ATE418562T1 - Ctl epitope des epstein-barr virus - Google Patents

Ctl epitope des epstein-barr virus

Info

Publication number
ATE418562T1
ATE418562T1 AT98931834T AT98931834T ATE418562T1 AT E418562 T1 ATE418562 T1 AT E418562T1 AT 98931834 T AT98931834 T AT 98931834T AT 98931834 T AT98931834 T AT 98931834T AT E418562 T1 ATE418562 T1 AT E418562T1
Authority
AT
Austria
Prior art keywords
seq
ebv
epstein
barr virus
ctl epitopes
Prior art date
Application number
AT98931834T
Other languages
English (en)
Inventor
Scott Burrows
Rajiv Khanna
Original Assignee
Queensland Inst Med Res
Commw Scient Ind Res Org
Univ Melbourne
Inst Medical W & E Hall
Csl Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queensland Inst Med Res, Commw Scient Ind Res Org, Univ Melbourne, Inst Medical W & E Hall, Csl Ltd filed Critical Queensland Inst Med Res
Application granted granted Critical
Publication of ATE418562T1 publication Critical patent/ATE418562T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98931834T 1997-07-10 1998-07-10 Ctl epitope des epstein-barr virus ATE418562T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPO7841A AUPO784197A0 (en) 1997-07-10 1997-07-10 Treatment of nasopharyngeal carcinoma

Publications (1)

Publication Number Publication Date
ATE418562T1 true ATE418562T1 (de) 2009-01-15

Family

ID=3802132

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98931834T ATE418562T1 (de) 1997-07-10 1998-07-10 Ctl epitope des epstein-barr virus

Country Status (11)

Country Link
US (2) US6723695B1 (de)
EP (1) EP1003773B1 (de)
JP (1) JP2001509514A (de)
CN (1) CN100526331C (de)
AT (1) ATE418562T1 (de)
AU (1) AUPO784197A0 (de)
CA (1) CA2294732A1 (de)
DE (1) DE69840383D1 (de)
NZ (1) NZ501944A (de)
WO (1) WO1999002550A1 (de)
ZA (1) ZA986084B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037868A1 (en) * 1999-11-24 2001-05-31 Oklahoma Medical Research Foundation Assays and therapies for latent viral infection
GB0210682D0 (en) * 2002-05-09 2002-06-19 Glaxosmithkline Biolog Sa Novel use
WO2004041849A1 (en) * 2002-11-07 2004-05-21 The Council Of The Queensland Institute Of Medical Research Epstein barr virus peptide epitopes, polyepitopes and delivery system therefor
US8067535B2 (en) 2003-01-24 2011-11-29 The University Of Massachusetts Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes
ATE516045T1 (de) 2003-01-24 2011-07-15 Univ Massachusetts Medical Identifikation von vaccinia-virus-dominanten t- zell-epitopen
FR2850384A1 (fr) * 2003-01-28 2004-07-30 Centre Nat Rech Scient Antigenes mimant les domaines extracellulaires de proteines membranaires de type iii issues de microorganismes intracellulaires pathogenes, anticorps conformationnels derives, et leurs applications
US8451808B2 (en) 2006-02-18 2013-05-28 Intel Corporation Techniques for 40 megahertz (MHz) channel switching
EP1826264A1 (de) * 2006-02-24 2007-08-29 Deutsches Primatenzentrum GmbH Primatmodell für Orthopoxvirus-Infektionen
GB0706070D0 (en) * 2007-03-28 2007-05-09 Scancell Ltd Nucleic acids
KR20120059581A (ko) 2009-08-24 2012-06-08 윌슨 울프 매뉴팩처링 다중 종양 항원 또는 다중 바이러스에 대해 특이성을 갖는 ｃｔｌ주의 생성
EP2501722A4 (de) * 2009-11-19 2013-05-01 Univ Singapore Verfahren zur herstellung t-zellen-rezeptor-ähnlicher monoklonaler antikörper und anwendungen davon
US20140086888A1 (en) * 2010-09-01 2014-03-27 Helen E. Heslop Ebv-specific cytotoxic t-lymphocytes for the treatment of locoregional nasopharyngeal carcinoma (npc)
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
JP6081483B2 (ja) 2011-12-12 2017-02-15 セル・メディカ・リミテッド Ｔ細胞を増殖させるプロセス
EP2812431B1 (de) 2012-02-09 2019-07-17 Baylor College Of Medicine Peptidmischungen zur erzeugung multiviraler ctl mit breiter spezifität
EP2827889A1 (de) 2012-03-19 2015-01-28 Deutsches Krebsforschungszentrum B-zell-rezeptorkomplexbindendende proteine mit t-zell-epitopen
CA2889064A1 (en) 2012-10-19 2014-04-24 The Council Of The Queensland Institute Of Medical Research Improved human herpesvirus immunotherapy
CN105555756B (zh) 2013-06-28 2018-12-07 奥克兰联合服务有限公司 氨基酸缀合物和肽缀合物及缀合方法
US10016494B2 (en) 2014-02-07 2018-07-10 Valorisation-Hsj, Limited Partnership Antigenic epitopes from EBV gp350/220 and uses thereof
CN106794236B (zh) 2014-04-15 2021-09-03 格里菲斯大学 A群链球菌疫苗
TWI673365B (zh) 2014-11-05 2019-10-01 美國紀念斯隆 凱特琳癌症中心 選擇用於過繼性細胞療法之ｔ細胞株及其供體之方法
US10253062B2 (en) 2014-12-23 2019-04-09 Margaret Anne Brimble Amino acid and peptide conjugates and uses thereof
MX386334B (es) 2015-05-12 2025-03-18 Memorial Sloan Kettering Cancer Center Cèlulas t y sus usos en el tratamiento de trastornos linfoproliferativos asociados al virus de epstein-barr.
KR101794304B1 (ko) * 2015-09-01 2017-11-06 가톨릭대학교 산학협력단 Ｅｂｖ 항원 특이 ｔ―세포 수용체 및 이의 용도
IL298359B2 (en) 2015-09-18 2025-12-01 Baylor College Medicine Immunogenic antigen identification from a pathogen and correlation to clinical efficacy
KR101968452B1 (ko) * 2015-12-04 2019-04-11 에이전시 포 사이언스, 테크놀로지 앤드 리서치 면역요법 효능의 임상적 상관물
US11464853B2 (en) 2016-02-26 2022-10-11 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process
MX2018013959A (es) * 2016-05-25 2019-08-22 Council Queensland Inst Medical Res Metodos para tratar enfermedad autoinmune usando celulas t alogenicas.
MX2019002497A (es) 2016-09-02 2019-08-14 Univ James Cook Peptido con actividad para cicatrizacion de heridas.
AU2017330379B2 (en) 2016-09-23 2023-07-13 Memorial Sloan Kettering Cancer Center Generation and use in adoptive immunotherapy of stem cell-like memory T cells
CN106397574A (zh) * 2016-10-21 2017-02-15 上海交通大学医学院附属新华医院 抗原表位肽及其应用
KR102703633B1 (ko) 2016-11-09 2024-09-05 그리피스 유니버시티 서브틸라제 세포독소 b 서브유닛 돌연변이체
CN107267481A (zh) * 2017-05-09 2017-10-20 上海交通大学医学院附属新华医院 Cdk5抗原表位肽及其应用
WO2018217203A1 (en) 2017-05-25 2018-11-29 Oreilly Richard John Use of the il-15/il-15ra complex in the generation of antigen-specific t cells for adoptive immunotherapy
AU2018355145A1 (en) 2017-10-23 2020-04-30 Atara Biotherapeutics, Inc. Methods of managing tumor flare in adoptive immunotherapy
NL2023863B1 (en) 2019-09-20 2021-05-25 Univ Griffith Protein particles and uses thereof
JP7825273B2 (ja) 2019-11-25 2026-03-06 グリフィス ユニバーシティー 淋菌感染症に対する免疫原性タンパク質
CN113621070A (zh) 2020-05-06 2021-11-09 华夏英泰（北京）生物技术有限公司 一种t细胞抗原受体、其多聚体复合物及其制备方法和应用
IL301535A (en) * 2020-10-07 2023-05-01 Council Queensland Inst Medical Res Herpesvirus polyepitope vaccines
US20240325539A1 (en) 2020-10-20 2024-10-03 The Chancellor, Masters And Scholars Of The University Of Oxford Methods and compositions for treating epstein barr virus-associated cancer
CN115786509A (zh) * 2022-10-21 2023-03-14 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种鼻咽癌患病风险预测试剂盒

