ATE385801T1 - Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere - Google Patents

Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere

Info

Publication number
ATE385801T1
ATE385801T1 AT03786759T AT03786759T ATE385801T1 AT E385801 T1 ATE385801 T1 AT E385801T1 AT 03786759 T AT03786759 T AT 03786759T AT 03786759 T AT03786759 T AT 03786759T AT E385801 T1 ATE385801 T1 AT E385801T1
Authority
AT
Austria
Prior art keywords
block copolymers
dioxane
ortho
esters
ketenacetals
Prior art date
Application number
AT03786759T
Other languages
English (en)
Inventor
Jorge Heller
Steven Ng
Original Assignee
A P Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A P Pharma Inc filed Critical A P Pharma Inc
Application granted granted Critical
Publication of ATE385801T1 publication Critical patent/ATE385801T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • C08G2/18—Copolymerisation of aldehydes or ketones
    • C08G2/24—Copolymerisation of aldehydes or ketones with acetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyethers (AREA)
AT03786759T 2002-11-15 2003-11-13 Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere ATE385801T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/298,151 US7045589B2 (en) 2002-11-15 2002-11-15 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them

Publications (1)

Publication Number Publication Date
ATE385801T1 true ATE385801T1 (de) 2008-03-15

Family

ID=32297370

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03786759T ATE385801T1 (de) 2002-11-15 2003-11-13 Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere

Country Status (11)

Country Link
US (2) US7045589B2 (de)
EP (1) EP1569664B1 (de)
JP (1) JP2006506514A (de)
KR (1) KR20050075414A (de)
CN (1) CN1726043A (de)
AT (1) ATE385801T1 (de)
AU (1) AU2003295563B2 (de)
CA (1) CA2506241A1 (de)
DE (1) DE60319128T2 (de)
ES (1) ES2299746T3 (de)
WO (1) WO2004046328A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
GB0329654D0 (en) * 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
KR20070122521A (ko) * 2005-03-31 2007-12-31 에이피 파마, 인코포레이티드 Ｐｅｇ-폴리아세탈 및 ｐｅｇ-폴리아세탈-ｐｏｅ 그래프트공중합체 및 약학 조성물
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070281870A1 (en) * 2006-06-02 2007-12-06 Halliburton Energy Services, Inc. Stimuli-degradable gels
US7306040B1 (en) * 2006-06-02 2007-12-11 Halliburton Energy Services, Inc. Stimuli-degradable gels
EP2044142A2 (de) 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester)polymere sowie herstellungs- und verwendungsverfahren dafür
EP2042538A1 (de) * 2007-09-18 2009-04-01 Nirvana's Tree House Amphiphile Copolymere und Zusammensetzungen mit solchen Polymeren
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8940315B2 (en) * 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US20100120811A1 (en) 2008-07-17 2010-05-13 Peter Hanson Long-acting injectable analgesic formulations for animals
AU2009324545A1 (en) * 2008-12-11 2011-06-30 A.P. Pharma, Inc. Methods for enhancing stability of polyorthoesters and their formulations
WO2013142152A1 (en) * 2012-03-23 2013-09-26 Regents Of The University Of Minnesota Semi-solid delivery systems
CN105358129A (zh) 2013-03-15 2016-02-24 赫伦治疗有限公司 聚原酸酯和质子惰性溶剂的组合物
KR102063027B1 (ko) 2013-10-31 2020-01-07 (주)아모레퍼시픽 캡슐화된 향기를 포함하는 조성물
JP6232280B2 (ja) * 2013-12-25 2017-11-15 株式会社ダイセル 含酸素飽和ヘテロ環を有する重合体及びその製造方法
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
CN114886840B (zh) * 2020-07-10 2023-08-25 南京海鲸药业股份有限公司 一种具有酸敏感降解、温敏性质的系列聚合物及其载药组合物

