ATE365798T1 - Mittel und verfahren zur diagnose und behandlung affektiver störungen - Google Patents

Mittel und verfahren zur diagnose und behandlung affektiver störungen

Info

Publication number
ATE365798T1
ATE365798T1 AT04018640T AT04018640T ATE365798T1 AT E365798 T1 ATE365798 T1 AT E365798T1 AT 04018640 T AT04018640 T AT 04018640T AT 04018640 T AT04018640 T AT 04018640T AT E365798 T1 ATE365798 T1 AT E365798T1
Authority
AT
Austria
Prior art keywords
nucleic acid
acid molecules
present
methods
relates
Prior art date
Application number
AT04018640T
Other languages
English (en)
Inventor
Nicholas Barden
Inge Sillaber
Marcelo Paez-Pereda
Original Assignee
Affectis Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affectis Pharmaceuticals Ag filed Critical Affectis Pharmaceuticals Ag
Application granted granted Critical
Publication of ATE365798T1 publication Critical patent/ATE365798T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/304—Mood disorders, e.g. bipolar, depression

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
AT04018640T 2003-04-17 2004-04-16 Mittel und verfahren zur diagnose und behandlung affektiver störungen ATE365798T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03008753 2003-04-17
EP03019626 2003-09-04

Publications (1)

Publication Number Publication Date
ATE365798T1 true ATE365798T1 (de) 2007-07-15

Family

ID=33300969

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04018640T ATE365798T1 (de) 2003-04-17 2004-04-16 Mittel und verfahren zur diagnose und behandlung affektiver störungen
AT04009160T ATE371738T1 (de) 2003-04-17 2004-04-16 Mittel und verfahren zur diagnose und behandlung affektiver störungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT04009160T ATE371738T1 (de) 2003-04-17 2004-04-16 Mittel und verfahren zur diagnose und behandlung affektiver störungen

Country Status (12)

