ATE348149T1 - Isolated islets, comprising insulin producing cells, coated with heparin - Google Patents
Isolated islets, comprising insulin producing cells, coated with heparinInfo
- Publication number
- ATE348149T1 ATE348149T1 AT00906843T AT00906843T ATE348149T1 AT E348149 T1 ATE348149 T1 AT E348149T1 AT 00906843 T AT00906843 T AT 00906843T AT 00906843 T AT00906843 T AT 00906843T AT E348149 T1 ATE348149 T1 AT E348149T1
- Authority
- AT
- Austria
- Prior art keywords
- producing cells
- heparin
- coated
- insulin producing
- isolated islets
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title 1
- 229960002897 heparin Drugs 0.000 title 1
- 229920000669 heparin Polymers 0.000 title 1
- 238000002054 transplantation Methods 0.000 abstract 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000035602 clotting Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000004153 islets of langerhan Anatomy 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9900398A SE523817C2 (sv) | 1999-02-05 | 1999-02-05 | Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE348149T1 true ATE348149T1 (de) | 2007-01-15 |
Family
ID=20414376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00906843T ATE348149T1 (de) | 1999-02-05 | 2000-02-04 | Isolated islets, comprising insulin producing cells, coated with heparin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7981873B1 (de) |
| EP (1) | EP1171156B1 (de) |
| JP (1) | JP2003501346A (de) |
| AT (1) | ATE348149T1 (de) |
| AU (1) | AU769063B2 (de) |
| CA (1) | CA2361949C (de) |
| DE (1) | DE60032346T2 (de) |
| SE (1) | SE523817C2 (de) |
| WO (1) | WO2000045837A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0200198D0 (sv) | 2002-01-23 | 2002-01-23 | Astrazeneca Ab | New use |
| US20060275274A1 (en) * | 2003-03-26 | 2006-12-07 | Daria Onichtchouk | Use of saposin-related proteins for preventing and treating obesity, diabetes and/or metabolic syndrome |
| CA2612621C (en) * | 2005-07-01 | 2014-11-18 | Corline Systems Ab | Heparin coating of biological tissue |
| SE530716C2 (sv) * | 2006-10-06 | 2008-08-19 | Corline Systems Ab | Molekylärt aggregat på ett substrat |
| CA2792610A1 (en) * | 2010-03-12 | 2011-09-15 | The Australian National University | Heparan sulfate replacement therapy |
| US9795629B2 (en) | 2011-12-22 | 2017-10-24 | Corline Systems Ab | Aqueous solution comprising a macromolecular conjugate of heparin for the treatment of blood vessels |
| WO2017149391A1 (en) * | 2016-03-02 | 2017-09-08 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | The use of antithrombin for coating organs during transplantation |
| WO2024205479A1 (en) | 2023-03-30 | 2024-10-03 | Corline Biomedical Ab | Heparin-functionalized surface, method for its preparation and use thereof |
| EP4688028A1 (de) | 2023-03-30 | 2026-02-11 | Corline Biomedical AB | Verfahren zur bereitstellung einer verbesserten heparinfunktionalisierten oberfläche |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135916A (en) | 1989-06-12 | 1992-08-04 | Oklahoma Medical Research Foundation | Inhibition of complement mediated inflammatory response |
| ATE139562T1 (de) * | 1989-10-12 | 1996-07-15 | Imutran Ltd | Modifiziertes biologisches material |
| SE470006B (sv) | 1991-09-26 | 1993-10-25 | Corline Systems Ab | Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet |
| JPH07503943A (ja) * | 1991-10-29 | 1995-04-27 | クローバー コンソリデイテッド，リミテッド | 封入及び薬剤放出に有用な架橋性の多糖類、ポリカチオン及び脂質 |
| DK0641222T3 (da) | 1992-05-21 | 2000-12-11 | Diatide Inc | Peptider mærket med technetium-99m til trombeafbildning |
| AU721737B2 (en) | 1995-09-27 | 2000-07-13 | Bristol-Myers Squibb Company | Method of inhibiting immune system destruction of transplanted viable cells |
| DE19623440A1 (de) * | 1996-06-12 | 1997-12-18 | Wagner Karl Heinz Dr Med | Immobilisiertes organisches Material mit definiertem Wirkstoff-Release |
| US6423316B1 (en) | 1997-03-26 | 2002-07-23 | Imperial College Innovative Limited | Anticoagulant fusion protein anchored to cell membrane |
-
1999
- 1999-02-05 SE SE9900398A patent/SE523817C2/sv not_active IP Right Cessation
-
2000
- 2000-02-04 AU AU28399/00A patent/AU769063B2/en not_active Ceased
- 2000-02-04 EP EP00906843A patent/EP1171156B1/de not_active Expired - Lifetime
- 2000-02-04 AT AT00906843T patent/ATE348149T1/de not_active IP Right Cessation
- 2000-02-04 WO PCT/SE2000/000223 patent/WO2000045837A1/en not_active Ceased
- 2000-02-04 JP JP2000596956A patent/JP2003501346A/ja active Pending
- 2000-02-04 US US09/890,936 patent/US7981873B1/en not_active Expired - Fee Related
- 2000-02-04 CA CA2361949A patent/CA2361949C/en not_active Expired - Fee Related
- 2000-02-04 DE DE60032346T patent/DE60032346T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| SE9900398D0 (sv) | 1999-02-05 |
| EP1171156B1 (de) | 2006-12-13 |
| SE523817C2 (sv) | 2004-05-18 |
| EP1171156A1 (de) | 2002-01-16 |
| US7981873B1 (en) | 2011-07-19 |
| WO2000045837A1 (en) | 2000-08-10 |
| CA2361949C (en) | 2010-08-03 |
| JP2003501346A (ja) | 2003-01-14 |
| DE60032346T2 (de) | 2007-07-19 |
| CA2361949A1 (en) | 2000-08-10 |
| AU769063B2 (en) | 2004-01-15 |
| DE60032346D1 (en) | 2007-01-25 |
| SE9900398L (sv) | 2000-08-06 |
| AU2839900A (en) | 2000-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |