ATE401331T1 - 6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh) - Google Patents

6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh)

Info

Publication number
ATE401331T1
ATE401331T1 AT03792485T AT03792485T ATE401331T1 AT E401331 T1 ATE401331 T1 AT E401331T1 AT 03792485 T AT03792485 T AT 03792485T AT 03792485 T AT03792485 T AT 03792485T AT E401331 T1 ATE401331 T1 AT E401331T1
Authority
AT
Austria
Prior art keywords
thienä2
bupyrrole
gnrh
antagonists
derivatives
Prior art date
Application number
AT03792485T
Other languages
English (en)
Inventor
Kevin Michael Foote
Zbigniew Matusiak
Alexander G Dossetter
Jean Claude Arnould
Maryannick Andree Lamorlette
Benedicte Delouvrie
Annie Hamon
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE401331T1 publication Critical patent/ATE401331T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03792485T 2002-08-21 2003-08-19 6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh) ATE401331T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02292074 2002-08-21

Publications (1)

Publication Number Publication Date
ATE401331T1 true ATE401331T1 (de) 2008-08-15

Family

ID=31896979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03792485T ATE401331T1 (de) 2002-08-21 2003-08-19 6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh)

Country Status (10)

Country Link
US (3) US7132442B2 (de)
EP (1) EP1543012B1 (de)
JP (1) JP2006501232A (de)
AR (1) AR041029A1 (de)
AT (1) ATE401331T1 (de)
AU (1) AU2003255818A1 (de)
DE (1) DE60322237D1 (de)
ES (1) ES2308018T3 (de)
TW (1) TW200407127A (de)
WO (1) WO2004018480A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200407127A (en) * 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
WO2005012311A1 (en) 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands
GB0403781D0 (en) * 2004-02-20 2004-03-24 Astrazeneca Ab Chemical compounds
EP1730155A1 (de) * 2004-02-20 2006-12-13 AstraZeneca AB Thienopyrrole als antagonisten von gnrh
TW200600513A (en) * 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
CA2590182A1 (en) * 2004-12-14 2006-06-22 Shionogi & Co., Ltd. Indolomorphinan derivatives having carboxy at the 6'-position
WO2011035139A1 (en) * 2009-09-17 2011-03-24 Vertex Pharmaceuticals Incorporated Process for preparing azabicyclic compounds
CN102875535B (zh) * 2011-07-12 2016-06-08 上海药明康德新药开发有限公司 1,5-[(取代)-甲桥]-四氢-1H-吡咯[1,2-c]-咪唑-3(2H)-酮衍生物及制备方法
KR101665301B1 (ko) 2013-08-07 2016-10-11 카딜라 핼쓰캐어 리미티드 야누스 키나제의 억제제로서 n-시아노메틸아미드

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04356029A (ja) 1990-07-02 1992-12-09 Japan Synthetic Rubber Co Ltd 非線形光学素子
JPH04179949A (ja) 1990-11-15 1992-06-26 Fuji Photo Film Co Ltd 新規な色素形成カプラーおよび該カプラーを用いたハロゲン化銀カラー写真感光材料
WO1997021707A1 (en) 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
PL327146A1 (en) 1995-12-14 1998-11-23 Merck & Co Inc Antagonists of the gonadotrophin liberating hormone
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997021435A1 (en) 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
KR19990072124A (ko) 1995-12-14 1999-09-27 애쉬톤 왈레이스 티 고나도트로핀 방출 호르몬의 길항제
AU729663B2 (en) 1997-06-05 2001-02-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6156772A (en) 1997-06-05 2000-12-05 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1998055123A1 (en) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP0986550A1 (de) 1997-06-05 2000-03-22 Merck & Co., Inc. Antagonisten des gonadotropin freisetzenden hormons
EP0986385A4 (de) 1997-06-05 2001-05-16 Merck & Co Inc Antagonisten des gonadorelins
WO1998055119A1 (en) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP1027046A4 (de) 1997-10-28 2002-04-03 Merck & Co Inc Antagonisten des gonadotropin freisetzenden hormons
AU1197299A (en) 1997-10-28 1999-05-17 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2317451A1 (en) 1998-02-11 1999-08-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2318957A1 (en) 1998-02-11 1999-08-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999051234A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999051595A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2325995A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP1067930A4 (de) 1998-04-02 2002-09-18 Merck & Co Inc Antagonisten des gonadoliberins
EP1070064A1 (de) 1998-04-02 2001-01-24 Merck & Co., Inc. Antagonisten des gonadotropin freisetzenden hormons
AU3210799A (en) 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO2000053178A1 (en) 1999-03-10 2000-09-14 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
EP1161431A4 (de) * 1999-03-10 2002-04-24 Merck & Co Inc 6-azaindol-verbindungen als antagonisten des gonadotropin-freisetzungs hormones
AU3396000A (en) 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
EP1165075A4 (de) 1999-03-10 2002-04-10 Merck & Co Inc 6-azaindolverbindungen als antagonisten des gonadoliberins
AU3868900A (en) 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
CA2367130A1 (en) 1999-03-10 2000-09-14 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
CA2413702A1 (en) * 2000-06-28 2002-01-03 Teva Pharmaceuticals Industries Ltd. Carvedilol
JP4977940B2 (ja) * 2000-09-22 2012-07-18 エム・エス・ディー・オス・ベー・フェー 二環式ヘテロ芳香族化合物
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
DE60318716T2 (de) * 2002-08-21 2009-01-08 Astrazeneca Ab Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
TW200407127A (en) * 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
AR041029A1 (es) 2005-04-27
TW200407127A (en) 2004-05-16
US20060004082A1 (en) 2006-01-05
WO2004018480A1 (en) 2004-03-04
EP1543012A1 (de) 2005-06-22
JP2006501232A (ja) 2006-01-12
US20080045517A1 (en) 2008-02-21
DE60322237D1 (de) 2008-08-28
US7547722B2 (en) 2009-06-16
ES2308018T3 (es) 2008-12-01
US7132442B2 (en) 2006-11-07
US7268158B2 (en) 2007-09-11
EP1543012B1 (de) 2008-07-16
AU2003255818A1 (en) 2004-03-11
US20060235067A1 (en) 2006-10-19

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