ATE356223T1 - Gen und protein mit bezug zu hepatozellulärem karzinom - Google Patents
Gen und protein mit bezug zu hepatozellulärem karzinomInfo
- Publication number
- ATE356223T1 ATE356223T1 AT02765617T AT02765617T ATE356223T1 AT E356223 T1 ATE356223 T1 AT E356223T1 AT 02765617 T AT02765617 T AT 02765617T AT 02765617 T AT02765617 T AT 02765617T AT E356223 T1 ATE356223 T1 AT E356223T1
- Authority
- AT
- Austria
- Prior art keywords
- gene
- hepatocellular carcinoma
- protein related
- protein
- domain
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 title 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 title 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 abstract 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 abstract 1
- 101000708574 Homo sapiens Histone-lysine N-methyltransferase SMYD3 Proteins 0.000 abstract 1
- 108090000944 RNA Helicases Proteins 0.000 abstract 1
- 102000004409 RNA Helicases Human genes 0.000 abstract 1
- 102000051614 SET domains Human genes 0.000 abstract 1
- 108700039010 SET domains Proteins 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 210000005228 liver tissue Anatomy 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32426101P | 2001-09-25 | 2001-09-25 | |
| US39166602P | 2002-06-26 | 2002-06-26 | |
| CA 2399569 CA2399569A1 (en) | 2001-09-25 | 2002-08-23 | Diagnostic markers and drug targets for treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356223T1 true ATE356223T1 (de) | 2007-03-15 |
Family
ID=27171637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02765617T ATE356223T1 (de) | 2001-09-25 | 2002-09-25 | Gen und protein mit bezug zu hepatozellulärem karzinom |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7767392B2 (https=) |
| EP (1) | EP1430152B1 (https=) |
| JP (1) | JP4353798B2 (https=) |
| CN (1) | CN1628179B (https=) |
| AT (1) | ATE356223T1 (https=) |
| AU (1) | AU2002329061A1 (https=) |
| DE (1) | DE60218710T2 (https=) |
| ES (1) | ES2283592T3 (https=) |
| WO (1) | WO2003027143A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628179B (zh) | 2001-09-25 | 2011-04-20 | 肿瘤疗法科学股份有限公司 | 肝细胞癌的检测 |
| CA2399569A1 (en) | 2001-09-25 | 2003-03-25 | Yusuke Nakamura | Diagnostic markers and drug targets for treatment of cancer |
| DE602004032114D1 (de) * | 2003-02-28 | 2011-05-19 | Oncotherapy Science Inc | Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen |
| CN1890382A (zh) * | 2003-09-24 | 2007-01-03 | 肿瘤疗法科学股份有限公司 | 检测、诊断和治疗肝细胞癌(hcc)的方法 |
| TWI350373B (en) * | 2004-01-23 | 2011-10-11 | Oncotherapy Science Inc | Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators |
| US20060189560A1 (en) * | 2005-01-27 | 2006-08-24 | Ajit Kumar | Molecular method to augment RNA mediated gene silencing |
| WO2006092958A1 (en) * | 2005-02-28 | 2006-09-08 | Oncotherapy Science, Inc. | Breast cancer related gene znfn3a1 |
| WO2006121208A1 (en) * | 2005-05-12 | 2006-11-16 | Oncotherapy Science, Inc. | Polymorphisms of the e2f-1 binding element and methods of determining cancer susceptibility |
| TW200741009A (en) * | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| EP2171082B1 (en) | 2007-06-14 | 2012-11-28 | Oncotherapy Science, Inc. | Methods of identifying agents that modulate methylation of vegfr1 by smyd3 |
| CN102356316B (zh) | 2009-03-05 | 2015-07-08 | 独立行政法人产业技术综合研究所 | 肝内胆管癌的检出、辨别方法 |
| WO2011011366A2 (en) * | 2009-07-20 | 2011-01-27 | Constellation Pharmaceuticals | Agents for stimulating activity of methyl modifying enzymes and methods of use thereof |
| EP2785870B1 (en) | 2011-12-02 | 2017-05-03 | OncoTherapy Science, Inc. | Smyd2 as a target gene for cancer therapy and diagnosis |
| WO2014141652A1 (en) * | 2013-03-11 | 2014-09-18 | Oncotherapy Science, Inc. | Smyd3 peptides and vaccines containing the same |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999039200A1 (en) | 1998-01-29 | 1999-08-05 | Thomas Jefferson University | Molecular markers for diagnosing hepatocellular carcinoma |
