ATE397461T1 - Auf tgf-beta 1 ansprechende knochenmarkzellen - Google Patents
Auf tgf-beta 1 ansprechende knochenmarkzellenInfo
- Publication number
- ATE397461T1 ATE397461T1 AT97947454T AT97947454T ATE397461T1 AT E397461 T1 ATE397461 T1 AT E397461T1 AT 97947454 T AT97947454 T AT 97947454T AT 97947454 T AT97947454 T AT 97947454T AT E397461 T1 ATE397461 T1 AT E397461T1
- Authority
- AT
- Austria
- Prior art keywords
- bone marrow
- cells
- tgf
- beta
- marrow cells
- Prior art date
Links
- 210000002798 bone marrow cell Anatomy 0.000 title 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 210000001185 bone marrow Anatomy 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/495—Transforming growth factor [TGF]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/747,514 US6063593A (en) | 1996-11-12 | 1996-11-12 | TGFβ1 responsive bone marrow derived cells to express a recombinant protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE397461T1 true ATE397461T1 (de) | 2008-06-15 |
Family
ID=25005386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97947454T ATE397461T1 (de) | 1996-11-12 | 1997-11-12 | Auf tgf-beta 1 ansprechende knochenmarkzellen |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US6063593A (de) |
| EP (1) | EP0946199B1 (de) |
| JP (2) | JP2001503989A (de) |
| AT (1) | ATE397461T1 (de) |
| AU (1) | AU5253498A (de) |
| CA (1) | CA2271734A1 (de) |
| DE (1) | DE69738753D1 (de) |
| DK (1) | DK0946199T3 (de) |
| ES (1) | ES2308790T3 (de) |
| NZ (1) | NZ335753A (de) |
| PT (1) | PT946199E (de) |
| WO (1) | WO1998020907A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063593A (en) * | 1996-11-12 | 2000-05-16 | University Of Southern California University Park Campus | TGFβ1 responsive bone marrow derived cells to express a recombinant protein |
| ATE408667T1 (de) * | 1999-07-20 | 2008-10-15 | Univ Southern California | Identifizierung pluripotenter prämesenchymaler, prähämotopoietischer vorläuferzellen |
| JP2003018984A (ja) * | 2001-07-06 | 2003-01-21 | Mitsubishi Chemicals Corp | 多分化能を有する細胞の製造法 |
| WO2003051283A2 (en) * | 2001-10-26 | 2003-06-26 | The Children's Hospital Of Philadelphia | Engineered bone marrow |
| US20040076622A1 (en) * | 2002-03-02 | 2004-04-22 | Board Of Regents, The University Of Texas System | Local production and/or delivery of anti-cancer agents by stromal cell precursors |
| AU2003233428B2 (en) * | 2002-04-01 | 2008-07-31 | The University Of Texas Medical Branch | Treatment of lung disorder |
| US20040052771A1 (en) * | 2002-07-12 | 2004-03-18 | Lim Sai Kiang | Hemangioblast progenitor cells |
| WO2004007698A1 (en) * | 2002-07-12 | 2004-01-22 | National University Of Singapore | Hemangioblast progenitor cells |
| US20040091503A1 (en) * | 2002-08-20 | 2004-05-13 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
| WO2005072780A2 (en) | 2004-01-16 | 2005-08-11 | Carnegie Mellon University | Cellular labeling for nuclear magnetic resonance techniques |
| US20050169908A1 (en) * | 2004-01-23 | 2005-08-04 | Kazunori Murakami | Use of aerosolized antithrombin to treat acute lung injury |
| US20050192226A1 (en) * | 2004-02-20 | 2005-09-01 | Perenlei Enkhbaatar | Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants |
| JP2006249072A (ja) * | 2005-02-09 | 2006-09-21 | Osaka Univ | タンパク質導入用担体、前記担体を用いたタンパク質導入剤、タンパク質導入方法、およびタンパク質導入細胞ならびにその製造方法 |
| WO2007120911A2 (en) | 2006-04-14 | 2007-10-25 | Carnegie Mellon University | Cellular labeling and quantification for nuclear magnetic resonance techniques |
| EP2377923A1 (de) | 2006-04-14 | 2011-10-19 | Advanced Cell Technology, Inc. | Haemangiokoloniebildende Zellen |
| CA2693678C (en) | 2007-07-10 | 2017-02-14 | Carnegie Mellon University | Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques |
| EP2712921B1 (de) | 2008-05-06 | 2018-07-11 | Astellas Institute for Regenerative Medicine | Koloniebildende Hemangiozellen und nichtimplantierende Hemangiozellen |
| BRPI0912517A2 (pt) | 2008-05-06 | 2019-09-24 | Advanced Cell Tech Inc | métodos para a produção de células eritroides anucleadas dericadas de células-tronco pluripotentes |
| US8583299B2 (en) * | 2009-03-17 | 2013-11-12 | General Electric Company | System and method for communicating data in a train having one or more locomotive consists |
| KR101808751B1 (ko) | 2009-11-13 | 2017-12-13 | 그리폴스 테라퓨틱스 인코포레이티드 | 폰 빌레브란트 인자(ｖＷＦ)-함유 제제, 및 그와 관련된 방법, 키트 및 용도 |
| US10420820B2 (en) * | 2014-09-29 | 2019-09-24 | Counterpoint Biomedia LLC | Targeting of pharmaceutical agents to pathologic areas using bifunctional fusion polypeptides |
