ATE368737T1 - Kontrolle der genexpression durch verwendung eines komplexes aus einem oligonucleotid und einem regulatorischen peptid - Google Patents

Kontrolle der genexpression durch verwendung eines komplexes aus einem oligonucleotid und einem regulatorischen peptid

Info

Publication number
ATE368737T1
ATE368737T1 AT02801387T AT02801387T ATE368737T1 AT E368737 T1 ATE368737 T1 AT E368737T1 AT 02801387 T AT02801387 T AT 02801387T AT 02801387 T AT02801387 T AT 02801387T AT E368737 T1 ATE368737 T1 AT E368737T1
Authority
AT
Austria
Prior art keywords
gene expression
molecule
nucleic acid
methods
modulating
Prior art date
Application number
AT02801387T
Other languages
English (en)
Inventor
Stephen Hart
Simak Ali
Boris Pufong
Andrew Porter
Laki Buluwela
Satu Vainikka
John Jenkinson
Patrick Kanda
Original Assignee
Imp Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9923615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE368737(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imp Innovations Ltd filed Critical Imp Innovations Ltd
Application granted granted Critical
Publication of ATE368737T1 publication Critical patent/ATE368737T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01048—Histone acetyltransferase (2.3.1.48)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02801387T 2001-10-11 2002-10-11 Kontrolle der genexpression durch verwendung eines komplexes aus einem oligonucleotid und einem regulatorischen peptid ATE368737T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0124391.4A GB0124391D0 (en) 2001-10-11 2001-10-11 Control of gene expression

Publications (1)

Publication Number Publication Date
ATE368737T1 true ATE368737T1 (de) 2007-08-15

Family

ID=9923615

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02801387T ATE368737T1 (de) 2001-10-11 2002-10-11 Kontrolle der genexpression durch verwendung eines komplexes aus einem oligonucleotid und einem regulatorischen peptid

Country Status (11)

Country Link
EP (1) EP1470226B1 (de)
AT (1) ATE368737T1 (de)
AU (1) AU2002334142B2 (de)
CA (1) CA2474216C (de)
CY (1) CY1107754T1 (de)
DE (1) DE60221572T2 (de)
DK (1) DK1470226T3 (de)
ES (1) ES2291536T3 (de)
GB (2) GB0124391D0 (de)
PT (1) PT1470226E (de)
WO (1) WO2003033701A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2508052A1 (en) * 2002-12-05 2004-06-17 Imperial College Innovations Limited Control of apoptosis using a complex of an oligonucleotide and a regulatory peptide
NL1027311C2 (nl) * 2004-10-21 2006-05-01 Synvolux Ip B V Vehikel voor transport van een DNA-modificerend enzym naar een genoom.
NL1027479C2 (nl) * 2004-10-21 2006-05-01 Synvolux Ip B V Bescherming van biologisch actieve moleculen met behulp van amphifielen.
US8883507B2 (en) 2005-10-18 2014-11-11 The Regents Of The University Of Colorado Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells
WO2009139930A2 (en) 2008-05-16 2009-11-19 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
DK2966084T3 (en) 2008-08-28 2018-08-06 Taiga Biotechnologies Inc MODULATORS OF MYC, PROCEDURES FOR USING SAME AND PROCEDURES FOR IDENTIFYING SUBSTANCES MODULATING MYC
WO2011154542A1 (en) * 2010-06-11 2011-12-15 Artisense Pharma Gmbh Method for selective oligonucleotide modification
CA3133302A1 (en) 2012-07-20 2014-01-23 Taiga Biotechnologies, Inc. Enhanced reconstitution and autoreconstitution of the hematopoietic compartment comprising a myc polypeptide
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US9758786B2 (en) 2016-02-09 2017-09-12 Autotelic, Llc Compositions and methods for treating pancreatic cancer
CA3045017A1 (en) 2016-12-02 2018-06-07 Taiga Biotechnologies, Inc. Nanoparticle formulations
MX2019015188A (es) 2017-06-15 2020-08-03 Univ California Inserciones de adn no virales orientadas.
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
MX2020004325A (es) 2017-10-27 2020-11-09 Univ California Reemplazo dirigido de receptores de células t endógenos.
IL311570A (en) 2021-10-14 2024-05-01 Arsenal Biosciences Inc Immune cells with common expression chain and logic gate systems

