ATE356797T1 - Azidfreies verfahren zur herstellung von 1,2- diaminoverbindungen - Google Patents

Azidfreies verfahren zur herstellung von 1,2- diaminoverbindungen

Info

Publication number
ATE356797T1
ATE356797T1 AT04718940T AT04718940T ATE356797T1 AT E356797 T1 ATE356797 T1 AT E356797T1 AT 04718940 T AT04718940 T AT 04718940T AT 04718940 T AT04718940 T AT 04718940T AT E356797 T1 ATE356797 T1 AT E356797T1
Authority
AT
Austria
Prior art keywords
sup
azide
producing
diamine compounds
free process
Prior art date
Application number
AT04718940T
Other languages
English (en)
Inventor
Jack D Brown
Peter John Harrington
Robert C Hughes
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE356797T1 publication Critical patent/ATE356797T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/90—Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
    • C07C211/50—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton with at least two amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04718940T 2003-03-13 2004-03-10 Azidfreies verfahren zur herstellung von 1,2- diaminoverbindungen ATE356797T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/388,064 US7122684B2 (en) 2003-03-13 2003-03-13 Process for preparing 1,2-diamino compounds

Publications (1)

Publication Number Publication Date
ATE356797T1 true ATE356797T1 (de) 2007-04-15

Family

ID=32962044

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04718940T ATE356797T1 (de) 2003-03-13 2004-03-10 Azidfreies verfahren zur herstellung von 1,2- diaminoverbindungen

Country Status (13)

Country Link
US (1) US7122684B2 (de)
EP (1) EP1606242B1 (de)
JP (1) JP4237224B2 (de)
KR (1) KR100724170B1 (de)
CN (1) CN100545145C (de)
AT (1) ATE356797T1 (de)
CA (1) CA2517458C (de)
DE (1) DE602004005323T2 (de)
DK (1) DK1606242T3 (de)
ES (1) ES2282851T3 (de)
MX (1) MXPA05009668A (de)
TW (1) TWI351394B (de)
WO (1) WO2004080944A1 (de)

Families Citing this family (27)

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WO2007077570A1 (en) * 2006-01-02 2007-07-12 Hetero Drugs Limited Process for obtaining pure oseltamivir
US20080009639A1 (en) * 2006-07-10 2008-01-10 Apotex Pharmachem Inc. Preparation of oseltamivir phosphate (Tamiflu) and intermediates starting from D-glucose or D-xylose
AU2008261076B2 (en) * 2007-06-05 2013-10-24 Akzo Nobel Coatings Inc. Radiation curable coating composition derived from epoxidized vegetable oils
MX2011009155A (es) 2009-03-05 2011-10-10 Akzo Nobel Coatings Int Bv Copolimeros insertados de acrilico de poliol de aceite con funcion de hidroxilo.
CN102267961B (zh) * 2010-06-02 2013-10-02 上海迪赛诺医药发展有限公司 制备(3r,4r,5s)-4,5-环氧基-3-(1-乙基丙氧基)-1-环己烯-1-甲酸乙酯的方法
CA2822527C (en) 2010-12-28 2019-07-02 Akzo Nobel Coatings International B.V. Radiation curable coating compositions for metal
EP2794703B1 (de) 2011-12-21 2016-07-20 Akzo Nobel Coatings International B.V. Beschichtungszusammensetzungen auf lösungsmittelbasis
ES2629692T3 (es) 2011-12-21 2017-08-14 Akzo Nobel Coatings International B.V. Composiciones de revestimiento basadas en agua
CN103304437B (zh) * 2013-05-16 2015-07-01 广州同隽医药科技有限公司 一种无叠氮合成磷酸奥司他韦的方法
RU2639158C1 (ru) * 2016-07-01 2017-12-20 Общество с ограниченной ответственностью Научно-производственный центр "Химические технологии" Этил (3s,4r,5s)-4-ацетамидо-5-амино-3-(1-этилпропокси)циклогекс-1-ен-1-карбоксилата этоксисукцинат в качестве противовирусного препарата и способ его получения
WO2018233562A1 (zh) * 2017-06-20 2018-12-27 广东东阳光药业有限公司 一种奥司他韦及其异构体的制备方法
CN109627180B (zh) * 2018-12-29 2021-07-30 博瑞生物医药（苏州）股份有限公司 磷酸奥司他韦的制备方法
CN109574869B (zh) * 2018-12-29 2021-11-05 博瑞生物医药（苏州）股份有限公司 一种磷酸奥司他韦的制备方法
CN111978195B (zh) * 2019-05-23 2023-04-28 好医生药业集团有限公司 奥司他韦的合成方法
US12492164B2 (en) 2019-10-25 2025-12-09 Northwestern University Fluorine substituted cyclohexene analogues of gamma-aminobutyric acid (GABA)
CN113024396B (zh) * 2019-12-25 2024-01-30 上海奥博生物医药股份有限公司 一种奥司他韦的制备方法及其中间体
CN111153818B (zh) * 2020-03-13 2023-03-28 遂成药业股份有限公司 一种制备抗病毒药物达菲中间体叔丁胺衍生物i的方法
CN111253276B (zh) * 2020-03-30 2021-01-08 宜昌东阳光长江药业股份有限公司 一种磷酸奥司他韦的制备方法
CN111747861A (zh) * 2020-06-16 2020-10-09 宜昌东阳光长江药业股份有限公司 一种叠氮工艺制备磷酸奥司他韦的方法
CN113277957A (zh) * 2021-05-29 2021-08-20 弘健制药(上海)有限公司 一种磷酸奥司他韦关键中间体盐酸盐的制备方法
CN113307744A (zh) * 2021-05-29 2021-08-27 弘健制药(上海)有限公司 一种磷酸奥司他韦的制备方法
CN113549033A (zh) * 2021-07-29 2021-10-26 福建省福抗药业股份有限公司 一种高纯度的奥司他韦磷酸盐的中间体5的结晶方法
CN114478290A (zh) * 2022-01-24 2022-05-13 广东中润药物研发有限公司 奥司他韦中间体的合成方法
CN116693719A (zh) * 2022-09-06 2023-09-05 湖南津安生物科技有限公司 一种新型的超高阳离子生物高分子及其合成方法
CN115490591A (zh) * 2022-09-29 2022-12-20 浙江普洛康裕制药有限公司 一种磷酸奥司他韦中间体杂质化合物及其制备方法和用途
CN118206464A (zh) 2022-12-15 2024-06-18 浙江华海药业股份有限公司 一种奥司他韦中间体的制备方法
CN115850102A (zh) * 2022-12-29 2023-03-28 浙江工业大学 一种奥司他韦的制备方法