| US6783961B1 (en) | 1999-02-26 | 2004-08-31 | Genset S.A. | Expressed sequence tags and encoded human proteins |
| WO2000017355A2 (en) | 1998-09-18 | 2000-03-30 | Incyte Pharmaceuticals, Inc. | Human cytoskeleton associated proteins |
| JP2003521231A (ja) * | 1999-01-29 | 2003-07-15 | インサイト・ファーマスーティカルズ・インコーポレイテッド | 核酸結合タンパク質 |
| CA2296792A1 (en) | 1999-02-26 | 2000-08-26 | Genset S.A. | Expressed sequence tags and encoded human proteins |
| WO2001029221A2 (en) | 1999-10-20 | 2001-04-26 | Zymogenetics, Inc. | Proteins and polynucleotides encoding them |
| AU783762B2 (en) | 1999-12-23 | 2005-12-01 | Arca Biopharma, Inc. | Methods and materials relating to prothrombinase-like polypeptides and polynucleotides |
| EP1591448A3 (en) | 2000-04-18 | 2006-01-11 | Nuvelo, Inc. | Novel nucleic acids and polypeptides |
| JP2005503760A (ja) | 2001-01-24 | 2005-02-10 | プロテイン デザイン ラブス， インコーポレイテッド | 乳癌の診断方法、組成物および乳癌のモジュレーターのスクリーニング方法 |
| GB0111218D0 (en) | 2001-05-08 | 2001-06-27 | Cancer Res Ventures Ltd | Assays methods and means |
| US6989245B2 (en) | 2001-05-11 | 2006-01-24 | The Burnham Institute | Screening, diagnostic and therapeutic methods relating to RIZ |
| DK2280070T3 (en) | 2001-07-23 | 2015-08-24 | Univ Leland Stanford Junior | Methods and compositions for use in RNAi-mediated inhibition of gene expression in mammals |
| CA2399569A1 (en) | 2001-09-25 | 2003-03-25 | Yusuke Nakamura | Diagnostic markers and drug targets for treatment of cancer |
| CN1628179B (zh) * | 2001-09-25 | 2011-04-20 | 肿瘤疗法科学股份有限公司 | 肝细胞癌的检测 |
| US8003315B2 (en) * | 2001-12-13 | 2011-08-23 | Exelixis, Inc. | TAOJIKs as modifiers of the beta-catenin pathway and methods of use |
| DE602004032114D1 (de) | 2003-02-28 | 2011-05-19 | Oncotherapy Science Inc | Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen |
| TWI350373B (en) | 2004-01-23 | 2011-10-11 | Oncotherapy Science Inc | Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators |
| WO2006092958A1 (en) | 2005-02-28 | 2006-09-08 | Oncotherapy Science, Inc. | Breast cancer related gene znfn3a1 |
| TW200741009A (en) | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| EP2171082B1 (en) | 2007-06-14 | 2012-11-28 | Oncotherapy Science, Inc. | Methods of identifying agents that modulate methylation of vegfr1 by smyd3 |
-
2002
- 2002-09-25 CN CN028234014A patent/CN1628179B/zh not_active Expired - Fee Related
- 2002-09-25 DE DE2002618710 patent/DE60218710T2/de not_active Expired - Lifetime
- 2002-09-25 EP EP02765617A patent/EP1430152B1/en not_active Expired - Lifetime
- 2002-09-25 JP JP2003530730A patent/JP4353798B2/ja not_active Expired - Fee Related
- 2002-09-25 ES ES02765617T patent/ES2283592T3/es not_active Expired - Lifetime
- 2002-09-25 WO PCT/JP2002/009876 patent/WO2003027143A2/en not_active Ceased
- 2002-09-25 AT AT02765617T patent/ATE356223T1/de not_active IP Right Cessation
- 2002-09-25 AU AU2002329061A patent/AU2002329061A1/en not_active Abandoned
-
2004
- 2004-02-27 US US10/788,847 patent/US7767392B2/en not_active Expired - Fee Related
-
2010
- 2010-03-19 US US12/727,370 patent/US8148080B2/en not_active Expired - Fee Related
-
2012
- 2012-02-23 US US13/403,623 patent/US20120149762A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003027143A3 (en) | 2003-10-30 |
| US20040235018A1 (en) | 2004-11-25 |
| JP4353798B2 (ja) | 2009-10-28 |
| CN1628179B (zh) | 2011-04-20 |
| WO2003027143A2 (en) | 2003-04-03 |
| DE60218710D1 (de) | 2007-04-19 |
| AU2002329061A1 (en) | 2003-04-07 |
| US7767392B2 (en) | 2010-08-03 |
| EP1430152A2 (en) | 2004-06-23 |
| US20120149762A1 (en) | 2012-06-14 |
| EP1430152B1 (en) | 2007-03-07 |
| US8148080B2 (en) | 2012-04-03 |
| US20100248240A1 (en) | 2010-09-30 |
| DE60218710T2 (de) | 2007-12-06 |
| CN1628179A (zh) | 2005-06-15 |
| JP2005511023A (ja) | 2005-04-28 |
| ES2283592T3 (es) | 2007-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |