ATE421593T1 - Polymerpfropfung mittels polysaccharide-synthase - Google Patents
Polymerpfropfung mittels polysaccharide-synthaseInfo
- Publication number
- ATE421593T1 ATE421593T1 AT99958858T AT99958858T ATE421593T1 AT E421593 T1 ATE421593 T1 AT E421593T1 AT 99958858 T AT99958858 T AT 99958858T AT 99958858 T AT99958858 T AT 99958858T AT E421593 T1 ATE421593 T1 AT E421593T1
- Authority
- AT
- Austria
- Prior art keywords
- present
- relates
- synthase
- bioadhesive
- biomaterial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
- Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
- Y10S977/898—Enzymatic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Enzymes And Modification Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Graft Or Block Polymers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10792998P | 1998-11-11 | 1998-11-11 | |
US28340299A | 1999-04-01 | 1999-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE421593T1 true ATE421593T1 (de) | 2009-02-15 |
Family
ID=26805343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99958858T ATE421593T1 (de) | 1998-11-11 | 1999-11-10 | Polymerpfropfung mittels polysaccharide-synthase |
Country Status (8)
Country | Link |
---|---|
US (3) | US6444447B1 (de) |
EP (1) | EP1129209B1 (de) |
JP (1) | JP2002529064A (de) |
AT (1) | ATE421593T1 (de) |
CA (1) | CA2351593C (de) |
DE (1) | DE69940353D1 (de) |
IL (1) | IL143080A0 (de) |
WO (1) | WO2000027437A2 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7091008B1 (en) | 1994-07-01 | 2006-08-15 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase genes and expression thereof in Bacillus hosts |
JP4731013B2 (ja) * | 1997-10-31 | 2011-07-20 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ オクラホマ | ヒアルロナンシンターゼ遺伝子およびその使用 |
US20060188966A1 (en) | 1998-04-02 | 2006-08-24 | Deangelis Paul L | Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same |
DE69943276D1 (de) * | 1998-04-02 | 2011-04-21 | Univ Oklahoma State | Chondroitin-Synthase kodierendes DNA der Pasteurella multocida und Verwendungsverfahren |
US20030104601A1 (en) | 1999-04-01 | 2003-06-05 | Deangelis Paul L. | Chondroitin synthase gene and methods of making and using same |
US7223571B2 (en) | 1998-04-02 | 2007-05-29 | The Board Of Regents Of The Universtiy Of Oklahoma | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
WO2000027437A2 (en) * | 1998-11-11 | 2000-05-18 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
US6987023B2 (en) * | 1998-04-02 | 2006-01-17 | The Board Of Regents Of The University Of Oklahoma | DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use |
US20060105431A1 (en) * | 1998-11-11 | 2006-05-18 | Deangelis Paul L | Polymer grafting by polysaccharide synthases using artificial sugar acceptors |
US7642071B2 (en) | 1999-04-01 | 2010-01-05 | The Board Of Regents Of The University Of Oklahoma | Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts |
AU2001253805B2 (en) * | 2000-04-25 | 2006-08-03 | De Angelis, Paul L | Chondroitin synthase gene and methods of making and using same |
US8580290B2 (en) * | 2001-05-08 | 2013-11-12 | The Board Of Regents Of The University Of Oklahoma | Heparosan-based biomaterials and coatings and methods of production and use thereof |
EP1470235A4 (de) * | 2001-07-13 | 2008-05-21 | Univ Oklahoma | Glycosaminoglycanpolymere und verfahren zur deren herstellung und anwendung |
JP4702819B2 (ja) | 2001-08-01 | 2011-06-15 | 生化学工業株式会社 | コンドロイチン合成酵素 |
JP4101548B2 (ja) | 2001-08-10 | 2008-06-18 | 生化学工業株式会社 | コンドロイチン合成酵素及びそれをコードするdna |
PL212928B1 (pl) | 2001-12-21 | 2012-12-31 | Novozymes Biopolymer As | Sposób wytwarzania kwasu hialuronowego i komórka gospodarz Bacillus |
JP4333880B2 (ja) * | 2002-05-31 | 2009-09-16 | 生化学工業株式会社 | コンドロイチン合成酵素および該酵素をコードするdna |