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
DE1593775A1 (de) 1967-04-13 1971-03-25 Basf Ag Verfahren zur Herstellung von 1,2-Diaminen
US5866601A (en) 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
CN100409844C (zh) 1995-02-27 2008-08-13 吉里德科学公司 神经氨酸苷酶抑制剂
US5763483A (en) 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US6518438B2 (en) * 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
ES2173480T3 (es) 1996-08-23 2002-10-16 Gilead Sciences Inc Preparacion de derivados de ciclohexeno carboxilato.
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US5994377A (en) 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
US5886213A (en) 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
JP2001516739A (ja) 1997-09-17 2001-10-02 ギリアード サイエンシーズ， インコーポレイテッド ６員環を含む化合物、それらの調製プロセス、および医薬としてのそれらの使用
ES2198244T3 (es) 1999-06-11 2004-02-01 F. Hoffmann-La Roche Ag Procedimiento para la preparacion de inhibidor ro-64-0796 de la neuraminidasa.
BR0010525A (pt) 1999-10-19 2002-11-26 Abbott Lab cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidase
US6403824B2 (en) 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
US6518048B2 (en) * 2000-04-10 2003-02-11 Hoffmann-La Roche Inc. Stereo-specific synthesis of shimikic acid derivatives with improved efficiency

Also Published As

Publication number Publication date
JP2006521305A (ja) 2006-09-21
US7122684B2 (en) 2006-10-17
EP1606242B1 (de) 2007-03-14
DE602004005323D1 (de) 2007-04-26
CN100545145C (zh) 2009-09-30
TWI351394B (en) 2011-11-01
EP1606242A1 (de) 2005-12-21
CA2517458C (en) 2011-04-19
CN1759093A (zh) 2006-04-12
JP4237224B2 (ja) 2009-03-11
WO2004080944A1 (en) 2004-09-23
KR20050107796A (ko) 2005-11-15
DK1606242T3 (da) 2007-07-23
TW200424148A (en) 2004-11-16
MXPA05009668A (es) 2005-10-20
ES2282851T3 (es) 2007-10-16
CA2517458A1 (en) 2004-09-23
DE602004005323T2 (de) 2008-02-21
KR100724170B1 (ko) 2007-05-31
US20040180933A1 (en) 2004-09-16

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