Country Link
US (4) US20050147604A1 (de)
EP (2) EP1473367B1 (de)
JP (2) JP2006523648A (de)
AT (2) ATE365798T1 (de)
CA (1) CA2522985A1 (de)
DE (2) DE602004007184T2 (de)
DK (2) DK1473367T3 (de)
ES (2) ES2293114T3 (de)
MX (1) MXPA05011008A (de)
PL (2) PL1469072T3 (de)
PT (2) PT1469072E (de)
WO (1) WO2004092384A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1360203E (pt) 2001-01-17 2009-04-03 Intreat Pty Ltd Anticorpos de receptor p2x7 não funcional para diagnóstico e tratamento de cancros e outros estados
WO2004090097A2 (en) 2003-04-03 2004-10-21 Bristol-Myers Squibb Company Polynucleotide encoding a novel human p2x7 splice variant, hbmyp2x7v
US8124730B1 (en) 2004-04-02 2012-02-28 Bristol-Myers Squibb Company Polynucleotide encoding a novel human P2X7 splice variant, HBMYP2X7v
RU2410430C2 (ru) * 2004-08-31 2011-01-27 Силентис С.А.У. Способы и композиции для ингибирования экспрессии рецептора p2х7
US20100074884A1 (en) * 2005-05-31 2010-03-25 Duska Scientific Co. Inhibition of neuronal damage
WO2007115095A2 (en) * 2006-03-29 2007-10-11 The Trustees Of Columbia University In The City Ofnew York Systems and methods for using molecular networks in genetic linkage analysis of complex traits
US20070249666A1 (en) * 2006-03-31 2007-10-25 Bratcher Natalie A P2X7 Antagonists to Treat Affective Disorders
WO2008043146A1 (en) * 2006-10-10 2008-04-17 Biosceptre International Limited Antibodies against non functional p2x7 receptor
AU2007306924A1 (en) * 2006-10-10 2008-04-17 Biosceptre International Limited Hybridomas producing antibodies against non functional P2X7 receptor
EP1938801A1 (de) * 2006-12-22 2008-07-02 Biofrontera Bioscience GmbH Nanoemulsion
WO2009019503A2 (en) * 2007-08-03 2009-02-12 Astrazeneca Ab P2x7 antagonists for use in the treatment of mood disorders
US8293491B2 (en) 2007-09-14 2012-10-23 Biosceptre International Limited Purinergic (P2X) receptors in extra-cellular body fluid
CA2737126C (en) * 2007-09-14 2018-05-01 Biosceptre International Limited Novel p2x7 epitopes
CA2700972A1 (en) * 2007-10-04 2009-04-09 Merck Sharp & Dohme Corp. N-substituted oxindoline derivatives as calcium channel blockers
AU2009266430B2 (en) 2008-07-04 2014-08-14 Biosceptre International Limited Anti- P2X7 peptides and epitopes
EP2966090B1 (de) 2009-08-20 2018-10-10 Biosceptre (Aust) Pty Ltd Antikörper gegen den p2x7-rezeptor und fragmente davon
WO2011075789A1 (en) 2009-12-24 2011-06-30 Biosceptre International Limited Antibodies to non-functional oligomeric p2x7 receptors
CN106310245A (zh) 2010-09-10 2017-01-11 生物权威(澳大利亚)有限责任公司 陪伴动物治疗
AU2012278921B2 (en) 2011-07-01 2016-11-10 Biosceptre International Limited Combination therapy
WO2014182601A1 (en) 2013-05-08 2014-11-13 Children's Medical Center Corporation A method of preventing and treating type 1 diabetes, allograft rejection and lung fibrosis (by targeting the atp/p2x7r axis)
JP6728657B2 (ja) * 2015-12-04 2020-07-22 東洋紡株式会社 核酸増幅法
WO2017165423A1 (en) * 2016-03-21 2017-09-28 Indiana University Research & Technology Corporation Drugs, pharmacogenomics and biomarkers for active longevity
CN115381950B (zh) * 2022-09-06 2023-08-18 天津医科大学总医院 Rab 35或其下游调控分子在治疗骨折后慢性疼痛中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214581B1 (en) * 1998-01-16 2001-04-10 Abbott Laboratories Nucleic acids encoding a functional human purinoreceptor P2X3 and P2X6, and methods of production and use thereof
WO1999055901A2 (en) * 1998-04-30 1999-11-04 Abbott Laboratories Screening assay for identifying human purinoreceptor ligands
JP2000095695A (ja) * 1998-07-23 2000-04-04 Nippon Koutai Kenkyusho:Kk 精神分裂病治療薬
ATE294577T1 (de) * 1999-02-24 2005-05-15 Univ Cincinnati Verwendung von sulfamat derivaten zur behandlung von impulsiven störungen
US7303867B2 (en) 1999-12-16 2007-12-04 Katayanagi Institute Method for detecting target nucleotide sequences
SE9904652D0 (sv) * 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
AU2001233955A1 (en) * 2000-02-24 2001-09-03 Oxford Glycosciences (Uk) Limited Diagnosis and treatment of bipolar affective disorder
JP2002330787A (ja) * 2000-10-21 2002-11-19 Astrazeneca Ab 化学物質
JP2003135075A (ja) * 2001-11-05 2003-05-13 Research Association For Biotechnology 新規な全長ｃＤＮＡ
WO2003042190A1 (en) * 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
PA8557501A1 (es) * 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
CA2471562A1 (en) * 2001-12-21 2003-07-24 King Pharmaceuticals Research And Development, Inc. Tyrosyl derivatives and their use as p2x7 receptor modulators
US20040029841A1 (en) * 2002-04-18 2004-02-12 Renshaw Perry F. Purinergic antagonists for treating depression
US20050037983A1 (en) * 2003-03-11 2005-02-17 Timothy Dinan Compositions and methods for the treatment of depression and other affective disorders
WO2004090097A2 (en) 2003-04-03 2004-10-21 Bristol-Myers Squibb Company Polynucleotide encoding a novel human p2x7 splice variant, hbmyp2x7v
US6759435B1 (en) * 2003-07-03 2004-07-06 A.P. Group Inc. Antidepressant drugs and methods
FR2867784B1 (fr) 2004-03-17 2006-06-09 Commissariat Energie Atomique Aptameres selectionnes a partir de cellules vivantes tumorales et leurs applications

Also Published As

Publication number Publication date
EP1469072B1 (de) 2007-08-29
PL1469072T3 (pl) 2008-03-31
JP2006523648A (ja) 2006-10-19
PL1473367T3 (pl) 2007-11-30
US20080200411A1 (en) 2008-08-21
WO2004092384A3 (en) 2005-06-02
CA2522985A1 (en) 2004-10-28
DE602004007184D1 (de) 2007-08-09
ES2286543T3 (es) 2007-12-01
PT1473367E (pt) 2007-09-10
US20080057504A1 (en) 2008-03-06
DE602004007184T2 (de) 2008-02-28
DK1473367T3 (da) 2007-10-01
ATE371738T1 (de) 2007-09-15
JP2010011855A (ja) 2010-01-21
PT1469072E (pt) 2007-10-29
MXPA05011008A (es) 2006-03-08
EP1469072A3 (de) 2004-11-24
US20050147604A1 (en) 2005-07-07
ES2293114T3 (es) 2008-03-16
EP1469072A2 (de) 2004-10-20
US7767398B2 (en) 2010-08-03
WO2004092384A2 (en) 2004-10-28
DE602004008528D1 (de) 2007-10-11
EP1473367B1 (de) 2007-06-27
DK1469072T3 (da) 2008-01-07
DE602004008528T2 (de) 2008-05-21
EP1473367A1 (de) 2004-11-03
US20060110385A1 (en) 2006-05-25

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