ATE385801T1 - Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere - Google Patents

Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere

Info

Publication number
ATE385801T1
ATE385801T1 AT03786759T AT03786759T ATE385801T1 AT E385801 T1 ATE385801 T1 AT E385801T1 AT 03786759 T AT03786759 T AT 03786759T AT 03786759 T AT03786759 T AT 03786759T AT E385801 T1 ATE385801 T1 AT E385801T1
Authority
AT
Austria
Prior art keywords
block copolymers
dioxane
ortho
esters
ketenacetals
Prior art date
Application number
AT03786759T
Other languages
German (de)
English (en)
Inventor
Jorge Heller
Steven Ng
Original Assignee
A P Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A P Pharma Inc filed Critical A P Pharma Inc
Application granted granted Critical
Publication of ATE385801T1 publication Critical patent/ATE385801T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • C08G2/18—Copolymerisation of aldehydes or ketones
    • C08G2/24—Copolymerisation of aldehydes or ketones with acetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyethers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT03786759T 2002-11-15 2003-11-13 Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere ATE385801T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/298,151 US7045589B2 (en) 2002-11-15 2002-11-15 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them

Publications (1)

Publication Number Publication Date
ATE385801T1 true ATE385801T1 (de) 2008-03-15

Family

ID=32297370

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03786759T ATE385801T1 (de) 2002-11-15 2003-11-13 Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere

Country Status (11)

Country Link
US (2) US7045589B2 (https=)
EP (1) EP1569664B1 (https=)
JP (1) JP2006506514A (https=)
KR (1) KR20050075414A (https=)
CN (1) CN1726043A (https=)
AT (1) ATE385801T1 (https=)
AU (1) AU2003295563B2 (https=)
CA (1) CA2506241A1 (https=)
DE (1) DE60319128T2 (https=)
ES (1) ES2299746T3 (https=)
WO (1) WO2004046328A2 (https=)

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US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
AU2009270695A1 (en) 2008-07-17 2010-01-21 Ap Pharma Methods for enhancing the stability of polyorthoesters and their formulations
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CN105358129A (zh) * 2013-03-15 2016-02-24 赫伦治疗有限公司 聚原酸酯和质子惰性溶剂的组合物
KR102063027B1 (ko) 2013-10-31 2020-01-07 (주)아모레퍼시픽 캡슐화된 향기를 포함하는 조성물
JP6232280B2 (ja) * 2013-12-25 2017-11-15 株式会社ダイセル 含酸素飽和ヘテロ環を有する重合体及びその製造方法
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法
CN113980254A (zh) * 2020-07-10 2022-01-28 南京泛太化工医药研究所 一种具有酸敏感降解、温敏性质的系列聚合物及其载药组合物
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Also Published As

Publication number Publication date
EP1569664A4 (en) 2006-11-02
DE60319128T2 (de) 2009-02-05
CA2506241A1 (en) 2004-06-03
ES2299746T3 (es) 2008-06-01
US7163694B2 (en) 2007-01-16
CN1726043A (zh) 2006-01-25
JP2006506514A (ja) 2006-02-23
WO2004046328A2 (en) 2004-06-03
WO2004046328A3 (en) 2004-08-26
KR20050075414A (ko) 2005-07-20
US20040096506A1 (en) 2004-05-20
AU2003295563B2 (en) 2009-01-08
AU2003295563A1 (en) 2004-06-15
US7045589B2 (en) 2006-05-16
DE60319128D1 (de) 2008-03-27
EP1569664A2 (en) 2005-09-07
US20060155101A1 (en) 2006-07-13
EP1569664B1 (en) 2008-02-13

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