ATE346154T1 - G-beta-gamma regulierte phosphatidylinositil-3' kinase - Google Patents

G-beta-gamma regulierte phosphatidylinositil-3' kinase

Info

Publication number
ATE346154T1
ATE346154T1 AT97931459T AT97931459T ATE346154T1 AT E346154 T1 ATE346154 T1 AT E346154T1 AT 97931459 T AT97931459 T AT 97931459T AT 97931459 T AT97931459 T AT 97931459T AT E346154 T1 ATE346154 T1 AT E346154T1
Authority
AT
Austria
Prior art keywords
proteins
kinase
enzyme
protein
subunit
Prior art date
Application number
AT97931459T
Other languages
English (en)
Inventor
Len Stephens
Phillip T Hawkins
Sylvia Braselmann
Original Assignee
Onyx Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onyx Pharma Inc filed Critical Onyx Pharma Inc
Application granted granted Critical
Publication of ATE346154T1 publication Critical patent/ATE346154T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/9121Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/829Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
AT97931459T 1996-06-27 1997-06-26 G-beta-gamma regulierte phosphatidylinositil-3' kinase ATE346154T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/672,211 US5874273A (en) 1996-06-27 1996-06-27 G-beta-gamma regulated phosphatidylinositol-3' kinase

Publications (1)

Publication Number Publication Date
ATE346154T1 true ATE346154T1 (de) 2006-12-15

Family

ID=24697610

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931459T ATE346154T1 (de) 1996-06-27 1997-06-26 G-beta-gamma regulierte phosphatidylinositil-3' kinase

Country Status (12)

Country Link
US (6) US5874273A (de)
EP (2) EP1676918A3 (de)
JP (1) JP4240537B2 (de)
CN (1) CN1306576A (de)
AT (1) ATE346154T1 (de)
AU (1) AU722324B2 (de)
CA (1) CA2259143C (de)
DE (1) DE69736983T2 (de)
DK (1) DK0939821T3 (de)
ES (1) ES2278392T3 (de)
PT (1) PT939821E (de)
WO (1) WO1997049818A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2242311A1 (en) * 1997-09-01 1999-03-01 Smithkline Beecham P.L.C. Novel compounds
US6238886B1 (en) 1998-02-16 2001-05-29 Smithkline Beecham Plc Compounds
JP2002503470A (ja) * 1998-02-16 2002-02-05 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー P101タンパク質のスプライス変異体
WO2000011143A1 (en) * 1998-08-24 2000-03-02 Smithkline Beecham Plc Human phosphatidylinositol 3-kinase regulatory p101 subunit (ec 2.7.1.137)
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
GB9903416D0 (en) * 1999-02-15 1999-04-07 Smithkline Beecham Plc Novel compounds
GB9908897D0 (en) * 1999-04-19 1999-06-16 Smithkline Beecham Plc Novel compounds
AU770402B2 (en) * 1999-10-20 2004-02-19 Qiagen North American Holdings, Inc. Mixing and pouring apparatus with rotatable arm and related vessel
IL135310A0 (en) * 2000-03-28 2001-05-20 Compugen Ltd Novel nucleic acid and amino acid sequences
US20030044803A1 (en) * 2000-09-22 2003-03-06 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of JAK1
US20030077590A1 (en) * 2000-09-22 2003-04-24 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of neurogranin
MXPA03011376A (es) 2001-06-11 2004-04-05 Applied Research Systems Pruebas de proximidad de cintilacion para moleculas aglutinantes de aminoglicosido (abms).
US20070098728A1 (en) * 2001-09-24 2007-05-03 Pedersen Finn S Novel compositions and methods in cancer
US6933246B2 (en) * 2002-06-14 2005-08-23 Trikon Technologies Limited Dielectric film
WO2004005532A2 (en) * 2002-07-10 2004-01-15 Massachusetts Institute Of Technology Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans
US8569229B2 (en) 2008-02-07 2013-10-29 The Children's Hospital Of Philadelphia Compositions and methods which modulate G-protein signaling for the treatment of inflammatory disorders such as asthma and allergic conjunctivitis
EP2255189B8 (de) * 2008-02-07 2015-05-06 Michael M. Grunstein Zusammensetzungen und verfahren, die die g-protein-signalgebung modulieren, zur behandlung von asthma
JP2013006772A (ja) * 2009-10-14 2013-01-10 Hokkaido Univ ウイルスの感染を抑制する物質のスクリーニング方法およびウイルス感染抑制剤
US20140113869A1 (en) * 2011-06-13 2014-04-24 Albert Einstein College Of Medicine Of Yeshiva University Gbetagamma BINDING SITE ON THE PIK3CB GENE PRODUCT AND METHODS OF USE
CN108559715A (zh) * 2018-04-19 2018-09-21 西南大学 筛选与G蛋白βγ二聚体相互作用蛋白质的酵母转化子及其筛选方法
CN117813120A (zh) * 2021-06-07 2024-04-02 旗舰先锋创新Vii有限责任公司 用于靶向递送治疗剂的组合物和方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9208135D0 (en) * 1992-04-13 1992-05-27 Ludwig Inst Cancer Res Polypeptides having kinase activity,their preparation and use
CA2202519C (en) * 1994-10-13 2012-12-11 Borislav Stoyanov Cloning, expression and characterization of a new form of phosphatidylinositol-3-kinase

Also Published As

Publication number Publication date
US5859201A (en) 1999-01-12
US5856133A (en) 1999-01-05
DE69736983T2 (de) 2007-07-26
WO1997049818A2 (en) 1997-12-31
AU722324B2 (en) 2000-07-27
AU3508397A (en) 1998-01-14
JP4240537B2 (ja) 2009-03-18
CN1306576A (zh) 2001-08-01
WO1997049818A3 (en) 1998-02-26
EP1676918A2 (de) 2006-07-05
ES2278392T3 (es) 2007-08-01
US5869271A (en) 1999-02-09
US5856132A (en) 1999-01-05
CA2259143A1 (en) 1997-12-31
CA2259143C (en) 2010-05-18
US5874273A (en) 1999-02-23
EP0939821B1 (de) 2006-11-22
DK0939821T3 (da) 2007-03-26
EP1676918A3 (de) 2006-07-12
JP2000511062A (ja) 2000-08-29
US6017763A (en) 2000-01-25
DE69736983D1 (de) 2007-01-04
EP0939821A2 (de) 1999-09-08
PT939821E (pt) 2007-02-28

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