ATE364173T1 - Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe - Google Patents

Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe

Info

Publication number
ATE364173T1
ATE364173T1 AT03779036T AT03779036T ATE364173T1 AT E364173 T1 ATE364173 T1 AT E364173T1 AT 03779036 T AT03779036 T AT 03779036T AT 03779036 T AT03779036 T AT 03779036T AT E364173 T1 ATE364173 T1 AT E364173T1
Authority
AT
Austria
Prior art keywords
tissue
raman signal
detection unit
signal
wave number
Prior art date
Application number
AT03779036T
Other languages
English (en)
Inventor
Gerwin Puppels
Rolf Wolthuis
Senada Koljenovic
Original Assignee
River Diagnostics B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by River Diagnostics B V filed Critical River Diagnostics B V
Application granted granted Critical
Publication of ATE364173T1 publication Critical patent/ATE364173T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/44Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/44Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441Skin evaluation, e.g. for skin disorder diagnosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4848Monitoring or testing the effects of treatment, e.g. of medication
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • G01N2021/656Raman microprobe

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT03779036T 2002-12-02 2003-12-02 Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe ATE364173T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02080032 2002-12-02

Publications (1)

Publication Number Publication Date
ATE364173T1 true ATE364173T1 (de) 2007-06-15

Family

ID=32405739

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03779036T ATE364173T1 (de) 2002-12-02 2003-12-02 Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe

Country Status (10)

