ATE375994T1 - Leber x rezeptoragonisten - Google Patents

Leber x rezeptoragonisten

Info

Publication number
ATE375994T1
ATE375994T1 AT02731581T AT02731581T ATE375994T1 AT E375994 T1 ATE375994 T1 AT E375994T1 AT 02731581 T AT02731581 T AT 02731581T AT 02731581 T AT02731581 T AT 02731581T AT E375994 T1 ATE375994 T1 AT E375994T1
Authority
AT
Austria
Prior art keywords
sub
alkyl
haloalkyl
independently
liver
Prior art date
Application number
AT02731581T
Other languages
English (en)
Inventor
Shutsung Liao
Ching Song
Original Assignee
Univ Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Chicago filed Critical Univ Chicago
Application granted granted Critical
Publication of ATE375994T1 publication Critical patent/ATE375994T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT02731581T 2001-05-03 2002-05-02 Leber x rezeptoragonisten ATE375994T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28864301P 2001-05-03 2001-05-03

Publications (1)

Publication Number Publication Date
ATE375994T1 true ATE375994T1 (de) 2007-11-15

Family

ID=23108009

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02731581T ATE375994T1 (de) 2001-05-03 2002-05-02 Leber x rezeptoragonisten

Country Status (11)

Country Link
US (1) US7012069B2 (de)
EP (1) EP1392713B1 (de)
JP (1) JP4309661B2 (de)
CN (1) CN100360550C (de)
AT (1) ATE375994T1 (de)
CA (1) CA2446314C (de)
DE (1) DE60223020T2 (de)
DK (1) DK1392713T3 (de)
ES (1) ES2296928T3 (de)
PT (1) PT1392713E (de)
WO (1) WO2002090375A2 (de)

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US20030153541A1 (en) * 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
US20030060425A1 (en) * 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
NZ515810A (en) * 1999-04-30 2004-05-28 Arch Dev Corp Steroid derivatives
JP2005508281A (ja) * 2001-02-08 2005-03-31 ザ ユニバーシティー オブ シカゴ ステロイド誘導体
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
US7078396B2 (en) 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
EP1450816A4 (de) * 2001-11-08 2008-02-13 Univ Chicago Verfahren zur behandlung von störungen im zusammenhang mit erhöhter cholesterinkonzentration
AU2003220521A1 (en) * 2002-03-27 2003-10-13 Smithkline Beecham Corporation Methods of treatment with lxr modulators
CA2520124A1 (en) * 2003-03-28 2004-10-14 Chiron Corporation Use of benzazole compounds for immunopotentiation
BRPI0417543A (pt) 2003-12-12 2007-03-27 Wyeth Corp quinolinas úteis no tratamento de doença cardiovascular
US20070032464A1 (en) * 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
WO2007121462A2 (en) * 2006-04-18 2007-10-25 Bristol-Myers Squibb Company CRYSTAL STRUCTURE OF LXR-ß AND LXR-α
JP5447954B2 (ja) 2007-09-19 2014-03-19 公益財団法人名古屋産業科学研究所 神経栄養因子様作用剤
WO2009059239A2 (en) * 2007-11-02 2009-05-07 Mayo Foundation For Medical Education And Research REDUCING Aβ42 LEVELS AND Aβ AGGREGATION
CN101592648A (zh) * 2008-05-30 2009-12-02 国鼎生物科技股份有限公司 肝脏x受体激动剂的筛选方法
CA2769203A1 (en) * 2009-07-29 2011-02-03 University Of Chicago Liver x receptor agonists
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
EP2759295A1 (de) 2013-01-29 2014-07-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Schaumzellenspezifischer Leber-X-Rezeptor-(LXR)-alpha-Agonist, SIRT1-Hemmer sowie p300-Hemmer als pharmazeutische aktive Wirkstoffe
SI3461834T1 (sl) 2013-03-13 2021-11-30 Sage Therapeutics, Inc. Nevroaktivni steroidi
JP2016193835A (ja) * 2013-09-04 2016-11-17 学校法人常翔学園 核内受容体肝臓ｘ受容体アゴニスト
KR20240051283A (ko) 2013-12-24 2024-04-19 버지니아 커먼웰스 유니버시티 산소첨가된 콜레스테롤 술페이트 (ocs) 의 용도
CA2939120A1 (en) 2014-01-10 2015-07-16 Rgenix, Inc. Lxr agonists and uses thereof
PE20180482A1 (es) 2015-07-06 2018-03-07 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos
JP7025022B2 (ja) 2016-01-11 2022-02-24 ザ ロックフェラー ユニバーシティー 骨髄系由来抑制細胞関連障害の治療のための方法
AU2017240157B2 (en) 2016-04-01 2022-10-20 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP2019524772A (ja) 2016-08-02 2019-09-05 ヴァージニア コモンウェルス ユニバーシティ ５−コレステン−３，２５−ジオール，３−サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物
JP7149266B2 (ja) 2016-09-30 2022-10-06 セージ セラピューティクス， インコーポレイテッド Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
EP3529257B1 (de) 2016-10-18 2023-05-10 Sage Therapeutics, Inc. Oxysterole und verfahren zur verwendung davon
AU2018373028A1 (en) 2017-11-21 2020-04-30 Inspirna, Inc. Polymorphs and uses thereof
JPWO2021033766A1 (de) * 2019-08-22 2021-02-25
CN114728875A (zh) 2019-12-13 2022-07-08 因思博纳公司 金属盐及其用途

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Also Published As

Publication number Publication date
CN100360550C (zh) 2008-01-09
CA2446314A1 (en) 2002-11-14
JP2005507855A (ja) 2005-03-24
WO2002090375A3 (en) 2003-12-18
EP1392713A4 (de) 2004-11-17
WO2002090375A8 (en) 2004-05-27
DE60223020D1 (de) 2007-11-29
DE60223020T2 (de) 2008-07-24
US7012069B2 (en) 2006-03-14
DK1392713T3 (da) 2008-02-18
EP1392713B1 (de) 2007-10-17
WO2002090375A2 (en) 2002-11-14
JP4309661B2 (ja) 2009-08-05
PT1392713E (pt) 2008-01-25
CN1585777A (zh) 2005-02-23
US20020193357A1 (en) 2002-12-19
EP1392713A2 (de) 2004-03-03
CA2446314C (en) 2011-02-22
ES2296928T3 (es) 2008-05-01

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