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0173254B1 (de) 1984-08-23 1991-07-24 Hans Joachim Wolf DNA-Sequenzen des EBV-Genoms, rekombinante DNA-Moleküle, Verfahren zur Herstellung von EBV-verwandten Antigenen sowie diagnostische Zusammensetzungen und pharmazeutische Zusammensetzungen, die die genannten Antigene enthalten
US4879213A (en) 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
WO1993019092A1 (fr) 1992-03-19 1993-09-30 Centre National De La Recherche Scientifique Adenovirus recombinants defectifs exprimant des proteines caracteristiques du virus epstein-barr
AU1942595A (en) * 1994-03-16 1995-10-03 Csl Limited Cytotoxic t-cell epitopes
AUPM446594A0 (en) * 1994-03-16 1994-04-14 Csl Limited Cytotoxic t-cell epitopes identified within epstein-barr virus
MY114769A (en) * 1994-04-18 2003-01-31 Aviron Inc Non-splicing variants of gp350/220
NZ290089A (en) 1994-07-27 1999-05-28 Queensland Inst Med Res Recombinant polyepitope cytotoxic t lymphocyte (ctl) vaccines
AU3072395A (en) * 1994-07-27 1996-02-22 Csl Limited Polyepitope vaccines
GB9501300D0 (en) 1995-01-24 1995-03-15 Boughton Brian J Peptides which inhibit viruses
AU712364B2 (en) * 1996-05-24 1999-11-04 Council Of The Queensland Institute Of Medical Research, The EBV CTL epitopes
AUPO007396A0 (en) * 1996-05-24 1996-06-20 Csl Limited Ebv ctl epitopes

Also Published As

Publication number Publication date
EP1003773A4 (de) 2002-08-07
EP1003773B1 (de) 2008-12-24
JP2001509514A (ja) 2001-07-24
US20030152582A1 (en) 2003-08-14
WO1999002550A1 (en) 1999-01-21
ZA986084B (en) 1999-01-26
AUPO784197A0 (en) 1997-08-07
DE69840383D1 (de) 2009-02-05
NZ501944A (en) 2001-11-30
CN1269804A (zh) 2000-10-11
WO1999002550A8 (en) 2000-06-15
US6723695B1 (en) 2004-04-20
EP1003773A1 (de) 2000-05-31
CN100526331C (zh) 2009-08-12
CA2294732A1 (en) 1999-01-21

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