Country Link
US (1) US7499153B2 (de)
EP (2) EP1567852B1 (de)
JP (1) JP4870356B2 (de)
CN (1) CN100533127C (de)
AT (1) ATE364173T1 (de)
AU (1) AU2003285815A1 (de)
DE (1) DE60314282T2 (de)
DK (1) DK1567852T3 (de)
ES (1) ES2289344T3 (de)
WO (1) WO2004051242A1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080105096A1 (en) * 1999-01-15 2008-05-08 Cutting Edge Designs, Llc Liquid transport cavity saw blade
CN1890557A (zh) 2003-11-28 2007-01-03 Bc肿瘤研究所 根据拉曼和背景荧光谱多峰检测组织异常
DE102004015946B3 (de) * 2004-03-25 2006-01-12 Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh Vorrichtung und Verfahren zur Raman-spektroskopischen Charakterisierung eines Prozessmediums
US7697576B2 (en) 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
US7292323B2 (en) * 2004-11-12 2007-11-06 Alcon, Inc. Optical fiber detection method and system
GB0426993D0 (en) 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
US8406858B2 (en) 2005-04-29 2013-03-26 The Regents Of The University Of Colorado, A Body Corporate Multi-excitation diagnostic system and methods for classification of tissue
JP4675149B2 (ja) * 2005-05-13 2011-04-20 独立行政法人理化学研究所 血管診断用分光プローブ
US8253936B2 (en) 2008-08-08 2012-08-28 Chemimage Corporation Raman characterization of transplant tissue
GB0606891D0 (en) 2006-04-05 2006-05-17 Council Cent Lab Res Councils Raman Analysis Of Pharmaceutical Tablets
JP2009544356A (ja) * 2006-07-21 2009-12-17 プレサイエント メディカル, インコーポレイテッド 適合可能な組織接触カテーテル
US20080129993A1 (en) * 2006-10-23 2008-06-05 Brennan James F Windowless fiber optic raman spectroscopy probes
US20120059254A1 (en) * 2007-03-14 2012-03-08 Wang Lifan Apparatus and method for phase-space reduction for imaging of fluorescing, scattering and/or absorbing structures
US7952706B2 (en) * 2007-05-17 2011-05-31 Prescient Medical, Inc. Multi-channel fiber optic spectroscopy systems employing integrated optics modules
JP2010529465A (ja) 2007-06-08 2010-08-26 プレサイエント メディカル, インコーポレイテッド ラマン分光法を光ファイバ系低コヒーレンスリフレクトメトリと結合した光カテーテル構成
WO2009014820A1 (en) * 2007-07-20 2009-01-29 Prescient Medical, Inc. Wall-contacting intravascular ultrasound probe catheters
US20090076395A1 (en) * 2007-09-19 2009-03-19 Prescient Medical, Inc. Optimized intravascular ultrasound probe catherers
SE531527C2 (sv) * 2007-10-01 2009-05-12 Bioresonator Ab Förfarande vid och en anordning för opåverkad materialundersökning
JP5198037B2 (ja) * 2007-11-02 2013-05-15 株式会社 資生堂 皮膚外用剤の有効性評価方法、有効性評価装置、及び有効性評価プログラム
CN102015020A (zh) * 2008-05-09 2011-04-13 休·贝克曼 用于诊断和治疗异常组织的医疗设备及其使用方法
US8416405B2 (en) 2008-08-08 2013-04-09 Chemimage Corporation Raman chemical imaging of implantable drug delivery devices
US20100113906A1 (en) * 2008-11-06 2010-05-06 Prescient Medical, Inc. Hybrid basket catheters
US20100317974A1 (en) * 2009-01-09 2010-12-16 Research Foundation Of The City University Of New York Detection of vulnerable plaques by raman spectroscopy
EP2416708B1 (de) * 2009-04-01 2019-05-08 Erasmus University Medical Center Rotterdam Verfahren zur bestimmung von ein oder mehr mutationen
JP2013511341A (ja) * 2009-11-17 2013-04-04 ヴェラライト,インコーポレイテッド 冠動脈石灰化又は冠動脈疾患を検出する方法及び装置
US8175423B2 (en) * 2009-12-03 2012-05-08 Marple Eric T Filtered fiber optic probe
US8702321B2 (en) 2009-12-03 2014-04-22 Eric T. Marple Filtered fiber optic probe
US8582096B2 (en) * 2009-12-18 2013-11-12 The Regents Of The University Of California System and method for efficient coherence anti-stokes raman scattering endoscopic and intravascular imaging and multimodal imaging
WO2011088580A1 (en) * 2010-01-22 2011-07-28 British Columbia Cancer Agency Branch Apparatus and methods for characterization of lung tissue by raman spectroscopy
DE102010052434A1 (de) 2010-11-24 2012-05-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Überwachung einer kryokonservierten biologischen Probe
