ATE364173T1 - Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe - Google Patents

Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe

Info

Publication number
ATE364173T1
ATE364173T1 AT03779036T AT03779036T ATE364173T1 AT E364173 T1 ATE364173 T1 AT E364173T1 AT 03779036 T AT03779036 T AT 03779036T AT 03779036 T AT03779036 T AT 03779036T AT E364173 T1 ATE364173 T1 AT E364173T1
Authority
AT
Austria
Prior art keywords
tissue
raman signal
detection unit
signal
wave number
Prior art date
Application number
AT03779036T
Other languages
English (en)
Inventor
Gerwin Puppels
Rolf Wolthuis
Senada Koljenovic
Original Assignee
River Diagnostics B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by River Diagnostics B V filed Critical River Diagnostics B V
Application granted granted Critical
Publication of ATE364173T1 publication Critical patent/ATE364173T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/44Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/44Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441Skin evaluation, e.g. for skin disorder diagnosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4848Monitoring or testing the effects of treatment, e.g. of medication
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • G01N2021/656Raman microprobe

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
AT03779036T 2002-12-02 2003-12-02 Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe ATE364173T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02080032 2002-12-02

Publications (1)

Publication Number Publication Date
ATE364173T1 true ATE364173T1 (de) 2007-06-15

Family

ID=32405739

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03779036T ATE364173T1 (de) 2002-12-02 2003-12-02 Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe

Country Status (10)

