ATE335492T1 - Verfahren zur behandlung der ziliardyskinesie mit uridintriphosphaten und verwandten verbindungen - Google Patents
Verfahren zur behandlung der ziliardyskinesie mit uridintriphosphaten und verwandten verbindungenInfo
- Publication number
- ATE335492T1 ATE335492T1 AT97917688T AT97917688T ATE335492T1 AT E335492 T1 ATE335492 T1 AT E335492T1 AT 97917688 T AT97917688 T AT 97917688T AT 97917688 T AT97917688 T AT 97917688T AT E335492 T1 ATE335492 T1 AT E335492T1
- Authority
- AT
- Austria
- Prior art keywords
- ciliary
- spermatozoa
- utp
- impairment
- analog
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 230000001886 ciliary effect Effects 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title 1
- 239000001226 triphosphate Substances 0.000 title 1
- PGAVKCOVUIYSFO-XVFCMESISA-N UTP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-XVFCMESISA-N 0.000 abstract 3
- PGAVKCOVUIYSFO-UHFFFAOYSA-N uridine-triphosphate Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-UHFFFAOYSA-N 0.000 abstract 3
- 230000035559 beat frequency Effects 0.000 abstract 2
- 230000006735 deficit Effects 0.000 abstract 2
- 208000025678 Ciliary Motility disease Diseases 0.000 abstract 1
- 208000003892 Kartagener syndrome Diseases 0.000 abstract 1
- 208000007466 Male Infertility Diseases 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 210000005069 ears Anatomy 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 239000006194 liquid suspension Substances 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 239000007923 nasal drop Substances 0.000 abstract 1
- 229940100662 nasal drops Drugs 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 238000002663 nebulization Methods 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000009266 primary ciliary dyskinesia Diseases 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical class OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62491496A | 1996-03-27 | 1996-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE335492T1 true ATE335492T1 (de) | 2006-09-15 |
Family
ID=24503854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97917688T ATE335492T1 (de) | 1996-03-27 | 1997-03-27 | Verfahren zur behandlung der ziliardyskinesie mit uridintriphosphaten und verwandten verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0889728B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4271730B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1229114C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE335492T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU727314B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2250188C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69736468T2 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ332426A (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997035591A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673779B2 (en) * | 1996-03-27 | 2004-01-06 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues |
| US6420347B1 (en) * | 1997-03-27 | 2002-07-16 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
| US5900407A (en) | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US5789391A (en) * | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5968913A (en) * | 1996-07-03 | 1999-10-19 | Inspire Pharmaceuticals, Inc. | Pharmaceutical compositions of uridine triphosphate |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| US6921755B2 (en) | 1998-02-06 | 2005-07-26 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| US6696425B2 (en) | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| AU747196B2 (en) * | 1997-07-25 | 2002-05-09 | Merck Sharp & Dohme Corp. | Method for large-scale production of di(uridine 5'-tetraphosphate) and salts thereof |
| US6872710B2 (en) | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