WO2012096689A1 (en) 2011-01-10 2012-07-19 Emvision Llc Fiber optic probes utilizing grin lenses for spatially precise optical spectroscopy
DE102011100507B4 (de) * 2011-04-29 2020-05-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Tragbares optisches Analysegerät
WO2013177061A1 (en) 2012-05-21 2013-11-28 The Regents Of The University Of Colorado, A Body Corporate Three-dimensional mapping and therapy of prostate cancer
US9814448B2 (en) 2012-05-21 2017-11-14 Precision Biopsy, Inc. Three-dimensional optical imaging and therapy of prostate cancer
US10058284B2 (en) * 2012-12-21 2018-08-28 Volcano Corporation Simultaneous imaging, monitoring, and therapy
GB201301280D0 (en) * 2013-01-24 2013-03-06 Univ St Andrews Optical apparatus for use with a medical imager
GB201302886D0 (en) 2013-02-19 2013-04-03 Univ Singapore Diagnostic instrument and method
US10722292B2 (en) 2013-05-31 2020-07-28 Covidien Lp Surgical device with an end-effector assembly and system for monitoring of tissue during a surgical procedure
EP3019855A4 (de) * 2013-07-11 2017-03-01 Henry Ford Health System Vorrichtung und verfahren zum unterscheiden zwischen unterschiedlichen gewebetypen mit spezifischen ramanspektralbereichen
CN103645170B (zh) * 2013-12-03 2016-03-02 北京航空航天大学 一种利用拉曼光谱检测肿瘤性质的装置
GB201401727D0 (en) * 2014-01-31 2014-03-19 Univ Bristol A low background raman probe for optical biopsy of brain tissue
CN104155002B (zh) * 2014-07-17 2016-03-02 中国科学院遥感与数字地球研究所 扫描成像光谱仪系统
JP6893877B2 (ja) 2014-10-29 2021-06-23 スペクトラル エムディー, インコーポレイテッドSpectral Md, Inc. 組織を分類するための反射モードマルチスペクトル時間分解型光学イメージングの方法および装置
US11154186B2 (en) 2015-07-31 2021-10-26 University Of Utah Research Foundation Devices, systems, and methods for imaging and treating a selected tissue
US10161870B2 (en) 2015-10-05 2018-12-25 Nxgen Partners Ip, Llc System and method for multi-parameter spectroscopy
EP3367887A4 (de) * 2015-10-28 2019-05-22 Spectral MD Inc. Verfahren und vorrichtungen zur multispektralen, zeitaufgelösten optischen bildgebung zur gewebeklassifizierung
WO2017111576A1 (en) 2015-12-21 2017-06-29 Erasmus University Medical Center Rotterdam Optical probe for measuring a tissue sample
EP3403067A4 (de) * 2016-01-13 2019-08-28 NxGen Partners IP, LLC System und verfahren zur multiparameterspektroskopie
EP3405095B1 (de) 2016-01-18 2023-12-20 Erasmus University Medical Center Rotterdam Gewebeprobenanalyse
EP3203215B1 (de) 2016-02-08 2019-08-14 Leibniz-Institut für Astrophysik Potsdam (AIP) Optische bildgebende spektroskopie von grossflächigen proben
CN105997000B (zh) * 2016-05-30 2023-04-14 福建师范大学 一种基于纤维内窥镜的拉曼光谱检测装置及其实现方法
WO2018116363A1 (ja) * 2016-12-19 2018-06-28 オリンパス株式会社 ラマンプローブおよびラマンスペクトル測定装置
CN106770176A (zh) * 2016-12-26 2017-05-31 同方威视技术股份有限公司 拉曼光谱检测设备和拉曼光谱检测设备的安全监控方法
US11602270B2 (en) 2017-02-01 2023-03-14 University Of Utah Research Foundation Devices and methods for mapping cardiac tissue
CN110573066A (zh) 2017-03-02 2019-12-13 光谱Md公司 用于多光谱截肢部位分析的机器学习系统和技术
US11375897B2 (en) 2017-04-20 2022-07-05 Henry Ford Health System System and method for characterization of a brain tissue sample using Raman marker regions
US10684226B2 (en) 2018-03-09 2020-06-16 Samsung Electronics Co., Ltd. Raman probe, Raman spectrum obtaining apparatus, and method of obtaining Raman spectrum and detecting distribution of target material using Raman probe
US11555742B2 (en) 2018-09-04 2023-01-17 Provincial Health Services Authority Image guided micro-Raman spectroscopy
US10740884B2 (en) 2018-12-14 2020-08-11 Spectral Md, Inc. System and method for high precision multi-aperture spectral imaging
KR102812782B1 (ko) 2018-12-14 2025-05-23 스펙트랄 엠디, 인크. 고정밀도 다중-애퍼쳐 스펙트럼 이미징을 위한 시스템 및 방법