Country Link
US (1) US7499153B2 (de)
EP (2) EP1567852B1 (de)
JP (1) JP4870356B2 (de)
CN (1) CN100533127C (de)
AT (1) ATE364173T1 (de)
AU (1) AU2003285815A1 (de)
DE (1) DE60314282T2 (de)
DK (1) DK1567852T3 (de)
ES (1) ES2289344T3 (de)
WO (1) WO2004051242A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080105096A1 (en) * 1999-01-15 2008-05-08 Cutting Edge Designs, Llc Liquid transport cavity saw blade
CN1890557A (zh) 2003-11-28 2007-01-03 Bc肿瘤研究所 根据拉曼和背景荧光谱多峰检测组织异常
DE102004015946B3 (de) * 2004-03-25 2006-01-12 Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh Vorrichtung und Verfahren zur Raman-spektroskopischen Charakterisierung eines Prozessmediums
US7697576B2 (en) 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
US7292323B2 (en) * 2004-11-12 2007-11-06 Alcon, Inc. Optical fiber detection method and system
GB0426993D0 (en) 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
WO2006119166A2 (en) * 2005-04-29 2006-11-09 The Regents Of The University Of Colorado Multi-excitation diagnostic systems and methods for classification of tissue
JP4675149B2 (ja) * 2005-05-13 2011-04-20 独立行政法人理化学研究所 血管診断用分光プローブ
US8253936B2 (en) 2008-08-08 2012-08-28 Chemimage Corporation Raman characterization of transplant tissue
GB0606891D0 (en) 2006-04-05 2006-05-17 Council Cent Lab Res Councils Raman Analysis Of Pharmaceutical Tablets
WO2008011163A2 (en) * 2006-07-21 2008-01-24 Prescient Medical, Inc. Conformable tissue contact catheter
WO2008051950A2 (en) * 2006-10-23 2008-05-02 Prescient Medical Inc. Windowless fiber optic raman spectroscopy probes
US20120059254A1 (en) * 2007-03-14 2012-03-08 Wang Lifan Apparatus and method for phase-space reduction for imaging of fluorescing, scattering and/or absorbing structures
WO2008144600A1 (en) * 2007-05-17 2008-11-27 Prescient Medical, Inc. Multi-channel fiber optic spectroscopy systems employing integrated optics modules
WO2008154460A1 (en) * 2007-06-08 2008-12-18 Prescient Medical, Inc. Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry
US20090024040A1 (en) * 2007-07-20 2009-01-22 Prescient Medical, Inc. Wall-Contacting Intravascular Ultrasound Probe Catheters
US20090076395A1 (en) * 2007-09-19 2009-03-19 Prescient Medical, Inc. Optimized intravascular ultrasound probe catherers
SE531527C2 (sv) * 2007-10-01 2009-05-12 Bioresonator Ab Förfarande vid och en anordning för opåverkad materialundersökning
JP5198037B2 (ja) * 2007-11-02 2013-05-15 株式会社 資生堂 皮膚外用剤の有効性評価方法、有効性評価装置、及び有効性評価プログラム
WO2009137740A1 (en) * 2008-05-09 2009-11-12 Hugh Beckman Medical device for diagnosing and treating anomalous tissue and method for doing the same
US8416405B2 (en) 2008-08-08 2013-04-09 Chemimage Corporation Raman chemical imaging of implantable drug delivery devices
US20100113906A1 (en) * 2008-11-06 2010-05-06 Prescient Medical, Inc. Hybrid basket catheters
US20100317974A1 (en) * 2009-01-09 2010-12-16 Research Foundation Of The City University Of New York Detection of vulnerable plaques by raman spectroscopy
EP2416708B1 (de) * 2009-04-01 2019-05-08 Erasmus University Medical Center Rotterdam Verfahren zur bestimmung von ein oder mehr mutationen
WO2011063032A1 (en) * 2009-11-17 2011-05-26 Veralight, Inc. Method and apparatus to detect coronary artery calcification or disease
US8702321B2 (en) 2009-12-03 2014-04-22 Eric T. Marple Filtered fiber optic probe
US8175423B2 (en) * 2009-12-03 2012-05-08 Marple Eric T Filtered fiber optic probe
US8582096B2 (en) * 2009-12-18 2013-11-12 The Regents Of The University Of California System and method for efficient coherence anti-stokes raman scattering endoscopic and intravascular imaging and multimodal imaging
WO2011088580A1 (en) * 2010-01-22 2011-07-28 British Columbia Cancer Agency Branch Apparatus and methods for characterization of lung tissue by raman spectroscopy
DE102010052434A1 (de) * 2010-11-24 2012-05-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Überwachung einer kryokonservierten biologischen Probe
WO2012096689A1 (en) 2011-01-10 2012-07-19 Emvision Llc Fiber optic probes utilizing grin lenses for spatially precise optical spectroscopy
DE102011100507B4 (de) * 2011-04-29 2020-05-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Tragbares optisches Analysegerät
US20130310680A1 (en) 2012-05-21 2013-11-21 The Regents Of The University Of Colorado, A Body Corporate Three-dimensional optical imaging and therapy of prostate cancer
US9814448B2 (en) 2012-05-21 2017-11-14 Precision Biopsy, Inc. Three-dimensional optical imaging and therapy of prostate cancer
US10058284B2 (en) * 2012-12-21 2018-08-28 Volcano Corporation Simultaneous imaging, monitoring, and therapy
GB201301280D0 (en) * 2013-01-24 2013-03-06 Univ St Andrews Optical apparatus for use with a medical imager
GB201302886D0 (en) 2013-02-19 2013-04-03 Univ Singapore Diagnostic instrument and method
US10722292B2 (en) 2013-05-31 2020-07-28 Covidien Lp Surgical device with an end-effector assembly and system for monitoring of tissue during a surgical procedure
EP3019855A4 (de) * 2013-07-11 2017-03-01 Henry Ford Health System Vorrichtung und verfahren zum unterscheiden zwischen unterschiedlichen gewebetypen mit spezifischen ramanspektralbereichen
CN103645170B (zh) * 2013-12-03 2016-03-02 北京航空航天大学 一种利用拉曼光谱检测肿瘤性质的装置
GB201401727D0 (en) * 2014-01-31 2014-03-19 Univ Bristol A low background raman probe for optical biopsy of brain tissue
CN104155002B (zh) * 2014-07-17 2016-03-02 中国科学院遥感与数字地球研究所 扫描成像光谱仪系统
US11304604B2 (en) 2014-10-29 2022-04-19 Spectral Md, Inc. Reflective mode multi-spectral time-resolved optical imaging methods and apparatuses for tissue classification
US11154186B2 (en) 2015-07-31 2021-10-26 University Of Utah Research Foundation Devices, systems, and methods for imaging and treating a selected tissue
US10161870B2 (en) 2015-10-05 2018-12-25 Nxgen Partners Ip, Llc System and method for multi-parameter spectroscopy
KR102634161B1 (ko) * 2015-10-28 2024-02-05 스펙트랄 엠디, 인크. 조직 분류를 위한 반사 모드 멀티스펙트럴 시간 분해된 광학 이미징 방법들 및 장치들
WO2017111576A1 (en) 2015-12-21 2017-06-29 Erasmus University Medical Center Rotterdam Optical probe for measuring a tissue sample
CN108780042A (zh) * 2016-01-13 2018-11-09 尼克根合伙Ip有限责任公司 用于多参数光谱的系统和方法
WO2017126955A1 (en) 2016-01-18 2017-07-27 Erasmus University Medical Center Rotterdam Tissue sample analysis
EP3203215B1 (de) 2016-02-08 2019-08-14 Leibniz-Institut für Astrophysik Potsdam (AIP) Optische bildgebende spektroskopie von grossflächigen proben
CN105997000B (zh) * 2016-05-30 2023-04-14 福建师范大学 一种基于纤维内窥镜的拉曼光谱检测装置及其实现方法
JPWO2018116363A1 (ja) 2016-12-19 2019-10-24 オリンパス株式会社 ラマンプローブおよびラマンスペクトル測定装置
CN106770176A (zh) * 2016-12-26 2017-05-31 同方威视技术股份有限公司 拉曼光谱检测设备和拉曼光谱检测设备的安全监控方法
WO2018144648A1 (en) 2017-02-01 2018-08-09 University Of Utah Research Foundation Devices and methods for mapping cardiac tissue
EP3589191A4 (de) 2017-03-02 2020-11-11 Spectral MD Inc. Maschinenlernsysteme und verfahren für multispektrale amputationsstellenanalyse
WO2018195466A1 (en) 2017-04-20 2018-10-25 Henry Ford Health System System and method for characterization of a brain tissue sample using raman marker regions
US10684226B2 (en) 2018-03-09 2020-06-16 Samsung Electronics Co., Ltd. Raman probe, Raman spectrum obtaining apparatus, and method of obtaining Raman spectrum and detecting distribution of target material using Raman probe
CN112930470A (zh) 2018-09-04 2021-06-08 省卫生服务局 图像引导显微拉曼光谱分析
US10740884B2 (en) 2018-12-14 2020-08-11 Spectral Md, Inc. System and method for high precision multi-aperture spectral imaging
BR112021011113A2 (pt) 2018-12-14 2021-08-31 Spectral Md, Inc. Sistema e método para formação de imagem espectral de múltiplas aberturas de alta precisão
US10783632B2 (en) 2018-12-14 2020-09-22 Spectral Md, Inc. Machine learning systems and method for assessment, healing prediction, and treatment of wounds
WO2020123724A1 (en) 2018-12-14 2020-06-18 Spectral Md, Inc. Machine learning systems and methods for assessment, healing prediction, and treatment of wounds
JP2023507412A (ja) 2019-12-17 2023-02-22 ユニバーシティ オブ ユタ リサーチ ファウンデーション カテーテル挿入式光散乱分光法を用いた心臓組織性状診断
FI130864B1 (en) * 2020-02-03 2024-04-29 Spectrocor Oy Myocardial spectrometer probe
US20210298604A1 (en) * 2020-03-30 2021-09-30 TimeGate Instruments Oy Method and apparatus for measuring spectrum of raman-scattered light using time gated detection
US12038383B2 (en) 2021-03-05 2024-07-16 Cytoveris Inc. Method and system for identifying tissue type based on peak-fitted parameters in high-wavenumber Raman spectrum
US11821841B2 (en) 2021-03-05 2023-11-21 Cytoveris, Inc. System and method for classification of tissue based on Raman and fluorescence in high-wavenumber Raman spectrum
EP4372365A4 (de) * 2021-07-30 2025-04-23 Canon Kabushiki Kaisha Verfahren zur klassifizierung von zellen unter verwendung eines zellautofluoreszenzbildes und analysevorrichtung
CN116077016A (zh) * 2022-12-22 2023-05-09 四川大学 一种基于拉曼光谱和红外线光谱的便携式信息诊断装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318024A (en) * 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
EP0380586B1 (de) * 1987-09-24 1999-12-08 Massachusetts Institute Of Technology Kathetersystem zur abbildung
US6690966B1 (en) * 1991-02-26 2004-02-10 Massachusetts Institute Of Technology Methods of molecular spectroscopy to provide for the diagnosis of tissue
US5638172A (en) * 1994-05-27 1997-06-10 Eastman Chemical Company On-line quantitative analysis of chemical compositions by raman spectrometry
US5621522A (en) * 1995-04-05 1997-04-15 The United States Of America As Represented By The Secretary Of The Navy Fiber optic probe for determination of trace levels of organic pollutants using Raman spectroscopy
US5953477A (en) * 1995-11-20 1999-09-14 Visionex, Inc. Method and apparatus for improved fiber optic light management
CN1089165C (zh) * 1996-01-24 2002-08-14 大连理工大学 一种用激光诱导血清的自体荧光-喇曼光谱诊断癌症的设备
AU2534197A (en) * 1996-03-13 1997-10-01 Visionex, Inc. Method and apparatus for improved fiber optic light management
US5911017A (en) * 1996-07-31 1999-06-08 Visionex, Inc. Fiber optic interface for laser spectroscopic Raman probes
GB2338299A (en) 1997-03-14 1999-12-15 Rosemount Analytical Inc Improved Rayleigh backscatter control apparatus and method
US5864397A (en) * 1997-09-15 1999-01-26 Lockheed Martin Energy Research Corporation Surface-enhanced raman medical probes and system for disease diagnosis and drug testing
US6205272B1 (en) 1998-02-27 2001-03-20 Equitech Int'l Corp. Fiber optic probe for attenuated total internal reflection spectrophotometry
JP2000131145A (ja) * 1998-10-23 2000-05-12 Jasco Corp 分光分析装置
JP3992090B2 (ja) * 1999-01-11 2007-10-17 日本分光株式会社 ラマン分光用プローブ
US6623977B1 (en) * 1999-11-05 2003-09-23 Real-Time Analyzers, Inc. Material for surface-enhanced Raman spectroscopy, and SER sensors and method for preparing same