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US152630A (en) * 1874-06-30 Improvement in cars for transporting coal
US168336A (en) * 1875-10-05 Improvement in horseshoe-machines
US82362A (en) * 1868-09-22 Samuel swes
US37300A (en) * 1863-01-06 Improvement in window-blind fastenings
US138474A (en) * 1873-05-06 Improvement in wave-powers
US130472A (en) * 1872-08-13 Improvement in hinges for sewing-machine tables
US176844A (en) * 1876-05-02 Improvement in beer-taps
US3268550A (en) * 1963-08-26 1966-08-23 Ibm Nu-butenyl carbazoles
US4180064A (en) * 1972-12-27 1979-12-25 Alza Corporation System for delivering agent to environment of use over prolonged time
US4014987A (en) * 1974-06-04 1977-03-29 Alza Corporation Device for delivery of useful agent
US4180646A (en) * 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4131648A (en) * 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
DE2601681A1 (de) * 1976-01-17 1977-07-21 Degussa Verfahren zur herstellung von 4,4'- isopropyliden-bis(2,6-dibromphenol)
US4079038A (en) * 1976-03-05 1978-03-14 Alza Corporation Poly(carbonates)
US4131848A (en) * 1976-12-03 1978-12-26 Gulf & Western Industries, Inc. Digital loop detector with automatic tuning
US4131662A (en) * 1978-01-03 1978-12-26 Mobay Chemical Corporation Talc-based external mold release agent for polyurethane foams
US4261969A (en) * 1979-05-03 1981-04-14 World Health Organization Controlled drug release composition
US4249531A (en) * 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4304767A (en) * 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4502976A (en) * 1982-10-25 1985-03-05 Bend Research, Inc. Water soluble polyesters
US4513143A (en) * 1982-12-01 1985-04-23 Sri International Preparation of ketene acetals
US4532335A (en) * 1983-03-07 1985-07-30 Sri International Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals
IT1205640B (it) * 1983-04-06 1989-03-23 Yason Srl Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US4710497A (en) * 1983-05-20 1987-12-01 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents
US4765973A (en) * 1984-06-06 1988-08-23 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4639366A (en) * 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4549010A (en) * 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4855132A (en) * 1986-02-25 1989-08-08 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4713441A (en) * 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4801457A (en) * 1986-08-01 1989-01-31 Sandoz Pharm. Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4898928A (en) * 1988-03-07 1990-02-06 Sandoz Pharmaceuticals Corp. Polyacetal and polyketal hydrogels formed from acetals or ketals and polyols
US4957998A (en) * 1988-08-22 1990-09-18 Pharmaceutical Delivery Systems, Inc. Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US4946931A (en) * 1989-06-14 1990-08-07 Pharmaceutical Delivery Systems, Inc. Polymers containing carboxy-ortho ester and ortho ester linkages
WO1991003510A1 (en) 1989-08-28 1991-03-21 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5030457A (en) * 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5047464A (en) 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
US5133739A (en) * 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
US5211951A (en) 1991-07-24 1993-05-18 Merck & Co., Inc. Process for the manufacture of bioerodible poly (orthoester)s and polyacetals
MX9301823A (es) * 1992-03-30 1994-01-31 Alza Corp Composicion para el suministro de liberacion controlado de un agente biologicamente activo.
US5461140A (en) * 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5518730A (en) * 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
MY113268A (en) 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
GB2273874A (en) * 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix
PT754032E (pt) * 1994-04-08 2002-05-31 Atrix Lab Inc Composicoes liquidas para difusao
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5607686A (en) * 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
US5811510A (en) 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
US5968543A (en) * 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
EP0869986B1 (de) * 1996-01-05 2000-11-02 Advanced Polymer Systems, Inc. Polymere mit kontrolliertem physikalischen zustand und bioerodierbarkeit
AU710109B2 (en) 1996-01-16 1999-09-16 Ap Pharma, Inc. Topical delivery of drugs to the lower gastrointestinal tract
US5993858A (en) * 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US5993856A (en) * 1997-01-24 1999-11-30 Femmepharma Pharmaceutical preparations and methods for their administration
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
EP1142596A1 (de) 2000-04-03 2001-10-10 Universiteit Gent Zusammensetzung von vernetzbaren Prepolymeren zum Gebrauch in therapeutisch aktiven, bioabbaubaren Implantaten
US6613355B2 (en) * 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
ATE311904T1 (de) 2000-05-11 2005-12-15 Ap Pharma Inc Halbfester verabreichungsträger und arzneimittel
DE60131177T2 (de) 2000-09-06 2008-08-07 AP Pharma, Inc., Redwood Abbaubare polyacetal-polymere
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
WO2002092661A1 (en) 2001-05-11 2002-11-21 Ap Pharma, Inc. Peg-poe, peg-poe-peg, and poe-peg-poe block copolymers
US20030152630A1 (en) 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US20020176844A1 (en) * 2001-05-11 2002-11-28 Ng Steven Y. Bioerodible polyorthoesters containing hydrogen bonding groups
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups

Also Published As

Publication number Publication date
US7045589B2 (en) 2006-05-16
CN1726043A (zh) 2006-01-25
WO2004046328A3 (en) 2004-08-26
US20040096506A1 (en) 2004-05-20
JP2006506514A (ja) 2006-02-23
US7163694B2 (en) 2007-01-16
AU2003295563A1 (en) 2004-06-15
EP1569664B1 (de) 2008-02-13
WO2004046328A2 (en) 2004-06-03
AU2003295563B2 (en) 2009-01-08
DE60319128D1 (de) 2008-03-27
DE60319128T2 (de) 2009-02-05
CA2506241A1 (en) 2004-06-03
EP1569664A2 (de) 2005-09-07
KR20050075414A (ko) 2005-07-20
ES2299746T3 (es) 2008-06-01
US20060155101A1 (en) 2006-07-13
EP1569664A4 (de) 2006-11-02

Similar Documents

Publication Publication Date Title
ATE385801T1 (de) Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere
WO2003044076A8 (en) Bioerodible poly(ortho esters) containing amine groups, and block copolymers containing them
ATE313586T1 (de) Mehrarmige blockcopolymere und pharmazeutische zusammensetzung
AU2273302A (en) Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof
ATE461961T1 (de) Mehrarmige polypeptid-poly(ethylenglykol)- blockcopolymere als arzneistoffzufuhrvehikel
TR201908857T4 (tr) Biyolojik olarak parçalanabilen oküler implant.
DE602004018772D1 (de) Pharmazeutische zusammensetzungen - ph-sensitive blockcopolymere und einen hydrophoben wirkstoff enthaltend
AU2001245988A1 (en) Microspheres for active embolization
WO2003068144A3 (en) Cytotoxic agents
WO2006039336A3 (en) Conveniently implantable sustained release drug compositions
BR0212475A (pt) Composições farmacêuticas
FI913410A (fi) Kontinuerligt frigoerande farmaceutiska kompositioner.
WO2003061578A3 (en) Compositions for treatment or prevention of bioterrorism
WO2004085712A3 (en) Multi-functional polymeric materials and their uses
EP1183538A4 (de) Zyklodexrinpolymere zum gebrauch als medikamententräger
WO2006002366A3 (en) Biodegradable ocular devices, methods and systems
DK1392254T3 (da) Micelle-lægemiddelindgivelsessystem for hydrofobe lægemidler
MD20070267A (en) Gastroresistant pharmaceutical formulation containing rifaximin
MXPA04003076A (es) Productos para debajo del brazo con un componente de fijacion de agua.
WO2004104021A3 (en) Controlled release of active agents utilizing repeat sequence protein polymers
KR101066763B1 (ko) 온도 반응성 전달계
ATE173578T1 (de) Implantierbare formkörper zur verabreichung von wirkstoffen an pflanzen
BR9508888A (pt) Agente de contraste utilização de um agente de contraste processos para gerar imagens melhoradas de um corpo humano ou de animal não humano e para preparar de um agente de contraste e um polímero polímeros biodegradáveis e implante cirúrgico
Kumar et al. Rheumatoid arthritis: basic pathophysiology and role of chitosan nanoparticles in therapy
UY27373A1 (es) Formulaciones de interferón beta-humano

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties