publication of ATE424795T1 publication Critical patent/ATE424795T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5115Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5138Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • GPHYSICS
    • G02OPTICS
    • G02CSPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00Optical parts
    • G02C7/02Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04Contact lenses for the eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eyeglasses (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03757353T 2002-06-05 2003-06-05 Ophthalmisches arzneimittelabgabesystem ATE424795T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38557102P 2002-06-05 2002-06-05

Publications (1)

Publication Number Publication Date
ATE424795T1 true ATE424795T1 (de) 2009-03-15

Family

ID=29736101

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03757353T ATE424795T1 (de) 2002-06-05 2003-06-05 Ophthalmisches arzneimittelabgabesystem

Country Status (12)

Country Link
US (1) US7638137B2 (de)
EP (1) EP1534202B1 (de)
JP (1) JP4448441B2 (de)
KR (1) KR20050037992A (de)
CN (1) CN100369593C (de)
AT (1) ATE424795T1 (de)
AU (1) AU2003248624B2 (de)
BR (1) BR0311585A (de)
CA (1) CA2487940C (de)
DE (1) DE60326597D1 (de)
HK (1) HK1080349A1 (de)
WO (1) WO2003103549A1 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
ATE478657T1 (de) * 2001-12-21 2010-09-15 Alcon Inc Verwendung von synthetischen anorganischen nanoteilchen als träger für augenmedikamente
US8071121B2 (en) * 2002-06-05 2011-12-06 University Of Florida Research Foundation, Incorporated Dispersions of microemulsions in hydrogels for drug delivery
TWI347847B (en) * 2003-08-20 2011-09-01 Santen Pharmaceutical Co Ltd Drug delivery system for sub-tenon administration of fine particles
WO2006014138A1 (en) * 2004-08-03 2006-02-09 Agency For Science, Technology And Research Polymer having interconnected pores for drug delivery and method
US20060057216A1 (en) * 2004-09-15 2006-03-16 Salamone Joseph C Low-obscuration image transmitting particulate ocular therapeutic formulations
EP1817003B1 (de) 2004-10-29 2018-02-21 The Regents of The University of California Poröse silicium-micropartikeln zur verabreichung von wirkstoffen ins auge
AU2006210416A1 (en) * 2005-02-04 2006-08-10 Auburn University Contact drug delivery system
US8388995B1 (en) 2006-02-03 2013-03-05 Auburn University Controlled and extended delivery of hyaluronic acid and comfort molecules via a contact lens platform
US9238003B2 (en) 2005-02-04 2016-01-19 Auburn University Extended or continuous wear silicone hydrogel contact lenses for the extended release of comfort molecules
US8349352B2 (en) * 2005-02-04 2013-01-08 Auburn University Therapeutic contact lenses with anti-fungal delivery
WO2007005249A2 (en) * 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
US20090062909A1 (en) 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
AU2006313447A1 (en) * 2005-09-30 2007-05-18 Galderma S.A. Use of at least one avermectin or milbemycin in the treatment of ophthalmic pathologies
JP2009519975A (ja) * 2005-12-16 2009-05-21 ユニバーシティ・オブ・カンザス 治療薬を送達するナノクラスター
US20070184076A1 (en) * 2006-02-07 2007-08-09 Unger Evan C Liquid-filled nanodroplets for anti-cancer therapy
WO2007139808A2 (en) * 2006-05-25 2007-12-06 Ayyala Ramesh S Device for delivery of antifibrotic agents & method
US7793535B2 (en) * 2006-10-31 2010-09-14 Johnson & Johnson Vision Care, Inc. Devices and methods to simulate an ocular environment
WO2008060575A2 (en) * 2006-11-13 2008-05-22 Auburn University Drug delivery system and method
WO2008060249A1 (en) * 2006-11-17 2008-05-22 Agency For Science, Technology And Research Porous polymeric material with cross-linkable wetting agent
CN101711137B (zh) 2007-01-08 2014-10-22 米歇尔技术公司 具有可生物降解层的支架
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
US20080317822A1 (en) * 2007-06-20 2008-12-25 Nugene Methods for Delivery of Nanosome Encapsulated Agents
WO2009032266A2 (en) * 2007-09-04 2009-03-12 University Of Florida Dispersions of microparticles and microgels in hydrogels for drug delivery
