ATE366732T1 - Verfahren zur herstellung von pyrrolidin-1,2- dicarbonsäure-1 -(phenyl(-amid))-2-(phenyl(- amid)) derivaten und 1-(phenylcarbamoyl)- pyrrolidin-2-carbonsäurederivate als zwischenprodukte - Google Patents

Verfahren zur herstellung von pyrrolidin-1,2- dicarbonsäure-1 -(phenyl(-amid))-2-(phenyl(- amid)) derivaten und 1-(phenylcarbamoyl)- pyrrolidin-2-carbonsäurederivate als zwischenprodukte

Info

Publication number
ATE366732T1
ATE366732T1 AT04718646T AT04718646T ATE366732T1 AT E366732 T1 ATE366732 T1 AT E366732T1 AT 04718646 T AT04718646 T AT 04718646T AT 04718646 T AT04718646 T AT 04718646T AT E366732 T1 ATE366732 T1 AT E366732T1
Authority
AT
Austria
Prior art keywords
amid
phenyl
pyrrolidine
derivatives
phenylcarbamoyl
Prior art date
Application number
AT04718646T
Other languages
German (de)
English (en)
Inventor
Werner Mederski
Christos Tsaklakidis
Dieter Dorsch
Bertram Cezanne
Johannes Gleitz
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10315377A external-priority patent/DE10315377A1/de
Priority claimed from DE10327428A external-priority patent/DE10327428A1/de
Priority claimed from DE2003129295 external-priority patent/DE10329295A1/de
Priority claimed from DE2003134174 external-priority patent/DE10334174A1/de
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE366732T1 publication Critical patent/ATE366732T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT04718646T 2003-04-03 2004-03-09 Verfahren zur herstellung von pyrrolidin-1,2- dicarbonsäure-1 -(phenyl(-amid))-2-(phenyl(- amid)) derivaten und 1-(phenylcarbamoyl)- pyrrolidin-2-carbonsäurederivate als zwischenprodukte ATE366732T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10315377A DE10315377A1 (de) 2003-04-03 2003-04-03 Carbonylverbindungen
DE10327428A DE10327428A1 (de) 2003-06-18 2003-06-18 Ethinylprolinderivate
DE2003129295 DE10329295A1 (de) 2003-06-30 2003-06-30 Carbonylverbindungen
DE10329457A DE10329457A1 (de) 2003-04-03 2003-07-01 Ethinylprolinderivate
DE2003134174 DE10334174A1 (de) 2003-07-26 2003-07-26 Pyrrolidinderivate und Verfahren zur Herstellung

Publications (1)

Publication Number Publication Date
ATE366732T1 true ATE366732T1 (de) 2007-08-15

Family

ID=33136213

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04718646T ATE366732T1 (de) 2003-04-03 2004-03-09 Verfahren zur herstellung von pyrrolidin-1,2- dicarbonsäure-1 -(phenyl(-amid))-2-(phenyl(- amid)) derivaten und 1-(phenylcarbamoyl)- pyrrolidin-2-carbonsäurederivate als zwischenprodukte

Country Status (16)

Country Link
US (1) US7504500B2 (enExample)
EP (1) EP1608646B1 (enExample)
JP (1) JP4634369B2 (enExample)
KR (1) KR20050118709A (enExample)
AR (1) AR043831A1 (enExample)
AT (1) ATE366732T1 (enExample)
AU (1) AU2004226280B2 (enExample)
BR (1) BRPI0408888A (enExample)
CA (1) CA2520893C (enExample)
DE (2) DE10329457A1 (enExample)
ES (1) ES2287708T3 (enExample)
MX (1) MXPA05010433A (enExample)
PE (1) PE20050395A1 (enExample)
PL (1) PL377138A1 (enExample)
TW (1) TW200500339A (enExample)
WO (1) WO2004087695A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050119266A1 (en) * 2003-10-01 2005-06-02 Yan Shi Pyrrolidine and piperidine derivatives as factor Xa inhibitors
DE102004004731A1 (de) * 2004-01-30 2005-08-18 Merck Patent Gmbh Harnstoffderivate
DE102004045796A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
DE102004047254A1 (de) * 2004-09-29 2006-04-13 Merck Patent Gmbh Carbonylverbindungen
DE102004050283A1 (de) * 2004-10-15 2006-04-27 Lanxess Deutschland Gmbh 4-Aminophenyl-morpholinon-Derivate und deren Herstellung
US7301817B2 (en) 2005-10-27 2007-11-27 Sandisk Corporation Method for programming of multi-state non-volatile memory using smart verify
KR101020440B1 (ko) * 2005-11-16 2011-03-08 에프. 호프만-라 로슈 아게 응고 인자 Ｘａ의 억제제로서의 피롤리딘 유도체
EP1818330A1 (de) * 2006-02-14 2007-08-15 Boehringer Ingelheim Pharma GmbH & Co.KG Substituierte Prolinamide, deren Herstellung und deren Verwendung als Arzneimittel
JP5263686B2 (ja) 2006-05-16 2013-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換プロリンアミド、その製造及び薬物としての使用
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2632465B1 (en) 2010-10-27 2015-12-30 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058134A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CA2844310A1 (en) 2011-08-19 2013-02-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TW201317213A (zh) 2011-09-16 2013-05-01 Merck Sharp & Dohme 腎外髓質鉀通道抑制劑
EP2771005B1 (en) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013062900A1 (en) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2773351B1 (en) 2011-10-31 2017-08-23 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9108947B2 (en) 2011-10-31 2015-08-18 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
US9139585B2 (en) 2011-10-31 2015-09-22 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
WO2013090271A1 (en) 2011-12-16 2013-06-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
WO2014085210A1 (en) 2012-11-29 2014-06-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014099633A2 (en) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2956142B1 (en) 2013-02-18 2017-09-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2968288B1 (en) 2013-03-15 2018-07-04 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2015017305A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp Inhibitors of the renal outer medullary potassium channel
WO2015065866A1 (en) 2013-10-31 2015-05-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5822111B2 (ja) 1977-10-29 1983-05-06 協和醗酵工業株式会社 柑橘類果実の改質剤
JPS63232846A (ja) 1987-03-20 1988-09-28 Haruo Ogura 新規な固定相担体
WO1998022432A1 (en) * 1996-11-18 1998-05-28 Yamanouchi Pharmaceutical Co., Ltd. Novel acylamino-substituted acylanilide derivatives or pharmaceutical composition comprising the same
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade

Also Published As

Publication number Publication date
AU2004226280A1 (en) 2004-10-14
PE20050395A1 (es) 2005-06-04
US20060211692A1 (en) 2006-09-21
KR20050118709A (ko) 2005-12-19
EP1608646A1 (de) 2005-12-28
PL377138A1 (pl) 2006-01-23
AU2004226280B2 (en) 2010-06-17
TW200500339A (en) 2005-01-01
CA2520893C (en) 2012-07-10
AR043831A1 (es) 2005-08-17
MXPA05010433A (es) 2005-11-04
ES2287708T3 (es) 2007-12-16
JP4634369B2 (ja) 2011-02-16
BRPI0408888A (pt) 2006-04-11
DE10329457A1 (de) 2005-01-20
JP2006522037A (ja) 2006-09-28
WO2004087695A1 (de) 2004-10-14
CA2520893A1 (en) 2004-10-14
US7504500B2 (en) 2009-03-17
EP1608646B1 (de) 2007-07-11
DE502004004294D1 (de) 2007-08-23

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