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9718609D0 (en) * 1997-09-02 1997-11-05 Imp College Innovations Ltd Fusion protein
AU1395999A (en) * 1997-11-10 1999-05-31 Salk Institute For Biological Studies, The Methods for the use of inhibitors of co-repressors for the treatment of neoplastic diseases
JP2002519688A (ja) * 1998-07-02 2002-07-02 インダストリアル リサーチ リミテッド コリオリ式流体流量計
GB9915126D0 (en) * 1999-06-30 1999-09-01 Imp College Innovations Ltd Control of gene expression
CA2316036A1 (en) * 1999-08-27 2001-02-27 Keqiang Wu Repressing gene expression in plants
WO2001059094A2 (en) * 2000-02-11 2001-08-16 The Salk Institute For Biological Studies Method of regulating transcription in a cell by altering remodeling of cromatin

Also Published As

Publication number Publication date
ES2291536T3 (es) 2008-03-01
DE60221572D1 (de) 2007-09-13
GB2382581A (en) 2003-06-04
EP1470226B1 (de) 2007-08-01
CA2474216C (en) 2012-03-13
PT1470226E (pt) 2007-11-02
WO2003033701A1 (en) 2003-04-24
GB0223605D0 (en) 2002-11-20
AU2002334142B2 (en) 2007-12-13
GB0124391D0 (en) 2001-11-28
EP1470226A1 (de) 2004-10-27
CA2474216A1 (en) 2003-04-24
CY1107754T1 (el) 2013-04-18
DE60221572T2 (de) 2008-04-17
DK1470226T3 (da) 2007-12-10

Similar Documents

Publication Publication Date Title
CY1107754T1 (el) Ελεγχος γονιδιακης εκφρασης χρησιμοποιωντας συμπλεγμα ολιγονουκλεοτιδιου και ρυθμιστικου πεπτιδιου
Pickart et al. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data
Nair et al. Chromatin dynamics in genome stability: roles in suppressing endogenous DNA damage and facilitating DNA repair
Gill Something about SUMO inhibits transcription
Gomis-Rüth Structure and mechanism of metallocarboxypeptidases
Hassan et al. Promoter targeting of chromatin-modifying complexes
NO331251B1 (no) Faktor VII-polypeptidvariant, nukleinsyrekonstruksjon, rekombinant vertscelle, ikke-humant transgent dyr, fremgangsmate for fremstilling av faktor VII-poly¬peptidet, samt anvendelse av et faktor VII-polypeptid til fremstilling av et medi¬kament for behandling av blodningsepisoder
Pinitglang et al. A classical enzyme active center motif lacks catalytic competence until modulated electrostatically
AU5753598A (en) Novel genes coding for amino acid deacetylases with specificity for N-acetyl-L-phosphinothricin, their isolation and use
DK0941318T3 (da) Håndvægtformede konstruerede ekspressionssystemer til genterapi
EP1229134A3 (de) Verwendung von post-transkriptioneller Genabschaltung zur Identifizierung von Nukleinsäuresequenzen die die Funktion einer Zelle beeinflussen
DK1641818T3 (da) Polypeptider der har bindingsaffinitet for HER2
EP2261362A3 (de) Verfahren zur besserung der architektur und des ertrags von getreide pflanzen
Hocharoen et al. Metallotherapeutics: novel strategies in drug design
WO2003076561A3 (en) Recombinase fusion protein with enhanced cellular uptake
WO2000053776A3 (en) Human kallikrein-like genes
WO2004050885A3 (en) Control of apoptosis using a complex of an oligonucleotide and a regulatory peptide
BR0209085A (pt) Moléculas de ácido nucléico relacionadas com o amadurecimento de mamão papaia
Hori et al. Artificial zinc finger peptide containing a novel His4 domain
DE60214867D1 (en) Histonedeacetylase 9
WO1995030009A3 (en) Identification, production and use of saponin glyclosyl hydrolases
MX9702776A (es) Proteinas de proteasa de pulgas, moleculas de acido nucleico, y usos de las mismas.
Davis et al. Probing the effects of DNA–protein interactions on DNA hole transport: the N-terminal histone tails modulate the distribution of oxidative damage and chemical lesions in the nucleosome core particle
Oh et al. Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors
HUP0203724A2 (hu) Humán heparanázzal rokon polipeptidek és nukleinsavak

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1470226

Country of ref document: EP