US8480638B2 (en) * 2007-10-04 2013-07-09 Aciont, Inc. Intraocular iontophoretic device and associated methods
CN101181227B (zh) * 2007-12-10 2012-05-30 沈阳药科大学 生物黏附性环孢素a固体脂质纳米粒原位凝胶制剂及其制备方法
US8961448B2 (en) * 2008-01-28 2015-02-24 Peter Forsell Implantable drainage device
CN102083397B (zh) 2008-04-17 2013-12-25 米歇尔技术公司 具有生物可吸收层的支架
WO2010009335A1 (en) 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug delivery medical device
CA2683467C (en) * 2008-10-24 2016-01-26 Jin Zhang Contact lens integrated with a biosensor for detection of glucose and other components in tears
US8414912B2 (en) * 2008-12-11 2013-04-09 Massachusetts Institute Of Technology Contact lens drug delivery device
EP3243504A1 (de) * 2009-01-29 2017-11-15 Arbutus Biopharma Corporation Verbesserte lipidformulierung
US8513353B2 (en) 2009-03-19 2013-08-20 Agency For Science, Technology And Research Forming copolymer from bicontinuous microemulsion comprising monomers of different hydrophilicity
WO2010120552A2 (en) 2009-04-01 2010-10-21 Micell Technologies, Inc. Coated stents
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US10105317B2 (en) 2009-07-07 2018-10-23 Anpac Bio-Medical Science Co., Ltd. Method of drug delivery
EP2453834A4 (de) 2009-07-16 2014-04-16 Micell Technologies Inc Medizinische wirkstofffreisetzungsvorrichtung
CA2780274C (en) 2009-11-09 2018-06-26 Spotlight Technology Partners Llc Fragmented hydrogels
CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
WO2011097103A1 (en) 2010-02-02 2011-08-11 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8828246B2 (en) 2010-02-18 2014-09-09 Anpac Bio-Medical Science Co., Ltd. Method of fabricating micro-devices
US8889193B2 (en) 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
US9931296B2 (en) 2010-04-03 2018-04-03 Praful Doshi Medical devices including medicaments and methods of making and using same
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
CA2797110C (en) 2010-04-22 2020-07-21 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
US9327037B2 (en) 2011-02-08 2016-05-03 The Johns Hopkins University Mucus penetrating gene carriers
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
TW201302244A (zh) * 2011-07-08 2013-01-16 Univ Nat Chiao Tung 載藥型隱形眼鏡及其製備方法
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
US9046699B2 (en) * 2012-03-13 2015-06-02 Johnson & Johnson Vision Care, Inc. Dynamic fluid zones in contact lenses
JP5883539B2 (ja) 2012-03-16 2016-03-15 ザ・ジョンズ・ホプキンス・ユニバーシティー Hif−1阻害剤の送達のための放出制御製剤
WO2013138346A1 (en) 2012-03-16 2013-09-19 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
US9533068B2 (en) 2012-05-04 2017-01-03 The Johns Hopkins University Drug loaded microfiber sutures for ophthalmic application
EP2895156B1 (de) 2012-09-17 2019-05-08 Pfizer Inc. Verfahren zur herstellung therapeutischer nanopartikel
KR20150056619A (ko) * 2012-09-17 2015-05-26 바인드 쎄라퓨틱스, 인크. 치료제를 포함하는 치료 나노입자 및 그의 제조 및 사용 방법
KR101371685B1 (ko) * 2012-10-30 2014-03-10 김선호 치료용 콘택트렌즈
CN103848852B (zh) * 2012-11-28 2019-02-19 杨子剑 含有头孢菌素结构的新化合物以及制备方法和用途
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
KR20150143476A (ko) 2013-03-12 2015-12-23 미셀 테크놀로지즈, 인코포레이티드 생흡수성 생체의학적 임플란트
WO2014186532A1 (en) 2013-05-15 2014-11-20 Micell Technologies, Inc. Bioabsorbable biomedical implants
EP3016637B1 (de) 2013-07-04 2020-11-11 Yeda Research and Development Co., Ltd. Reibungsarme hydrogele und hydrogelhaltige verbundwerkstoffe
AP2016009088A0 (en) 2013-09-16 2016-03-31 Astrazeneca Ab Therapeutic polymeric nanoparticles and methods of making and using same
US9668916B2 (en) 2013-11-04 2017-06-06 Vance M. Thompson Conjunctival cover and methods therefor
WO2015066616A1 (en) * 2013-11-04 2015-05-07 Thompson Vance M Conjunctival cover and methods therefor
TWI693937B (zh) 2014-03-14 2020-05-21 美商輝瑞大藥廠 包含治療劑之治療性奈米顆粒及其製造及使用方法
EP3148491B1 (de) 2014-05-29 2020-07-01 Glaukos Corporation Implantate mit kontrollierter arzneimittelfreisetzung und herstellungsverfahren davon