US7232676B2 (en) * | 2002-05-31 | 2007-06-19 | Seikagaku Kogyo Kabushiki Kaisha | Chondroitin synthase and nucleic acid encoding the enzyme |
US7299805B2 (en) * | 2002-06-07 | 2007-11-27 | Marctec, Llc | Scaffold and method for implanting cells |
WO2004032830A2 (en) * | 2002-08-16 | 2004-04-22 | University Of Oklahoma | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
US9150902B2 (en) * | 2005-06-28 | 2015-10-06 | Seikagaku Corporation | Method for determination of N-deacetylase/N-sulfotransferase activity |
US8129148B2 (en) | 2005-08-24 | 2012-03-06 | Seikagaku Corporation | Process for preparation of chondroitin fraction |
EP1964924B1 (de) | 2005-12-15 | 2015-09-30 | Seikagaku Corporation | Langkettige chondroitinzuckerkette und verfahren zur herstellung davon sowie verfahren zur förderung der chondroitinsynthese |
EP2049572A1 (de) | 2006-08-04 | 2009-04-22 | Novozymes Biopolymer A/S | Verzweigte hyaluronsäure und herstellungsverfahren dafür |
PL2173360T3 (pl) * | 2007-03-30 | 2016-01-29 | The Board Of Regents For The Univ Of Oklahoma | Biomateriały oparte na heparosanie i powłoki oraz sposoby ich wytwarzania i zastosowania |
US7989615B2 (en) * | 2007-07-13 | 2011-08-02 | The Penn State Research Foundation | Separation of different isoforms of plasmid DNA using ultrafiltration |
US9109051B2 (en) | 2007-12-19 | 2015-08-18 | Evonik Goldschmidt Gmbh | Crosslinked hyaluronic acid in emulsion |
EP2262480B1 (de) * | 2008-03-04 | 2018-02-14 | Liquidia Technologies, Inc. | Immunomodulator-teilchen |
US9925209B2 (en) | 2008-03-19 | 2018-03-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same |
US9687559B2 (en) | 2008-03-19 | 2017-06-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
EP2538969A4 (de) * | 2010-02-22 | 2013-11-27 | Liquidia Technologies Inc | Impfstoffe aus polysaccharidpartikeln |
US8697398B2 (en) | 2010-03-01 | 2014-04-15 | Dsm Ip Assets B.V. | Compositions and methods for bacterial production of chondroitin |
EP2670781A4 (de) * | 2011-01-31 | 2014-12-24 | Univ Oklahoma | Testosteronan, ein neues heparosan-analog, testosteronansynthase und verfahren zu ihrer herstellung und verwendung |
KR20140034853A (ko) | 2011-05-30 | 2014-03-20 | 노보자임스 바이오파마 디케이 에이/에스 | 고분자량 히알루론산의 분무 건조 |
WO2012170504A2 (en) | 2011-06-06 | 2012-12-13 | The Cleveland Clinic Foundation | Treatment of extracellular matrix to reduce inflammation |
KR20140058581A (ko) | 2011-09-02 | 2014-05-14 | 노보자임스 바이오파마 디케이 에이/에스 | 지연된 약물 방출용 히알루론산 함유 경구 제형 |
DK2831237T3 (en) | 2012-03-30 | 2018-03-05 | Univ Oklahoma | HIGH-MOLECULAR HEPAROSAN POLYMERS AND METHODS OF PRODUCING AND USING THEREOF |
WO2014100837A1 (en) | 2012-12-17 | 2014-06-26 | Bui The Duy | Computer aided implantation of body implants |
RU2719140C1 (ru) | 2019-07-26 | 2020-04-17 | Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" | Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
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GB2098506B (en) * | 1981-05-14 | 1984-10-03 | Biomed Res Inc | Drug coated materials |
US4511478A (en) | 1983-11-10 | 1985-04-16 | Genetic Systems Corporation | Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides |
US4615697A (en) | 1983-11-14 | 1986-10-07 | Bio-Mimetics, Inc. | Bioadhesive compositions and methods of treatment therewith |
US4983392A (en) | 1983-11-14 | 1991-01-08 | Bio-Mimetics, Inc. | Bioadhesive compositions and methods of treatment therewith |
US5336747A (en) * | 1984-11-02 | 1994-08-09 | Mitsui Petrochemical Industries, Ltd. | Random 1-butene/ethylene copolymer |
US5171689A (en) | 1984-11-08 | 1992-12-15 | Matsushita Electric Industrial Co., Ltd. | Solid state bio-sensor |
US4822867A (en) | 1987-02-02 | 1989-04-18 | Semih Erhan | Protein polymer grafts |