| US11406721B2 (en) | 2016-02-22 | 2022-08-09 | The Regents Of The University Of California | Compositions and methods for imaging cell populations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US6063593A (en) * | 1996-11-12 | 2000-05-16 | University Of Southern California University Park Campus | TGFβ1 responsive bone marrow derived cells to express a recombinant protein |
-
1996
- 1996-11-12 US US08/747,514 patent/US6063593A/en not_active Expired - Lifetime
-
1997
- 1997-11-12 NZ NZ335753A patent/NZ335753A/en not_active IP Right Cessation
- 1997-11-12 ES ES97947454T patent/ES2308790T3/es not_active Expired - Lifetime
- 1997-11-12 JP JP52274798A patent/JP2001503989A/ja not_active Withdrawn
- 1997-11-12 PT PT97947454T patent/PT946199E/pt unknown
- 1997-11-12 CA CA002271734A patent/CA2271734A1/en not_active Abandoned
- 1997-11-12 EP EP97947454A patent/EP0946199B1/de not_active Expired - Lifetime
- 1997-11-12 AU AU52534/98A patent/AU5253498A/en not_active Abandoned
- 1997-11-12 DE DE69738753T patent/DE69738753D1/de not_active Expired - Lifetime
- 1997-11-12 WO PCT/US1997/020558 patent/WO1998020907A1/en not_active Ceased
- 1997-11-12 AT AT97947454T patent/ATE397461T1/de active
- 1997-11-12 DK DK97947454T patent/DK0946199T3/da active
-
2000
- 2000-03-17 US US09/528,696 patent/US6277369B1/en not_active Expired - Fee Related
- 2000-05-11 US US09/569,323 patent/US6410015B1/en not_active Expired - Fee Related
-
2002
- 2002-02-15 US US10/076,981 patent/US6844191B2/en not_active Expired - Fee Related
-
2008
- 2008-03-05 JP JP2008054437A patent/JP4767983B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU5253498A (en) | 1998-06-03 |
| US6277369B1 (en) | 2001-08-21 |
| DE69738753D1 (de) | 2008-07-17 |
| US6063593A (en) | 2000-05-16 |
| US6844191B2 (en) | 2005-01-18 |
| JP2008206520A (ja) | 2008-09-11 |
| US20020141982A1 (en) | 2002-10-03 |
| NZ335753A (en) | 2001-02-23 |
| EP0946199A1 (de) | 1999-10-06 |
| CA2271734A1 (en) | 1998-05-22 |
| DK0946199T3 (da) | 2008-08-25 |
| JP4767983B2 (ja) | 2011-09-07 |
| EP0946199B1 (de) | 2008-06-04 |
| PT946199E (pt) | 2008-09-01 |
| WO1998020907A1 (en) | 1998-05-22 |
| JP2001503989A (ja) | 2001-03-27 |
| EP0946199A4 (de) | 2002-11-27 |
| US6410015B1 (en) | 2002-06-25 |
| ES2308790T3 (es) | 2008-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE397461T1 (de) | Auf tgf-beta 1 ansprechende knochenmarkzellen | |
| AU8476698A (en) | Human mesenchymal stem cells from peripheral blood | |
| ATE298253T1 (de) | In vivo gentransfermethoden zur wundheilung | |
| EP0765386A4 (de) | Methode zur in vivo aktivierung von t-zellen mit antigen inkubierten dendritischen zellen | |
| ATE110108T1 (de) | Genetische modifizierung von endothelialen zellen. | |
| TW428026B (en) | Bifunctional protein, preparation and use | |
| ATE213271T1 (de) | Verfahren zur herstellung von rekombinanten proteinen in e. coli mittels hochzelldichte- fermentation | |
| DE69940507D1 (de) | Biotechnisch erzeugte gefässprothese für die implantation | |
| ES8704546A1 (es) | Metodo de produccion de una proteina con actividad procoagu-lante del tipo de factor viii:c humano | |
| WO1997026322A3 (en) | Methods and compositions for inhibiting hexokinase | |
| DE69940753D1 (de) | Verfahren zur Einführung von heterologischen Zellen in Fische | |
| BR9708049A (pt) | Processo para matar células alvo indesejadas em uma população de células imunotoxinas para matar células uso das mesmas e kit para realizar o processo | |
| GR3031229T3 (en) | Anti-sickling beta-globin protein, compositions and methods for treating sickle cell disease | |
| DE69734464D1 (de) | Verfahren zur expression und herstellung von rekombinantem, menschlichem beta-cis-interferon | |
| WO2002050111A3 (en) | Isolated laminin 10 | |
| IL128569A0 (en) | Fibroblast growth factor homologous factor S(FHFs) and methods of use | |
| DE69916829D1 (de) | Genetisch veränderte fibroblasten und ihre verwendung | |
| DE69737597D1 (de) | Vektoren zur inhibierung von viralem und tumorwachstum | |
| EP2295578A3 (de) | Cyp1b1-Nukleinsäuren und Verwendungsverfahren dafür | |
| WO1994006447A3 (en) | 60a protein-induced morphogenesis | |
| DE69733571D1 (de) | Eine methode zur erhöhung der transfektion von zellen | |
| MX9706725A (es) | Mezclas enzimaticas definidas, novedosas para obtener celulas y para tratamientos de heridas. | |
| MX9705612A (es) | Induccion dirigida por linaje de la diferenciacion de celulas mesenquimatosas humanas de origen. | |
| AU1420497A (en) | Method for immunizing and treating human cells in animal organs maintained in vitro | |
| SE8901715L (sv) | En plasmid dna-konstruktion innehaallande dna-sekvenser |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0946199 Country of ref document: EP |