ATE387447T1 - Neue imidazo(1,5-c)chinazoline; eine neue klasse von liganden für gaba-rezeptoren im gehirn - Google Patents

Neue imidazo(1,5-c)chinazoline; eine neue klasse von liganden für gaba-rezeptoren im gehirn

Info

Publication number
ATE387447T1
ATE387447T1 AT97915905T AT97915905T ATE387447T1 AT E387447 T1 ATE387447 T1 AT E387447T1 AT 97915905 T AT97915905 T AT 97915905T AT 97915905 T AT97915905 T AT 97915905T AT E387447 T1 ATE387447 T1 AT E387447T1
Authority
AT
Austria
Prior art keywords
compounds
aryl
alkyl
new
optionally substituted
Prior art date
Application number
AT97915905T
Other languages
English (en)
Inventor
Paul Chen
Alan Hutchison
Guolin Cai
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of ATE387447T1 publication Critical patent/ATE387447T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT97915905T 1996-03-13 1997-03-12 Neue imidazo(1,5-c)chinazoline; eine neue klasse von liganden für gaba-rezeptoren im gehirn ATE387447T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/614,878 US5792766A (en) 1996-03-13 1996-03-13 Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands

Publications (1)

Publication Number Publication Date
ATE387447T1 true ATE387447T1 (de) 2008-03-15

Family

ID=24463085

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97915905T ATE387447T1 (de) 1996-03-13 1997-03-12 Neue imidazo(1,5-c)chinazoline; eine neue klasse von liganden für gaba-rezeptoren im gehirn

Country Status (6)

Country Link
US (3) US5792766A (de)
EP (1) EP0896578B1 (de)
AT (1) ATE387447T1 (de)
AU (1) AU2321597A (de)
DE (1) DE69738534D1 (de)
WO (1) WO1997033889A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792766A (en) * 1996-03-13 1998-08-11 Neurogen Corporation Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
US6281355B1 (en) * 1997-12-03 2001-08-28 Taisho Pharmaceutical Co., Ltd. Nitrogen-containing tetracyclic compounds
US6362371B1 (en) * 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
US6207908B1 (en) * 1998-08-31 2001-03-27 Mitsuku Denki Kogyo K.K. Mode switch
EP1165542B1 (de) 1999-03-29 2003-08-20 Neurogen Corporation 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
US6310212B1 (en) 2000-03-28 2001-10-30 Neurogen Corporation 4-substituted quinoline derivatives
US6423844B1 (en) 2001-06-06 2002-07-23 The United States Of America As Represented By The Secretary Of The Navy Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine
US7910208B2 (en) * 2004-03-03 2011-03-22 Kraton Polymers U.S. Llc Elastomeric bicomponent fibers comprising block copolymers having high flow
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
AU2008261888A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline urea derivatives
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
UA113280C2 (xx) 2010-11-11 2017-01-10 АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ
GB2575490A (en) * 2018-07-12 2020-01-15 Recordati Ind Chimica E Farmaceutica Spa P2X3 receptor antagonists

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Publication number Priority date Publication date Assignee Title
DE7910976U1 (de) 1979-04-14 1979-07-19 Roehm, Guenter Horst, 7927 Sontheim Nachspannendes bohrfutter
US4713383A (en) 1984-10-01 1987-12-15 Ciba-Geigy Corporation Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
EP0181282A1 (de) * 1984-10-01 1986-05-14 Ciba-Geigy Ag Triazolochinazolinverbindungen
DE3677445D1 (de) * 1985-09-30 1991-03-14 Ciba Geigy Ag 2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
US4831013A (en) 1986-03-20 1989-05-16 Ciba-Geigy Corporation 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmaceutical compositions, and uses thereof
DK160876C (da) * 1987-12-08 1991-10-14 Novo Nordisk As Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) * 1988-06-01 1989-12-15 Ferrosan As Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
US5175273A (en) * 1988-07-01 1992-12-29 Genentech, Inc. Nucleic acid intercalating agents
DK626288D0 (da) * 1988-11-10 1988-11-10 Ferrosan As Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
DK588489D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
FR2659329B1 (fr) * 1990-03-09 1994-06-03 Adir Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DK151890D0 (da) * 1990-06-22 1990-06-22 Ferrosan As Heterocykliske forbindelser deres fremstilling og brug
CA2110942A1 (en) * 1991-06-14 1992-12-23 Pharmacia & Upjohn Company Llc Imidazo¬1,5-a|quinoxalines
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
US5212310A (en) * 1991-12-19 1993-05-18 Neurogen Corporation Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
WO1993017025A1 (en) * 1992-02-19 1993-09-02 The Upjohn Company 3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity
US5306819A (en) * 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
US5792766A (en) 1996-03-13 1998-08-11 Neurogen Corporation Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
US6297252B1 (en) 2001-10-02
EP0896578B1 (de) 2008-02-27
US5792766A (en) 1998-08-11
US6103731A (en) 2000-08-15
DE69738534D1 (de) 2008-04-10
AU2321597A (en) 1997-10-01
WO1997033889A1 (en) 1997-09-18
EP0896578A1 (de) 1999-02-17

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