US5015577A (en) * | 1989-08-29 | 1991-05-14 | Board Of Regents, The University Of Texas System | DNA encoding hyaluronate synthase |
FR2652736A1 (fr) | 1989-10-06 | 1991-04-12 | Neftel Frederic | Dispositif implantable d'evaluation du taux de glucose. |
IT1250421B (it) | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. |
AU3124793A (en) | 1991-10-29 | 1993-06-07 | Clover Consolidated, Limited | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
US5217743A (en) | 1992-02-07 | 1993-06-08 | Paradigm Biotechnologies Partnership | Biomaterials of enhanced biocompatibility |
US5826667A (en) * | 1993-06-09 | 1998-10-27 | Notaras; John Arthur | Lawn edger |
EP0785988A1 (de) * | 1993-07-15 | 1997-07-30 | Neose Pharmaceuticals, Inc | Verfahren zur synthese von saccharidzusammensetzungen |
CA2140298C (en) | 1994-01-14 | 1998-12-08 | Thomas L. Meade | Rumen by-pass feed supplement |
JP3591837B2 (ja) | 1994-02-17 | 2004-11-24 | ニューヨーク・ブラッド・センター・インコーポレイテッド | フィブリン膠およびリポソームを含有する生物学的生体接着剤組成物、その製造方法および使用 |
IT1268954B1 (it) | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche |
US5473034A (en) | 1994-03-18 | 1995-12-05 | Hyogo Prefectural Government | Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby |
US5928667A (en) | 1994-06-24 | 1999-07-27 | University Of Maryland | Drug delivery device and method for employing the same |
ES2187564T3 (es) * | 1994-07-27 | 2003-06-16 | Kao Corp | Composicion para suavizante liquido y sal de amonio cuaternario. |
BE1008955A3 (fr) | 1994-11-14 | 1996-10-01 | Univ Catholique Louvain | Procede d'obtention de biomateriaux et produits obtenus. |
WO1996029102A1 (en) | 1995-03-17 | 1996-09-26 | Regents Of The University Of Minnesota | Biocompatible materials |
WO1997020061A1 (en) | 1995-11-30 | 1997-06-05 | The Scripps Research Institute | Synthesis of hyaluronic acid |
US5610241A (en) | 1996-05-07 | 1997-03-11 | Cornell Research Foundation, Inc. | Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers |
US5885609A (en) | 1997-05-23 | 1999-03-23 | Northeastern University | Biocompatible articles and method for making same |
US5945457A (en) | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
WO2000027437A2 (en) * | 1998-11-11 | 2000-05-18 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
DE69943276D1 (de) * | 1998-04-02 | 2011-04-21 | Univ Oklahoma State | Chondroitin-Synthase kodierendes DNA der Pasteurella multocida und Verwendungsverfahren |
-
1999
- 1999-11-10 WO PCT/US1999/026501 patent/WO2000027437A2/en active IP Right Grant
- 1999-11-10 US US09/437,277 patent/US6444447B1/en not_active Expired - Lifetime
- 1999-11-10 DE DE69940353T patent/DE69940353D1/de not_active Expired - Lifetime
- 1999-11-10 AT AT99958858T patent/ATE421593T1/de not_active IP Right Cessation
- 1999-11-10 EP EP99958858A patent/EP1129209B1/de not_active Expired - Lifetime
- 1999-11-10 IL IL14308099A patent/IL143080A0/xx unknown
- 1999-11-10 JP JP2000580666A patent/JP2002529064A/ja active Pending
- 1999-11-10 CA CA2351593A patent/CA2351593C/en not_active Expired - Fee Related
-
2002
- 2002-06-27 US US10/184,485 patent/US20030077763A1/en not_active Abandoned
-
2005
- 2005-07-11 US US11/178,560 patent/US7575904B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2351593A1 (en) | 2000-05-18 |
EP1129209A4 (de) | 2004-04-07 |
EP1129209B1 (de) | 2009-01-21 |
DE69940353D1 (en) | 2009-03-12 |
US6444447B1 (en) | 2002-09-03 |
IL143080A0 (en) | 2002-04-21 |
CA2351593C (en) | 2012-02-21 |
US7575904B2 (en) | 2009-08-18 |
US20030077763A1 (en) | 2003-04-24 |
EP1129209A2 (de) | 2001-09-05 |
WO2000027437A9 (en) | 2001-06-28 |
WO2000027437A2 (en) | 2000-05-18 |
WO2000027437A3 (en) | 2000-07-20 |
JP2002529064A (ja) | 2002-09-10 |
US20060116348A1 (en) | 2006-06-01 |
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