| US6420331B1 (en) | 1998-06-10 | 2002-07-16 | Procter & Gamble Company | Detergent compositions comprising a mannanase and a bleach system |
| KR100475008B1 (ko) * | 1998-10-02 | 2005-03-08 | 야마사 쇼유 가부시키가이샤 | 디우리딘 테트라포스페이트 또는 그의 염의 결정 및 그의제조법, 그리고 그 화합물의 제조법 |
| US6576224B1 (en) | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7452870B2 (en) | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
| AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
| JP2005508297A (ja) | 2001-06-25 | 2005-03-31 | インスパイアー ファーマシューティカルズ，インコーポレイティド | Ｐ２ｙプリン受容体作用物質による関節潤滑 |
| MXPA04000654A (es) | 2001-07-27 | 2004-03-19 | Vital Health Sciences Pty Ltd | Terapia dermica usando derivados de fosfato de agente de transferencia de electrones. |
| KR20050043761A (ko) | 2001-11-06 | 2005-05-11 | 인스파이어 파마슈티컬스 인코퍼레이티드 | 염증성 질환의 치료 또는 예방 방법 |
| AU2002350272B1 (en) * | 2001-12-13 | 2003-06-23 | Vital Health Sciences Pty Ltd | Transdermal transport of compounds |
| AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
| WO2005084678A1 (en) | 2004-03-03 | 2005-09-15 | Vital Health Sciences Pty Ltd | Alkaloid formulations |
| US9168216B2 (en) | 2005-06-17 | 2015-10-27 | Vital Health Sciences Pty. Ltd. | Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
| IT1395255B1 (it) * | 2009-07-09 | 2012-09-05 | Mastelli S R L | Composizione per il trattamento di infertilita' maschile |
| US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
| CN102198264B (zh) * | 2010-03-23 | 2013-10-09 | 中国科学院上海生命科学研究院 | 大鼠附睾特异抗菌肽β-防御素15及其用途 |
| CN102821791B (zh) | 2010-03-30 | 2015-06-17 | 磷肌酸有限公司 | 透皮递送贴剂 |
| JP5922111B2 (ja) * | 2010-06-23 | 2016-05-24 | ピーツー−サイエンス・エペイエス | 充血剤注入と同時に血圧測定を行う診断目的の動脈用複合カテーテル |
| EP2685992A4 (en) | 2011-03-15 | 2014-09-10 | Phosphagenics Ltd | AMINOCHINOLINE AS A KINASEHEMMER |
| CN108601732A (zh) | 2015-12-09 | 2018-09-28 | 磷肌酸有限公司 | 药物制剂 |
| US20190330260A1 (en) | 2016-12-21 | 2019-10-31 | Avecho Biotechnology Limited | Process |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1297862A1 (ru) * | 1980-07-03 | 1987-03-23 | Институт цитологии и генетики СО АН СССР | Средства дл лечени пигментной дегенерации сетчатки |
| EP0517573A1 (fr) * | 1991-06-05 | 1992-12-09 | Synthelabo | Compositions pharmaceutiques pour le traitement des affections des voies respiratoires |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| WO1995010287A1 (en) * | 1993-10-15 | 1995-04-20 | Wisconsin Alumni Research Foundation | Substituted purine nucleoside analogs and method for treating endotoxin shock |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US6423694B1 (en) * | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
-
1997
- 1997-03-27 CA CA002250188A patent/CA2250188C/en not_active Expired - Lifetime
- 1997-03-27 EP EP97917688A patent/EP0889728B1/en not_active Expired - Lifetime
- 1997-03-27 AT AT97917688T patent/ATE335492T1/de not_active IP Right Cessation
- 1997-03-27 NZ NZ332426A patent/NZ332426A/xx unknown
- 1997-03-27 CN CNB971942595A patent/CN1229114C/zh not_active Expired - Lifetime
- 1997-03-27 WO PCT/US1997/005101 patent/WO1997035591A2/en not_active Ceased
- 1997-03-27 JP JP53465397A patent/JP4271730B2/ja not_active Expired - Fee Related
- 1997-03-27 AU AU25948/97A patent/AU727314B2/en not_active Expired
- 1997-03-27 DE DE69736468T patent/DE69736468T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4271730B2 (ja) | 2009-06-03 |
| CA2250188A1 (en) | 1997-10-02 |
| EP0889728B1 (en) | 2006-08-09 |
| DE69736468T2 (de) | 2007-03-29 |
| CN1229114C (zh) | 2005-11-30 |
| EP0889728A2 (en) | 1999-01-13 |
| WO1997035591A3 (en) | 1998-01-22 |
| CN1233181A (zh) | 1999-10-27 |
| AU2594897A (en) | 1997-10-17 |
| JP2000507557A (ja) | 2000-06-20 |
| AU727314B2 (en) | 2000-12-07 |
| WO1997035591B1 (en) | 2001-04-26 |
| DE69736468D1 (de) | 2006-09-21 |
| CA2250188C (en) | 2008-12-09 |
| NZ332426A (en) | 2000-09-29 |
| WO1997035591A2 (en) | 1997-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |