ATE405293T1 - Selbstemulgierende und selbstmicroemulgierende formulierungen zur oralen verabreichung von taxoiden - Google Patents

Selbstemulgierende und selbstmicroemulgierende formulierungen zur oralen verabreichung von taxoiden

Info

Publication number
ATE405293T1
ATE405293T1 AT04741330T AT04741330T ATE405293T1 AT E405293 T1 ATE405293 T1 AT E405293T1 AT 04741330 T AT04741330 T AT 04741330T AT 04741330 T AT04741330 T AT 04741330T AT E405293 T1 ATE405293 T1 AT E405293T1
Authority
AT
Austria
Prior art keywords
self
microemulsifiing
emulsifiing
taxoids
formulations
Prior art date
Application number
AT04741330T
Other languages
English (en)
Inventor
Maria-Teresa Peracchia
Sophie Cote
Gilbert Gaudel
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE405293T1 publication Critical patent/ATE405293T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04741330T 2003-07-18 2004-07-15 Selbstemulgierende und selbstmicroemulgierende formulierungen zur oralen verabreichung von taxoiden ATE405293T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03291798A EP1498143A1 (de) 2003-07-18 2003-07-18 Selbstemulgierende und selbstmicroemulgierende Formulierungen zur oralen Verabreichung von Taxoiden

Publications (1)

Publication Number Publication Date
ATE405293T1 true ATE405293T1 (de) 2008-09-15

Family

ID=33462261

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04741330T ATE405293T1 (de) 2003-07-18 2004-07-15 Selbstemulgierende und selbstmicroemulgierende formulierungen zur oralen verabreichung von taxoiden

Country Status (16)

Country Link
US (2) US20050025792A1 (de)
EP (2) EP1498143A1 (de)
JP (1) JP2009513557A (de)
KR (1) KR20060052834A (de)
CN (1) CN100566758C (de)
AR (1) AR045911A1 (de)
AT (1) ATE405293T1 (de)
AU (1) AU2004262495B2 (de)
BR (1) BRPI0412740A (de)
CA (1) CA2532566A1 (de)
DE (1) DE602004015994D1 (de)
IL (1) IL173112A0 (de)
MX (1) MXPA06000633A (de)
MY (1) MY139106A (de)
TW (1) TWI337870B (de)
WO (1) WO2005014048A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006112541A1 (ja) * 2005-04-20 2006-10-26 Chugai Seiyaku Kabushiki Kaisya 自己乳化型製剤処方の設計方法
PT1767545E (pt) 2005-09-22 2010-02-05 Biocompatibles Uk Ltd Polipéptidos de fusão glp-1 (péptido 1 do tipo glucagom) com resistência aumentada à peptidase
FR2922107B1 (fr) * 2007-10-10 2010-02-26 Aventis Pharma Sa Nouvelles compositions a base de taxoides
US8558019B2 (en) * 2007-11-08 2013-10-15 Virginia Tech Intellectual Properties, Inc. Thiolated paclitaxels for reaction with gold nanoparticles as drug delivery agents
CN101829052B (zh) * 2010-03-16 2011-12-14 王国强 紫杉烷类化合物的自乳化制剂及其制备方法
CN102228431A (zh) * 2010-03-16 2011-11-02 王国强 紫杉烷类化合物的自乳化药物组合物
SG185389A1 (en) 2010-05-03 2012-12-28 Teikoku Pharma Usa Inc Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
JP2013209294A (ja) * 2010-07-30 2013-10-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 液状医薬組成物
GB2488788B (en) * 2011-03-07 2013-07-10 Natco Pharma Ltd Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
KR101542364B1 (ko) * 2014-10-31 2015-08-07 대화제약 주식회사 탁산을 포함하는 경구 투여용 약학 조성물
TWI715636B (zh) * 2015-09-30 2021-01-11 香港商慧源香港創新有限公司 口服紫杉烷組合物及方法
CN109589305B (zh) * 2018-12-03 2021-03-19 昆明积大制药股份有限公司 多西他赛-环孢素a共包载自乳化制剂及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698582A (en) * 1991-07-08 1997-12-16 Rhone-Poulenc Rorer S.A. Compositions containing taxane derivatives
AU679013B2 (en) * 1992-10-16 1997-06-19 Ibah, Inc. Convertible microemulsion formulations
EP0684834A4 (de) * 1993-02-17 1996-09-25 Smithkline Beecham Corp Mikroemulsionen, die therapeutische peptide enthalten.
US6964946B1 (en) * 1995-10-26 2005-11-15 Baker Norton Pharmaceuticals, Inc. Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
BE1011216A3 (fr) * 1997-06-13 1999-06-01 Thissen En Abrege L T B Lab Forme pharmaceutique pour l'administration de paclitaxel, procede de preparation d'une composition de paclitaxel prete a l'emploi et utilisation de cette composition.
CN100341485C (zh) * 1998-04-01 2007-10-10 斯凯伊药品加拿大公司 抗癌组合物
CN1273526A (zh) * 1998-07-14 2000-11-15 Em工业股份有限公司 微分散给药系统
NZ512287A (en) * 1998-12-11 2002-12-20 Pharmasolutions Inc Pharmaceutical compositions comprising a lipophilic drug in a propylene glycol ester of a higher fatty acid carrier, where 60% of the ester is a monoester
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
DE19925211B4 (de) * 1999-06-01 2006-01-12 PBS Pharmaceutical Bulk Substances SA Kit zur Herstellung einer Formulierung von Paclitaxel
WO2001028518A1 (de) * 1999-10-20 2001-04-26 Vesifact Ag Cyclosporine enthaltende mikroemulsion-prekonzentrate und mikroemulsionen
EP1365759A2 (de) * 2001-01-18 2003-12-03 PHARMACIA & UPJOHN COMPANY Paclitaxel-enthaltende chemotherapeutische mikroemulsionen mit verbesserter oraler bioverfügbarkeit
CA2445763A1 (en) * 2001-05-01 2002-11-07 Angiotech Pharmaceuticals Inc. Compositions comprising an anti-microtubule agent and a polypeptide or a polysaccharide and the use thereof for the preparation of a medicament for the treatment of inflammatory conditions
AU2002357012A1 (en) * 2001-11-27 2003-06-10 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
EP1498120A1 (de) * 2003-07-18 2005-01-19 Aventis Pharma S.A. Halbfeste Formulierung für die orale Verabreichung des Taxols

Also Published As

Publication number Publication date
WO2005014048A1 (en) 2005-02-17
TWI337870B (en) 2011-03-01
MY139106A (en) 2009-08-28
IL173112A0 (en) 2006-06-11
BRPI0412740A (pt) 2006-09-26
US20050025792A1 (en) 2005-02-03
DE602004015994D1 (de) 2008-10-02
AU2004262495A1 (en) 2005-02-17
US20090069411A1 (en) 2009-03-12
AR045911A1 (es) 2005-11-16
EP1648517B1 (de) 2008-08-20
EP1498143A1 (de) 2005-01-19
JP2009513557A (ja) 2009-04-02
CN100566758C (zh) 2009-12-09
HK1089951A1 (zh) 2006-12-15
AU2004262495B2 (en) 2011-02-03
KR20060052834A (ko) 2006-05-19
CA2532566A1 (en) 2005-02-17
EP1648517A1 (de) 2006-04-26
MXPA06000633A (es) 2006-04-19
TW200518772A (en) 2005-06-16
CN1822859A (zh) 2006-08-23

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