US10159642B2 (en) * 2014-06-12 2018-12-25 Seed Co., Ltd. Functional polymer gel containing organic nanotubes and method for producing same
EP3154550B1 (de) 2014-06-15 2021-08-04 Yeda Research and Development Co. Ltd. Oberflächenbehandlung durch wasserlösliche polymere und lipide/liposome
EA035620B1 (ru) 2014-08-11 2020-07-16 Борд Оф Сьюпервайзорз Оф Луизиана Стэйт Юниверсити Энд Эгрикалчурал Энд Мекэникал Колледж Способы и композиция для лечения или профилактики катаракты
EP3250184A1 (de) 2015-01-27 2017-12-06 The Johns Hopkins University Hypotone hydrogelformulierungen für den verbesserten transport von wirkstoffen an schleimhautoberflächen
US9869883B2 (en) 2015-03-11 2018-01-16 Vance M. Thompson Tear shaping for refractive correction
EP3103485A1 (de) * 2015-06-11 2016-12-14 Commissariat A L'energie Atomique Et Aux Energies Alternatives Material mit einem polymer, welches zur bildung eines hydrogels und von nanopartikeln in der lage ist
US10702474B2 (en) 2015-07-09 2020-07-07 The Regents Of The University Of California Fusogenic liposome-coated porous silicon nanoparticles
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
EP3442479A1 (de) 2016-04-20 2019-02-20 Harold Alexander Heitzmann Vorrichtung zur verabreichung eines bioresorbierbaren okularen medikaments
US10353220B2 (en) 2016-10-17 2019-07-16 Vance M. Thompson Tear shaping for refractive correction
CZ2016827A3 (cs) 2016-12-23 2018-02-07 Contipro A.S. Oftalmologický prostředek
EP3583177B1 (de) 2017-02-16 2020-12-23 Momentive Performance Materials Inc. Ionisch modifizierte silikone, zusammensetzungen und daraus hergestellte medizinische vorrichtungen
US10678067B2 (en) 2018-04-06 2020-06-09 Vance M. Thompson Tear shaping for refractive correction
CN114269397A (zh) * 2019-08-30 2022-04-01 寺雅凝胶有限责任公司 一种获得用于眼部治疗的离子交换聚合物水凝胶的方法及其水凝胶镜片
KR102357782B1 (ko) * 2020-04-06 2022-02-04 포항공과대학교 산학협력단 약물 충진 콜레스테롤-히알루론산 고분자 마이셀이 함유된 약물 방출 콘택트렌즈
CN111481513B (zh) * 2020-04-20 2021-07-23 芜湖荣灿医药材料科技有限公司 缓释微球药物递送系统及其制备方法
CN112618480B (zh) * 2020-11-10 2022-07-12 南昌大学 一种眼部药物递送体系的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786812A (en) * 1972-03-10 1974-01-22 C Neefe Contact lens for olar drug delivery
US3937680A (en) * 1973-05-29 1976-02-10 Global Vision, Inc. Hydrophilic gel terpolymers from hydrophilic n-vinyl monomers, hydroxyalkyl acrylates or methacrylates and polymerizable unsaturated carboxylic acids
US3957049A (en) * 1973-10-09 1976-05-18 Neefe Charles W Rechargeable drug delivery method
US4254509A (en) * 1979-04-09 1981-03-10 Tennant Jerald L Accommodating intraocular implant
US4484922A (en) * 1981-06-25 1984-11-27 Rosenwald Peter L Occular device
US4668506A (en) * 1985-08-16 1987-05-26 Bausch & Lomb Incorporated Sustained-release formulation containing and amino acid polymer
CA2009668A1 (en) * 1989-02-16 1990-08-16 Ashok R. Thakrar Colored contact lenses and method of making same
US5723131A (en) * 1995-12-28 1998-03-03 Johnson & Johnson Vision Products, Inc. Contact lens containing a leachable absorbed material
JPH10339857A (ja) * 1997-06-05 1998-12-22 Menicon Co Ltd 薬剤徐放性コンタクトレンズの製法およびそれによってえられた薬剤徐放性コンタクトレンズ
US6410045B1 (en) * 1999-02-22 2002-06-25 Clyde Lewis Schultz Drug delivery system for antiglaucomatous medication
US20020141760A1 (en) * 2001-03-29 2002-10-03 Resnick Joseph A. Transverse reflective-protective contact eye lenses and coating for conventional face-mounted apparatus, manufacturing method and kit

Also Published As

Publication number Publication date
WO2003103549A1 (en) 2003-12-18
CA2487940A1 (en) 2003-12-18
EP1534202A4 (de) 2006-04-12
DE60326597D1 (de) 2009-04-23
AU2003248624A1 (en) 2003-12-22
JP2005528185A (ja) 2005-09-22
US7638137B2 (en) 2009-12-29
US20040096477A1 (en) 2004-05-20
HK1080349A1 (en) 2006-04-28
KR20050037992A (ko) 2005-04-25
CN1674841A (zh) 2005-09-28
BR0311585A (pt) 2005-05-10
CN100369593C (zh) 2008-02-20
AU2003248624B2 (en) 2006-04-06
EP1534202A1 (de) 2005-06-01
CA2487940C (en) 2009-09-22
EP1534202B1 (de) 2009-03-11
JP4448441B2 (ja) 2010-04-07

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