US10783632B2 (en) 2018-12-14 2020-09-22 Spectral Md, Inc. Machine learning systems and method for assessment, healing prediction, and treatment of wounds
KR20240163190A (ko) 2018-12-14 2024-11-18 스펙트랄 엠디, 인크. 상처들의 평가, 치유 예측 및 치료를 위한 머신 학습 시스템들 및 방법들
EP4078255B1 (de) 2019-12-17 2025-11-26 The University of Utah Research Foundation Charakterisierung von herzgewebe mittels katheterisierter lichtstreuungsspektroskopie
FI130864B1 (en) * 2020-02-03 2024-04-29 Spectrocor Oy Measuring head for myocardial spectrometer
EP3901618A1 (de) * 2020-03-30 2021-10-27 TimeGate Instruments Oy Verfahren und vorrichtung zur messung des spektrums von raman-gestreutem licht unter verwendung von zeitgesteuerter detektion
US12038383B2 (en) 2021-03-05 2024-07-16 Cytoveris Inc. Method and system for identifying tissue type based on peak-fitted parameters in high-wavenumber Raman spectrum
US11821841B2 (en) 2021-03-05 2023-11-21 Cytoveris, Inc. System and method for classification of tissue based on Raman and fluorescence in high-wavenumber Raman spectrum
WO2022212413A1 (en) 2021-03-30 2022-10-06 Spectral Md, Inc. System and method for high precision snapshot multi-spectral imaging based on multiplexed illumination
WO2023008369A1 (ja) * 2021-07-30 2023-02-02 キヤノン株式会社 細胞自家蛍光の画像を用いて細胞を分類する方法及び解析装置
CN116077016A (zh) * 2022-12-22 2023-05-09 四川大学 一种基于拉曼光谱和红外线光谱的便携式信息诊断装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318024A (en) * 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
ATE187315T1 (de) * 1987-09-24 1999-12-15 Massachusetts Inst Technology Kathetersystem zur abbildung
EP0573535B1 (de) * 1991-02-26 2000-12-27 Massachusetts Institute Of Technology Molekularspektroskopieverfahren und -einrichtungen zur gewebediagnose
US5638172A (en) * 1994-05-27 1997-06-10 Eastman Chemical Company On-line quantitative analysis of chemical compositions by raman spectrometry
US5621522A (en) * 1995-04-05 1997-04-15 The United States Of America As Represented By The Secretary Of The Navy Fiber optic probe for determination of trace levels of organic pollutants using Raman spectroscopy
US5953477A (en) * 1995-11-20 1999-09-14 Visionex, Inc. Method and apparatus for improved fiber optic light management
CN1089165C (zh) * 1996-01-24 2002-08-14 大连理工大学 一种用激光诱导血清的自体荧光-喇曼光谱诊断癌症的设备
IL125986A (en) * 1996-03-13 2004-05-12 Visionex Inc Device and method for improved operation of light in optical fiber
US5911017A (en) * 1996-07-31 1999-06-08 Visionex, Inc. Fiber optic interface for laser spectroscopic Raman probes
WO1998041849A1 (en) 1997-03-14 1998-09-24 Rosemount Analytical Inc. Improved rayleigh backscatter control apparatus and method
US5864397A (en) * 1997-09-15 1999-01-26 Lockheed Martin Energy Research Corporation Surface-enhanced raman medical probes and system for disease diagnosis and drug testing
US6205272B1 (en) * 1998-02-27 2001-03-20 Equitech Int'l Corp. Fiber optic probe for attenuated total internal reflection spectrophotometry
JP2000131145A (ja) * 1998-10-23 2000-05-12 Jasco Corp 分光分析装置
JP3992090B2 (ja) * 1999-01-11 2007-10-17 日本分光株式会社 ラマン分光用プローブ
US6623977B1 (en) * 1999-11-05 2003-09-23 Real-Time Analyzers, Inc. Material for surface-enhanced Raman spectroscopy, and SER sensors and method for preparing same

Also Published As

Publication number Publication date
JP4870356B2 (ja) 2012-02-08
ES2289344T3 (es) 2008-02-01
DK1567852T3 (da) 2007-08-06
US7499153B2 (en) 2009-03-03
AU2003285815A1 (en) 2004-06-23
CN100533127C (zh) 2009-08-26
WO2004051242A1 (en) 2004-06-17
EP1567852A1 (de) 2005-08-31
CN1745294A (zh) 2006-03-08
EP1567852B1 (de) 2007-06-06
JP2006508358A (ja) 2006-03-09
DE60314282T2 (de) 2008-03-20
EP1821097A1 (de) 2007-08-22
US20060139633A1 (en) 2006-06-29
DE60314282D1 (de) 2007-07-19

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