ATE343591T1 - Antagonist für die multimerisierung von hiv-1 vif-protein - Google Patents

Antagonist für die multimerisierung von hiv-1 vif-protein

Info

Publication number
ATE343591T1
ATE343591T1 AT02764001T AT02764001T ATE343591T1 AT E343591 T1 ATE343591 T1 AT E343591T1 AT 02764001 T AT02764001 T AT 02764001T AT 02764001 T AT02764001 T AT 02764001T AT E343591 T1 ATE343591 T1 AT E343591T1
Authority
AT
Austria
Prior art keywords
vif
multimerization
hiv
antagonist
multimerization domain
Prior art date
Application number
AT02764001T
Other languages
German (de)
English (en)
Inventor
Hui Zhang
Roger Pomerantz
Bin Yang
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Application granted granted Critical
Publication of ATE343591T1 publication Critical patent/ATE343591T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02764001T 2001-04-06 2002-04-08 Antagonist für die multimerisierung von hiv-1 vif-protein ATE343591T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28227001P 2001-04-06 2001-04-06

Publications (1)

Publication Number Publication Date
ATE343591T1 true ATE343591T1 (de) 2006-11-15

Family

ID=23080751

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02764001T ATE343591T1 (de) 2001-04-06 2002-04-08 Antagonist für die multimerisierung von hiv-1 vif-protein

Country Status (8)

Country Link
US (4) US6653443B2 (https=)
EP (1) EP1373308B1 (https=)
JP (1) JP4234999B2 (https=)
AT (1) ATE343591T1 (https=)
AU (1) AU2002307229B2 (https=)
CA (1) CA2442909C (https=)
DE (1) DE60215626T2 (https=)
WO (1) WO2002081504A2 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20030108539A1 (en) * 2000-02-14 2003-06-12 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US7138496B2 (en) * 2002-02-08 2006-11-21 Genetastix Corporation Human monoclonal antibodies against human CXCR4
WO2002068676A2 (en) * 2001-02-27 2002-09-06 University Of Rochester METHODS AND COMPOSITIONS FOR MODIFYING APOLIPOPROTEIN B mRNA EDITING
EP1373308B1 (en) 2001-04-06 2006-10-25 Thomas Jefferson University Antagonist for multimerization of hiv-1 vif protein
DK2093286T3 (da) 2001-10-01 2013-05-13 Dyax Corp Flerkædede, eukaryote displayvektorer og anvendelser deraf
WO2003057725A2 (en) * 2002-01-09 2003-07-17 University Of Lausanne Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US20050123973A1 (en) * 2002-02-08 2005-06-09 Shaobing Hua Methods for generating monoclonal antibody against fusion protein containing peptide fragment derived from membrane protein
EP1575992A4 (en) * 2002-08-05 2007-02-21 Univ Rochester CHEMICAL PROTEINS FROM PROTEIN TRANSDUCATING DOMAIN / DEAMINASE, RELATED COMPOUNDS AND THEIR USES
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
US7220554B2 (en) * 2003-05-23 2007-05-22 Oregon Health And Science University Methods for identifying inhibitors
US20050014137A1 (en) * 2003-07-17 2005-01-20 Agouron Pharmaceuticals, Inc. Lentivirus assay system including Vif protein activity
CA2537798A1 (en) * 2003-09-03 2005-03-17 University Of Rochester Cytidine deaminase activators, deoxycytidine deaminase activators, vif antagonists, and methods of screening for molecules thereof
WO2005047483A2 (en) * 2003-11-12 2005-05-26 Medical Research Council Renta: an hiv immunogen and uses thereof
US8158770B2 (en) * 2004-05-06 2012-04-17 University Of Rochester Content dependent inhibitors of cytidine deaminases and uses thereof
CA2596448A1 (en) 2005-02-11 2006-08-11 University Of Rochester Methods and compositions related to heightened apobec-1 related protein (arp) expression
WO2007031098A1 (en) * 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US8080517B2 (en) * 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
CA2671410C (en) * 2006-12-06 2016-11-22 Thomas Jefferson University Peptide and treatment for hiv-1 infection
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP3124497B1 (en) 2007-09-14 2020-04-15 Adimab, LLC Rationally designed, synthetic antibody libraries and uses therefor
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
WO2009143864A1 (en) * 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
JP5457813B2 (ja) * 2009-12-16 2014-04-02 ルネサスエレクトロニクス株式会社 Ａｄｐｌｌ回路、半導体装置及び携帯情報機器
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
KR102318383B1 (ko) 2010-07-16 2021-10-27 아디맵 엘엘씨 항체 라이브러리
WO2012048721A1 (en) 2010-10-14 2012-04-19 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2014055944A1 (en) * 2012-10-04 2014-04-10 Oyagen, Inc. Small molecules as anti-hiv agents that disrupt vif self-association and methods of use thereof
WO2014210082A2 (en) * 2013-06-24 2014-12-31 Oyagen, Inc. Camptothecin derivatives as anti-hiv agents and methods of identifying agents that disrupt vif self-association
KR20160023669A (ko) 2013-06-26 2016-03-03 자이겐 인플라메이션 리미티드 다양한 질병의 치료를 위한 jnk 신호 전달 경로의 세포 투과성 펩타이드 억제자의 새로운 용도
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
CA3047000A1 (en) 2017-01-04 2018-07-12 Oyagen, Inc. Compounds, compositions, and methods for treating human immunodeficiency virus
EP3678699A1 (en) 2017-09-07 2020-07-15 University Of Oslo Vaccine molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330359A3 (en) * 1988-02-25 1991-06-05 Bio-Rad Laboratories, Inc. Composition useful in the diagnosis and treating of hiv-1 infection
AU7568794A (en) 1993-08-20 1995-03-21 St. Luke's-Roosevelt Hospital Center Hiv (vif)-related compositions, and prophylactic and therapeutic uses thereof
EP0980388A1 (en) 1997-05-20 2000-02-23 YISSUM RESEARCH DEVELOPMENT COMPANY of the Hebrew University of Jerusalem Vif-derived hiv protease inhibitors
EP0959136A1 (en) * 1998-05-20 1999-11-24 Introgene B.V. Targeted delivery through a cationic amino acid transporter
EP1373308B1 (en) 2001-04-06 2006-10-25 Thomas Jefferson University Antagonist for multimerization of hiv-1 vif protein

Also Published As

Publication number Publication date
CA2442909C (en) 2011-11-29
EP1373308A2 (en) 2004-01-02
CA2442909A1 (en) 2002-10-17
US6653443B2 (en) 2003-11-25
US20030013844A1 (en) 2003-01-16
US20040086512A1 (en) 2004-05-06
AU2002307229B2 (en) 2007-05-24
DE60215626T2 (de) 2007-08-30
JP4234999B2 (ja) 2009-03-04
WO2002081504A2 (en) 2002-10-17
EP1373308B1 (en) 2006-10-25
US20040146522A1 (en) 2004-07-29
US20080167199A1 (en) 2008-07-10
JP2005516885A (ja) 2005-06-09
US7226741B2 (en) 2007-06-05
US7498138B2 (en) 2009-03-03
DE60215626D1 (de) 2006-12-07
WO2002081504A3 (en) 2003-04-10

Similar Documents

Publication Publication Date Title
ATE343591T1 (de) Antagonist für die multimerisierung von hiv-1 vif-protein
ES2505144T3 (es) Agentes de unión selectivos antagonistas de proteína de unión de osteoprotegerina
ATE540319T1 (de) Verfahren für die bestimmung von fk506
ATE544870T1 (de) Profilierung einer rezeptorfamilie
WO2007035633A3 (en) Screening assays and methods
EA200901646A1 (ru) Ингибиторы рецепторных тирозинкиназ и их применение
CY1108580T1 (el) Αυτοανοσες παθησεις και ελλειμματα nadph οξειδασης
DE60330893D1 (de) Intrazelluläre antikörper
ATE524561T1 (de) Verfahren zur bestimmung einer allergenreaktion unter verwendung von mikroarray-immunoassay- techniken
DE602004015791D1 (de) Screening-Verfahren zur Identifizierung von Tau-Protein modulierenden Substanzen.
DE602004017884D1 (de) Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren
DK1864131T3 (da) Naturlig ligand af G protein koblet receptor RCC356 og anvendelser deraf
WO2005114219A3 (en) Assays to identify irreversibly binding inhibitors of receptor tyrosine kinases
TW200700089A (en) Recombinant protein comprising starch binding domain and use thereof
ATE466884T1 (de) Holo-transcobalamin bindungspartner und ihre verwendung in cobalamintest
ATE426807T1 (de) Proteomanalyse verfahren zum drogen vergleich
ATE455862T1 (de) Verbesserter rezeptornachweis
ATE331038T1 (de) Verbessertes verfahren für reverses n-hybrid- screening
ATE368750T1 (de) Screening-verfahren zum identifizieren von g- proteinen und anderen verbindungen,die die phosphodiesterase (pde)-aktivität beeinflussen
ATE447610T1 (de) Kristalliner vap-1 und verwendung
ATE412187T1 (de) Screening test
NO20035771L (no) Assays for EPF-reseptorforbindelser samt terapeutiske sammensetninger
DK1294924T3 (da) Kompetitivt assay til identificering af allosteriske inhibitorer
ATE364095T1 (de) Gtp cyclohydrolase ii als ziel für fungizide
ATE403738T1 (de) Verfahren zur identifizierung von agonisten oder antagonisten für den gpr45like/gpr63 rezeptor

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties