ATE360028T1 - Nicht-kovalente urokinase-und angiogenese- inhibitoren - Google Patents

Nicht-kovalente urokinase-und angiogenese- inhibitoren

Info

Publication number
ATE360028T1
ATE360028T1 AT00126874T AT00126874T ATE360028T1 AT E360028 T1 ATE360028 T1 AT E360028T1 AT 00126874 T AT00126874 T AT 00126874T AT 00126874 T AT00126874 T AT 00126874T AT E360028 T1 ATE360028 T1 AT E360028T1
Authority
AT
Austria
Prior art keywords
covalent
activity
compounds
urocinasis
angiogenesis inhibitors
Prior art date
Application number
AT00126874T
Other languages
English (en)
Inventor
Joseph Edward Semple
Michael I Weinhouse
Odile Ester Levy
Edwin L Madison
Original Assignee
Dendreon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dendreon Corp filed Critical Dendreon Corp
Application granted granted Critical
Publication of ATE360028T1 publication Critical patent/ATE360028T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00126874T 2000-08-11 2000-12-07 Nicht-kovalente urokinase-und angiogenese- inhibitoren ATE360028T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63748300A 2000-08-11 2000-08-11

Publications (1)

Publication Number Publication Date
ATE360028T1 true ATE360028T1 (de) 2007-05-15

Family

ID=24556134

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07006986T ATE517910T1 (de) 2000-08-11 2000-12-07 NICHT-KOVALENTE INHIBITOREN VON UROKINASE UND BLUTGEFÄßBILDUNG
AT00126874T ATE360028T1 (de) 2000-08-11 2000-12-07 Nicht-kovalente urokinase-und angiogenese- inhibitoren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07006986T ATE517910T1 (de) 2000-08-11 2000-12-07 NICHT-KOVALENTE INHIBITOREN VON UROKINASE UND BLUTGEFÄßBILDUNG

Country Status (8)

Country Link
US (1) US6586405B2 (de)
EP (2) EP1808440B1 (de)
KR (1) KR100879673B1 (de)
AT (2) ATE517910T1 (de)
DE (1) DE60034447T2 (de)
ES (1) ES2285989T3 (de)
IL (1) IL149042A (de)
ZA (1) ZA200202825B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638977B1 (en) 1999-11-19 2003-10-28 Corvas International, Inc. Plasminogen activator inhibitor antagonists
US7700341B2 (en) * 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
US7001887B2 (en) * 2001-02-02 2006-02-21 Chugai Seiyaku Kabushiki Kaisha Peptide derivatives
WO2002064140A1 (en) * 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
US7125703B2 (en) 2001-03-13 2006-10-24 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
EP1383884A4 (de) 2001-03-22 2004-12-15 Dendreon Corp Serinprotease cvsp14 codierende nukleinsäuremoleküle, die codierten polypeptide sowie darauf beruhende verfahren
WO2002077267A2 (en) 2001-03-27 2002-10-03 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon
KR20040080940A (ko) * 2001-05-14 2004-09-20 덴드레온 코포레이션 트랜스막 세린 프로테아제 10을 암호화하는 핵산 분자,암호화된 폴리펩티드 및 이에 근거한 방법
WO2003048127A1 (en) * 2001-12-04 2003-06-12 Corvas International, Inc. Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
ATE399175T1 (de) * 2002-03-11 2008-07-15 Curacyte Ag Hemmstoffe der urokinase, ihre herstellung und verwendung
US7019019B2 (en) * 2002-12-23 2006-03-28 Dendreon Corporation Matriptase inhibitors and methods of use
DE10301300B4 (de) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10323898A1 (de) * 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe
DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
US7252834B2 (en) * 2005-04-25 2007-08-07 Clemson University Research Foundation (Curf) Elastin stabilization of connective tissue
DE602006009257D1 (de) 2005-06-24 2009-10-29 Wilex Ag Verwendung von urokinase-inhibitoren zur behandlunklerose (als)
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
WO2008148057A2 (en) 2007-05-23 2008-12-04 Vical Incorporated Cationic lipids compositions and methods for enhancing immune responses to vaccines
US20090155337A1 (en) * 2007-11-12 2009-06-18 Endologix, Inc. Method and agent for in-situ stabilization of vascular tissue
US20100261662A1 (en) * 2009-04-09 2010-10-14 Endologix, Inc. Utilization of mural thrombus for local drug delivery into vascular tissue
DE102009022794A1 (de) * 2009-05-27 2010-12-02 Philipps-Universität Marburg Verwendung von Hemmstoffen der HAT und TMPRSS2 als Arzneimittel
WO2011044455A1 (en) * 2009-10-09 2011-04-14 Vatrix Medical, Inc. In vivo chemical stabilization of vulnerable plaque
ES2483802T3 (es) 2010-07-07 2014-08-07 The Medicines Company (Leipzig) Gmbh Inhibidores de serina proteasa
US8911468B2 (en) 2011-01-31 2014-12-16 Vatrix Medical, Inc. Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection
WO2012158944A1 (en) 2011-05-18 2012-11-22 Vatrix Medical, Inc. Coated balloons for blood vessel stabilization
US9283241B2 (en) 2012-07-10 2016-03-15 Clemson University Treatment to render implants resistant to diabetes
EP2960232A1 (de) * 2014-06-25 2015-12-30 DSM IP Assets B.V. Verfahren zur Herstellung eines Dipeptidderivats
US9777116B2 (en) 2014-10-16 2017-10-03 International Business Machines Corporation Porous/nanoporous PHT
CN113135842A (zh) * 2018-09-25 2021-07-20 四川什邡市三高生化实业有限公司 一种o-叔丁基-l-丝氨酸甲酯及o-叔丁基-l-丝氨酸水溶液的制备方法
JP2022541398A (ja) * 2019-07-08 2022-09-26 リゾルート，インコーポレイティド 血漿カリクレイン阻害薬の調製プロセス
KR20220050942A (ko) * 2019-08-21 2022-04-25 칼비스타 파마슈티컬즈 리미티드 효소 저해제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
CA2140598C (en) 1994-01-27 2010-03-09 Masahiro Ohshima Prolineamide derivatives
DE4443390A1 (de) * 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
KR19980702112A (ko) 1995-02-10 1998-07-15 페라 스타르크,요헨 카르크 트롬빈 억제제
US6576613B1 (en) * 1998-07-24 2003-06-10 Corvas International, Inc. Title inhibitors of urokinase
SK14232001A3 (sk) 1999-04-09 2002-06-04 Basf Aktiengesellschaft Nízkomolekulové inhibítory komplementárnych proteáz
DE10029014A1 (de) 2000-06-15 2001-12-20 Univ Schiller Jena Urokinase-Hemmstoffe
DE10029015A1 (de) * 2000-06-15 2001-12-20 Curacyte Ag Hemmstoffe für den Gerinnungsfaktor Xa

Also Published As

Publication number Publication date
EP1182207A3 (de) 2002-09-04
EP1182207A2 (de) 2002-02-27
US20020037857A1 (en) 2002-03-28
ES2285989T3 (es) 2007-12-01
KR20020063562A (ko) 2002-08-03
IL149042A (en) 2011-01-31
EP1808440A1 (de) 2007-07-18
ZA200202825B (en) 2003-07-10
EP1182207B1 (de) 2007-04-18
DE60034447D1 (de) 2007-05-31
DE60034447T2 (de) 2008-02-14
KR100879673B1 (ko) 2009-01-21
ATE517910T1 (de) 2011-08-15
EP1808440B1 (de) 2011-07-27
US6586405B2 (en) 2003-07-01

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