Also Published As

Publication number Publication date
EP1567852B1 (de) 2007-06-06
DE60314282T2 (de) 2008-03-20
WO2004051242A1 (en) 2004-06-17
EP1567852A1 (de) 2005-08-31
DK1567852T3 (da) 2007-08-06
DE60314282D1 (de) 2007-07-19
CN100533127C (zh) 2009-08-26
CN1745294A (zh) 2006-03-08
ES2289344T3 (es) 2008-02-01
AU2003285815A1 (en) 2004-06-23
JP4870356B2 (ja) 2012-02-08
JP2006508358A (ja) 2006-03-09
EP1821097A1 (de) 2007-08-22
US20060139633A1 (en) 2006-06-29
US7499153B2 (en) 2009-03-03

Similar Documents

Publication Publication Date Title
ATE364173T1 (de) Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe
Stevens et al. Developing fibre optic Raman probes for applications in clinical spectroscopy
US6006001A (en) Fiberoptic assembly useful in optical spectroscopy
US9804092B2 (en) Integrated spectral probe for raman, reflectance and fluorescence spectral measurements
US10531790B2 (en) Method and system of spectrally encoded imaging
Santos et al. Fiber-optic probes for in vivo Raman spectroscopy in the high-wavenumber region
JP3737579B2 (ja) 歯の状態の認識装置
US6069689A (en) Apparatus and methods relating to optical systems for diagnosis of skin diseases
US8804115B2 (en) Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe
US7184142B2 (en) Raman probe and Raman spectrum measuring apparatus utilizing the same
US20030156788A1 (en) Method and device for recognizing dental caries, plaque, concrements or bacterial attacks
WO2004064627B1 (en) In vivo raman endoscopic probe and methods of use
JP5476547B2 (ja) ラマン散乱測定装置
EP1196088A4 (de) Verfahren und gerät zum non-invasiven messen von karotenoiden und verwandten chemischen substanzen in biologischem gewebe
Iping Petterson et al. Characterisation of a fibre optic Raman probe within a hypodermic needle
Katagiri et al. High axial resolution Raman probe made of a single hollow optical fiber
Schulmerich et al. Transcutaneous Raman spectroscopy of bone tissue using a non-confocal fiber optic array probe
Ribeiro et al. A preliminary investigation of a spectroscopic technique for the diagnosis of natural caries lesions
Zeng et al. Raman spectroscopy for in vivo tissue analysis and diagnosis, from instrument development to clinical applications
JPWO2018116363A1 (ja) ラマンプローブおよびラマンスペクトル測定装置
US20090153852A1 (en) Optical fiber for spectroscopic analysis system
CN101903762B (zh) 光纤探针
CN216622169U (zh) 一种基于荧光和拉曼融合技术的皮肤组织光谱检测装置
CN108780041A (zh) 用于漫反射光谱法的便携式光学设备
JP2009233404A (ja) 非侵襲型生体成分の定量装置

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1567852

Country of ref document: EP